This book is a treatise on cardiomyocytes, the most important cell for the contractile function of the heart. There has been significant progress in our understanding of the function-related structure, developmental processes and their determinants, mechanisms of cell cycle regulation, post-natal growth, energy metabolism, and reversible and irreversible response of cardiomyocytes to diverse forms of physiological stress and injury. There is also more clarity on the alterations in the biological mechanisms in cardiomyocytes that lead to pathological states and the changes in the cells that occur secondary to disease conditions. Thanks to these advances in knowledge, there have been great gains in attempts to identify disease biomarkers and therapeutic targets for better management of patients with heart diseases. Possibilities to induce regeneration or proliferation of cardiomyocytes and thus repair and or regenerate the damaged heart are also on the horizon.

Heart disease is currently the leading cause of maternal mortality in developed countries and is expected to increase further due to advanced maternal age and conditions such as type 2 diabetes. Maternal Cardiac Care: A Guide to Managing Pregnant Women with Heart Disease is an up-to-date, multidisciplinary resource for physicians and advanced practice nurses caring for pregnant patients with a variety of preexisting and emerging cardiac issues. Offers comprehensive information on caring for women with heart disease, in an easy-to-follow, quick-access format. Shares knowledge from a multidisciplinary group of experts who are well versed in the team approach needed to treat this high-risk patient population. Includes extensive references for readers who want to delve more deeply into specific subjects. Ideal for obstetricians, internists, cardiologists, critical care specialists, and advanced practice nurses involved in caring for pregnant patients, as well as institutions and departments that need detailed guidance on establishing a maternal cardiac care program. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Nutrition and Sensation, Second Edition continues to explore how sensations unravel the hidden sensory universe which acts to control our appetite and nutritional desires. The sensory influence on food is found everywhere-whether it is the color of soda, the viscosity of maple syrup, or the aroma of chocolate-the sensory experience fuels consumption. This book continues to discuss the impact of olfaction, gustation, retronasal olfaction, vision, vestibular function, hearing, and somatosensory and tactile nature on nutrition. It also focuses on the use of the sensory system to treat nutritional disorders including obesity, with attention to the mechanisms encompassing smell and taste and how this can influence satiety and weight. Nutrition and Sensation, Second Edition provides a deeper understanding of the fascinating link between the sensory system and nutrition.

Surgical Management of Heart Failure brings together the current knowledge on the surgical management of heart failure into one volume. It is designed to have copious illustrations and photographic material that will explain the techniques and surgical management of patients with heart failure in an effective modern format.

It has been known or suspected for centuries that there is an association between mind and emotions and the occurrence of heart disease apd sudden death. During the past fifty years this relationship has become identified with the concept of Stress, a notion developed and popularized by Hans Selye. In recent years there has been an upward surge of interest in stress by scientists in several disciplines and by the general public. Although, books, journal articles, seminars and media programs devoted to stress now abound, the definition, manifestations, mechanisms, and management of stress remain uncertain and controversial. In an attempt to clarify the situation an International Symposium on Stress and Heart Disease was held in Winnipeg, Canada, June 26-29, 1984, and the proceedings form the basis of this book and its companion volume "Patho genesis of Stress-Induced Heart Disease." Although most species which have ever existed are now extinct through countless millenia, the human species has successfully adapted to changing conditions ("stressors") such as ice ages, predators and parasites, wars, famine and plague, and now it is coping with rapidly changing social, economic and political circumstances. Such adaptation occurs at all levels of life- at the molecular level within the cell, at the level of the whole cell, in the groups of cells as organs, in the entire organism or individual, and in some cases, in the society in which the individual lives."

There are over 400 CHD risk factors that need to be evaluated, prevented, and treated. It is crucial that we have tests for early identification, prevention and treatment of CHD and MI. CHD remains the number one cause of morbidity and mortality in the United States. This book discusses not only older traditional risk factors of heart disease, but new considerations including updated genetic material which is state of the art. This book provides a new and detailed explanation of the causes of CHD and MI based on genetics, blood tests, urine tests. vascular tests and cardiac tests. Once this information is understood and applied to the patient the control of CHD risk factors, cardiovascular complications such as MI and heart failure will be improved with fewer adverse effects and lower cost. No other heart book on the market has this updated and extensive data based on published trials and the experience of the author. Chapters are written in an easy- to -understand format and all medical terms are defined for the reader. Tables and figures are provided each chapter to better illustrate what is described in the text, provide concise, understandable, and valuable information. All references are numbered in the text and then listed at the end of each chapter - the references provide additional medical information. Summaries and Key Take Away Points are provided at the end of each chapter. A sources section is listed at the end of the book which lists contact information for the best nutritional supplement companies, lab, and testing companies, as well as other important sources mentioned in the text of the book.

Originally published in 1985, and authored by an epidemiologists, a medical immunologist, a chemist and a clinical psychologist, this books shows that unravelling the links between diet and disease is a very complex task, and while the evidence is strong in many cases, in others if is of doubtful validity. Many of the diseases prevalent in developed countries are discussed here: cancer, arterial heart disease, food allergies and intolerances as well as the impact of diet on mental health.

The Intelligent Heart

Access the power of your heart's intelligence to improve your focus and creativity, elevate your emotional clarity, lower your stress and anxiety levels, strengthen your immune system, promote your body's optimal performance, and slow the aging process.

Calcium sensitizers are a new class of drug which increases the force of contraction of the heart by increasing the calcium sensitivity of contractile proteins. Their development represents the first major innovation in the treatment of heart failure for over 200 years. Unlike other drugs in this area, they do not increase the intracellular calcium concentration and do not have the side effects associated with that mechanism of action. These drugs offer an exciting alternative approach to the treatment of heart failure, and this volume provides an authoritative overview of the physiology, biochemistry, and clinical issues involved. It will be of interest to pharmacologists, research and clinical cardiologists, and physiologists.

A basic understanding of cardiovascular physiology is essential for optimal patient care. This practical book provides a concise tutorial of all the essential aspects of cardiovascular hemodynamics and the techniques used to assess cardiovascular performance. A high-yield reference, this book is replete with figures, tracings, tables, and clinical pearls that reinforce the basic tenets of hemodynamics. From identifying key findings of the patient history and physical exam to correlating hemodynamic tracings with acute clinical presentations, this book arms the reader with the tools necessary to handle any hemodynamic-related situation.

* Includes coverage of treatment plans taking into consideration individual differences in age, health status, and culture * Effectively describes the bidirectional relationship between cardiovascular disease and trauma, ethics, cultural considerations, and personality pathology. * Provides specific instruction about how to navigate the relationship with medical doctors while illustrating the unique ethical challenges or limitations of the health psychologist working with patients, their families, and providers in clinical practice. * Adds the unique contribution of best practices in interacting between the multiple disciplines (e.g. primary care, cardiology, psychologists, and other allied professionals).

During the past decade, remarkable progress has been made in the development of newer drugs to prevent and treat thromboembolic disorders, such as oral direct anti-Xa and anti-IIa antagonists, as well as oral antiplatelet ADP antagonists with rapid onset and offset. In addition, there has been concentrated effort aimed at identifying novel uses of traditional antithrombotic drugs, such as aspirin, heparin, and oral anticoagulants, as well as combinations of agents, such as more than one antiplatelet, antiplatelet with anticoagulant, antiplatelet with or without thrombolytic. Anticoagulants, Antiplatelets, and Thrombolytics, Second Edition provides updates on various strategies in thrombosis, experimental models, and clinical and recent advances in the discovery and development of novel antithrombotics. As a volume in the highly successful Methods in Molecular Biology(TM) series, this collection provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Easy to use and up to date, Anticoagulants, Antiplatelets, and Thrombolytics, Second Edition is an ideal guide for researchers aiming for the future of this vital field, focusing on the prevention of thromboembolic disorders and the protection of the vascular endothelium.

This book highlights the multifaceted roles of Reactive Oxygen Species (ROS) in modulating normal cellular and molecular mechanisms during the development of different types of heart disease. Each chapter in the book deals with the role that altered redox homeostasis plays in the pathophysiology of heart disease. In addition, the book explains how reactive oxidant species interact with their targets and provides novel strategies for attenuating oxidative stress-induced types of heart disease. The book not only covers ROS-induced response in heart disease at the cellular level, but also demonstrates that an imbalance of redox states has its roots in our genes, and explains the ways gene expression is regulated. In turn, it reviews potential sources of ROS, their pathological effects on the heart, and potential sites for therapeutic interventions.

BL The first book devoted to human baroreflexes A comprehensive review of baroreflex involvement in human diseases, this book places the most recent understanding of human physiology solidly in the context of knowledge from animals. This book secures a place for human studies in the understanding of baroreflex physiology and pathophysiology and celebrates the advances made. By describing clearly the existing deficiencies in the understanding of baroreflex mechanisms, it points a way for future research in this exciting and important area of medical science. Nerve endings in the walls of the carotid sinuses and the aortic arch transduce arterial pressure changes and provide the central nervous system with a steady stream of encoded information. On the basis of this information, efferent autonomic neural activity is modulated finely, and the neurohumoral milieu of the heart and blood vessels is adjusted on a second-to-second basis. The arterial baroreflex may be the most important of the cardiovascular control mechanisms, because the baroreflex, above all other reflex mechanisms is the one whose speed is most adequate to respond rapidly to the abrupt transients of arterial pressure that occur in daily life. This book will help to fix a place for human studies in the understanding of baroreflex physiology and pathophysiology. It is intended as a celebration of the advances that have been made and, by describing clearly the existing deficiencies in the understanding of baroreflex mechanisms, it points a way for future research in this exciting and important area of medical science.

This text serves as a convenient one-stop resource on the pathogenesis, diagnosis and treatment of kidney diseases in context of advanced heart failure and presence of ventricular assist devices. Advances in managing heart failure, evidence-based practices and therapies are covered, along with the management of this unique and complex subset of patients. The book also provides insights into combined heart and kidney transplantation. Authored by leaders in nephrology, cardiology and transplantation, this book fills a critical knowledge gap in understanding and treating patients with acute or chronic dysfunction of the heart and kidneys and how one induces dysfunction in the other organ.

Despite 40 years of aggressive pharmaceutical and surgical interventions, coronary artery disease remains the number one killer of women and men in Western civilization. Cardiovascular disease, more than ever, demonstrates the landscape has changed so significantly, that new information must be given to the young and old health professionals seeing patients on a day to day basis. Dr. Sinatra has 40 plus years of experience in cardiovascular disease and is board-certified in internal medicine and cardiology. Dr. Mark Houston practices integrative nutritional preventive cardiology and has superb expertise in hypertension, and dyslipidemia which are major factors in the genesis of cardiovascular disease. The information in this book will give doctors-to-be, and even doctors-that-are the overlooked information they need for a balanced approach to cardiovascular treatment that includes a healing/healthy diet, nutritional supplementation, exercise and weight management. Those are crucial and powerful additions to the toolbox with which to maintain health and fix problems. That's the integrative approach that Dr. Sinatra, Dr Houston and his fellow authors, have been using with great success for decades. The Table of Contents shows a true revision - all new material - this is more of a companion volume to the original edition.

In order to become a registered dietitian starting in January 2024, candidates will have to obtain a graduate degree from the present requirement of a bachelor's degree. Currently in the United States, there are ~ 3,000 dietitians graduating each year. While some of these candidates will choose other graduate pathways such as Food Science or an MBA, the vast majority will likely obtain a graduate degree of Masters of Science in Nutrition and Dietetics. An anticipated 2,000 dietitians per year will enroll in a graduate degree program that will in turn expect them to take in course in pediatric nutrition. Chapter design in ADIME format (see standard blurb) will prepare individuals on how to document a pediatric assessment. This book is written by practicing experts in the field and will represent presence throughout the United States. While this book is written to fulfil needs of the dietetic student population, it serves as a resource for the practicing pediatric dietitian.

This book explains in detail the potential value of the hybrid modalities, SPECT-CT and PET-CT, in the imaging of cardiac innervation in a wide range of conditions and diseases, including ischemic heart disease, diabetes mellitus, heart failure, amyloidosis, heart transplantation, and ventricular arrhythmias. Imaging of the brain-heart axis in neurodegenerative disease and stress and of cardiotoxicity is also discussed. The roles of the various available tracers are fully considered, and individual chapters address radiopharmaceutical development under GMP, imaging physics, and kinetic modeling software. Highly relevant background information is included on the autonomic nervous system of the heart and its pathophysiology, and in addition future perspectives are discussed. Awareness of the importance of autonomic innervation of the heart for the optimal management of cardiac patients is growing, and there is an evident need for objective measurement techniques or imaging modalities. In this context, Autonomic Innervation of the Heart will be of wide interest to clinicians, researchers, and industry.

This text is an especially timely new text as the number of studies focusing on the impact of the Mediterranean diet on disease prevention increases every year. The fundamental question addressed in this text is how food components and behavior of the Mediterranean diet reduce the risk of chronic diseases. In-depth chapters provide an overview of preclinical and clinical studies on Mediterranean dietary patterns, food components and lifestyle and their impact on health and disease. Large-scale "omic" approaches are highlighted to educate the reader about the molecular mechanisms through which specific components of the Mediterranean diet improves health and the opportunities and challenges for translating into practice the food recommendations of the Mediterranean pyramid. The volume concludes with information about the nutritional adequacy of Mediterranean foods and provides selected recipes. Mediterranean Diet: Impact on Health and Disease will be of great interest to students, clinicians, and scientists engaged in promoting health through nutrition and physical activity.

This book provides a concise yet comprehensive review of the morphological, biochemical, electrical, mechanical, and metabolic properties of vascular smooth muscle, the regulation of vascular activities and the intracellular signaling involved. It particularly focuses on newly identified vasoactive agents, enzymes and transduction mechanisms. It also discusses the latest findings in the regulation of cerebral, coronary and pulmonary circulation as well as vascular activity under hypoxia and ageing. The second edition intends to update the contents of the first edition with the latest achievements in the regulation of vascular activities from biochemical, structural, genetic, physiological, and pharmacological aspects. In addition, two new chapters related to microRNA and extracellular vesicles have been added to reflect their newly discovered important roles in vascular activities. The contraction and dilatation activities of vasculature are of fundamental importance for maintaining circulation homeostasis and adapting to physiological changes. Over the last four decades, there have been significant advances in our understanding of the biochemical, structural, genetic, physiological, and pharmacological aspects of vascular activity regulation, and these insights into the responsiveness of blood vessels under normal and pathophysiological conditions help to provide valuable weapons in the fight vascular diseases. The book is of interest to researchers and graduate students, both in basic research and in clinic settings, in the field of vascular biology.

This new edition is devoted to a broad array of topics involving the circadian variation in cardiovascular diseases, with focuses on hypertension, stroke, and coronary disease. The volume covers clinical and device research related to home and ambulatory BP monitoring, as there have been significant advances in technology since the publication of the previous edition. In addition, there is an increased focus on the applicability of home and ambulatory BP monitoring in drug development in all therapeutic arenas. The text features contributions from chapter authors from around the world and who have great expertise in cardiovascular medicine, therapeutics, clinical trials, and evidence-based medicine. Blood Pressure Monitoring in Cardiovascular Medicine and Therapeutics, Third Edition is essential reading for a large audience, including those practicing cardiology and nephrology with a special focus in hypertension, geriatrics and internal medicine, clinical trialists, regulators in the US, Europe, and Japan, and physicians in training in cardiology, hypertension, pharmacology, nephrology and neurology.

Endocrinology, and diabetes care in particular, is a dynamic field where clinicians must translate new evidence into clinical practice at a rapid pace. Designed in an engaging, case-based format, Endocrinology and Diabetes: A Problem Oriented Approach offers a wide range of thought-provoking case studies that reflect contemporary, challenging, hands-on clinical care. Further, by providing a list of specific clinical problems, this format offers the reader a more convenient and pointed way to solve precise clinical problems in a timely manner. Developed by a renowned, international group of experts, this comprehensive title covers the most common clinical problems in endocrinology and diabetes and should be of great interest to endocrinologists, diabetologists, internal medicine physicians, family physicians, fellows, and residents.

Translational Cardiology: Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques provides an up-to-date introduction to the role circadian rhythms, cardiac plasticity, and mechanotransduction play in the heart, while at the same time introducing new developments in cellular, viral, and non-biologic therapies that are in the process of being developed. Importantly, the focus of this book is on topics that, due to their novelty, are largely not covered in the other major textbooks. A special emphasis is placed on the molecular basis of cardiac metabolism, new concepts in cardiac remodeling, and translational therapies and imaging techniques currently under development for clinical use. The chapters are written by experts from diverse clinical and biomedical research backgrounds. Translational Cardiology: Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques simplifies the complexity of the molecular basis of disease by focusing on patient-oriented disease mechanisms and therapies and is of great value to a broad audience including physicians (e.g. cardiologists, cardiovascular surgeons, pathologists) as well as translational biomedical researchers in a wide range of disciplines.