Chronic pain places a tremendous burden on both the patient and the healthcare system. The use of opioids to address pain has resulted in negative impacts. As practitioners work to undo the current opioid crisis, options to manage pain need a new approach. Advanced Therapeutics in Pain Medicine offers pioneering approaches to this intransigent problem providing a functional medicine approach toward treating pain. This book is dedicated to the advancement of non-opioid therapeutic options that offer real progress in reaching a future of better pain management. With an emphasis on pathophysiology, chapters review various types of pain and propose comprehensive treatment plans. These include manual therapies, novel pharmacologic and plant-based approaches, hormonal effects on pain pathways, as well as psychological and lifestyle interventions. Features * Written by a multi-discplinary team, the book provides clinicians with multiple non-opioid treatment considerations. * Enables practitioners to shift from a "one size fits all' treatment approach toward individualized patient care. * Includes case studies to help educate the provider on how to implement treatment plans in practice. Written by a team of physicians, pharmacists, psychologists and researchers, this important book offers a much needed step forward in optimizing pain care and benefits practitioners who care for patients experiencing chronic pain.

A comprehensive review of all aspects of hypertension in the elderly using the most current clinical data. Topics range from basic concepts, epidemiology and trials, and evaluation and management, to pharmacologic treatment, special populations, and adherence, all presented with an emphasis on the optimal management of patients. The authors examine in detail the mechanisms of hypertension in the elderly, the lifestyle trials and outcomes trials that were conducted in older persons, as well as the problems of clinical evaluation, secondary hypertension, adherence, and target organ damage. Extensive discussions of pharmacologic therapy detail the role of all the major drug classes.

From its early beginnings in the 1960s, the academic field of biochemistry of exercise has expanded beyond examining and describing metabolic responses to exercise and adaptations to training to include a wide understanding of molecular biology, cell signalling, interorgan communication, stem cell physiology, and a host of other cellular and biochemical mechanisms regulating acute responses and chronic adaptations related to exercise performance, human health/disease, nutrition, and cellular functioning. The Routledge Handbook on Biochemistry of Exercise is the first book to pull together the full depth and breadth of this subject and to update a rapidly expanding field of study with current issues and controversies and a look forward to future research directions. Bringing together many experts and leading scientists, the book emphasizes the current understanding of the underlying metabolic, cellular, genetic, and cell signalling mechanisms associated with physical activity, exercise, training, and athletic performance as they relate to, interact with, and regulate cellular and muscular adaptations and consequent effects on human health/disease, nutrition and weight control, and human performance. With more emphasis than ever on the need to be physically active and the role that being active plays in our overall health from a whole-body level down to the cell, this book makes an important contribution for scholars, medical practitioners, nutritionists, and coaches/trainers working in research and with a wide range of clients. This text is important reading for all students, scholars, and others with an interest in health, nutrition, and exercise/training in general.

This book will interest practitioners and researchers in the food science and nutrition fields, and possibly others with an interest in the interaction between diet and health. There have been considerable advances in scientific techniques in the last few decades and these have been used to examine the composition and applications of traditional cures. Modern science has also seen the investigation of herbs, spices and botanicals beyond their traditional usage. The evidence-based approach that the Editors propose is relatively rare for this type of topic.

This unique volume provides the latest information on secondary metabolites obtained from selected organisms (plants or microorganisms) that have beneficial effects in the treatment of cardiovascular diseases and an ability to offer protection against their progress. A detailed description of their source, chemistry and mechanism of action is provided, together with results of clinical studies. Here, a clear connection is made between chemical structures, in vitro studies and their clinical significance.The topic is extensive and the audience gains an understanding of the medicinal applications of these groups of secondary metabolites that have the potential to improve cardiovascular health. Features: The latest information on secondary metabolites with beneficial effects in the treatment of cardiovascular diseases. Written by an outstanding team of authors, their work provides new insights into the beneficial effects of different components present in well known plant products, evidencing their impressive cardiovascular effects. This volume discusses novel targets to screen for new drugs and the need for data obtained from clinical studies using natural products in order to better analyze the significance of in vitro experimental data. Here the reader will find a unique and timely volume with an international flavor. This book describes the source, chemistry and mechanism of action of natural products with the potential to improve cardiovascular health.

Cardiovascular disease is the leading cause of death in developed countries, but is quickly becoming an epidemic in such well-populated countries as China, India, and other developing nations. Cardiovascular research is the key to the prevention, diagnosis, and management of cardiovascular disease. Vigorous and cross-disciplinary approaches are required for successful card- vascular research. As the boundries between different scientific disciplines, particularly in the life sciences, are weakening and disappearing, a successful investigator needs to be competent in many different areas, including genetics, cell biology, biochemistry, physiology, and structural biology. The newly developed field of molecular medicine is a cross-disciplinary science that seeks to comprehend disease causes and mechanisms at the molecular level, and to apply this basic research to the prevention, diagnosis, and treatment of diseases and disorders. This volume in the Methods in Molecular Medicine series, C- diovascular Disease, provides comprehensive coverage of both basic and the most advanced approaches to the study and characterization of cardiovascular disease. These methods will advance knowledge of the mechanisms, diagnoses, and treatments of cardiovascular disease. Cardiovascular Disease is a timely volume in which the theory and pr- ciples of each method are described in the Introduction section, followed by a detailed description of the materials and equipment needed, and step-by-step protocols for successful execution of the method. A notes section provides advice for potential problems, any modifications, and alternative methods.

This book focuses on established cardiovascular principles and highlights some of the progress achieved by recent research in the cardiovascular field. The authors report the basic concepts related to the functioning of the cardiovascular system necessary for medical students to understand. To foster learning, in each chapter the fundamental points are highlighted in italics and/or bold. In addition, we have added boxes that contain some more detailed information about physiological mechanisms or clinical aspects are analyzed and described in greater detail. The book describes the structure and function of the heart and vascular system for the reader to understand how the cardiovascular system responds in both health and disease. The book conveys a unified vision of the function of the heart and the vascular system, explaining the complexity of the system that goes far beyond the integrated connection between preload, afterload and cardiac contractility. The endothelium covers the internal part of the whole cardiovascular system; therefore, endothelial physiology is treated in several chapters. Given the importance of coronary circulation in cardiac pathophysiology, this special circulation is described in detail and enriched with the most up-to-date information. Several paragraphs and boxes on clinical implications are dedicated to the principles of electrophysiology and the electrocardiogram. A space is also dedicated to myocardial ischemia/reperfusion injury and cardioprotective procedures. The book is written in a linear and simple language without compromising the scientific rigor of the various topics covered.

As our knowledge about arterial disease is greatly expanding, the aim of this book is to explore all aspects of arterial pathology, including classification, clinical manifestations, pathogenesis, and therapeutic options. The discussion of pathophysiologic mechanisms of arterial disease is wide ranging, encompassing hemodynamic, metabolic, humoral, inflammatory, genetic and environmental factors. Particular emphasis is placed on recent concepts, such as: the role of age-associated arterial alterations in the initiation and progression of cardiovascular diseases in older persons, the importance of mineral metabolism-bone vascular interactions, the clinical and prognostic significance of the renal resistive index, retinal circulation, toxemia of pregnancy as an arterial disease, and the role of pulmonary/vascular interaction in pulmonary hypertension and cross-talk of macrocirculation and microcirculation in target organ involvement. Evaluation procedures are carefully explained, and the full range of currently available therapeutic options, including lifestyle modifications and pharmacologic approaches, are described and appraised.

This book comprehensively covers the latest information about ventricular-vascular morphology and function in congenital heart disease (CHD) assessed by various innovative methodologies. Anatomical (morphological) abnormalities in CHD are generally accompanied with abnormal loading conditions, which, in turn, cause ventricular and vascular functional impairments. The functional impairments may also exist independently of the anatomical abnormalities. These two (morphological and functional abnormalities) importantly interact to determine underlying pathophysiology and generate clinical symptoms in CHD. Therefore, detailed and precise assessment of morphology and function is essential to better understand and treat this disease. Recent advances in technology have provided useful tools for this purpose, and novel findings are accumulating. The information contained here will provide researchers and clinicians with invaluable knowledge in this field.

This book provides a comprehensive overview of the author's work which includes significant developments of coronary CT angiography in the diagnosis of coronary plaques. The main contributions of the book lie in the following areas: both 2D and 3D analysis of coronary plaques with coronary CT angiography, diagnostic value of coronary CT angiography with use of different multislice CT scanners, quantitative analysis of coronary plaques in terms of lumen assessment, and bifurcation angle analysis, in particular, the diagnostic performance of coronary CT angiography in calcified plaques, and finally, hemodynamic analysis of plaques with regard to the effects of plaques on coronary blood flow, and CT-derived fractional flow reserve (FFRCT).

"Only once in a great while does a book come along that really does the job in addressing a major medical issue. When this happens, all can be joyful... Readers will find ALL their favorite dietary puzzlements dealt with... With consummate scholarship, clarity and brevity, Truswell sifts out the chaff and identifies the critical questions, the responsible investigators, and the key studies." So says Emeritus Professor Henry Blackburn from the University of Minnesota in the foreword to this remarkable concise book on the history of research on diet and heart disease. This was a theme of scientific, medical and public interest in the 20th Century, a century marked by the rise and fall of coronary heart disease as the major cause of death in the first world, followed by the rise of this cause of death in the developing world. There is obviously much to learn, and this book is an excellent starting point, tracing dietary factors and their role in heart disease one by one: fats, sugar, salt, alcohol, coffee, trans-fats, etc. Without an understanding of the role of diet and the changes that have been seen in the North American and NW European diet, the story of the decline in the heart disease death rate may have been very different.

Bamboo is an ordinary plant with extraordinary properties. With its high growth rate and self-renewing ability, bamboo's sustainability is unparalleled. Bamboo is an important resource for a healthy planet, and its shoots hold manifold nutritional benefits. Based on 18 years of research, Bamboo Shoot: Superfood for Nutrition, Health and Medicine details health-promoting bioactive compounds found in bamboo and offers practical guidance on how this vegetable, bamboo shoot, is used for food fortification. Already a delicacy in many Asian countries, bamboo shoots aid in the prevention of cardiovascular disease, cancer, diabetes, hypertension and obesity. Exploring the tradition and culture of bamboo in Asian countries, this book also provides information on the science behind the nutritional value of bamboo shoots. Written by individuals with expertise in bamboo shoot nutrition and fully illustrated in colour, this book reveals the antioxidant activity of bamboo shoots and discusses the potential for bamboo to be used as an ingredient in functional foods and nutraceuticals. This highly practical book discusses processing and packaging of shoots for long term storage and using bamboo in the development of novel food products. Features: Elucidates the nutrients and phytochemicals in over 30 bamboo species and includes a glossary of scientific names Highlights the nutraceutical and antioxidant properties of bamboo Describes novel healthy food products fortified with bamboo shoots and provides food recipes using bamboo Explains how bamboo can help countries achieve their sustainable development goals, from poverty reduction, food security, improved nutrition and prevention of diseases to climate change mitigation and inclusive green economic development Aimed at professionals in the nutrition and food processing industry, this book appeals to those with an interest in incorporating bamboo into a healthier lifestyle. Endorsements This is a unique book interestingly crafted to highlight the important nutritional, health and medicinal aspects of Bamboo, an area that is greatly underexplored. It will bring awareness that bamboo shoots are a low calorie, high fibre nutritious vegetable packed with vitamins and minerals. - Prof. Cherla Sastry, Founding Director General INBAR and Adjunct Professor, University of Toronto, Canada This book brings a series of answers to all questions related to bamboo as a superfood [and will] enlighten readers how to transform bamboo shoots using either traditional or modern techniques, how to package them and how to use them as a functional and nutraceutical food. It also provides a series of cooking recipes for healthy eating while we enjoy our food. - Ximena Londono, Founder, A Bamboo and Guadua Paradise, Colombia

The Short QT Syndrome (SQTS) is characterized by abbreviated QT intervals on the electrocardiogram, increased risk of cardiac arrhythmias and sudden death. Although several gene mutations have been identified in SQT patients, the role of these mutations in promoting arrhythmogenesis is still not completely understood. Consequently, this thesis employs multidisciplinary approaches to develop a 3D virtual heart, which is then used to elucidate how the short QT syndrome facilitates and maintains ventricular arrhythmias and to determine its effects on ventricular mechanical contraction. The findings in this thesis provide a comprehensive and mechanistic explanation for a number of gene mutations associated with potassium channels in terms of susceptibility to arrhythmia. The multiphysics models developed provide a powerful platform for identifying the root causes of various arrhythmias and investigating therapeutic interventions for these diseases.

The thesis was examined by Prof. Chris Huang of the University of Cambridge, the most authoritative figure in cardiac electrophysiology, who has described the work as outstanding. "

Biochemical parameters represent better, precise, and objective tools toward the assessment of the nutritional status of children in comparison to anthropometric, clinical, and dietary methods. They constitute laboratory tests to estimate the concentration of circulating nutrients in body fluids. Biochemical parameters are suggestive of acute or subclinical conditions when other methods of nutritional assessment fail to interpret the condition. These parameters exhibit substantial variability in their reproducibility. Moreover, these parameters are novel tools in the hands of clinicians for screening of the nutritional status of children. Key Features Covers the latest biochemical parameters for nutritional assessment Updated content is useful for clinicians, nutritionists, and general practitioners A unique and concise treatise covering descriptive and research-based work on a crucial health issue of worldwide prevalence About the Author Anil Gupta, PhD, is the Dean of Research at Desh Bhagat University and Professor and Head, Department of Physiology and Biochemistry at Desh Bhagat Dental College and Hospital, Mandi Gobindgarh, Punjab, India.

"Practical Cardiovascular Hemodynamics" provides an in-depth understanding of waveforms and tracings seen in various disease states as well as pathophysiology behind those findings. Practical issues that are rarely discussed or focused upon in textbooks are highlighted in this book with detailed waveform analysis. Pitfalls in the hemodynamic assessment of valvular diseases, constriction, tamponade, pulmonary hypertension, shunt pathology, congenital heart disease, coronary disease, and right and left ventricular failure are provided.

"Practical Cardiovascular Hemodynamics" also includes case-based and tracingbased self-assessment problems. e reader will learn to identify disease states and waveform subtleties from single tracings or from case studies and will increase skills in interpreting tracings, understanding notches and artifacts, and formulating a diagnosis.

"Practical Cardiovascular Hemodynamics" Features: Complete presentation of basic and advanced hemodynamics Numerous case studies allow the reader to learn real-life application of hemodynamic data in clinical decision making Questions and explanations provides the reader with self-assessment and problem-solving skills 325 illustrations and 25 tables with detailed legends allowing for illustrated learning

Cardiology is an area of great recent triumphs in pharmacological and surgical treatment, yet cardiovascular disease remains the leading cause of death and disability in the industrialized world. Coronary disease, heart failure, stroke and sudden arrhythmic cardiac death challenge both medical practitioners and scientists. With the dawning of the new molecular' era, there is an awakened hope that a more fundamental understanding of biologic processes may eventually lead to new progress in the prevention and treatment of these persistent and seemingly intransigent problems. Molecular Cardiology in Clinical Practice brings together an outstanding panel of experts in cardiovascular disease who have been at the forefront of the application of molecular medicine to cardiology. Its intent is to help bridge the gap between modern medical practice and modern science, in the belief that an understanding of basic principles can lead to new insight into the problems of cardiac patients.

A critical and comprehensive look at current state-of-the-art scientific and translational research being conducted internationally, in academia and industry, to address new ways to provide effective treatment to victims of ischemic and hemorrhagic stroke and other ischemic diseases. Currently stroke can be successfully treated through the administration of a thrombolytic, but the therapeutic window is short and many patients are not able to receive treatment. Only about 30% of patients are "cured" by available treatments. In 5 sections, the proposed volume will explore historical and novel neuroprotection mechanisms and targets, new and combination therapies, as well as clinical trial design for some of the recent bench-side research.

This new title provides a systematic review of complex cases in peripheral vascular interventions (PVI), a minimal invasive endovascular approach to treating peripheral arteries. This increasingly evolving area in interventional therapies offers reduced risk for complications compared to conventional surgery and takes advantage of advanced techniques to treat more complex lesions in severely diseased patients. This book edited by two highly respected professors from the University of Vienna, Medical School describes typical and atypical complex cases for all peripheral vessel areas, and outlines methods to successfully and safely handle these interventions. The text is divided into two sections. The first reviews general aspects on managing complex patients in PVI, and the second discusses complex cases in specific vessel areas, examining the interventions from puncture to closure, head to toe. Each of the chapters in this section is further divided into three parts and provides: An introduction to each vessel, specific information on the complexities of this lesion and the hazards of treatment, and a checklist for readers of recommended equipment when treating this specific vessel area Selected teaching cases, whereby specific vessel areas are described step-by-step A summary of the key issues for the successful and safe treatment of complex lesions in this vessel area. . Complex Cases in Peripheral Vascular Interventions offers readers the opportunity to tap into the knowledge of those working on complex cases in this cutting edge field and receive both theoretical information and practical tips on how to approach specific vascular lesions. This book is a highly recommended read for beginners in endovascular interventions who want to get an impression on the advanced scope of treatment options as well as for experienced interventionists who want t

Ancestral Diets and Nutrition supplies dietary advice based on the study of prehuman and human populations worldwide over the last two million years. This thorough, accessible book uses prehistory and history as a laboratory for testing the health effects of various foods. It examines all food groups by drawing evidence from skeletons and their teeth, middens, and coprolites along with written records where they exist to determine peoples' health and diet. Fully illustrated and grounded in extensive research, this book enhances knowledge about diet, nutrition, and health. It appeals to practitioners in medicine, nutrition, anthropology, biology, chemistry, economics, and history, and those seeking a clear explanation of what humans have eaten across the ages and what we should eat now. Features: Sixteen chapters examine fat, sweeteners, grains, roots and tubers, fruits, vegetables, and animal and plant sources of protein. Integrates information about diet, nutrition, and health from ancient, medieval, modern and current sources, drawing from the natural sciences, social sciences, and humanities. Provides comprehensive coverage based on the study of several hundred sources and the provision of over 2,000 footnotes. Presents practical information to help shape readers' next meal through recommendations of what to eat and what to avoid.

This issue of Cardiac Electrophysiology Clinics, Guest Edited by Drs. Giuseppe Bagliani, Roberto De Ponti, and Fabio Leonelli is dedicated to The Complex World of Cardiac Pre-Excitation: towards Precision Electrocardiology. This is one of four issues selected each year by the series Consulting Editors, Ranjan K. Thakur and Andrea Natale. Topics include, but are not limited to, Anatomy of the AV junction, Pre-excitation, Algorithms to identify accessory pathways location on 12-lead ECG, Pathophysiology of accessory pathways-mediated arrhythmias, Arrhythmias with by-stander accessory pathways, Arrhythmias involving unusual accessory pathways, Sudden cardiac death in patients with ventricular pre-excitation, Clinical approach to symptomatic and asymptomatic patients with ventricular pre-excitation, Methodology of accessory pathway ablation, Ablation of accessory pathways with unusual anatomic location, Ablation of accessory pathways with uncommon electrophysiologic properties, and Ablation in pediatric patients and in association with congenital heart disease.

The topic of heart failure although extensively researched and reported, has several gray areas. This is especially seen in determining strategies for combating advanced heart failure. The global burden of ischemic heart disease is increasing at an alarming rate to almost pandemic proportions. Even in the presence of state-of the art technology for prompt and successful coronary reperfusion, the population progressing to ischemic cardiomyopathy is substantial. The treatment strategies for ischemic cardiomyopathy do not always ensure optimal clinical results, the reasons for which are varied. The proper patient selection is vital as is the tailoring of suitable therapy. The approach is thus multi-pronged, of which surgical ventricular restoration (SVR) has a definite role. Despite various randomized studies like the STICH-hypothesis 2, where there was a huge selection bias, with patients subjected to an erroneous technique of SVR, with inadequate ventricular remodelling assessment. The present need is to understand the unique anatomy of the left ventricle, its function and perturbations with the onset of heart failure, in order to plan therapeutic strategies to restore near normal anatomy and function. A study of the hemodynamics in ischemic cardiomyopathy is essential, as it differs in certain aspects from other causes of heart failure like idiopathic dilated cardiomyopathy and valvular heart diseases. Since information on these aspects are scattered in various scholarly articles, a concise source in the form of a book would be appropriate and useful for both cardiologists and cardiac surgeons. This project represents a concise review of normal and abnormal cardiac anatomy and physiology, the evolution of SVR to EVLPP with validation of near normal ventricular restoration, plus act as a reference guide for cardiac surgeons with interest in SVR.

This book aims to clarify the potential association between frailty and cardiovascular disease in older people. Covering the biological as well as the clinical point of view, it allows researchers and clinicians to discover the significance of this topic. The contributions cover the most important aspects in the potential relationship between frailty and cardiovascular disease. In particular, authoritative authors in this field have clarified the definition and the epidemiology of frailty and cardiovascular disease in older people. A large part of the volume is dedicated to the biological mechanisms of frailty and cardiovascular disease, trying to find those in common between these two conditions. Since this book is dedicated to both researchers and clinicians, we have proposed some chapters to the importance of comprehensive geriatric assessment in the evaluation and treatment of cardiovascular diseases and frailty. In this regard, the importance of geriatric evaluation in cardiac surgery for older people is well covered. Finally, the importance of cardiac rehabilitation and physical exercise is summarized, being, actually, the most important treatments for both frailty and cardiovascular disease. Written by many well-known and widely published experts in their respective fields, this book will appeal to a wide readership such as researchers in the field and clinicians, especially suited in geriatric medicine and cardiology who, every day, face frail older patients.

With a step-by-step method for accurate interpretation of the ECG, this third edition of Rapid ECG Interpretation describes a systematic approach consistent with the changes in cardiology practice over the past decade. All diagnostic ECG criteria are given with relevant and instructive ECGs, providing a quick review or refresher for proficiency tests and for physicians preparing for the ECG section of the Cardiovascular Diseases Board Examination. This edition contains over 320 ECGs and instructive illustrations, including 81 new ECG tracings. Clear and concise 11-step methods are set out in a user-friendly synopsis format.

This issue of Interventional Cardiology Clinics, guest edited by Dr. Hitinder Gurm, will discuss Renal Disease and coronary, peripheral and structural interventions. This issue is one of four selected each year by the series Editor-in-Chief, Dr. Matthew Price. Topics discussed in this issue will include: Contrast induced nephropathy, Pathophysiology of CIN, Implications of Renal disease in patients undergoing peripheral arterial interventions, Implications of renal disease in patients undergoing Structural interventions, Different types of contrast media, Biomarkers of CIN, Pharmacological prophylaxis of CIN, A practical approach to preventing renal complications in the catheterization laboratory, and several other topics.