Written by established researchers, this two-volume publication provides timely, comprehensive and insightful reviews on recent discoveries in the etiology of hypertension. Structural changes of the blood vessels in hypertension in relation to connective tissue, cerebral vessel structure and innervation, smooth muscle cell hypertrophy and/or hyperplasia, and rarefaction of microvessels are discussed.
Also presented are the effects of antihypertensive therapy on vessel structure and function. A unique feature is the inclusion of a chapter on pulmonary vascular changes in pulmonary hypertension, which shows certain changes that are similar to systemic hypertension. This book is of major interest to researchers involved in the study of hypertension and the biology of the blood vessels.

Given current trends toward obesity, sedentary lifestyles, and poor diets, hypertension is increasingly becoming a disease of the young as well as the elderly, affecting about 1 billion people worldwide. Many patients, especially the younger ones, would prefer alternative treatments. While natural remedies have been used for much longer than pharmaceutical-based treatments, few Western physicians are trained in alternative treatments of hypertension. Written by a dual board-certified nephrologist and internist as well as a Harvard-trained doctor of chemistry, Integrative Treatment of Hypertension: A Clinical and Mechanistic Approach offers an alternative approach to treating hypertension, providing sound mechanisms of action and practical implementation advice. The author meticulously analyzes the efficacy of treatments based on data from respected medical journals. The book begins with an introduction to the subject and explains the mechanisms of blood pressure and hypertension, describes common causes of hypertension, and reviews standard medications and their side effects. The author examines alternative methods of treatment, emphasizing mechanisms of action, similarities to standard medications, and practical recommendations for employing these methods. Chapters cover dietary factors in treating hypertension, alternative yet common diets, the efficacy of nonconsumptive methods of treatment, and descriptions of natural supplements in treating hypertension. The book also addresses blood pressure goals and categorizes each standard and alternative method of treatment, suggesting ways of implementing an integrative approach to hypertension treatment. A useful companion to any health care provider, this book presents a unique work that fills a niche within the medical community.

The definitive guide to the clinical and scientific aspects of pulmonary medicine-fully updated with the latest advances in the field Fishman's Pulmonary Diseases and Disorders delivers unparalleled coverage of pulmonary medicine. With 2,000+ photos and illustrations, 60 videos, and 18,000 references, this peerless two-volume resource provides a comprehensive overview of the scientific basis of lung function in healthy people and in those with disease. You'll find detailed coverage of the broad array of diseases and disorders affecting the respiratory system, including obstructive and restrictive diseases, pulmonary vascular disorders, sleep-disordered breathing, lung neoplasms, respiratory infections, and respiratory failure. And you'll learn all the latest advances, including molecular development of the lung, stem cells and respiratory disease, genetics of pulmonary disease and the growth of personalized medicine, technical advances in lung transplantation, and many more. Fishman's Pulmonary Diseases and Disorders provides state-of-the-art coverage of the latest topics in critical care medicine, such as early diagnosis and management of sepsis, multiple organ dysfunction syndrome (MODS), acute respiratory distress syndrome (ARDS), management of agitation and delirium in the ICU, and the newly defined entity of "chronic critical illness" New to this edition: *State-of-the-art reviews of the literature made available online *Expanded editorial team provides new perspectives *References streamlined to include only the latest information in pulmonary clinical medicine *Table of Contents revised to highlight the most important areas of concern for clinicians

As a heart attack survivor, you know that you must do everything within your power to prevent yourself from having another heart attack. The reason is simple; as a heart attack survivor, you are at greater risk of suffering another heart attack, one that could end your life. A Woman's Guide to Heart Attack Recovery provides heart attack survivors with a multi-faceted approach to preventing subsequent heart attacks. First, you need to empower yourself, and the way to do that is to learn as much as you can about your heart, the heart attack treatments you may have undergone, and, if you've only recently had your heart attack, the key steps to recuperation. You also need to know what to do in an emergency in case you experience another heart attack. Many chapters in this book - such as the ones on high blood pressure, diabetes, weight control, diet and exercise - are filled with information on how to achieve these specific goals. A heart attack can be a life-affirming wake-up call and many women find their life afterward to be better than it was before. Many of you will find it to be the impetus you need to make changes towards living a healthier life. A Women's Guide to Heart Attack Recovery is devoted to helping you do just that.

Laboratory studies in hemostasis have traditionally focused on abn- malities of platelet function or the quantitative and qualitative disorders that affect the proteins involved in blood coagulation. However, over the last 10 years there has been an explosion in our understanding of the molecular bases that underlie many of the inherited and acquired disorders of hemostasis. Many of these disorders are now routinely diagnosed and assessed by methods that involve genotypic analysis. Indeed in the late 1990s the distinction between molecular methods for research and for routine diagnosis is becoming incre- ingly blurred. The techniques and approaches that are used in hemostasis are manifold and published in isolation in a variety of publications. The aim, therefore, of this volume Hemostasis and Thrombosis Protocols is to pull together, into a single volume, the variety of techniques that are frequently used in the field of hemostasis. We have targeted this volume at laboratories who wish to move into the field of molecular hemostasis or who may already have some expe- ence in this area but wish to develop new areas of research and diagnosis. The chapters are wide-ranging and hopefully provide a broad overview of the d- fering applications in which these standard techniques can be used. Though the articles may appear relatively specific, the techniques contained within them are applicable to the study of many different disorders and we hope that they provide a series of ideas and concepts well-suited to problem solving.

‘Jauhar weaves his own personal and family story into his history of the heart…very effectively… This gives a certain dramatic tension to the book, as it tells the fascinating and rather wonderful history of cardiology.’ –Henry Marsh, New Statesman

A Mail on Sunday Book of the Year

The heart lies at the centre of life. For cardiologist Sandeep Jauhar it is an obsession.

In this fascinating history he interweaves gripping scenes from the operating theatre with the moving tale of his family’s history of heart problems – from the death of his grandfather to the ominous signs of how he himself might die.

Jauhar looks at the pioneers who risked patients’ lives and their own careers, and confronts the limits of medical technology, arguing that how we live is more important than any device or drug we may invent. Heart is the all-encompassing story of the engine of life.

For centuries the analysis of the heart rhythm has belonged to the foundations of medical art. We know that doctors in ancient Tibet used the interpretation of the heart rate to draw prognostic conclusions-somehow a modern rationale-that deserves further attention. The rapid advancement of science is providing more and more information about the details, but the subatomic resolution of structures hides the risk and the complex procedures are fragmented into static impressions. The same has happened to the ECG. The revolutionary development, acknowledged by the Nobel Prize for Einthoven, ledfromtheanalysisofthedynamicheartratetothestaticanalysisofthe heartstream curve. It is only with the ECG Holter recording over longer periods that the cardiologists rediscovered the old dynamic. With the continuous recording of the heart rate and its periodicity, it became accessible to a new dimension, a dim- sion that requires technically well-de?ned foundations for accurate data coll- tion, detailed knowledge of the electrocardiologic particularities of arrhythmia, and medical knowledge for the translation of the results into a diagnostic synthesis. With the ECG Holter the issue is no longer just to detect an arrhythmia, but also to determine dynamic circumstance in which the critical event occurred. In fact, we investigate the trigger, the event, and the context, and we have to integrate all of that information within the clinical picture, from the pathology right through to the symptom-indeed a multi-dimensional task.

A collection of 200 high quality ECGs (Electrocardiogram's) that cover the entire spectrum of emergency electrocardiography. The first half of the book represents an intermediate level of difficulty and is ideal for residents in training and for the emergency medicine board review. The second half contains more advanced ECGs and will challenge even the most seasoned emergency medicine practitioner. When taken in its entirety, the book contains one of the best collections of ECGs ever assembled, targeted at advancing the ECG interpretation skills of emergency physicians and other acute health care providers.

The ECG is one of the most commonly used investigations in contemporary medicine. Interpretation of the ECG can appear daunting, but it is actually relatively straightforward as long as a systematic approach is taken. Pocket ECGs for Nurses assists with this task by providing a detailed yet readable introduction to ECG interpretation, supplemented by clinical information about how to act based on its findings. The book begins by covering the basics of cardiac anatomy and physiology and how these relate to the ECG. It then guides nurses on how to perform a high-quality ECG recording, interpret it and make sense of common ECG abnormalities. The book also includes a guide to ambulatory and bedside monitoring as well as useful chapter summaries. This pocketbook is an essential reference for the non-specialist who needs to be able to record and perform a basic and safe interpretation of an ECG. Written in plain language with clear explanations, bullet lists and summaries throughout, this handy guide will benefit nurses as well as paramedics and other allied health professionals in recording and reading ECGs.

This book not only discusses clinical applications, but also links HRV to systems biology and theories of complexity. This publication should be interesting for several groups of clinicians and scientists, including cardiologists, anesthesiologists, intensivists and physiologists. Heart Rate Variability is in principle easy and cheap, making it interesting for all kind of hospitals and private practice. The book will be an example of using translational medicine (bench to bedside) where newest theoretical results are linked to newest clinical research.

This book provides an introduction to the principles of both cardiovascular epidemiology and molecular pathophysiology; as a unique aspect, it also outlines and discusses the molecular concepts underlying epidemiological observations. This first volume is focused on the genetic and molecular basis of pathogenesis and the role of environmental factors triggering cardiovascular dysfunctions. The book promotes the use of interdisciplinary approaches in the field of preventive medicine based on recent advances in molecular and cellular pathophysiology. The book offers a valuable resourcefor researchers in basic biomedical fields and clinical scientists alike, as well as guidelines for novel avenues of research in both basic pathophysiology and cardiovascular therapy and prevention."

Cardiovascular and Neurovascular Imaging: Physics and Technology explains the underlying physical and technical principles behind a range of cardiovascular and neurovascular imaging modalities, including radiography, nuclear medicine, ultrasound, and magnetic resonance imaging (MRI). Examining this interdisciplinary branch of medical imaging from academic, clinical, and industrial perspectives, this comprehensive book: Covers each major imaging modality as well as special applications, time-resolved techniques, and image-guided therapies Discusses image quality and accuracy, radiation safety and dosimetry, and image formation and analysis Explores current and future trends in vascular imaging procedures and technologies Featuring chapters authored by field experts, Cardiovascular and Neurovascular Imaging: Physics and Technology combines the latest information on the physics and technology of cardiovascular and neurovascular imaging under one cover, providing students, professionals, and researchers with a single, state-of-the-art reference.

The new edition of the acclaimed reference text on the most critical tool in pediatric cardiology practice Echocardiography in Pediatric and Congenital Heart Disease provides comprehensive guidance on the use of non-invasive ultrasound imaging in the diagnosis and treatment of pediatric cardiac conditions. Written by a team of experts from the world's leading pediatric cardiology centers, this highly-illustrated, full-color reference covers anatomy, pathophysiology, ultrasound physics, laboratory setup, patient preparation and safety, pediatric echocardiogram protocols, quantitative methods of echocardiographic evaluation, and more. Offering a wealth of additional material on state-of-the-art techniques and technologies in echocardiography, the thoroughly revised third edition features entirely new chapters on examination guidelines and standards, quality improvement in the laboratory, perioperative echocardiography, hemodynamic assessment of the neonate, early fetal echocardiography, and multimodality imaging. This edition offers updated and expanded discussion of the latest advances in echocardiography, particularly those related to speckle tracking and 3D echocardiography. An essential resource for all practitioners, instructors, and trainees in the field, Echocardiography in Pediatric and Congenital Heart Disease: Provides up-to-date reference to ultrasound imaging of the hearts of fetuses, children, and adults with both acquired and congenital heart disease Covers the echocardiographic examination of congenital cardiovascular abnormalities before, during, and after treatment Describes quantitative methods of echocardiographic evaluation, including assessment of diastolic function, right ventricular function and assessment of the post-Fontan patient Discusses intraoperative echocardiography, heart disease in pregnancy, and other special techniques and topics Includes more than 1200 high-quality color images as well as a companion website with over 600 video clips Echocardiography in Pediatric and Congenital Heart Disease, Third Edition, remains an essential textbook for cardiac sonographers, pediatric and adult cardiologists, echocardiography nurses and technicians, and adult cardiologists with interest in congenital heart disease.

Management of cardiovascular disease has changed dramatically, and the second edition of "Primary Care Cardiology "provides a comprehensive review of new treatment strategies.

By "e"mphasizing the basic principles critical to understanding and managing heart disease while putting recent developments in the field into perspective, this practical guide also serves as a curriculum for doctors studying for board examinations or re-certification.

Helpful features include:

Over 50 classic cardiovascular diagrams
50 summary tables for quick reference
Concise overview of the vast body of cardiovascular literature
Straightforward, readable tone
Convenient pocket-size for rapid review

Written for primary care physicians, this book is also perfect for physician assistants and nurse practitioners.

The long QT syndrome has become the focus of considerable scientific attention in recent years because of the discovery of several genes responsible for its development. These discoveries have demonstrated the genetic heterogeneity of the syndrome and have given both the clinician and researcher the opportunity to relate phenotypic variants to different genotypes responsible for distinctly different ion channel abnormalities.These analyses - which are comprehensively reviewed and explored here for the first time - are now beginning to suggest treatment strategies specific to each genotype. The full power of such precise diagnosis promises highly targeted and very successful therapy. In the author's own words, there is the progressive realization that behind the surface of an infrequent disease may lie the key to understanding the mechanisms by which modulation of autonomic function may enhance or prevent the occurrence of life-threatening arrhythmias.The aim of the Clinical Approaches to Tachyarryhthmias series is to update the physician, cardiologist, and all those responsible for the the care of patients with cardiac arrhythmias. In this volume, one of the foremost research pioneers in the field provides a clear and comprehensively considered account of this syndrome's history, significance, and exciting current status. Readers will gain a better understanding of why the long QT syndrome has been the focus for numerous theories of arrhythmogenesis, why it has been the test bed for many antiarrhythmic treatments, and why it remains the paradigm for the diagnosis and management of cardiac arrhythmias.

Cardiovascular Pathology, Fifth Edition provides a comprehensive treatise on the pathology of cardiovascular diseases, combining presentations of detailed pathology of cardiovascular diseases coupled with contemporary insights into etiology and pathogenesis. Twenty-two chapters cover general topics, including cardiovascular genetics, heart failure, and transplantation, and specific congenital and acquired cardiovascular diseases, therapeutic interventions, and forensic aspects. New chapters address the scope of practice and training in cardiovascular pathology, with a focus on major diagnostic approaches used in contemporary practice and research in cardiovascular pathology, and a perspective on the field of cardiovascular regenerative medicine linked to the basic pathobiology of cell-based therapy. The book provides a unique combination of details of pathological anatomy essential for pathologists involved in the evaluation of cardiovascular specimens and cardiovascular diseases, and is an excellent reference for anyone interested in the natural history and therapeutic advances in the cardiovascular field.

The Effects of Hypertension chart takes a look at the potential problems associated with high blood pressure. Topics that are covered by graphics and text include damage to the heart, eyes, brain, kidneys and blood vessels, as well as the progression of plaque build-up. Heavy cover stock with protective varnish for durability.

This book provides a balanced presentation of the fundamental principles of cardiovascular biomechanics research, as well as its valuable clinical applications. Pursuing an integrated approach at the interface of the life sciences, physics and engineering, it also includes extensive images to explain the concepts discussed. With a focus on explaining the underlying principles, this book examines the physiology and mechanics of circulation, mechanobiology and the biomechanics of different components of the cardiovascular system, in-vivo techniques, in-vitro techniques, and the medical applications of this research. Written for undergraduate and postgraduate students and including sample problems at the end of each chapter, this interdisciplinary text provides an essential introduction to the topic. It is also an ideal reference text for researchers and clinical practitioners, and will benefit a wide range of students and researchers including engineers, physicists, biologists and clinicians who are interested in the area of cardiovascular biomechanics.

Cardioprotective Natural Products: Promises and Hopes focuses on the recent advances in the research of bioactive natural products with cardioprotective potential against various cardiovascular diseases/disorders. The aim of this book is to underline the promise and future hope in bioactive natural molecules, herbal formulations, natural dietary supplements and related materials in the prevention and cure of cardiovascular diseases in a scientific way.This book, which comprises a variety of about 9 chapters written by active researchers and leading experts, brings together an overview of current discoveries and trends in this field. This volume is also an outstanding source of information with regard to the industrial application of natural products for medicinal purposes. The broad interdisciplinary approach adopted in this book ensures that it is much more interesting to scientists deeply engaged in the research and/or use of bioactive natural products. It will serve not only as a valuable resource for researchers in their own fields to predict promising leads for developing pharmaceuticals to prevent and treat disease manifestations, but will hopefully also motivate young scientists to engage in the dynamic field of natural products research.

The hemostasis laboratory has a vital role in the diagnosis and management of patients with familial and acquired haemorrhagic and thrombotic disorders. Its role in the monitoring of traditional anticoagulant therapy, as well as therapy using new anticoagulants, presents new challenges to the laboratory. This new edition addresses these important issues, as well as international guidelines for testing, the development of international standard materials, management of haemostasis testing from the laboratory to the point-of-care, and molecular genetic testing.

Before Michael I. Handel died his colleagues and students compiled this collection of essays that were written for a conference on strategy held during 2001. The papers address Churchill's views and ideas on war, strategy and realpolitik.

Ultrasound is used to demonstrate and classify numerous vascular diseases and provides a firm basis for deciding the most appropriate interventional treatment. Practical Vascular Ultrasound: An Illustrated Guide delivers a hands-on, practical approach to the diagnosis of vascular disease.

Providing an overview of performing vascular ultrasounds, the physiology of blood flow, and vascular pathology, the book explores the various vascular conditions most investigated through ultrasound. Conditions covered range from extracranial cerebrovascular arterial diseases to chronic venous disease in the lower limbs. For each disorder, the authors discuss:

• Anatomy
• Pathology
• Clinical presentations
• Differential diagnosis
• What doctors need to know for each condition
• Normal findings and criteria for disease as seen by ultrasound
• Comprehensive protocols for scanning
• Ultrasound images and observations that should be collected for best practice reporting

The authors also discuss interventional vascular ultrasound procedures. Using easy-to-read, point-form text, this concise text is enhanced with high-resolution ultrasound images and clear line diagrams. It" "provides a consistent, comprehensive, and professional approach to vascular ultrasound.

There are many modalities available to image the heart and this variety and number of scan types can prove to be daunting to radiologists and cardiologists. In addition, there are the numerous devices, stents, valves and other paraphernalia which are employed in the management of cardiac disease, which need to be recognised and identified when interpreting any of these various scans. Containing 75 challenging clinical cases and illustrated with superb, high quality images, Cardiac Imaging covers a wide range of cardiac imaging problems from basic radiographic cases to more challenging and esoteric cases involving echocardiography, cardiac MRI, cardiac CT and myocardial perfusion imaging. The book uses an accessible format for quick assimilation. It remains an invaluable text for all radiology and cardiology professionals in practice and in training, from hospital-based doctors preparing for higher examinations to established physicians in their continuing professional development.

Rupture of an abdominal aortic aneurysm is one of the leading causes of death. The risk of rupture has been a controversial topic for years and only recently have population-based studies provided better evidence for clinical management.

This book includes material by an internationally renowned group of authorities directed by a prominent vascular surgeon at Mayo Clinic. The contents represent a well-balanced clinical endovascular approach to the exciting area of vascular medicine and surgery.

"We are living in a period of exciting transformation. The message for anyone interested in the treatment of vascular disease is to embrace the new endovascular techniques -- learn them and improve them. This is the beginning of a new era." A. G. Hakaim