Now in softcover, this book aims to provide the definitive guide to the diagnosis and treatment of various blistering skin diseases. It offers the reader a succinct clinical description for quick recognition of different types of blistering diseases and their relative urgency. It also provides information on the clinical features of blistering skin diseases, differential diagnoses, laboratory findings, and therapeutic strategy. There is also a section on pathogenesis to enhance the readers understanding on the molecular events underlying the blistering disease process. This book will be useful for dermatologists in training and in practice, physicians working in emergency departments, candidates for post- registration qualifications, general practitioners and medical students.

DermOPix(r)" ist ein kleiner, manchmal etwas frecher Ritter der Hautchirurgie. Er fuhrt Sie in seiner Art durch das DERMALAND(r)," das fur alle offen ist. Seine Wegmarken geben lediglich Orientierung, manchmal fuhren sie an den eingefahrenen Wegen vorbei.

DermOPix will neben der Dauerheilung auch ein gutes asthetisches Ergebnis erzielen. Notwendig dafur sind vor allem vertiefte Kenntnisse in der Anwendung von Hautlappenplastiken.

DermOPix und seine Getreuen verfugen uber einen reichen Schatz an Erfahrung in Chirurgie und Dermatologie. Seit uber 25 Jahren kamen ihre Waffen weit mehr als 200 000 mal zum Einsatz, insbesondere auf dem Gebiet der regionalen Lappenplastiken. DermOPix hat zudem jahrelang viele dieser Handlungen in Papers" aufgeschrieben. Er mochte Sie an seiner Erfahrung teilhaben lassen. DermOPix wird Sie mit detaillierten praktischen Hinweisen aus der Praxis fur die Praxis durch den Operationsalltag fuhren. Folgen Sie einfach dem kleinen DermOPix in sein DERMALAND."

Skin health has taken center stage for health care practitioners and patients alike. Not only has skin cancer quickly become the number one form of cancer in the United States, with 3.5 million cancers diagnosed in over 2 million patients annually, but concerns about sun protection and healthy aging have dominated both public media and individual patient concerns. As the largest and most visible organ, the skin displays all evidence of health and vitality, both real and perceived, thereby conferring a tremendous amount of psychological burden on those afflicted with cutaneous ailments. Clinicians are thus charged with the important task of caring for the whole person, mentally as well as physically, to achieve therapeutic success. Integrative Dermatology is the first comprehensive text in this growing field which strives to examine and combine best practices from both traditional medicine as well as complementary and alternative healing modalities such as: diet, supplements, and mind-body medicine. The book presents key concepts for synthesizing the best, comprehensive care plan for each individualized and contextualized dermatology patient.

Comprehensive and lavishly illustrated, McKee's Pathology of the Skin, 5th Edition, is your reference of choice for up-to-date, authoritative information on dermatopathology. You'll find clinical guidance from internationally renowned experts along with details on etiology, pathogenesis, histopathology, and differential diagnosis - making this unique reference unparalleled in its wealth of clinical and histopathological material. The 5th Edition of this classic text is a must-have resource for practicing dermatopathologists and general pathologists who sign out skin biopsies. Covers pathological aspects of skin diseases in addition to providing superb descriptions and illustrations of their clinical manifestations - the only available reference with this unique combination of features. Integrates dermatopathology, clinical correlations, and clinical photographs throughout, and features bulleted lists of clinical features and differential diagnosis tables for easy reference. Contains more than 5,000 superb histopathologic and clinical illustrations that demonstrate the range of histologic manifestations. Brings you fully up to date with key molecular aspects of disease, the capabilities and limitations of molecular diagnostics, and targeted/personalized medicine. Features up-to-date information on biologics, drug eruptions, and other developments in therapeutics. Helps you stay current with the latest diagnostic tumor markers and other new developments in immunohistochemistry. Includes a completely revised chapter on cutaneous lymphoma that reflects recent WHO-EORTC classification changes, as well as new coverage of sentinel lymph node biopsy for melanoma. Shares the knowledge of the main editor Dr. J. Eduardo Calonje, along with co-editors Thomas Brenn, and Alexander Lazar, and new co-editor Steven D. Billings who offers expertise on both dermatopathology and soft tissue tumors. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

In den zuruckliegenden vier Jahren hat die HIV-Medizin einen enormen und sich noch immer beschleunigenden Wissenszuwachs mit den kurzesten Innovationszyklen innerhalb der Medizin zu verzeichnen. Dieser Entwicklung wird in diesem Buch durch die Beitrage der bedeutendsten Experten Rechnung getragen. Das Besondere dieses Buches ist, dass ein aktueller UEberblick uber die gesamte Breite der HIV/AIDS-Erkrankung von der Epidemiologie/Pravention uber grundlagenwissenschaftliche Aspekte, diagnostische und klinische Behandlungsmoeglichkeiten sowie psychosoziale Fragestellungen vermittelt wird. Es handelt sich um eine aktuelle Zusammenstellung der wichtigsten auf dem 7. Deutschen AIDS-Kongress prasentierten wissenschaftlichen Arbeiten.

Durch die zunehmende Spezialisierung in der Medizin wird es immer schwieriger, komplexe Krankheitsbilder mit fachubergreifenden Symptomen zu erkennen und richtig zu klassifizieren.
Hier bietet Ihnen das Buch eine praxisgerechte Orientierungshilfe.
- Es fuhrt erstmals fachubergreifend dermatologische Leitsymptome und rontgendiagnostische Befunde zusammen.
- 85 Krankheitsbilder, mit denen Sie in der Praxis rechnen mussen, werden synoptisch aus dermatologischer und klinisch-radiologischer Sicht beschrieben.
- Suchtabellen, nach dermatologischen und radiologischen Leitsymptomen geordnet, geben Ihnen einen schnellen Uberblick.
Dieses diagnostische Mosaik bei Krankheitsbildern aus dem orthopadisch-rheumatologisch-radiologischen Bereich hilft Ihnen zuverlassig, Fehldiagnosen und therapeutische Verzogerungen zu vermeiden.
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The practice of dermatopathology has evolved from viewing predominantly haematoxylin and eosin (H&E)-stained sections through the microscope to include an array of more specialized tests. These are used as stand-alone tests or in addition to the H&E. Diagnostic Dermatopathology: A Guide to Ancillary Tests Beyond the H&E is a practical guide to the most important of these new diagnostic techniques. Aside from a brief review of H&E in the Introduction, the focus of the book is on the wide range of more recent ancillary tests commonly used by clinicians, including sections on special stains, immunohistochemistry, immunofluorescence, electron microscopy and molecular testing. Each section describes why each of these tests is performed, how to use them and how to interpret the results they provide. Abundantly illustrated with colour photographs, diagrams and algorithms Diagnostic Dermatopathology: A Guide to Ancillary Tests Beyond the H&E is packed with practical guidance on commonly-faced diagnostic dilemmas, how the tests described can be used to resolve them and how to avoid pitfalls in the diagnostic process. The book is an essential resource for trainee and practicing dermatopathologists, dermatologists and pathologists seeking an accessible guide to the diagnostic methods which are increasingly important in dermatopathology and which go beyond the H&E.   Key features Covers the full range of diagnostic tests in dermatopathology, aside from H&E, with a focus on practical clinical information such as how to run the test, when to use it and how to interpret the results Includes special stains, immunohistochemistry, immunofluorescence, electron microscopy, molecular testing and point of care tests including potassium hydroxide preparations, mineral oil preparations, and Tzanck smears Single author with hand-picked specialist contributors provide a consistent approach to the subject, replete with diagnostic tips and clinical advice based on extensive personal experience

Inflammatory markers, oncogenes, tumor suppressor genes and cell cycle regulators in skin growths represent a series of reports and reviews on skin cancers and precancers, their host immune responses and correlations with medical literature data. We were able to clearly identify an immune response in multiple skin cancers, as well as in cutaneous pre-cancerous conditions. In poorly differentiated tumor areas, some classic immunohistochemical stains did not stain as frequently described in the literature. Other important phenomena we observed are that many cell cycle regulators, cell cycle checkpoints, oncogenes and tumor suppressor gene markers were not only positive inside the tumors, but also in cells around the tumor. Portions of adjacent skin appendices and in supposedly normal adjacent epidermal and dermal tissue also showed signs of these components. These common findings raised questions concerning marginal definition of cutaneous surgery; that is, many of the immunologic findings could not be correlated on classical hematoxylin and eosin reviews. We also noted that many immunologic cells around skin cancers and/or pre-cancers showed high rates of division defined via markers such as Ki-67; our findings utilizing double color immunohistochemistry also showed that these immune cells are possibly actively duplicating as effector cells. Ki-67 has been cited as a superb proliferation marker in melanoma, but additional review of its utility is warranted given our results. Finally, we also found double staining immunohistochemistry to be of excellent value in detecting melanoma cells metastasizing in blood vessels, lymphatics and/or nerves.

Targeted cancer therapies have revolutionised the therapeutic management of many neoplasms, modifying patients' prognosis and overall survival. These drugs block the cancer's growth and spread by interfering with specific molecules which play a crucial role in the proliferation, differentiation and survival of cancer cells. Targeted therapies act selectively on specific molecular targets related to cancers, whereas most of the conventional chemotherapies act on all rapidly dividing normal and neoplastic cells. Moreover, targeted therapies are often cytostatic and non-cytotoxic as standard chemotherapies. Taken together, these aspects appear important in reducing systemic toxicity and ensuring an improved safety profile. The inhibition of epidermal growth factor receptor (EGFR), vascular growth factor (VEGF) and BRAF represents major achievements in research and development of solid tumour's epithelial therapy. This class of biologics is currently widely used in the treatment of metastatic and unresponsive neoplasms of the colon, pancreas, lung, (NSCLC), breast, head and neck and melanoma. This book aims to emphasize skin toxicity associated with EGFR-, VEGF- and BRAF- inhibitors, focusing particularly on their clinical presentation, histopathological findings, and specific therapeutic options.

Advances in Dermatology Research presents original research results on the leading edge of dermatology. Each chapter has been carefully selected in an attempt to present substantial advances across a broad spectrum. Some topics discusses in this book include pemphigoid; cyanosis, and acne.

The book is an extensive overview in the topic of superficial mycoses. The book deliberates on human fungi kingdom, pathogenesis of different superficial mycological diseases, its classical clinical manifestations and the variants clinical forms, with an emphasis on the relevant differential diagnosis, which sometimes might be confused with superficial mycoses. The book is written in a very practical approach accompanied with images and relevant explanations. The book has two main goals. First, to provide broad information regarding superficial dermatomycological diseases. In addition, it gives emphasis on correct diagnosis, focusing on precise and relevant interpretation of mycological laboratory analysis in order to prevent over-diagnosis and misinterpretation of the disease. The clinical approach -- practically -- is necessary for having correct diagnosis. The final diagnosis will be supported by using the standard laboratory analysis. A unique chapter elaborates widely on laboratory analysis, combined with relevant interpretation of the mycological results. This is due to many different saprophytes fungi which are irrelevant to skin diseases and might be interpreted as relevant, by mistake. Other laboratories techniques are discussed widely as well. The different approaches for mycological analysis are elaborated including the interpretation of false positive and false negative results. Other skin disorders such as psoriasis, atopic dermatitis and/or many other nails disorders which could be accompanied with relevant or irrelevant different fungi are discussed widely accompanied with very impressive clinical pictures and explanations of how and when to suspect combined disorders. Topical and systemic anti fungi treatment is listed clearly, focusing on the different antifungal mechanisms of each antifungal family. Drug interactions/contra-indications between the antifungal drug/s and other common drugs are presented in detail as well as the possible side effects of the antifungal drugs. New different drugs and devices such as lasers, photo dynamic therapy (PDT), and drilling of the nails also are examined.

In the 21st century, there has been a vast explosion in new information relating to the art and science of dermatology as well as fundamental cutaneous biology. Furthermore, this information is no longer exclusive to the interests of the small, but growing, specialty of dermatology. Clinicians and scientists from a wide variety of disciplines have recognized the broad implications of cutanous lesions in systemic diseases. At present, there is a multidisciplinary and worldwide interest in the progress of dermatology. It is difficult for most fully-booked physicians to spend too much time on searching secondary data for the textbook mentioned; this kind of literature-searching job is very time-consuming and remains somewhat incomplete. It should be very helpful to have textbook-matched handbooks with expanded information from topic-oriented experts. With these factors in mind, we have undertaken this series of books which are specifically oriented toward the advances of dermatology. The scope of the series is purposely broad, with books ranging from pure basic science to practical, applied and clinical dermatology. Thus, while there is something for everyone, all volumes in the series will ultimately prove to be valuable additions to a dermatologist's library. The book consists of 22 chapters prepared by authors from 9 countries between five continents. The organization of this international editorial group has ensured global opinions, avoided regional bias and racial preferences. The topics covered in this book are the core of dermatology: from the fundamental changes of skin biology to newly developed technologies and treatments. What makes this book quite unique is the inclusion of Chinese medicine, telemedicine and biologics.

Adverse drug reactions commonly affect the skin. In rare instances, they cause severe morbidity and possibly lead to drug-induced mortality. Toxic epidermal necrolysis (TEN) represents the archetype of such conditions. This book summarises the recent advances in the field of TEN as a major life-threatening adverse drug reaction. Indeed, this dramatic condition remains a puzzling topic for both the clinician at the bedside and in the laboratory. This book is fully updated about the putative biomechanisms, the clinico-pathological correlations and recent treatment advances. The most damaging effects of TEN reside in the skin, eyes and oral mucosa. Physicians keen in intensive care medicine, dermatology and ophthalmology should find here stimulating concepts applicable to the patient with the hope of reducing the TEN fatalities.

The skin is composed of three layers of differentiated tissues. The most external layer is the epidermis, followed by the dermis and the hypodermis, which is the most internal layer of the skin. The increasing incidence of skin cancer has led international health authorities to recommend protection measures to prevent the harmful effects of skin exposure to UV-radiation. Such measures include avoidance of sun exposure, especially at times when disease-inducing wavelengths are more intense, wearing protective clothing and use of topical sunscreens. This book discusses the various properties of sunscreens, the role sunscreens play in skin cancer, and other health effects for individuals using sunscreens.

The integument (the natural covering of an organism or an organ, such as its skin, husk, shell, or rind) is the largest organ system of the human body and is often described as the gatekeeper to every other system. Its integrity will not only determine the admission or rejection of many foreign invaders (bacteria, viruses, fungi, etc.), but also plays a significant role in providing the milieu for the immune system to do battle with these invaders. It is typically the first view of an examiner and often yields very important clues to seemingly non-dermatologic issues. This book takes us one step further, devoting chapters to the interplay between integument and heretofore generally unnoted strongly related psychosocial issues.

Pemphigus vulgaris (PV) is the most frequent condition inside the pemphigus group, especially in Europe and North America. It is the prototype of a genetically mediated disease. The HLA alleles associated with PV are well-known. Recent studies found an association between disease severity and some HLA DRB1 and DQB1 alleles. The author of this book discusses the management of PV that should be started with an evaluation of disease severity.

In the 21st century, there has been a vast explosion in new information relating to the art and science of dermatology, as well as fundamental cutaneous biology. Furthermore, this information is no longer exclusive to the interests of the small, but growing specialty of dermatology. Clinicians and scientists from a wide variety of disciplines have recognised the broad implications of cutanous lesions in systemic diseases. At present, there is a multidisciplinary and worldwide interest in the progress of dermatology. It is difficult for most fully-booked physicians to spend too much time on searching secondary data for the textbook mentioned; this kind of literature-searching job is very time-consuming and remains somewhat incomplete. It should be very helpful to have textbook-matched handbooks with expanded information from topic-oriented experts. With these factors in mind, we have undertaken this series of books which are specifically oriented toward the advances of dermatology. The scope of the series is purposely broad, with books ranging from pure basic science to practical, applied and clinical dermatology. Thus, while there is something for everyone, all volumes in the series will ultimately prove to be valuable additions to a dermatologist's library. The book consists of 18 chapters prepared by authors from nine countries between five continents. The organisation of this international editorial group has ensured global opinions, avoided regional bias and racial preferences. The topics covered in this book are the core of dermatology: from the fundamental changes of skin biology to newly developed technologies and treatments. What makes this book quite unique is the inclusion of Chinese medicine, telemedicine, biologics, and skin disorders newly categorized as auto-inflammatory, such as Still's Disease and Sweet's syndrome.

Urticaria is a common condition, affecting up to 20% of the population at some stage in their lives. It is an important entity to recognise and differentiate from other similar presenting conditions and the clinician ideally needs to be aware of the numerous forms and presentations of urticaria, which varies in terms of severity, chronicity, extent of organ involvement, therapeutic options and prognosis. The book contains 18 chapters, 17 of which are focused on a specific area of importance in this disease. After introducing the topic and discussing the epidemiology of urticaria, the book then comprehensively examines acute urticaria, the various forms of inducible urticaria, urticarial vasculitis, and chronic spontaneous urticaria, a relatively novel term that encompasses chronic autoimmune urticaria and chronic idiopathic urticaria. There is a chapter dedicated to urticaria in children as well as a chapter describing the use of basophil activation tests in chronic urticaria. The final three chapters are devoted to the treatment of urticaria; first line therapies, the role and options of immunosuppression, and the emerging use of omalizumab. The chapters have been written by clinicians and experts in the area from various renowned institutions with the aim of providing a comprehensive yet practical guide to general physicians, dermatologists, clinical immunologists, allergists, and emergency physicians who encounter the problem of urticaria in their practice.

In humans, actinic keratosis is the most frequent lesion of the skin initiating a cascade of tumors ending with the squamous cell carcinoma, actinic type. This health problem is increasing worldwide in incidence in the past decades. It is most prevalent in fair-skinned individuals who expose their skin to ultraviolet light from sunshine and artificial sources. The present book provides essential up-to-date information about this common condition. It is presented in a convenient and practical format. This book explains new developments in the understanding of the skin cancer cascade initiated in the field photocarcinogenesis giving rise to actinic keratosis at the source of invasive actinic squamous cell carcinoma and its metastases. Quandaries about nosology, clinical diagnosis, histopathologic assessment, molecular biology advances and management are addressed. This book assembles important new scientific information on all aspects about the skin cancer cascade induced by the environment. It covers the clinical features and epidemiology to support prevention and therapy. Early diagnosis and treatment are essential in the populations at risk. This actinic keratosis survey will be an invaluable reference for all clinical dermatologists and any other physicians and researchers interested in skin cancerology covering the spectrum of chronically sun-exposed skin. The thousand and one facets of actinic keratosis was written to fit the clinical needs of very busy dermatologists, oncologists, skin investigators, pharmacologists, physician assistants and any practitioner caring for patients particularly exposed to a sunny environment.

Alopecia areata (AA) is a common cause of reversible hair loss afflicting approximately 1-2% of the general population. It commonly presents itself as round patches of hair loss. The aetiology of AA is unknown but is characterised by hair cycle dysfunction and the presence of peribulbar and perifollicular mononuclear cell infiltrates. In this book, the authors present current research in the study of the causes, diagnosis and treatment of alopecia. Topics include radiation treatment and alopecia; the psychosocial aspects in alopecia areata; the classification, pathogenesis and treatment in alopecia areata and its genetic basis.

This book presents current research in the causes, diagnosis and treatment of psoriasis. Topics discussed include furocoumarins used in radiation therapy to treat psoriasis; comorbidities of psoriasis and the risk factors for cardiovascular disease; pharmacological management of psoriasis; nitric oxide syntases and its physiological functions in healthy skin and the vegetarian diet in relation to psoriasis.

Our skin is the visible barrier between what is inside and outside of our bodies. It can respond with sensitivity to tender contact, allowing us to experience pleasure, or, should harmful influences come to bear, it can contract or erupt, causing pain. The increasing prevalence in recent years of various types of skin conditions is an indication of the fact that toxic influences are on the increase.The dermatologist, allergist and physician Lueder Jachens offers wise advice in this helpful and expertly written handbook. His concern is not just to offer understanding of the individual conditions, their causes and how best to treat them, but to give a holistic comprehension of the skin itself - this largest of the human organs - to better enable us to develop health and harmony in the longer term. Jachens' authoritative guide begins with an anatomy of the skin and its relationship to the physical and spiritual levels of existence, and goes on to study various specific conditions and their treatment, including psoriasis, dermatitis, acne, boils, hayfever, alopecia (hair loss), melanoma, abscesses, impetigo, fungal infections, herpes, scabies, head lice, sunburn, and much more.

This bestselling guide to the complexities of botulinum toxins has now been extensively revised, updated, and expanded. Now in two volumes, Volume 1 examines clinical adaptations in the toxins in use today, use with other injectables, use for other parts of the body and other indications, and legal aspects, while Volume 2 documents in detail the functional anatomy and injection techniques for the face, neck, and upper chest. No practitioner of aesthetic medicine will want to be without this comprehensive and authoritative guide from the international experts.

Cutaneous lymphoid infiltrates which are suspicious for lymphoma, are always important challenges for the general pathologist who faces them occasionally. Many times they are also difficult even for the dermatopathologist, and the most modern diagnostic weapons sometimes play a crucial role in the differential diagnosis with other non-malignant entities, as well as between the different types of lymphomas. Clinically, they sometimes simulate many other conditions, and are not always easy to be recognise by the dermatologist. In 2005, a new classification of cutaneous lymphomas was published, in an attempt to achieve a better comprehension of the nature and behaviour of these tumours. Nevertheless, many new aspects of pathogenesis, diagnosis and differential diagnosis, are constantly appearing in medical literature. This current book is an attempt to present to the reader, the field of cutaneous lymphomas in a way that can be useful in daily practice, either as a general surgical pathologist, a dermatologist, or a dermatopathologist. At the same time, the reader will find updated information which will probably be very helpful in order to face confidently most of the difficult clinical and histopathologic cases. The book goes through most of the cutaneous lymphomas in systematic order, either B-cell, T-cell, or Hodgkin type, presenting the clinical, and morphological aspects, which include many of the most recent molecular contributions. Many of the chapters also provide a therapeutic approach.