This issue of Cardiac Electrophysiology Clinics, edited by Drs. Ravi Mandapati, Kalyanam Shivkumar, and Seshadri Balaji, will cover the latest in Cardiac Arrhythmias in Adults with Congenital Heart Disease. Topics covered in this issue include, but are not limited to Brady arrhythmia; Supraventricular Tachycardia in Adult Congenital Heart Disease; Atrial defects, Ebsteins; Drug therapy; Devices; and Surgery.

An international team of experts critically review the recent progress in basic and applied research in angiogenesis. Their cutting-edge discussion ranges from the stimulation and repression of angiogenesis to the discovery of novel targets and the use angiotherapy in the clinic. They also detail the fundamental concepts in the physiology and pathophysiology of angiogenesis and evaluate the potential of angiotherapy in the management of angiogenic disease, highlighting some of the angiogenics and antiangiogenics both in development and in clinical trials.

This issue of the Heart Failure Clinics of North America, guest edited by Drs. Daniel Lenihan and Douglas Sawyer, will cover several aspects of Cardio-oncology Related to Heart Failure. Subjects discussed in the volume include, but are not limited to: Proteasome Inhibitors as a potential cause of Heart Failure; EGFR target based therapy; Amyloidosis; How to manage Heart Failure in a patient with cancer; Advanced HF/Txp; Epidemiology and common risk factors; Pediatric Considerations; Alternative biomarkers for combined biology; How to develop a Cardio-Oncology Clinic; and How to structure a Cardio-Oncology fellowship program, among others.

Alpha-1-antitrypsin Deficiency: Biology, Diagnosis, Clinical Significance, and Emerging Therapies is the authoritative reference on AATD, providing standards for diagnosis, monitoring, treatment and appropriate avenues of research. The book covers the disease from basic biology and epidemiology, to clinical impact, and includes the understanding of the natural history of the disease and the significant advances that have been made in the last 20 years, including the three-dimensional structure of the molecule, its broad biological activity and improved therapeutic options, including replacement therapy and gene therapy. The editors have recruited international experts in the field to contribute evidence-based chapters and insights on future developments in the understanding of this disease.

This issue of Interventional Cardiology Clinics, guest edited by Dr. Ehrin Armstrong, will cover a wide variety of aspects of Endovascular Treatment of PAD and Critical Limb Ischemia. Topics covered in the issue include, but are not limited to: Current Status and Outcomes of Iliac Artery Endovascular Intervention; Current Endovascular Management of Acute Limb Ischemia; Mechanisms Underlying Drug Delivery to Peripheral Arteries; Biological Mechanisms of Restenosis After Endovascular Intervention; Drug Coated Balloons; Current Role of Atherectomy for Treatment of Femoropopliteal and Infrapopliteal Disease; Inframalleolar Intervention and Extreme Access for Limb Preservation; and Emerging and Future Therapeutic Options for Femoropopliteal and Infrapopliteal Endovascular Intervention, among others.

Covering the full spectrum of CHD from infants through adults, Perloff's Clinical Recognition of Congenital Heart Disease, 7th Edition, provides unparalleled guidance on the diagnosis and treatment of common and uncommon CHD in one definitive resource. The editors of this new edition, Drs. Ariane J. Marelli and Jamil A. Aboulhosn, have maintained Dr. Joseph Perloff's richly nuanced approach while bringing this classic text completely up to date with all the latest evidence and technologic advances in the field. With its comprehensive, step-by-step approach, you'll acquire a structured understanding of CHD across age ranges, allowing you to effectively detect these conditions as early as possible.NEW in the 7th Edition: Updated images throughout, as well as phonocardiograms, electrocardiograms, flow charts, and anatomic drawings Specific, integrated findings for individual patients with Dr Perloff's classic approach to diagnosis and treatment Streamlined review of sequelae and complications Historical Notes at the beginning of each chapter Tips on selecting among the increasing array of currently available procedures, helping foster and develop clinical judgment skills Update on genetic contributions to clinical recognition for a more complete presentation of patient diagnosis. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

The Cardiovascular System: Design, Control and Function, Volume 36A, a two- volume set, not only provides comprehensive coverage of the current knowledge in this very active and growing field of research, but also highlights the diversity in cardiovascular morphology and function and the anatomical and physiological plasticity shown by fish taxa that are faced with various abiotic and biotic challenges. Updated topics in this important work include chapters on Heart Morphology and Anatomy, Cardiomyocyte Morphology and Physiology, Electrical Excitability of the Fish Heart, Cardiac Energy Metabolism, Heart Physiology and Function, Hormonal and Intrinsic Biochemical Control of Cardiac Function, and Vascular Anatomy and Morphology. In addition, chapters integrate molecular and cellular data with the growing body of knowledge on heart and in vivo cardiovascular function, and as a result, provide insights into some of the most important questions that still need to be answered.

Profound mortality rates, due to cardiovascular disease, are a worldwide problem. Cardiovascular disease results from complications of a silent and chronic arterial disease: atherosclerosis. The challenge for the practitioner is adapting diagnostic and therapeutic responses to prevent this common and complex disease. Dyslipidemia, are disorders of the metabolism of soluble transporters of lipids in extracellular spaces of the human body (including blood), called lipoproteins. They are major cardiovascular risk factors, causally related with atherosclerosis and are themselves multifactorial diseases, resulting from interactions between genetic and environmental factors. The study of genetic factors has recently taken a new path with the study of DNA as an experimental object. More than fifty genes of lipoprotein metabolism have been identified in both their physiological actions and their contribution to the pathogenesis of human dyslipidemia. The diversity of observations has refined our current knowledge of the control of lipid metabolism and energy homeostasis in living organisms beyond the limits of the cardiovascular system (e.g., brain, immune system, and development). These studies have given way to a shake-up of former phenotypic classifications, distinguishing new entities, defining targeted therapeutic strategies, providing a basis for different patterns of disease distribution in human populations.

Surgical Treatment of Atrial Fibrillation: A Comprehensive Guide to Performing the Cox-Maze IV Procedure is the first all-inclusive description of this rapidly growing surgery, setting the standard in the field. The Cox-Maze IV procedure is a complex surgery, and its success depends critically on correct execution. With FDA approval, the first RF ablation device for treatment of the Cox-Maze IV procedure has become more important than ever to combine scientific information for the procedure with its connection to human application. This comprehensive text provides step-by-step instructions from an experienced Cox-Maze IV surgeon and is written in the style of a mentor advising his mentee in the operating room. It contains over a dozen lessons described in detail, with illustrations, photographs and a discussion of possible complications and appropriate ways to deal with them. Additionally, the book describes sequencing for the surgeries that are typically performed concomitant with the Cox-Maze IV procedure, determining the optimal way to combine surgeries. Cardiac surgeons, fellows in cardiac surgery, medical students inclined toward cardiac surgery and cardiology researchers will find this book to be of great importance to their work.

Dietary Fiber for the Prevention of Cardiovascular Disease: Fiber's Interaction between Gut Micoflora, Sugar Metabolism, Weight Control and Cardiovascular Health compiles the most up-to-date research discoveries to provide a timely and scientific rationale for the significant impact of a fiber rich diet for the prevention of heart disease. By focusing on the science behind how fiber, both soluble and insoluble can lead to lower rates of heart disease, this important reference will educate researchers, cardiologists, medical providers and students on how to improve patients' hearts via a fiber rich diet. Coverage includes the known mechanisms of how fiber works to reduce insulin resistance, control weight, reduce cholesterol by binding with bile, maintain stable glucose levels and influence gut microflora.

This issue of Medical Clinics, guest edited by Dr. Edward Frohlich, is devoted to Hypertension. Articles in this outstanding issue include The Kidney in Hypertension; Heart: Fibrosis, Apoptosis, and Cardiac Failure; Myocardial Ischemia; Oxidative Stress and Hypertensive Diseases; Adherence to Antihypertensive Therapy; Aging and Hypertension; Target Organs and Microbiological Considerations in Hypertensive Diseases; Obesity and Sodium Considerations; Diabetes, Hypertension and Cardiorenal Syndrome; Renal Arterial Disease; Cardiac Transplantation and Hypertensive Diseases; Cardiac Failure: Old and New Challenges; Diastolic Dysfunction and Hypertension; Stiffening of Large Arteries; Genetics and Mechanisms; New Guidelines for Hypertensive Diseases; and Local Renin Angiotensin Systems.

This issue of Cardiology Clinics, edited by Drs. Kenneth Jamerson and Brian Byrd will cover the current consensus on Hypertension, from Pre-Hypertension to Heart Failure. Topics covered in this issue include: genomic approaches to hypertension; drug and non-drug therapeutic approaches for pre-hypertension; air pollution and hypertension; social determinants of cardiovascular health; management of essential hypertension; devices; blood pressure management; systolic and diastolic failure; and contemporary approaches to heart failure.

The latest developments in the field of Cardiac Resynchronization Therapy are featured in this issue of Heart Failure Clinics. Edited by Drs. Luigi Padeletti, Martina Nesti, and Giuseppe Boriani, the issue includes more than 20 articles in the following areas: heart failure; cost of heart failure; ventricular dissynchrony and resynchronization; assessment of dissynchrony; indication for CRT implantation; implantation technique; measures to improve CRT benefit on AF patients; and many more.

This issue of Interventional Cardiology Clinics, edited by Drs. Dominick Angiolillo and Matthew Price, will focus on Antiplatelet and Anticoagulation Therapy in PCI. The topics covered in this volume will span across pretreatment with antiplatelet agents; optimal duration of antiplatelet therapy after PCI; Cangrelor and its role in percutaneous coronary intervention; Ticagrelor and its effects beyond the P2Y12 receptor; dyspnea and Reversibly-binding P2Y12 antagonists; PAR receptor inhibition post-PCI; switching P2Y12 receptor inhibiting therapies; antiplatelet and antithrombotic therapy in patients with atrial fibrillation undergoing coronary stenting; antithrombotic therapy to reduce ischemic events in ACS patients undergoing PCI; and the current role of platelet function testing in PCI and CABG, among other topics.

Clinical Cardio-oncology is a comprehensive, clinically focused title for cardiologists, oncologists, and specialists in cardio-oncology programs who need up-to-date knowledge about the cardiovascular effects of cancer treatment, especially on long-term cancer survivors. This brand-new resource covers the implementation of cardio-oncology into your practice, while a strong focus on patient management offers helpful information on coordinating care before, during, and after therapy. Its highly organized four-section format allows readers to quickly and easily locate relevant information. Comprised of four sections for quick and easy reference: Oncology and Hematology Principles; Cardiac Complications from Cancer Therapy; Coordination of Care; and Cardio-oncology in Practice. Includes online case studies focused on the structure and implementation of cardio-oncology care. Provides expert wisdom from cardio-oncology authorities around the world, as well as consultation and perspectives from pioneers in the field of oncology. Highlights the principles of cancer therapies, including radiation and tumor therapy, as well as pre-, intra-, and post-therapy cardiology evaluation. Boasts chapters on implementing cardio-oncology into practice: primary cancer centers, comprehensive referral centers, group practices, and educational needs and goals for fellowship programs. Advises on how to coordinate care for the patient at every stage of treatment (pre-therapy, during therapy, after therapy, and end-of-life). Presents detailed information on various cardiac complications from cancer therapy, such as cardiomyopathy, vascular disease, arrhythmias, and hypertension. Teaches the principles of oncology and hematology with coverage of different therapy types and cardiac tumors. Includes a comprehensive drug guide. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, and references from the book on a variety of devices.

This issue of the Heart Failure Clinics, edited by Drs. Eduardo Bossone and Raimund Erbel, will cover the current consensus on Takotsubo (Stress) Cardiomyopathy. Topics covered will include the influence of age and gender on TTS; current concepts in pathophysiology; the clinician's approach to TTS; imaging; genetics; and international perspectives, among other topics.

This issue of Interventional Cardiology Clinics, guest edited by Dr. Timothy Henry, will cover controversies in the management of STEMI. Topics discussed in this issue include: Systems of care; false positive activation; time to treatment; in hospital STEMI; optimal antiplatelet; advanced cardiogenic shock; out of hospital cardiac arrest; and global challenges, among other topics.

This issue of Cardiology Clinics on Sports Cardiology, edited by Drs. Aaron Baggish and Andre La Gerche, will cover a variety of aspects related to cardiovascular health and complications related to athletic activity. Topics covered in this issue include, but are not limited to, molecular aspects of exercise-induced cardiac remodeling; sudden cardiac death; atrial fibrillation in endurance athletes; congenital heart disease in athletes; exercise prescription for the athlete with cardiomyopathy; and advanced exercise testing for the sports cardiologist.

Atherogenesis: Lipid Accumulation and Plaque Disruption: Processes Triggering Clinical Instability in Coronary Disease-An Overview; B.G. Brown. Expression of 92 kDa Gelatinase in Human Atherosclerotic Lesions Following Recent Plaque Rupture; D.L. Brown. Atherogenic Lipoproteins: Current Concepts of the Plasma Lipoproteins and Their Role in Atherosclerosis-An Overview; H.B. Brewer, Jr. Homeostasis of Lipid Oxidation in the Artery Wall; A.M. Fogelman, et al. Antiatherogenesis/Cholesterol Removal Mechanisms: The Role of HDL Receptors in Removal of Cellular Cholesterol; J.F. Oram, et al. Signal Transduction in Vascular Proliferation: Identification of FGF1-Inducible Genes by Differential Display; J.A. Winkles, et al. Adhesion Pathobiology: Molecular Basis and Pathological Consequences of Neutrophil Adherence to Endothelium; J.M. Harlan, et al. Thrombosis/Fibrinolysis: Regulation of Vascular Fibrinolysis by Type 1 Plasminogen Activator Inhibitor (PAI1): D. Seiffert, et al. Modified Gene Expression/Clues to Cause, Prevention, and Treatment of Atherosclerosis: Genetic Factors Contributing to Atherosclerosis: From Humans to Mice and Back Again; C.H. Warden, A.J. Lusis. Atherosclerosis Prevention and Public Policy: Cholesterol and Mortality: What Can Metaanalysis Tell Us? D.J. Gordon. 35 additional articles. Index.

Poor diet and substandard nutrition are underlying causes of many diseases including cardiovascular disease, diabetes, and cancer. Collectively, these ailments are the leading causes of premature death, most of which are preventable. Cooking for Health and Disease Prevention: From the Kitchen to the Clinic helps demonstrate cooking as a fundamental bridge between ideal nutrition and long-term health. Clinicians, patients, and the public often lack adequate knowledge to help select and prepare foods for optimal disease management. This book provides information to clinicians and their patients about foods and cooking principles to help prevent common health conditions. Features: Focuses on disease endpoints, reviewing the disease biology and epidemiology and presenting dietary interventions for disease prevention. Provides recommendations for translating dietary and culinary principles of health prevention into clinical practice and includes a recipe appendix with practical examples. Features information on healthy cooking techniques as well as food selection, storage, and preparation to help maximize nutritional value. Introduces the reader to fundamental concepts in nutrition and culinary principles explaining the relationship between food processing and food preparation and nutritional quality of foods. This book is accessible to patients and offers evidence-based practical interventions for healthcare professionals. It is authored by Nicole Farmer, physician scientist at the NIH Clinical Center, and nutrition researcher Andres Ardisson Korat, awarded a doctorate degree in nutrition and epidemiology from the Harvard T.H. Chan School of Public Health.

This issue of the Cardiac Electrophysiology, edited by Dr. Masood Akhtar, will cover the physiological and pathological aspects of the His-Purkinje System in depth. This content will be supported by a variety of clinical cases that explore various aspects of and issues encountered involving the His-Purkinje System compliment the pathology and physiology.

The Royal College of Emergency Medicine (RCEM) has implemented a new 2021 curriculum, with a new Single Best Answer (SBA) paper for the fellowship examination. Featuring 200 Single Best Answer questions and answers, this text is the first on the market to help prepare for this new examination. Mapped to the curriculum, this book covers core areas such as cardiology, environmental emergencies, mental health, toxicology, trauma, resuscitation and quality improvement. All of the answers are fully referenced to up-to-date guidelines and research, to allow for further reading. This is an essential text for postgraduate doctors in Emergency Medicine studying for the Fellowship of the Royal College of Emergency Medicine (FRCEM) SBA examination.

Transcatheter Valve Repair discusses all aspects related to percutaneous and established valve repair methods. The book is divided into few major sections covering all four valves and other topics. Each section contains several chapters discussing everything related to that valve. Beginning with the pulmonary valve, since it was the first valve to be tackled in the catheterization laboratory, and then moving to the aortic, then the mitral and then finally end with the tricuspid valve. 1.5M US citizens alone have some degree of aortic valve stenosis, with half (750K) requiring aortic valve replacement. Aortic valve replacement, on the whole, is performed by surgeons, requiring bypass machines and technicians, as well as the usual operating team. The operation is expensive and occupies a considerable amount of operating room time. Mostly, the aortic valve is calcified and the usual option available to patients is valve replacement with a variety of choices, ranging from porcine valves to synthetic, for which there are many manufacturers. It should be noted that the aortic valve is the most problematic of valves. Percutaneous procedures are the answer. The bottom line is that given the growing elderly population, many more patients will require valve repair, thus increasing health care costs with not only surgical operations but also hospitalisation. Percutanous valve repair, whilst requiring a cath lab team, does not involve bypass machines nor extended hospitalisation. Like percutaneous transluminal coronary artery interventions (PTCA) has replaced coronary artery bypass grafts (once the golden standard), and now stenting having replaced PTCA and its balloons. We now see drug eluting stents replacing ordinary stents (though at a much higher cost. There will be a huge movement toward percutanous valve repair, which should presumably cut costs but also morbidity and mortality.