With the advent of sophisticated general programming environments like Mathematica, the task of developing new models of metabolism and visualizing their responses has become accessible to students of biochemistry and the life sciences in general. Modelling Metabolism with Mathematica presents the approaches, methods, tools, and algorithms for modelling the chemical-dynamics of metabolic pathways. The authors explain the concepts underpinning the deterministic theory of chemical and enzyme kinetics, present a graded series of computer models of metabolic pathways leading up to that of the human erythrocyte, and document a consistent set of rate equations and associated kinetic parameters.

The experimental and theoretical study of metabolism in mammalian cells has a long and fruitful history, but our understanding of cellular metabolism at the molecular level is far from complete. This book enables its readers to formulate their own models of time-dependent metabolic systems and aids them in the quest for the many fundamental and clinically relevant discoveries that remain to be made.

This book describes the development of a constitutive modeling platform for soil testing, which is one of the key components in geomechanics and geotechnics. It discusses the fundamentals of the constitutive modeling of soils and illustrates the use of these models to simulate various laboratory tests. To help readers understand the fundamentals and modeling of soil behaviors, it first introduces the general stress-strain relationship of soils and the principles and modeling approaches of various laboratory tests, before examining the ideas and formulations of constitutive models of soils. Moving on to the application of constitutive models, it presents a modeling platform with a practical, simple interface, which includes various kinds of tests and constitutive models ranging from clay to sand, that is used for simulating most kinds of laboratory tests. The book is intended for undergraduate and graduate-level teaching in soil mechanics and geotechnical engineering and other related engineering specialties. Thanks to the inclusion of real-world applications, it is also of use to industry practitioners, opening the door to advanced courses on modeling within the industrial engineering and operations research fields.

The extremes of constitutive and centrifuge modelling are explored here, with a range of lectures addressing specific areas of these two types of modelling as well as on specific design problems and the themes of failure, deformations and interfaces.

Modeling and machining are two terms closely related. The benefits of the application of modeling on machining are well known. The advances in technology call for the use of more sophisticated machining methods for the production of high-end components. In turn, more complex, more suitable, and reliable modeling methods are required. This book pertains to machining and modeling, but focuses on the special aspects of both. Many researchers in academia and industry, who are looking for ways to refine their work, make it more detailed, increase their accuracy and reliability, or implement new features, will gain access to knowledge in this book that is very scare to find elsewhere.

This manual describes the wide range of electromechanical, electrochemical and electro-optical transducers at the heart of current field-deployable ocean observing instruments. Their modes of operation, precision and accuracy are discussed in detail. Observing platforms ranging from the traditional to the most recently developed are described, as are the challenges of integrating instrument suits to individual platforms. Technical approaches are discussed to address environmental constraints on instrument and platform operation such as power sources, corrosion, biofouling and mechanical abrasion. Particular attention is also given to data generated by the networks of observing platforms that are typically integrated into value-added data visualization products, including numerical simulations or models. Readers will learn about acceptable data formats and representative model products. The last section of the book is devoted to the challenges of planning, deploying and maintaining coastal ocean observing systems. Readers will discover practical applications of ocean observations in diverse fields including natural resource conservation, commerce and recreation, safety and security, and climate change resiliency and adaptation. This volume will appeal to ocean engineers, oceanographers, commercial and recreational ocean data users, observing systems operators, and advanced undergraduate and graduate students in the field of ocean observing.

A discussion of the virtual testing of mechanical systems, presenting theories and techniques implemented in the FEDEM Multidisciplinary Simulation Software. The basis for this approach is the non-linear FE formulation and the Master-Slave techniques used for modelling joints and transmissions.

Designed for use in a second course on linear algebra, Matrix Theory and Applications with MATLAB covers the basics of the subject-from a review of matrix algebra through vector spaces to matrix calculus and unitary similarity-in a presentation that stresses insight, understanding, and applications. Among its most outstanding features is the integration of MATLAB throughout the text. Each chapter includes a MATLAB subsection that discusses the various commands used to do the computations in that section and offers code for the graphics and some algorithms used in the text.

All of the material is presented from a matrix point of view with enough rigor for students to learn to compose arguments and proofs and adjust the material to cover other problems. The treatment includes optional subsections covering applications, and the final chapters move beyond basic matrix theory to discuss more advanced topics, such as decompositions, positive definite matrices, graphics, and topology.

Filled with illustrations, examples, and exercises that reinforce understanding, Matrix Theory and Applications with MATLAB allows readers to experiment and visualize results in a way that no other text does. Its rigor, use of MATLAB, and focus on applications better prepares them to use the material in their future work and research, to extend the material, and perhaps obtain new results of their own.

Phylogenetic (evolutionary) trees and networks are widely used throughout evolutionary biology, epidemiology, and ecology to infer the historical relationships between species through inherited characteristics. Semple and Steel discuss the mathematics that underlies the reconstruction and analysis of these phylogenetic trees.

Expanded to include a broader range of problems than the bestselling first edition, Finite Element Method Using MATLAB: Second Edition presents finite element approximation concepts, formulation, and programming in a format that effectively streamlines the learning process. It is written from a general engineering and mathematical perspective rather than that of a solid/structural mechanics basis.

What's new in the Second Edition?

Each chapter in the Second Edition now includes an overview that outlines the contents and purpose of each chapter. The author has also added a new chapter of special topics in applications, including cracks, semi-infinite and infinite domains, buckling, and thermal stress. He discusses three different linearization techniques to solve nonlinear differential equations. Also included are new sections on shell formulations and MATLAB programs. These enhancements increase the book's already significant value both as a self-study text and a reference for practicing engineers and scientists.

Transfer function form, zpk, state space, modal, and state space modal forms. For someone learning dynamics for the first time or for engineers who use the tools infrequently, the options available for constructing and representing dynamic mechanical models can be daunting. It is important to find a way to put them all in perspective and have them available for quick reference.

It is also important to have a strong understanding of modal analysis, from which the total response of a system can be constructed. Finally, it helps to know how to take the results of large dynamic finite element models and build small MATLAB® state space models.

Vibration Simulation Using MATLAB and ANSYS answers all those needs. Using a three degree-of-freedom (DOF) system as a unifying theme, it presents all the methods in one book. Each chapter provides the background theory to support its example, and each chapter contains both a closed form solution to the problem-shown in its entirety-and detailed MATLAB code for solving the problem.

Bridging the gap between introductory vibration courses and the techniques used in actual practice, Vibration Simulation Using MATLAB and ANSYS builds the foundation that allows you to simulate your own real-life problems.

Features

o Demonstrates how to solve real problems, covering the vibration of systems from single DOF to finite element models with thousands of DOF
o Illustrates the differences and similarities between different models by tracking a single example throughout the book
o Includes the complete, closed-form solution and the MATLAB code used to solve each problem
o Shows explicitly how to take the results of a realistic ANSYS finite element model and develop a small MATLAB state-space model
o Provides a solid grounding in how individual modes of vibration combine for overall system response

This book offers readers fresh insights on applying Extended Reality to Digital Anatomy, a novel emerging discipline. Indeed, the way professors teach anatomy in classrooms is changing rapidly as novel technology-based approaches become ever more accessible. Recent studies show that Virtual (VR), Augmented (AR), and Mixed-Reality (MR) can improve both retention and learning outcomes. Readers will find relevant tutorials about three-dimensional reconstruction techniques to perform virtual dissections. Several chapters serve as practical manuals for students and trainers in anatomy to refresh or develop their Digital Anatomy skills. We developed this book as a support tool for collaborative efforts around Digital Anatomy, especially in distance learning, international and interdisciplinary contexts. We aim to leverage source material in this book to support new Digital Anatomy courses and syllabi in interdepartmental, interdisciplinary collaborations. Digital Anatomy - Applications of Virtual, Mixed and Augmented Reality provides a valuable tool to foster cross-disciplinary dialogues between anatomists, surgeons, radiologists, clinicians, computer scientists, course designers, and industry practitioners. It is the result of a multidisciplinary exercise and will undoubtedly catalyze new specialties and collaborative Master and Doctoral level courses world-wide. In this perspective, the UNESCO Chair in digital anatomy was created at the Paris Descartes University in 2015 (www.anatomieunesco.org). It aims to federate the education of anatomy around university partners from all over the world, wishing to use these new 3D modeling techniques of the human body.

This book is on urban resilience - how to design and operate cities that can withstand major threats such as natural disasters and economic downturns and how to recover from them. It is a collection of latest research results from two separate but collaborating research groups, namely, researchers in urban design and those on general resilience theory. The book systematically deals with the core aspects of urban resilience: systems, management issues and populations. The taxonomy can be broken down into threats, systems, resilience cycles and recovery types in the context of urban resilience. It starts with a discussion of systems resilience models, focusing on the central idea that resilience is a moving average of costs (a set of trajectories in a two-player game paradigm). The second section explores management issues, including planning, operating and emergency response in cities with specific examples such as land-use planning and carbon-neutral scenarios for urban planning. The next section focuses on urban dwellers and specific people-related issues in the context of resilience. Agent-based simulation of behaviour and perception-based resilience, as well as brand crisis management are representative examples of the topics discussed. A further section examines systems like public utilities - including managing power supplies, cyber-security issues and models for pandemics. It concludes with a discussion of the future challenges and risks facing complex systems, for example in resilient power grids, making it essential reading for a wide range of researchers and policymakers.

The latest from a computer graphics pioneer, An Introduction to NURBS is the ideal resource for anyone seeking a theoretical and practical understanding of these very important curves and surfaces. Beginning with Bezier curves, the book develops a lucid explanation of NURBS curves, then does the same for surfaces, consistently stressing important shape design properties and the capabilities of each curve and surface type. Throughout, it relies heavily on illustrations and fully worked examples that will help you grasp key NURBS concepts and deftly apply them in your work. Supplementing the lucid, point-by-point instructions are illuminating accounts of the history of NURBS, written by some of its most prominent figures.

Whether you write your own code or simply want deeper insight into how your computer graphics application works, An Introduction to NURBS will enhance and extend your knowledge to a degree unmatched by any other resource.
* Presents vital information with applications in many different areas: CAD, scientific visualization, animation, computer games, and more.
* Facilitates accessiblity to anyone with a knowledge of first-year undergraduate mathematics.
* Details specific NURBS-based techniques, including making cusps with B-spline curves and conic sections with rational B-spline curves.
* Presents all important algorithms in easy-to-read pseudocode-useful for both implementing them and understanding how they work.
* Provides C-code implementations of worked examples at http: //www.mkp.com/nurbs.
* Includes complete references to additional NURBS resources."

The Visible Human Project is a critical investigation of the spectacular, three-dimensional recordings of real human bodies - dissected, photographed and converted into visual data files - made by the US National Library of Medicine in Baltimore. Catherine Waldby uses new ideas from cultural studies, science studies and social studies of the computer to situate the Visible Human Project in its historical and cultural context, and to consider the meanings such an object has within a computerised culture.
In this fascinating and important book, Catherine Waldby explores how advances in medical technologies have changed the way we view and study the human body, and places the VHP within the history of technologies such as the X-ray and CT-scan, which allow us to view the human interior.
Bringing together medical conceptions of the human body with theories of visual culture from Foucault to Donna Haraway, Waldby links the VHP to a range of other biomedical projects, such as the Human Genome Project and cloning, which approach living bodies as data sources. She argues that the VHP is an example of the increasingly blurred distinction between `living' and 'dead' human bodies, as the bodies it uses are digitally preserved as a resource for living bodies, and considers how computer-based biotechnologies affect both medical and non-medical meanings of the body's life and death, its location and its limits.

The Visible Human Project is a critical investigation of the spectacular, three-dimensional recordings of real human bodies - dissected, photographed and converted into visual data files - made by the US National Library of Medicine in Baltimore. Catherine Waldby uses new ideas from cultural studies, science studies and social studies of the computer to situate the Visible Human Project in its historical and cultural context, and to consider the meanings such an object has within a computerised culture.
In this fascinating and important book, Catherine Waldby explores how advances in medical technologies have changed the way we view and study the human body, and places the VHP within the history of technologies such as the X-ray and CT-scan, which allow us to view the human interior.
Bringing together medical conceptions of the human body with theories of visual culture from Foucault to Donna Haraway, Waldby links the VHP to a range of other biomedical projects, such as the Human Genome Project and cloning, which approach living bodies as data sources. She argues that the VHP is an example of the increasingly blurred distinction between `living' and 'dead' human bodies, as the bodies it uses are digitally preserved as a resource for living bodies, and considers how computer-based biotechnologies affect both medical and non-medical meanings of the body's life and death, its location and its limits.

eBook available with sample pages: HB:0415174058

This book covers the whole spectrum of modeling goals to achieve optimal quality in the process model developed. It focuses on how to balance quality considerations across all semiotic levels when models are used for different purposes, and is based on SEQUAL, a framework for understanding the quality of models and modeling languages, which can take into account all main aspects relating to the quality of models. Chapter 1 focuses on the theoretical foundations, introducing readers to the topics of business processes and business process modeling, as well as the most important concept underlying the modeling of business processes. In turn, Chapter 2 addresses the quality of models in general and business process models in particular. Chapter 3 contains a specialization of SEQUAL for quality of business process models. In Chapter 4, examples of the practical uses of business process models are provided, together with the results of detailed case studies on how to achieve and maintain quality in business process models. Chapter 5 presents a process modeling value framework that demonstrates how to achieve more long-term and higher return on investment with regard to (business) process and enterprise models. Lastly, Chapter 6 reviews the main points of the book and discusses the potential for business process modeling in the future through its combination with other types of modeling. The book has two intended audiences. It is primarily intended for computer science, software engineering and information system students at the postgraduate level who want to know more about business process modeling and the quality of models in preparation for professional practice. The second audience consists of professionals with extensive experience in and responsibilities related to the development and evolution of process-oriented information systems and information systems methodologies in general, who need to formalize and structure their practical experience or update their knowledge as a way to improve their professional activity. The book also includes a number of real-world case studies that make it easier to grasp the main theoretical concepts, helping readers apply the approaches described.

As part of the Environmental and Ecological Modeling Handbooks series, the Handbook of Ecosystem Theories and Management provides a comprehensive overview of ecosystem theory and the tools - ecological engineering, ecological modeling, ecotoxicology and ecological economics -to manage these systems.
The book is laid out to provide a summary or survey of each topic, using many tables and figures. Concepts, definitions, important findings, basic hypotheses, important correlations between theories and observation with illustrative graphs are included.
The comprehensive treatment of ecosystem theory and application of theoretical tools, and the integration of classical theory and real world examples, sets this book apart. It covers newly emerging topical areas as well as nontraditional topical areas (i.e. chaos) that will interest professionals trained in previous decades and enlighten those now entering into formal training. The general approach taken by the authors makes this an essential reference and handbook for professionals and students.

Building on the author's earlier Applied Simulation and Optimization, this book presents novel methods for solving problems in industry, based on hybrid simulation-optimization approaches that combine the advantages of both paradigms. The book serves as a comprehensive guide to tackling scheduling, routing problems, resource allocations and other issues in industrial environments, the service industry, production processes, or supply chains and aviation. Logistics, manufacturing and operational problems can either be modelled using optimization techniques or approaches based on simulation methodologies. Optimization techniques have the advantage of performing efficiently when the problems are properly defined, but they are often developed through rigid representations that do not include or accurately represent the stochasticity inherent in real systems. Furthermore, important information is lost during the abstraction process to fit each problem into the optimization technique. On the other hand, simulation approaches possess high description levels, but the optimization is generally performed through sampling of all the possible configurations of the system. The methods explored in this book are of use to researchers and practising engineers in fields ranging from supply chains to the aviation industry.

The complexity of specifications and the number of materials options available today for concrete production mean that the traditional procedure of making trial mixes is now unnecessary, expensive and time consuming. However the data generated by trial mixes can be incorporated into the development of computer-based systems and combined with knowledge generated through research and practice. J.D Dewar has spent much of the 20 years between 1979 and 1999 developing systems by which a small amount of materials data can be used confidently to predict the composition of the ideal product to satisfy a specification with maximim economy, or to provide the "batch book" to fulfill all requirements using a specified combination of materials. Equally useful is the potential for forward control by the continuous adjustment of designs to take account of current or developing materials properties.

The book covers intimately all the topics necessary for the development of a robust magnetohydrodynamic (MHD) code within the framework of the cell-centered finite volume method (FVM) and its applications in space weather study. First, it presents a brief review of existing MHD models in studying solar corona and the heliosphere. Then it introduces the cell-centered FVM in three-dimensional computational domain. Finally, the book presents some applications of FVM to the MHD codes on spherical coordinates in various research fields of space weather, focusing on the development of the 3D Solar-InterPlanetary space-time Conservation Element and Solution Element (SIP-CESE) MHD model and its applications to space weather studies in various aspects. The book is written for senior undergraduates, graduate students, lecturers, engineers and researchers in solar-terrestrial physics, space weather theory, modeling, and prediction, computational fluid dynamics, and MHD simulations. It helps readers to fully understand and implement a robust and versatile MHD code based on the cell-centered FVM.

Building Product Models thoroughly presents the concepts, technology, and methods now used to work out what will become the building product model - a new, digital representation for architecture, civil engineering, and building construction.
Organized into three sections (history, current tools and concepts, and existing efforts and research issues), this resource provides the field of building product modeling with a standard reference as well as a single, comprehensive text for university courses.
Until now, all the efforts in building modeling have been reported in research journals and conference proceedings or been made available as draft standards on the Internet. Building Product Models is the only book available on this vital field, bringing together essential aspects of major efforts from the early 1970s to the present.

New to CINEMA 4D and looking for an accessible way to get up to speed quickly? Do you already know the basics of the software but need to know the new features or take your skills and understanding a little deeper? If so, look no further than CINEMA 4D Apprentice, your one-stop shop for learning this powerful application. With guidance that takes you beyond just the button-pushing, author Kent McQuilkin guides you through 10 core lessons, starting with the basics before moving onto more complex techniques and concepts and then tying it all together with a final project. CINEMA 4D Apprentice walks you through the software with a project-based approach, allowing you to put lessons learned into immediate practice. Best practices and workflows for motion graphics artists that can be applied to any software application are included. A companion website (www.focalpress.com/cw/mcquilkin) features project files and videos of the techniques in action. Topics covered include: creating basic scenes, modeling, texture mapping mograph in-depth integration with After Effects via CINEWARE lighting, animation, rendering and more motion tracking with the new tools included in R16

This textbook describes the hands-on application of data science techniques to solve problems in manufacturing and the Industrial Internet of Things (IIoT). Monitoring and managing operational performance is a crucial activity for industrial and business organisations. The emergence of low-cost, accessible computing and storage, through Industrial Digital Technologies (IDT) and Industry 4.0, has generated considerable interest in innovative approaches to doing more with data. Data science, predictive analytics, machine learning, artificial intelligence and general approaches to modelling, simulating and visualising industrial systems have often been considered topics only for research labs and academic departments. This textbook debunks the mystique around applied data science and shows readers, using tutorial-style explanations and real-life case studies, how practitioners can develop their own understanding of performance to achieve tangible business improvements. All exercises can be completed with commonly available tools, many of which are free to install and use. Readers will learn how to use tools to investigate, diagnose, propose and implement analytics solutions that will provide explainable results to deliver digital transformation.

One critical barrier leading to successful implementation of flexible manufacturing and related automated systems is the ever-increasing complexity of their modeling, analysis, simulation, and control. Research and development over the last three decades has provided new theory and graphical tools based on Petri nets and related concepts for the design of such systems. The purpose of this book is to introduce a set of Petri-net-based tools and methods to address a variety of problems associated with the design and implementation of flexible manufacturing systems (FMSs), with several implementation examples.There are three ways this book will directly benefit readers. First, the book will allow engineers and managers who are responsible for the design and implementation of modern manufacturing systems to evaluate Petri nets for applications in their work. Second, it will provide sufficient breadth and depth to allow development of Petri-net-based industrial applications. Third, it will allow the basic Petri net material to be taught to industrial practitioners, students, and academic researchers much more efficiently. This will foster further research and applications of Petri nets in aiding the successful implementation of advanced manufacturing systems.

This textbook teaches the fundamentals of building energy modeling and analysis using open source example applications built with the US DOE's OpenStudio modeling platform and EnergyPlus simulation engine. Designed by researchers at US National Laboratories to support a new generation of high performance buildings, EnergyPlus and OpenStudio are revolutionizing how building energy modeling is taught in universities and applied by professional architects and engineers around the world. The authors, all researchers at National Renewable Energy Laboratory and members of the OpenStudio software development team, present modeling concepts using open source software that may be generally applied using a variety of software tools commonly used by design professionals. The book also discusses modeling process automation in the context of OpenStudio Measures-small self-contained scripts that can transform energy models and their data-to save time and effort. They illustrate key concepts through a sophisticated example problem that evolves in complexity throughout the book. The text also examines advanced topics including daylighting, parametric analysis, uncertainty analysis, design optimization, and model calibration. Building Energy Modeling with OpenStudio teaches students to become sophisticated modelers rather than simply proficient software users. It supports undergraduate and graduate building energy courses in Architecture, and in Mechanical, Civil, Architectural, and Sustainability Engineering.