M. Gabriel Khan, MD, concisely assembles in a reader friendly format all the clinically useful information that an internist needs in both his daily rounds and abusy office practice to find correct clinical diagnoses and choose optimal pharmacologic therapies for their patients. Highlights include a simplified method for recognition of, and a practical therapeutic approach to, arrhythmias, as well as a more logical approach to drug management of hypertension than that given by the Joint National Committee, instructive algorithms that simplify the diagnosis and treatment of syncope, and extensive diagnostic information on hypertrophic cardiomyopathy. A large number of illustrative electrocardiograms that help to clarify the most often misinterpreted of all cardiologic tests and extensive discussions of practical cardiovascular pharmacology complete this magisterial survey.

The fibroblast growth factor (FGF) family of ligands and the corresponding family of FGF receptor tyrosine kinases comprise one of the most versatile and diverse growth factor signaling families in vertebrates, found virtually in every tissue and cell type where they regulate metabolic and physiologic function, maintain tissue homeostasis, and mediate injury response, tissue repair, and regeneration. As a result, FGFs play critical roles in a wide variety of normal biological and abnormalities in FGF signaling can lead to a variety of disease states from developmental malformations, to atherosclerosis, pulmonary hypertension and cancer among many others. A thorough understanding of this system is necessary for critical insights into both normal and disease biology and is essential to development of rationale therapeutic strategies aimed at treatment of FGF-dependent diseases states.Recent years have seen advances in our understanding of FGFs role in endothelial and, more general, vascular biology, the subject of this book. In particular, FGFs have been implicated in the maintenance of vascular homeostasis and control of blood vessel permeability while aberrant FGF signaling has been shown to be central to the development of pulmonary hypertension, and endothelial-to-mesenchymal transition, a process implicated in the development of atherosclerosis. Finally, FGFs ability to stimulate blood vessel growth has been explored in therapeutic angiogenesis approaches.With this in mind, the present monograph is structured to provide comprehensive information to a reader interested in FGFs in general and vascular biology in particular. To this end, we explore everything from the structure and signaling of FGFs and their receptors (Chapters 1, 2 and 3) to their role in the regulation of vascular homeostasis (Chapter 4) and cardiovascular diseases (Chapters 5 and 6). We then address new developments in FGF therapeutics (chapter 7) and explore FGF biology in the epithelium (Chapter 8) thereby providing a complete analysis of this growth factor family biology in two closely related but distinctly different environments - endothelium and epithelium. Finally, we examine FGF biology in eye disease and in cancer.It is our hope that this comprehensive treatment of FGF vascular biology and its application will provide the reader with the accurate and timely summary of this rapidly moving field.

Practical Handbook of Echocardiography: 101 Case Studies Echocardiography is now one of the most commonly used diagnostic imaging tools, yet many clinicians remain unaware of the range of conditions echo can reveal or how echo can be used to help plan therapy. Moreover, it can be quite challenging even for the most seasoned practitioners to spot unusual conditions. Compiled by three echocardiographers with more than 100 years of clinical experience between them, Practical Handbook of Echocardiography uses a case-based approach to explain in detail the full spectrum of echocardiographic modalities and how to optimize their use in the clinical setting. This practical new book: * Covers the full gamut of echocardiographic modalities, including M-mode, 2-D,3-D and Doppler (PW, CW, color flow, tissue and strain), transesophageal (intra-operative and routine) and contrast * Describes cases in both clinical and echocardiographic terms including very interesting cases and the new clinical techniques * Features beautifully reproduced, well-labeled, full color echocardiograms * Includes accompanying DVD with real-time video clips Appropriate for physician echocardiographers and all cardiologists, as well as echocardiographic technicians, Practical Handbook of Echocardiography is the ideal concise guide to using echocardiography to make definitive diagnoses and improve patient outcomes.

To achieve cardiac regeneration using pluripotent stem (iPS) cells, researchers must understand iPS cell generation methods, cardiomyocyte differentiation protocols, cardiomyocyte characterization methods, and tissue engineering. This book presents the current status and future possibilities in cardiac regeneration using iPS cells. Written by top researchers who present new data in these fields, this book reviews cardiac cell therapy for ischemic heart disease and explores in vitro generation of efficacious platelets from iPS cells. It also discusses modeling arrhythmogenic heart disease with patient-specific induced pluripotent stem cells.

Heart Failure, Second Edition has been updated to provide the latest advancements in heart failure research. Supplemented by more than 200 high-quality figures and illustrations, the book helps cardiologists and emergency care physicians quickly and accurately identify the cause and severity of a patient's cardiac impairment.

New topics in this edition include:

• Developments in mechanical and pharmacologic treatments
• Discoveries in developmental biology
• Up-and-coming imaging modalities
• Surgical options for mechanical circulatory support and cardiac transplantation
• Pharmacogenomics and gene-based and cell-based therapies
• Gene expression/recurrence in heart failure
• Changes in metabolic substrate utilization and pathways

This book focuses on the impact of nutritional disorders on the nervous system. Nutritional disorders are caused due to poverty, famine, infestations, ignorance in the developing world and due to food faddism, isolation, depression, addictions, and comorbidities in the developed countries. This book has chapters on various disorders covering basic knowledge, their clinical manifestations, basis and etiology, laboratory diagnosis, method of treatment and prognosis. It provides the guidelines to students and clinicians for dealing with such disorders which are easily preventable and amenable to treatment whose early diagnosis and management can avert morbidity and mortality. Key Features Deals with the unexplored topic of the neurological impact of nutritional disorders Will be essential for neurologists, general physicians, and pediatricians Includes key illustrated examples from authors' clinical practice.

Pericardial disease is a broad term that describes a wide range of pathologies. The clinical aspects of pericardial disease encompass acute pericarditis, pericardial tamponade, pericardial effusion, constrictive pericarditis, and effusive-constrictive pericarditis. Those disorders differ not only in clinical presentation but also in the timeline of disease development; for example, pericardial tamponade is commonly an acute, life-threatening event, whereas constrictive pericarditis is a chronic process developing over months to years. Therefore, pericardial disease management is challenging for most clinicians. The evidence base in the field is relatively scarce compared with other disease entities in cardiology. European Society of Cardiology released guidelines for the diagnosis and management of pericardial diseases. Currently there are no guidelines from American cardiology societies to help clinicians in dealing with pericardial disease. In this book, my goal is to provide extensive review of pericardial disease evaluation and management. A unified, stepwise pathway-based approach for the management of pericardial disease is provided at the end of the book.

Autopsy derives from the greek word autopsia, which means act of seeing with one's own eyes. It remains the most objective and accurate method to understand human. disease. Unfortunately, the volume of autopsies in teaching hospitals has decreased dramatically over the past years. The crucial factors that account for this are the recent progress and development of new technologies, especially in diagnostic imaging, immunology, cell biology and genetics. Additionally, the perpetual fear of legal liability by physicians accounts for its further decline. Consequently, physicians and medical students are engaged in fewer autopsies and are not reaping the rich educational rewards that accompany these examinations. The purpose of the autopsy is not only to establish the cause of death, but also to determine the nature and course of the disease process. Our goal with this book is to emphasize the importance of the post-mortem exam and the correlation between pathologic material and clinical data by analyzing actual cases with problem-based methodology. The focus of this handbook is on cardiovascular disease, and when appropriate, other disease categories are included if they have an impact on cardiovascular function. The approach is more than the usual clinico-pathological correlation. Rather, we attempt to present the material from the perspective of the autopsy table. We use the clinical data as the initial framework and the autopsy findings to develop a true understanding of the disease and the associated pathophysiology of the condition.

Accurately identify complex geometrical distortions of cardiac anatomy and make more informed decisions regarding diagnosis and treatment with Atlas of 3D Echocardiography. This new cardiology reference presents the authoritative, case-based, expert guidance you need to enhance your utilization and interpretation of this cutting-edge, dimensional diagnostic tool. Master the application of techniques to specific clinical situations with detailed case studies and discussions of challenging issues. See imaging findings as they appear in practice and discern subtle nuances with the aid of high-quality still images plus online videos. Reference the information you need quickly thanks to easy-to-follow, templated chapters, with an abundance of images and figures that facilitate visual learning. Take it with you anywhere! Access the full text, downloadable image library, videos, and more at www.expertconsult.com. Sharpen your interpretive and diagnostic skills in 3-D echo!

Key Features * Provides a detailed review of the unique challenges presented by young patients with small heart size, and patients of any age with distorted anatomy due to congenital heart disease, in this long overdue, updated text. * Intends to guide all cardiologists engaged in invasive electrophysiology at both the training level and established practice who are exposed to such exceptional cases. * Includes an internationally recognized group of experts who discuss the technical approach, success rate, complication rate, and special precautions needed to achieve optimal outcomes.

This book reviews the surgical management of patients with aortic disease, revealing many options open to cardiovascular specialists in this often controversial area of management. It reviews each controversy and provides clinical information for cardiac surgery, and discusses the spectrum of disorders and their management. With the knowledge base in this discipline changing rapidly, Controversies in Aortic Dissection and Aneurysmal Disease meets an important requirement to consolidate the wide-ranging information on which clinicians must base their practice. It is directed towards surgeons, physicians, and healthcare workers involved in the care of patients requiring cardiac, cardiothoracic and cardiovascular surgery. This book will be an essential resource for these professionals looking to accelerate the translation of basic research findings into clinical study and practice.

This comprehensive text follows an evidence-based approach to thoroughly discuss Atrial septal defects. Since this congenital heart disease mostly presents in adulthood, it becomes imperative to understand the embryology, pathophysiology and anatomy in detail, for effective management of these patients. This book has strong clinical focus on anatomy, natural history, indications, imaging methods and practical aspects of disease management, which inculcates best practice in the day to day management techniques employed by cardiologists, trainees and professionals. Key Features Covers all aspects of atrial septal defects with a logical flow of topics. Serves as a useful guide to clinical cardiologists aiming to specialize in atrial septal defects and professionals entering the field. Explores future directions in diagnosis and treatment, elaborating on the use of 3D echocardiography and Intracardiac echocardiography.

This comprehensive text follows an evidence-based approach to thoroughly discuss Atrial septal defects. Since this congenital heart disease mostly presents in adulthood, it becomes imperative to understand the embryology, pathophysiology and anatomy in detail, for effective management of these patients. This book has strong clinical focus on anatomy, natural history, indications, imaging methods and practical aspects of disease management, which inculcates best practice in the day to day management techniques employed by cardiologists, trainees and professionals. Key Features Covers all aspects of atrial septal defects with a logical flow of topics. Serves as a useful guide to clinical cardiologists aiming to specialize in atrial septal defects and professionals entering the field. Explores future directions in diagnosis and treatment, elaborating on the use of 3D echocardiography and Intracardiac echocardiography.

Heart failure is a major, cause of death worldwide, most frequently secondary toacardiomyopathicdisorder. The rolesofviruses, immunity, cytokines and genetics as sources of heart failure have been relatively understated in the rapidly developing world of clinical cardiology. Yet, great progress in molecular biology and the recent application of new techniquesto studiesoftheetiologyandpathogenesisofcardiomyopathies and heart failure has shed new light in an area ready to undergo major developmentsandadvances. This book is an effort to present an up-to-date account of eXIstmg knowledge,includingrecentdevelopmentsinthisfield. Chapterscovering severaldisciplinesincludingbiochemistry,immunology,molecularbiology, virology,epidemiologyandclinicalmedicinehavebeenincluded,offeringa "bench-to-bedside"and"bedside-to-bench"criticalreviewofeveryaspects of heart failure and cardiomyopathies, by world renowned, expert researchers and clinicians. These opinion leaders review all significant advances in our understandingofheart failure and cardiomyopathies, and describe theimprovements indiagnosis and treatment that areexpectedto optimize the overall management of patients. The identification of establishedornewlyrecognizedmolecules,cytokines,viruses,andgenes,as well as an understandingofthe mechanisms by which these factors may cause cardiomyopathic disorders and induce heart failure depends on a multidisciplinaryapproachwhichthisbookattemptstouniquelyencompass. Therefore,wehopethatitwillbeanimportantresource,notonlyforclinical cardiologists,butalso forgeneralpractitioners,pediatriciansandspecialists in infectious diseases, as well as trainees and graduates in biochemistry, immunology, genetics, molecular biology, virology, pharmacology, and epidemiology. AkiraMatsumori,MD,PhD Ie INTRODUCTORYCHAPTER CARDIOMYOPATHIESANDHEARTFAILURE Biomolecular,InfectiousandImmuneMechanisms AkiraMatsumori,MD,PhD DepartmentofCardiovascularMedicine KyotoUniversityGraduateSchoolofMedicine Kyoto,Japan 1 SUMMARY Theclinicalpresentationofviralmyocarditisisvariable. Whenmyocardial necrosis is diffuse, congestive heart failure develops, and later, dilated cardiomyopathy. If the myocardial lesions are localized, a ventricular aneurysmforms. Whencomplicatedbyarrhythmias,myocarditispresentsas arrhythmogenic right ventricular cardiomyopathy. When myocardial necrosisislocalizedtothesubendocardialregion,restrictivecardiomyopathy may develop. While it has not been established that hypertrophic cardiomyopathy maybeacomplicationofviral myocarditis, asymmetrical septal hypertrophy has, in fact, sometimesbeen observed in patients with myocarditis. TheimportanceofhepatitisCvirusinfectionhasrecentlybeen notedinpatientswithmyocarditis,dilatedandhypertrophiccardiomyopathy.

1.Provides clinical certainty about difficult and controversial areas of vascular malformation 2. Explains how to incorporate genetic studies to aid diagnosis 3. Illustrates and explains unique findings from world experts 4. Includes evidence-based material to reflect research from the last 2 decades 5.Multiple colour illustrations and clear explanations make the text easy to absorb.

Venous thrombo-embolism, venous thrombosis and pulmonary embolism are common complications in postoperative patients. This focused handbook covers the topics of epidemiology, screening, and prophylaxis along with diagnosis and management of venous thrombo-embolism. It covers both mechanical and pharmacological methods of prophylaxis and various drugs used in prevention and treatment viz. heparins (unfractionated and low molecular weight), anticoagulants (vitamin K antagonists and novel oral anticoagulants), etc. The A-Z format makes this book a useful practical guide. The approach will break the barriers to the use of venous thrombo-embolism prophylaxis in the minds of physicians. Key Features Discusses the content in an innovative A-Z format Contains practical tips for day-to-day clinical management Examines the use of venous thrombo-embolism prophylaxis by practicing physicians and residents

Venous thrombo-embolism, venous thrombosis and pulmonary embolism are common complications in postoperative patients. This focused handbook covers the topics of epidemiology, screening, and prophylaxis along with diagnosis and management of venous thrombo-embolism. It covers both mechanical and pharmacological methods of prophylaxis and various drugs used in prevention and treatment viz. heparins (unfractionated and low molecular weight), anticoagulants (vitamin K antagonists and novel oral anticoagulants), etc. The A-Z format makes this book a useful practical guide. The approach will break the barriers to the use of venous thrombo-embolism prophylaxis in the minds of physicians. Key Features Discusses the content in an innovative A-Z format Contains practical tips for day-to-day clinical management Examines the use of venous thrombo-embolism prophylaxis by practicing physicians and residents

Dr. Joseph Perloff is joined by Dr. Ariane Marelli to bring you a new edition of Clinical Recognition of Congenital Heart Disease. This medical reference book covers the full spectrum of CHD, from infants through adults, allowing you to effectively detect these conditions as early as possible. Be at the forefront of the field with extensive coverage of the latest innovations in clinical diagnostic methods. Recognize the clinical manifestations at all stages of life for malpositioned, malformed, or absent cardiovascular chambers and vessels. Grasp the full scope of the pathophysiology of CHD with well-organized, expert guidance. Quickly search the contents online, download images in JPG or PPT format, and view 70 echocardiogram videos at expertconsult.com. Understand the appropriate diagnostic findings for each stage of life and see rich, varied examples of characteristic findings. Obtain the most comprehensive core knowledge you need with coverage of commonly used clinically relevant diagnostic Dr. Perloff and Dr. Marelli cover the latest in clinical recognition detection of congenital heart disease from physical appearance to imaging.

This book provides an introduction to the principles of both cardiovascular epidemiology and molecular pathophysiology; as a unique aspect, it also outlines and discusses the molecular concepts underlying epidemiological observations. This second volume is focused on all aspects concerning "secondary risk factors" in terms of diseases associated with enhanced risk for cardiovascular events. The book promotes the use of interdisciplinary approaches in the field of preventive medicine based on recent advances in molecular and cellular pathophysiology. The book offers a valuable resource for researchers in basic biomedical fields and clinical scientists alike, as well as guidelines for novel avenues of research in both basic pathophysiology and cardiovascular therapy and prevention.

Key Features * Provides a detailed review of the unique challenges presented by young patients with small heart size, and patients of any age with distorted anatomy due to congenital heart disease, in this long overdue, updated text. * Intends to guide all cardiologists engaged in invasive electrophysiology at both the training level and established practice who are exposed to such exceptional cases. * Includes an internationally recognized group of experts who discuss the technical approach, success rate, complication rate, and special precautions needed to achieve optimal outcomes.

Transplantation of the Heart and HeartLungs (N.E. Shumway). Physiologic Principles and Clinical Use of Hypothermia (L.K. Davis, R.F. Davis). Anesthetic Evaluation and Management in Bloodless Surgery (N.S. Faithfull). Normothermic Mycocardial Preservation, an Optimal Approach for Myocardial Protection During All Forms of OpenHeart Surgery (R.E. Engelman et al.). Pharmacologic Manipulations to Minimize Bloodloss in Cardiac Surgery (A.C. Cernaianu, A.J. DelRossi). Sutureless Intraluminal Ring Grafts for Aortic Replacement (G.M. Lemole). Immunologic Consequences of Transfusion (P.I. Tartter). Traumatic Rupture of the Thoracic Aorta (R.C. Camishion, J.B. Alexander). Cardiomyoplasty (R.C.J. Chiu). Current Status of Autotransfusion (R.A. Vertrees, A.C. Cernaianu). Transesophageal Echocardiology (W.H. O'Connor). The Use of Circulatory Support in Cardiac Surgery (R.L. Kormos). 9 additional articles. Index.

Outlines the basics of nutrition for healthcare professionals. Directed towards an international audience; written from the holistic perspective. There has been a definite shift in our perception and understanding of foods and diet. More attention is being given towards how we grow and cultivate food sources whilst being mindful about the environmental impact this may have - this book is timely, the medical community is now giving due importance to dietary content.

Echocardiography in Congenital Heart Disease - a volume in the exciting new Practical Echocardiography Series edited by Dr. Catherine M. Otto - provides practical how-to-do-it guidance on echocardiography for an ever-growing number of pediatric and adult congenital heart disease patients. Drs. Mark B. Lewin and Karen Stout offer you definitive, expert instruction with a highly visual, case-based approach that facilitates understanding and equips you to accurately acquire and interpret images while avoiding pitfalls. Access the full text online at www.expertconsult.com along with cases, procedural videos, and abundant, detailed figures and tables that show you how to proceed, step by step, and get the best results. Master challenging and advanced techniques including 3-D echocardiography and transesophageal echocardiography through a practical, step-by-step format that provides a practical approach to data acquisition and analysis, technical details, pitfalls, and case examples. Expand your knowledge and apply the latest findings on congenital cardiovascular abnormalities and adult congenital heart disease Reference the information you need quickly thanks to easy-to-follow, templated chapters, with an abundance of figures and tables that facilitate visual learning. Access the complete text and illustrations online at www.expertconsult.com plus video clips, additional cases, and much more! Master echocardiography techniques for pediatric and adult patients with Congenital Heart Disease