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Books > Medicine > Clinical & internal medicine > Dermatology
Inflammatory markers, oncogenes, tumor suppressor genes and cell
cycle regulators in skin growths represent a series of reports and
reviews on skin cancers and precancers, their host immune responses
and correlations with medical literature data. We were able to
clearly identify an immune response in multiple skin cancers, as
well as in cutaneous pre-cancerous conditions. In poorly
differentiated tumor areas, some classic immunohistochemical stains
did not stain as frequently described in the literature. Other
important phenomena we observed are that many cell cycle
regulators, cell cycle checkpoints, oncogenes and tumor suppressor
gene markers were not only positive inside the tumors, but also in
cells around the tumor. Portions of adjacent skin appendices and in
supposedly normal adjacent epidermal and dermal tissue also showed
signs of these components. These common findings raised questions
concerning marginal definition of cutaneous surgery; that is, many
of the immunologic findings could not be correlated on classical
hematoxylin and eosin reviews. We also noted that many immunologic
cells around skin cancers and/or pre-cancers showed high rates of
division defined via markers such as Ki-67; our findings utilizing
double color immunohistochemistry also showed that these immune
cells are possibly actively duplicating as effector cells. Ki-67
has been cited as a superb proliferation marker in melanoma, but
additional review of its utility is warranted given our results.
Finally, we also found double staining immunohistochemistry to be
of excellent value in detecting melanoma cells metastasizing in
blood vessels, lymphatics and/or nerves.
Many healthcare practitioners understand the role microbiology has
within the management of their patients, particularly when this
involves wound care and the healing process. However, basic medical
and nursing training does not always cover the microbiology of
wound care in any great depth. Essential Microbiology for Wound
Care is an indispensable reference aid that covers the key areas
and science of microbiology from a point of view relevant to wound
care practitioners wishing to enhance their skills. Written by
specialists in the areas of microbiology and wound care, the book
explains the basic science of microbiology and how it applies to
wound care from simple infections to complex non-healing wounds,
covering areas such as the diagnosis of infection, antimicrobial
agents, virulence, and the treatment of infection, and infection
control. Current thought in the field is also discussed, covering
the improved understanding of the role of microorganisms and
biofilms, newly-arising management strategies, and the increasing
concern about the rapid development of antimicrobial resistance and
how this may impact the administration of antibiotics in the
future. Prevention and alternative forms of treatment in the field
of wound care for the diabetic foot, burns, acute, and chronic
wounds are also included. From the basic science to biofilms,
Essential Microbiology for Wound Care provides a thorough
understanding of the basic principles of microbiology in an
accessible style that makes it a key reference in the field of
wound care.
Do you have a black colored lesion in your skin that won't go away?
Or a blister formation every time you wear your favorite shoes? Any
anomaly in the skin gets noticed right away. It can strike our self
esteem and make us feel embarrassed. There are different types of
skin lesions such as papules, macules, moles, blisters and
vesicles. Skin cancer can arise from a pigmented nevi. Shingles
have blisters that follow the nerve pathways. These skin structures
are not a part of our integumentary system. This book contains the
facts regarding skin cancer, shingles, burns, pressure ulcers, skin
cuts and the different classification of skin lesions and wounds.
It also contains information regarding causes, diagnostic
procedures, treatments and caring for the different skin
conditions. The main goal is to make the reader more informed. The
chapters in this book are: Chapter 1: Anatomy and Physiology of the
Skin Chapter 2: Skin Integrity Chapter 3: Skin Lesions and Skin
Wounds Chapter 4: Wound Healing Chapter 5: Skin Wounds:
Intervention, Treatment, Care and Recovery Chapter 6: Skin Cancer
Lesions: Interventions, Treatment, Care and Recovery Chapter 7:
Shingles Lesions: Intervention, Treatment, Care and Recovery
Chapter 8: Pressure Ulcer Lesions and Wounds: Intervention,
Treatment, Care and Recovery Chapter 9: Burn Lesions and Wounds:
Intervention, Treatment, Care and Recovery
Skin aging is the result of two distinct, biological processes
which may occur concurrently: extrinsic and intrinsic aging. The
first chapter of this book focuses on the anti-skin aging effects
of natural products, such as polyphenols and terpenes using topical
application and oral administration. Future prospects for this
field of research will focus on natural products combined with
molecular techniques to help maximize the desired anti-skin aging
benefits. The second chapter provides a brief review of skin
characteristics, skin aging mechanisms and dermal applications. The
next chapter of the book reviews the types of pollution and
external aggression that skin is exposed to and reviews recently
published studies that report that cumulative exposure to the five
daily environmental aggressors (pollution, sun, cold, heat and
wind) increase this skin damage. The remaining chapters review the
role of inflammation in regulation of skin aging; the relevant
methods, the physiological structure and function of the Stratum
Corneum, as well as the effects of intrinsic and extrinsic aging on
these parameters; the physiology of skin photoaging and the
emerging therapies for combating photoaging and photocarcingenesis;
and the biological effects and the latest findings on the role of
macrophage migration inhibitory factors (MIF) in photoaging
following UV exposure.
Das vorliegende Essential bietet einen fundierten Einblick in die
photobiologischen Wirkmechanismen, die einer Phototherapie mit
UV-A, UV-B oder PUVA zu Grunde liegen. Es stellt zudem einen
Leitfaden fur die Durchfuhrung einer Phototherapie dar. Die
Phototherapie ist eine seit Langem genutzte und effektive
Behandlungsmodalitat in der Therapie verschiedenster Dermatosen. Im
Wesentlichen entfaltet sie ihre Wirkung durch drei Mechanismen.
Erstens fuhrt UV-Bestrahlung zu einer Induktion von DNS-Schaden,
was zum Zelltod fuhren kann. Zweitens beeinflusst Phototherapie
sowohl angeborene wie auch spezifische Anteile des Immunsystems und
entfaltet eine immunmodulatorische Wirkung. Drittens wird der
Kollagenstoffwechsel verandert.
Advances in Dermatology Research presents original research results
on the leading edge of dermatology. Each chapter has been carefully
selected in an attempt to present substantial advances across a
broad spectrum. Some topics discusses in this book include
pemphigoid; cyanosis, and acne.
The book is an extensive overview in the topic of superficial
mycoses. The book deliberates on human fungi kingdom, pathogenesis
of different superficial mycological diseases, its classical
clinical manifestations and the variants clinical forms, with an
emphasis on the relevant differential diagnosis, which sometimes
might be confused with superficial mycoses. The book is written in
a very practical approach accompanied with images and relevant
explanations. The book has two main goals. First, to provide broad
information regarding superficial dermatomycological diseases. In
addition, it gives emphasis on correct diagnosis, focusing on
precise and relevant interpretation of mycological laboratory
analysis in order to prevent over-diagnosis and misinterpretation
of the disease. The clinical approach -- practically -- is
necessary for having correct diagnosis. The final diagnosis will be
supported by using the standard laboratory analysis. A unique
chapter elaborates widely on laboratory analysis, combined with
relevant interpretation of the mycological results. This is due to
many different saprophytes fungi which are irrelevant to skin
diseases and might be interpreted as relevant, by mistake. Other
laboratories techniques are discussed widely as well. The different
approaches for mycological analysis are elaborated including the
interpretation of false positive and false negative results. Other
skin disorders such as psoriasis, atopic dermatitis and/or many
other nails disorders which could be accompanied with relevant or
irrelevant different fungi are discussed widely accompanied with
very impressive clinical pictures and explanations of how and when
to suspect combined disorders. Topical and systemic anti fungi
treatment is listed clearly, focusing on the different antifungal
mechanisms of each antifungal family. Drug
interactions/contra-indications between the antifungal drug/s and
other common drugs are presented in detail as well as the possible
side effects of the antifungal drugs. New different drugs and
devices such as lasers, photo dynamic therapy (PDT), and drilling
of the nails also are examined.
Targeted cancer therapies have revolutionised the therapeutic
management of many neoplasms, modifying patients' prognosis and
overall survival. These drugs block the cancer's growth and spread
by interfering with specific molecules which play a crucial role in
the proliferation, differentiation and survival of cancer cells.
Targeted therapies act selectively on specific molecular targets
related to cancers, whereas most of the conventional chemotherapies
act on all rapidly dividing normal and neoplastic cells. Moreover,
targeted therapies are often cytostatic and non-cytotoxic as
standard chemotherapies. Taken together, these aspects appear
important in reducing systemic toxicity and ensuring an improved
safety profile. The inhibition of epidermal growth factor receptor
(EGFR), vascular growth factor (VEGF) and BRAF represents major
achievements in research and development of solid tumour's
epithelial therapy. This class of biologics is currently widely
used in the treatment of metastatic and unresponsive neoplasms of
the colon, pancreas, lung, (NSCLC), breast, head and neck and
melanoma. This book aims to emphasize skin toxicity associated with
EGFR-, VEGF- and BRAF- inhibitors, focusing particularly on their
clinical presentation, histopathological findings, and specific
therapeutic options.
Sun protection practices play a prominent role in dermatology in
terms of photoaging, photocarcinogensis, and photodermatoses. This
book begins by outlining the various methods of sun protection. It
continues to discuss risk factors for sun exposure during spring
break among college students; the role sun exposure plays in skin
aging; and protection habits and vitamin D levels in children and
adolescents with a history of malignancy.
Adverse drug reactions commonly affect the skin. In rare instances,
they cause severe morbidity and possibly lead to drug-induced
mortality. Toxic epidermal necrolysis (TEN) represents the
archetype of such conditions. This book summarises the recent
advances in the field of TEN as a major life-threatening adverse
drug reaction. Indeed, this dramatic condition remains a puzzling
topic for both the clinician at the bedside and in the laboratory.
This book is fully updated about the putative biomechanisms, the
clinico-pathological correlations and recent treatment advances.
The most damaging effects of TEN reside in the skin, eyes and oral
mucosa. Physicians keen in intensive care medicine, dermatology and
ophthalmology should find here stimulating concepts applicable to
the patient with the hope of reducing the TEN fatalities.
The skin is composed of three layers of differentiated tissues. The
most external layer is the epidermis, followed by the dermis and
the hypodermis, which is the most internal layer of the skin. The
increasing incidence of skin cancer has led international health
authorities to recommend protection measures to prevent the harmful
effects of skin exposure to UV-radiation. Such measures include
avoidance of sun exposure, especially at times when
disease-inducing wavelengths are more intense, wearing protective
clothing and use of topical sunscreens. This book discusses the
various properties of sunscreens, the role sunscreens play in skin
cancer, and other health effects for individuals using sunscreens.
Pemphigus vulgaris (PV) is the most frequent condition inside the
pemphigus group, especially in Europe and North America. It is the
prototype of a genetically mediated disease. The HLA alleles
associated with PV are well-known. Recent studies found an
association between disease severity and some HLA DRB1 and DQB1
alleles. The author of this book discusses the management of PV
that should be started with an evaluation of disease severity.
Eczema can be a devastating condition, yet friends, family and even
healthcare professionals dismiss it. How many times do you hear
others say it is only eczema. Yet they are wrong, eczema ruins
lives. Your child is suffering, they are not sleeping, you are not
sleeping. Everywhere you turn there is different advice - it is
food allergy, it is a clothes allergy, use steroids, don't use
steroids. The internet, health professionals and book shops are
full of often contradictory advice of what to do. Why is this book
any different? I am a doctor who has spent my career specialising
in and treating children with eczema. I am also a father of two
children with eczema. As much as I have learned from my
professional career it is only since having my own children that I
have truly understood how overwhelming eczema can be. This book
balances the professional 'ideal' ways of treating eczema against
the practicalities of doing this in real life. There are hints,
tips and practical solutions to everyday situations and answers to
all the commonest questions parents ask me. This book is
purposefully short and pragmatic, so it can be read quickly and the
eczema can treated properly as soon as possible. If you follow the
advice in this book your child will get better and they will stay
better. It may not be easy but you will be amazed how much better
your child can be and how much this will improve your life. Dr
James Halpern MBChB, BMedSci, MRCP(UK)(Dermatology) Consultant
Dermatologist
Publisher's Note: Products purchased from Third Party sellers are
not guaranteed by the publisher for quality, authenticity, or
access to any online entitlements included with the product. Learn
how to perform basic and advanced skin surgery with this
combination text and atlasWritten in clear, concise language, and
backed by the latest evidence, Procedural Dermatology is a
practical guide for performing all types of skin procedures for
both medical and cosmetic problems. Procedural Dermatology opens
with a section onSurgical Principles, that discusses essentials
such as headand neck anatomy, preoperative evaluation,
anesthesia,aseptic technique, antibiotics, wound healing, and
postoperative care. The next four sections (Surgical Skills, Skin
Tumors, Aesthetic & Laser Procedures, and Aesthetic Problems)
cover the different types of surgical procedures, describing them
in step-by-step fashion, with each step illustrated with line
drawings and photographs. Procedural Dermatology compiles current,
state-of-the-art information valuable to all practitioners of
dermatologic surgery, from the trainees to seasoned surgeons
wishing to refine their skills.
Even those clinicians who feel themselves far from aesthetic
dermatology now recognise that BoNT-A is an extraordinary tool in
their therapeutic armamentarium for treating complex disorders such
as focal idiopathic hyperhidrosis. This has opened a therapeutic
scenario for a group of patients very difficult to treat
previously. Since the introduction of BoNT-A in the dermatological
therapeutic armamentarium, in 1990, things have changed to the
point that any dermatologist should now have knowledge of BoNT-A
basics, and the practicalities of BoNT-A vial reconstitution and
injection. Moreover, in the last years, a widespread availability
of multiple different commercially available forms of BoNT-A has
been for sale, thus the clinicians must now really know and
consider the advantages and disadvantages of the different
available products. These would include dosing/duration,
immunogenicity, and spread of effect. What has not changed over the
years is the safety profile of BoNT-A. The knowledge regarding its
side effects and complications have greatly increased, confirming
that, despite the attempts of some individuals to assert otherwise,
BoNT-A remains one of the safest forms of treatment available to us
as physicians. This edited collection provides a comprehensive
practical guide on the use of botulinum toxin in several
dermatological disorders, including focal idiopathic, axillary,
palmar and plantar, craniofacial or segmental hyperhidrosis,
chrono-aging, hidradenitis, and gives some suggestion on the use of
BoNT-A for the treatment of several orphan skin diseases, not
responding to conventional treatments like benign Hailey-Hiley
disease, lichen simplex, osmidrosis. Using clear explanations,
simple line drawings, diagrams and clinical pictures, it provides
suggestions to improve practical knowledge on the use of BTX-A in
dermatology. Hot topics include practical information for
clinicians regarding the correct counselling of the patients to be
treated; methods and ready to use tests to select patients to be
treated; the optimal dosage and dilution according to the site of
injection and the indication of use; the relevant injection sites
for each condition; the correct technique of injection in the
different areas of body surface; comparative dosage tables for the
various formulations of toxin used; how to manage and prevent side
effects related to the use of BoNT-A; common pitfalls and how to
optimize outcomes; timing for the follow-up of treated patients.
The authors hope that this book may be a starting point for the use
of a drug that is still growing, and a useful tool for those
clinicians who want to improve their knowledge about the use of
BoNT-A in dermatology.
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