This thoroughly researched study highlights the international community's failure to regulate contemporary state research, development, marketing and/or deployment of riot control agents and incapacitating chemical agent weapons.

During the last century, advances in the life sciences were used in the development of biological and chemical weapons in large-scale state offensive programmes, many of which targeted the nervous system. This study questions whether the development of novel biological and chemical neuroweapons can be prevented as neuroscience progresses.

Mycotoxins are made by different biosynthetic pathways, and they have an extremely wide range of pharmacological effects. This book will update readers on several cutting-edge aspects of mycotoxin research, including topics such as: new analytical methods for detection; the adoption of an ancient Mexican process for detoxification of aflatoxins; mycotoxin management in Ireland, Lithuania and South America; mycotoxin reduction through plant breeding and integrated management practices; and natural aflatoxin inhibitors from medicinal plants. Further contributions examine ochratoxins, selected trichothecenes, zearalenone, and aflatoxin-like gene clusters, as well as sclerotial development in Aspergillus flavus and A. parasiticus. Of particular interest are the chapters on the potential use of mycotoxins as bioweapons. This book will stimulate new thinking on the need to develop therapeutic as well as preventative interventions to reduce the toxicological threat of mycotoxins.

New and unpredicted technologies are emerging at an unprecedented pace around the world. Communication of those new discoveries is occurring faster than ever, meaning that the unique ownership of a piece of new technology is no longer a sufficient position, if not impossible. In today's world, recognition of the potential applications of a technology and a sense of purpose in exploiting it are far more important than simply having access to it. Technological surprise has and will continue to take many forms. A plethora of new technologies are under development for peaceful means but may have un- tended security consequences and will certainly require innovative counterme- ures. A relevant example is the tremendous development in biotechnology that has occurred since the advent of recombinant DNA and tissue culture-based processes in the 1970s. If US government agencies and the defense and academic commu- ties had more clearly recognized the potential for biotechnology to affect fun- mental security and warfighting doctrines 20 years ago, the situation today could be very different. Defense against chemical and biological weapons - from both states and nonstate actors - currently presents a threat that is difficult to predict and for which traditional solutions are increasingly less effective. Nanotechnology has emerged as a well-funded discipline that, like biote- nology, carries the potential for groundbreaking applications and the potential for unpredictable harm. The world is likely 20 years away from the full impact of the nanotechnology on defensive capabilities.

This book explores how revolutionary developments and convergence of the chemical, life and associated sciences are impacting contemporary toxin and bioregulator research, and examines the risks of such research being misused for malign purposes. Investigating illustrative cases of dual use research of potential concern in China, India, Iran, Russia, Syria and the USA, the authors discuss how states can ensure such research and related activities are not utilised in weapons development. Although toxins and bioregulators are, in theory, covered by both the Biological and Toxin Weapons Convention and Chemical Weapons Convention, this apparent overlap in reality masks a dangerous regulatory gap - with neither Convention implemented effectively to address threats of weaponisation. This book highlights the potentially damaging consequences for international peace and security, and proposes realistic routes for action by states and the scientific community.

Suburban Empire takes readers to the US missile base at Kwajalein Atoll in the Marshall Islands, at the matrix of postwar US imperial expansion, the Cold War nuclear arms race, and the tide of anti-colonial struggles rippling across the world. Hirshberg shows that the displacement of indigenous Marshallese within Kwajalein Atoll mirrors the segregation and spatial politics of the mainland US as local and global iterations of US empire took hold. Tracing how Marshall Islanders navigated US military control over their lands, Suburban Empire reveals that Cold War-era suburbanization was perfectly congruent with US colonization, military testing, and nuclear fallout. The structures of suburban segregation cloaked the destructive history of control and militarism under a veil of small-town innocence.

This book explores the origins, interpretations and meanings of the term biosecurity. It brings together contributors on issues relating to the perceptions of the threat of biological weapons and how states are responding, or not, to the challenges posed by the potential of the products of the life sciences to be used for destructive purposes.

The terrorist act with sarin gas in the Tokyo underground and the case with the spread of anthrax spores through the U.S. postal system stimulated the development of orga- zation of fight against terrorism on a national and global level. The goal of this wo- shop was assessment of scientific concepts and practical means for management of chemical and biological agents casualties in the area of terrorist attacks with emphasis on improving the problems and situation in Eastern European Countries. In this book are included the results of both theoretical and practical research of chemical and biological terrorism presented during the workshop. Different trends of research to fight against terrorism on both local and governmental level including some Eastern European countries are discussed. The scientific articles are grouped into those areas: - New approaches in counteraction to chemical and biological terrorism - Medical treatment and decontamination of casualties from chemical and biological agents - Diagnosis of exposure to chemical and biological agents - Development of protection against injuries from chemical and biological agents In these articles the following are emphasized: - Some aspects of national and global defense against chemical and biological terrorism - National action plans and global agreements on combating terrorism - The characteristics of the major specific injuries connected with chemical and biological terrorism - Threats of terroristic attacks - Epidemiological and clinical peculiarities, ways of diagnosing, medical tre- ment and preventive health care measures These problems are analyzed from an interdisciplinary perspective.

Stemming from the NATO Advanced Research Workshop, this book asserts that no single institution or country possesses all the resources to effectively address radiological and nuclear threats. Moreover, the book asserts that fundamental scientific challenges must be overcome to achieve new and improved technologies. In response, the book sets forth research strategies that advance the ability to counter nuclear and radiological threats.

Stemming from the NATO Advanced Research Workshop, this book asserts that no single institution or country possesses all the resources to effectively address radiological and nuclear threats. Moreover, the book asserts that fundamental scientific challenges must be overcome to achieve new and improved technologies. In response, the book sets forth research strategies that advance the ability to counter nuclear and radiological threats.

This book contains articles from leading experts in the various disciplines associated with risk assessment and risk communication associated with bioterrorism. These papers are based on presentations at a NATO Advanced Research Workshop in Israel in June 2005, which addressed these issues. The book offers a comprehensive, practical guide for approaching risk assessment and risk communication in a bioterrorism event.

The 2001 anthrax incident in the United States inspired a worldwide increase in bioterror readiness among public health and law enforcement professionals. Resources are being allocated to a variety of potential threats, from the reintroduction of smallpox to the possibility of new genetically-engineered pathogens. Despite the potentially devastating consequences, it remains remarkably difficult to quantify risk. Risk assessment is crucial to the appropriate allocation of resources for research and preparedness.This book includes articles from leading experts in the various disciplines associated with risk assessment and risk communication associated with bioterrorism. These papers are based on presentations at a NATO Advanced Research Workshop in Israel in June 2005, which adressed these issues.

This book represents a first considered attempt to study the factors that conditioned industrial chemistry for war in 1914-18. Taking a comparative perspective, it reflects on the experience of France, Germany, Austria, Russia, Britain, Italy and Russia, and points to significant similarities and differences. It looks at changing patterns in the organisation of industry, and at the emerging symbiosis between science, industry and the military.

Without sensationalizing or providing the technical details that would result in a terrorist's handbook, the volume reflects the concerns expressed by experts from 12 states (including many from Slavic regions adjoining or aspiring to membership of the European Union). A range of vulnerabilities are highlighted that are usually neglected. Assessments that focus on the horrifying potential of bioterrorism directly targeting people are commonplace. This book is exceptional because indirect impacts on human health and welfare through challenge to the security of food supplies are the focus. These urgently need to be recognised and made subjects of planned investment to counter the threat. Examples of past state-sponsored and independent actions are discussed. The evolution of biological (chemical defoliant) systems for controlling plant growth with unambiguously humanitarian aims is shown to have resulted in a range of counter terrorist uses.

Without sensationalizing or providing the technical details that would result in a terrorist's handbook, the volume reflects the concerns expressed by experts from 12 states (including many from Slavic regions adjoining or aspiring to membership of the European Union). A range of vulnerabilities are highlighted that are usually neglected. Assessments that focus on the horrifying potential of bioterrorism directly targeting people are commonplace. This book is exceptional because indirect impacts on human health and welfare through challenge to the security of food supplies are the focus. These urgently need to be recognised and made subjects of planned investment to counter the threat. Examples of past state-sponsored and independent actions are discussed. The evolution of biological (chemical defoliant) systems for controlling plant growth with unambiguously humanitarian aims is shown to have resulted in a range of counter terrorist uses.

Scientific and technological change in the life sciences is currently transforming the problem of preventing biological warfare and biological terrorism. This transformation will demand a radical and rigorous new approach to biochemical arms control, for which the existing prohibition regimes for chemical and biological weapons are necessary but insufficient building blocks. Examples from the areas of immunology, the neurosciences, and the neuroendocrine-immune system are used to show the magnitude of the problem. The final section of the book will then outline additional measures required to control biochemical weapons in the 21st century.

The threat of bioterrorism has become a major challenge for the twenty-?rst century. However, the potentials of infectious agents as bioweapons have been recognized for centuries. Throughout history there have been attempts to i- tiate infectious disease outbreaks and epidemics during warfare. In the last decade the attention of the biomedical community, as well as governments and the United Nations, has increasingly focused on the threat of bioterr- ism, especially the use of biological and/or chemical weapons against military and civilian populations. As an example, there is now much interest conce- ing microbial infection and bioterrorism in the medical microbiology and - munologycommunities. Thisvolumeaddressessuchconcernsandemphasizes bothbasicandclinicalconcepts, aswellasproblematicimplicationsofinfection by various microbes now recognized as potential bioterrorism agents. The ?rst chapter by Drs. Andrew Canons, Philip Amuso, and Burt And- son from the University of South Florida is an overview of the biotechnology of bioterrorismbothinthepublichealthresponsetopossibleactsofbioterrorism, aswellasfortheconcernsaboutthemisuseofbiotechnology. Thesecondch- ter is a historical perspective of microbial bioterrorism by Dr. Steven Morse, Director of the Bioterrorism Division at the Center for Disease Control and Prevention in Atlanta, GA. This chapter describes in detail historical aspects concerning the early use of biological agents in warfare, development and international conventions to prohibit the use of such weapons, and a brief - scription of important incidents of infectious agents as bioterrorist agents and use during the last few centuries. The next chapter by Dr. Sandra Gompf from the University of South Florida discusses the role of public health physicians and infectious diseases specialists in the control of microbial bioterrorism

This book provides an analysis of the development and deployment of chemical weapons from 700 BC to the present day. The First World War is examined in detail since it remains the most significant experience of the chemical threat, but the Second World War and post-war conflicts are also evaluated. Additionally, protocols attempting to control the proliferation and use of chemical weapons are assessed. Finally, the book examines the threat (real and imagined) from a chemical warfare attack today by rationally assessing to what extent terrorist groups around the world are capable of making and using such weapons.

This book provides an analysis of the development and deployment of chemical weapons from 700 BC to the present day. The First World War is examined in detail since it remains the most significant experience of the chemical threat, but the Second World War and post-war conflicts are also evaluated. Additionally, protocols attempting to control the proliferation and use of chemical weapons are assessed. Finally, the book examines the threat (real and imagined) from a chemical warfare attack today by rationally assessing to what extent terrorist groups around the world are capable of making and using such weapons.

Incidents of bioterrorism and biowarfare are likely to recur, leading to increased public concern and government action. The deficiencies of the Biological and Toxin Weapons Convention (BTWC) are in urgent need of attention: the BTWC is the central international agreement to prevent the proliferation of biological warfare programmes.

Uniquely, this book is written by diplomats involved in the decade-long effort (1991-2001) in which State Parties to the BTWC tried to agree a Protocol to the Convention with legally binding measures to strengthen its effectiveness, and academics concerned with the negotiations. Just before negotiations foundered, when the Chairman's proposed text was virtually complete, the problems and proposed solutions were examined thoroughly, leading to this book.

The book is wide-ranging in its review of the history of biological warfare, the reasons why the current biological revolution is of such concern, and the main features of the BTWC itself. The core of the book examines the key elements of the proposed protocol - declarations, visits, challenge-type investigations, and enhanced international cooperation - and the implications for government, industry and biodefence, giving us all a better understanding of what still remains to be done to avert a biowarfare catastrophe.

Incidents of bioterrorism and biowarfare are likely to recur, leading to increased public concern and government action. The deficiencies of the Biological and Toxin Weapons Convention (BTWC) are in urgent need of attention: the BTWC is the central international agreement to prevent the proliferation of biological warfare programmes. Uniquely, this book is written by diplomats involved in the decade-long effort (1991-2001) in which State Parties to the BTWC tried to agree a Protocol to the Convention with legally binding measures to strengthen its effectiveness, and academics concerned with the negotiations. Just before negotiations foundered, when the Chairman's proposed text was virtually complete, the problems and proposed solutions were examined thoroughly, leading to this book. The book is wide-ranging in its review of the history of biological warfare, the reasons why the current biological revolution is of such concern, and the main features of the BTWC itself. The core of the book examines the key elements of the proposed protocol - declarations, visits, challenge-type investigations, and enhanced international cooperation - and the implications for government, industry and biodefence, giving us all a better understanding of what still remains to be done to avert a biowarfare catastrophe.

Bacillus anthracis anthrax had largely faded from public consciousness until it resurfaced as a terrorist weapon in 2001. It was always with us , lurking in the soil and hosted by our livestock. Long before it was identified as a specific bacterium in the late 1800s, anthrax was a catchphrase for a variety of diseases and symptoms, from ancient biblical plagues to a painful carbuncle on George Washingtons leg. Only when industrialization turned anthrax into a widespread disease that threatened economies did a true understanding of Bacillus anthracis begin to emerge.

This history of anthrax follows the development of our understanding of the disease, beginning in the 18th century, when science began breaking ground on the subject, until the present, when anthrax is feared more as an agent of biowarfare than as a health hazard harbored by the environment. There are three appendices: the first outlines the reaction of Manchester, New Hampshire, to the 2001 anthrax attacks; the second documents workplace warnings to anthrax-prone workers; and the third lists novels that involve anthrax. Bibliographical references are also provided.

The Editors would like to thank the authors of the papers at the Advanced Research Workshops for their excellent presentations at the workshops and the production of their drafts. We are indebted to those who helped in the preparation of this volume. We should particularly like to acknowledge the help of Piers Millett, who compiled the papers, set them into camera-ready format and produced the index and Dr. Simon Whitby who made the final changes to the manuscript. Any remaining errors are, of course, our responsibility. Malcolm R. Dando Cyril Klement Marian Negut Graham S. Pearson IX ACHIEVING SECURITY BENEFITS FROM TECHNICAL COOPERATION UNDER THE BIOLOGICAL AND TOXIN WEAPONS CONVENTION GRAHAM S. PEARSON Visiting Professor of International Security, Department of Peace Studies, University of Bradford, Bradford, West Yorkshire BD7 IDP, UK 1. Background l The Biological and Toxin Weapons Convention which opened for signature in 1972 2 and entered into force in 1975 currently has 144 States Parties and 18 Signatory States Article I of the Convention is all-embracing in its complete prohibition of biological weapons stating that: Each State Party to this Convention undertakes never in any circumstances to develop, produce, stockpile or otherwise acquire or retain: (1) Microbial or other biological agents, or toxins whatever their origin or method of production, of types and in quantities that have no justification for prophylactic, protective or other peaceful purposes; (2) Weapons, equipment or means of delivery designed to use such

The Editors would like to thank the authors of the papers at the Advanced Research Workshops for their excellent presentations at the workshops and the production of their drafts. We are indebted to those who helped in the preparation of this volume. We should particularly like to acknowledge the help of Piers Millett, who compiled the papers, set them into camera-ready format and produced the index and Dr. Simon Whitby who made the final changes to the manuscript. Any remaining errors are, of course, our responsibility. Malcolm R. Dando Cyril Klement Marian Negut Graham S. Pearson IX ACHIEVING SECURITY BENEFITS FROM TECHNICAL COOPERATION UNDER THE BIOLOGICAL AND TOXIN WEAPONS CONVENTION GRAHAM S. PEARSON Visiting Professor of International Security, Department of Peace Studies, University of Bradford, Bradford, West Yorkshire BD7 IDP, UK 1. Background l The Biological and Toxin Weapons Convention which opened for signature in 1972 2 and entered into force in 1975 currently has 144 States Parties and 18 Signatory States Article I of the Convention is all-embracing in its complete prohibition of biological weapons stating that: Each State Party to this Convention undertakes never in any circumstances to develop, produce, stockpile or otherwise acquire or retain: (1) Microbial or other biological agents, or toxins whatever their origin or method of production, of types and in quantities that have no justification for prophylactic, protective or other peaceful purposes; (2) Weapons, equipment or means of delivery designed to use such

The Biological and Toxin Weapons Convention entirely prohibits biological warfare, but it has no effective verification mechanism to ensure that the 140-plus States Parties are living up to their obligations. From 1995-2001 the States Parties attempted to negotiate a Protocol to the Convention to remedy this deficiency. On 25 July 2001 the United States entirely rejected the final text which would probably have been acceptable to most other states. The book investigates how this disaster came about, and the potential consequences of the failure of American leadership.