Written by a single author in a clear and consistent writing style, presents a logical and easy to follow discussion about each phase of neural development Presents an accessible approach to developmental neurobiology for students who do not have an extensive background in neuroscience or cell and molecular biology Clear, informative, and easy-to-follow illustrations support the concepts presented in the text Highlights neurodevelopmental and neurodegenerative disorders where relevant and therapeutic approaches to neurological diseases

This third of 15 short atlases reimagines the classic 5-volume Atlas of Human Central Nervous System Development. This volume presents serial sections from specimens between 15 mm and 18 mm with detailed annotations, together with 3D reconstructions. An introduction summarizes human CNS development by using high-resolution photos of methacrylate-embedded rat embryos at a similar stage of development as the human specimens in this volume. The accompanying Glossary gives definitions for all the terms used in this volume and all the others in the Atlas. Features Classic anatomical atlas Detailed labeling of structures in the developing brain offers updated terminology and the identification of unique developmental features, such as germinal matrices of specific neuronal populations and migratory streams of young neurons Appeals to neuroanatomists, developmental biologists, and clinical practitioners A valuable reference work on brain development that will be relevant for decades

This book aims to comprehensively review the current cell-based strategies under investigation to achieve the regeneration of human hair follicles. The unique capacity of the human hair follicle to self-renew explains why this complex "mini-organ" has always attracted so much interest as a model for researchers to study stem cell biology and regenerative medicine. The hair follicle is considered a main reservoir of cutaneous stem cells, containing several pools of epithelial, melanocyte, and mesenchymal stem cells involved in hair follicle self-regeneration and pigmentation. In addition, while some of the different follicular cell types contribute to hair shaft growth, others participate in very important interfollicular functions such as dermal remodeling, re-epithelialization after wounding, and cutaneous stem cell homeostasis. The idea of human hair follicle regeneration either "de novo" or by activating dormant miniaturized follicles is not new, yet still continues to arouse enormous interest in the pursuit of a definitive cure for baldness. In contrast to hair follicle regeneration in mice, the attempts made with human follicles have been disappointing in terms of efficiency. However, recent advances in stem cell biology-as well as the appearance of new technologies like 3D printing-have revived expectations in this field of research. This book is divided into four sections. The first part includes an overview of the strategies used in hair follicle regeneration and a historical summary of the most important achievements to date. Parts two and three comprise the main body of the book, with detailed descriptions of the cells and tissue structures involved in hair follicle regeneration, followed by an elaboration of the different therapeutic strategies, engineering techniques, and a clinician's perspective of stem cell-based therapies in hair loss treatments. Finally, the fourth part reviews the important contribution of the hair follicle in healing cutaneous wounds through the regeneration and remodeling of the dermis and epidermis after injury, as well as wound induced hair follicle neogenesis that occurs when the skin is injured.

Of the three organizers of this NATO Advanced Research Workshop on "Neocortex: Onto geny and Phylogeny," one derived most of his knowledge about neocortex from studies on birds, another had never studied any animal but the cat and could probably recognize not more than ten animal species, and the third had very limited experience with mountaineering. They had in common the belief that evolutionary thinking permeates what biologists do, but that evolution of species and structures cannot be directly experimentally addressed. Although the fossil record can provide some major insights, the inroad to the evolution of the brain is indirect, via comparative anatomy and developmental biology. By identifying similarities and differences between brain structures in the species at hand, comparative anatomy generates hypotheses of evolutionary transformations. By understanding the rules of morphological transformation, developmental biology can, in principle, estimate the likelihood that a given transformation may have actually occurred. The meeting was a way to check if this notion is viable, by gathering together scientists from these two fields. Standing, left to right: F. Ebner, V. Caviness, M. Weisskopf, B. Fritszch, N. Swindale, J. Walter, H. Karten, J. Pettigrew, E. Welker, M. Cynader, D. Frost, L. Lopez-Mascaraque, P. Katz, H. Jerison, E. Soriano, Mayor of Alagna, Dr. G. Guglielmina, and associate, H. Van der Loos, B. Finlay, H. Scheich, C. Ruela. Seated: S. Pallas, T. Lohmann, J. De Carlos, F. Valverde, G. Innocenti, M. Diamond v "Gathering" does not accurately describe what really happened."

Bioactive compounds produced by natural sources, such as plants, microbes, endophytic fungi, etc., can potentially be applied in various fields, including agriculture, biotechnology and biomedicine. Several bioactive compounds have proved to be invaluable in mediating plant-microbe interactions, and promoting plant growth and development. Due to their numerous health-promoting properties, these compounds have been widely used as a source of medication since ancient times. However, there is an unprecedented need to meet the growing demand for natural bioactive compounds in the flavor and fragrance, food, and pharmaceutical industries. Moreover, discovering new lead molecules from natural sources is essential to overcoming the rising number of new diseases. In this regard, natural bioactive compounds hold tremendous potential for new drug discovery. Therefore, this field of research has become a vital area for researchers interested in understanding the chemistry, biosynthetic mechanisms, and pharmacological activities of these bioactive metabolites. This book describes the basics of bioactive plant compounds, their chemical properties, and their pharmacological biotechnological properties with regard to various human diseases and applications in the drug, cosmetics and herbal industries. It offers a valuable asset for all students, educators, researchers, and healthcare experts involved in agronomy, ecology, crop science, molecular biology, stress physiology, and natural products.

Cytokinesis, the latest volume in the Methods in Cell Biology series, looks at the latest advances in cytokinesis. Edited by leaders in the field, this volume presents proven, state-of-art techniques, along with relevant historical background and theory, to aid researchers in efficient design and effective implementation of experimental methodologies.

1) Classic anatomical atlases 2) Detailed labelling of the earliest phases of prenatal neurological development without abbreviations 3) Appeals to neuroanatomists, developmental biologists and clinical practioners 4) Persistent relevance - brain development is not going to change, but this Atlas offers updated terminology for primordial neural structures.

The population of the world continues to increase at an alarming rate. The trouble linked with overpopulation ranges from food and water scarcity to inadequacy of space for organisms. Overpopulation is also linked with several other demographic hazards, for instance, population blooming will not only result in exhaustion of natural repositories, but it will also induce intense pressure on the world economy. Today nanotechnology is often discussed as a key discipline of research but it has positive and negative aspects. Also, due to industrialization and ever-increasing population, nano-pollution has been an emerging topic among scientists for investigation and debate. Nanotechnology measures any substance on a macromolecular scale, molecular scale, and even atomic scale. More importantly, nanotechnology deals with the manipulation and control of any matter at the dimension of a single nanometer. Nanotechnology and nanoparticles (NPs) play important roles in sustainable development and environmental challenges as well. NPs possess both harmful and beneficial effects on the environment and its harboring components, such as microbes, plants, and humans. There are many beneficial impacts exerted by nanoparticles, however, including their role in the management of waste water and soil treatment, cosmetics, food packaging, agriculture, biomedicines, pharmaceuticals, renewable energies, and environmental remedies. Conversely, NPs also show some toxic effects on microbes, plants, as well as human beings. It has been reported that use of nanotechnological products leads to the more accumulation of NPs in soil and aquatic ecosystems, which may be detrimental for living organisms. Further, toxic effects of NPs on microbes, invertebrates, and aquatic organisms including algae, has been measured. Scientists have also reported on the negative impact of NPs on plants by discussing the delivery of NPs in plants. Additionally, scientists have also showed that NPs interact with plant cells, which results in alterations in growth, biological function, gene expression, and development. Thus, there has been much investigated and reported on NPs and plant interactions in the last decade. This book discusses the most recent work on NPs and plant interaction, which should be useful for scientists working in nanotechnology across a wide variety of disciplines.

This book reviews recent progress in cortical development research, focusing on the mechanisms of neural stem cell regulation, neuronal diversity and connectivity formation, and neocortical organization. Development of the cerebral cortex, the center for higher brain functions such as cognition, memory, and decision making, is one of the major targets of current research. The cerebral cortex is divided into many areas, including motor, sensory, and visual cortices, each of which consists of six layers containing a variety of neurons with different activities and connections. As this book explains, such diversity in neuronal types and connections is generated at various levels. First, neural stem cells change their competency over time, giving sequential rise to distinct types of neurons and glial cells: initially deep layer neurons, then superficial layer neurons, and lastly astrocytes. The activities and connections of neurons are further modulated via interactions with other brain regions, such as the thalamocortical circuit, and via input from the environment. This book on cortical development is essential reading for students, postdocs, and neurobiologists.

Imaging the Addicted Brain, the latest volume in the International Review of Neurobiology series will appeal to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume focusses on the imaging of the brain addicted to food, gambling, tobacco, and opiates.

Mammalian Preimplantation Development, the latest volume in the Current Topics in Developmental Biology series covers mammalian preimplantation development, and includes contributions from an international board of authors. The book's chapters provide a comprehensive set of reviews covering such topics as cell proliferation, cell differentiation, and biological significance.

The Geometric Induction of Bone Formation describes new biomimetic biomaterials that offer mechanistic osteogenic surfaces for the autonomous and spontaneous induction of bone formation without the addition of osteogenic soluble molecular signals of the transforming growth factor- supergene family. The chapters frame our understanding of regenerative medicine in primate species, including humans. The goal is to unravel the fundamental biological mechanisms of bone formation unique to non-human and human primates. The broad target audience dovetails with several disciplines both in the academic and private biotech sectors primarily involved in molecular biology, tissue biology, tissue engineering, biomaterial science, and reconstructive, orthopedic, plastic, and dental surgery. Key Features Includes outstanding images of undecalcified whole mounted sections Summarizes non-human primate research - ideal for clinical translation Reviews methods for creating devices capable of making bone autonomously, i.e. an intrinsically osteo-inductive bioreactor and/or biomaterial Describes the spontaneous induction of bone formation including a whole spectrum of tissue biology, from basic molecular biology to clear-cut morphology and pre-clinical application in non-human primate species Intended for audiences in both academic research and the biotech industry

Computational Systems Biology: Inference and Modelling provides an introduction to, and overview of, network analysis inference approaches which form the backbone of the model of the complex behavior of biological systems. This book addresses the challenge to integrate highly diverse quantitative approaches into a unified framework by highlighting the relationships existing among network analysis, inference, and modeling. The chapters are light in jargon and technical detail so as to make them accessible to the non-specialist reader. The book is addressed at the heterogeneous public of modelers, biologists, and computer scientists.

Development is a complex and highly dynamic process involving the cross talk among genes, maternal effects and environmental circumstances. Widespread evidence from plant to animal species show that variation in developmental conditions can modulate life history trajectories and influence key traits, such as growth, reproduction, and senescence. These effects are not limited to a single generation but can also be passed on future generations. This book aims to bring together studies of early life effects from the fields of evolutionary biology, global change biology, and biomedicine to synthesise and improve current knowledge of the mechanisms involved, and how variation in early life conditions translates into Darwinian fitness outcomes. Relying on examples of organisms' responses to the ongoing and future environmental challenges of the Anthropocene, this book takes a novel approach to address the adaptive meaning of early life effects. The book has a broad scientific approach, targeting eco-evolutionary biologists, behavioural biologists, eco-physiologists, eco-toxicologists, as well as epidemiologists and biomedical scientists.

The mechanisms that control region-specific and axial patterning of cell differentiation during embryogenesis have fascinated experimental biologists for over 100 years. This book describes recent advances in our knowledge of the cellular and molecular mechanisms of pattern formation. The contributors, all active experimentalists, describe research within the two main conceptual frameworks currently employed for analyzing patterning: positional information and induction. The developmental time frame covered extends from the oocyte to developing organ systems, and a wide range of research organisms, from hydrozoans to birds is represented.

Author Prof Jim Lynch is widely known and very experienced, well-connected with wide international networks, and globally distinguished. He was awarded the UNESCO Prize in Microbiology and Einstein Medal and Distinguished Scientist of the US Department of Agriculture. His OUP textbook Soil Microbiology was a bestseller. Taps directly into the topical area of the COVID-19 pandemic and One Health. Affordable and accessible to a wide interdisciplinary audience.

To identify some life history features of plants and environmental factors that accelerate species diversity and others decelerating it. To quantify and bring light to these features and highlight new findings. To bridge relevant information on aquatic and terrestrial plants on these aspects.

Is it possible that fully differential cells, cells that have acquired specialized functions and perhaps have lost some general properties, can change their nature, becoming cells of another type? Professor Okada has studied this problem extensively and introduced the term "transdifferentiation" to describe the phenomenon. Transdifferentiation is extremely controversial, since it challenges a number of biological orthodoxies. If transdifferentiation really does occur, the process of development and differentiation must be much more flexible than biologists have generally believed. In this book, the author brings together a vast amount of experimental evidence and examines it critically. This discussion clearly establishes that there is a real phenomenon to be explained and that the explanation forces us to change our understanding of a number of basic biological processes. Much of the evidence examined is derived from studies of cell biology but increasingly it has become possible to examine the process at the molecular level. Studies of gene expression provide several promising perspectives on the process of transdifferentiation. Although this monograph focuses on some rather specialized experiments and discusses questions of definition, the phenomenon is so compelling and is of such fundamental importance that postgraduates and researchers in developmental and cell biology, as well as scientists in basic cancer and eye research, will find it equally interesting.

This book is an overview of primary sensory maps of vertebrates, characterized by continuous and discrete properties. The eight primary sensory maps of vertebrates have unique features and use distinct molecular cues, cell cycle exit, and activity combinations during development, regeneration, and plasticity. As an introduction and overview, the book provides a short overview for all eight sensory senses and presents through evolution and gene regulatory networks, the molecular cues needed for sensory processing. Independent contributions are included for olfactory, vision, trigeminal, taste, vestibular, auditory, lateral line, and electroreception.

This book examines how the growing knowledge of the huge range of protist-, animal-, and plant-bacterial interactions, whether in shared ecosystems or intimate symbioses, is fundamentally altering our understanding of biology. The establishment and maintenance of these interactions and their contributions to the health and survival of all partners relies on continuous cell-to-cell communication between them. This dialogue may be concerned with all aspects of the biology of both partners. The book includes chapters devoted to exploring, explaining, and exposing these dialogues across a broad spectrum of plant and animal eukaryotes to a broad field of biologists. Key Features Explores the nature of the interactions between eukaryotic hosts and their microbial symbionts Examines the links between prostist, animal, and plant evolution and microbial communities Reviews specific taxa and the microbial diversity associated with these taxa Illustrates the role microbes play in the physiology and etiology of several model species Includes chapters by an international team of leading scholars

Among the most important innovations in the history of life is the transition from single-celled organisms to more complex, multicellular organisms. Multicellularity has evolved repeatedly across the tree of life, resulting in the evolution of new kinds of organisms that collectively constitute a significant portion of Earth's biodiversity and have transformed the biosphere. This volume examines the origins and subsequent evolution of multicellularity, reviewing the types of multicellular groups that exist, their evolutionary relationships, the processes that led to their evolution, and the conceptual frameworks in which their evolution is understood. This important volume is intended to serve as a jumping-off point, stimulating further research by summarizing the topics that students and researchers of the evolution of multicellularity should be familiar with, and highlighting future research directions for the field.

Provides historical context for the many contributions made by using the Xenopus model System. Chapters written by an international team of leading researchers using Xenopus as a model organism. Chapters deal with cell biology, developmental biology, genomics, and evolutionary biology and include the results of the research. Well illustrated with color diagrams and photos.

Plant Physiology is a dynamic science which goes on adding knowledge to already characterized basic processes in plants. The past decade has witnessed an unprecedented progress in biological sciences with the advent of innovative technologies viz. recombinant DNA techniques, omics approaches and advanced phenotyping platforms. These tools have helped to redefine many of the already accepted facts of plant life. The present publication will give an insight into the lesser known signals that can influence plant growth and development. Knowledge of plant physiological processes provides the base for research in cognate disciplines such as crop improvement, crop production and crop protection. With the impetus for clean cultivation, information provided in the book can motivate researchers in developing environment-friendly and non-chemical means of improving crop production and activate the innate ability of the plant to enhance their field performance. Note: T&F does not sell or distribute the hardback in India, Pakistan, Nepal, Bhutan, Bangladesh and Sri Lanka. This title is co-published with NIPA.

This contributed volume aims to reconsider the concept of individuation, clarifying its articulation with respect to contemporary problems in perceptual, neural, developmental, semiotic and social morphogenesis. The authors approach the ontogenetical issue by taking into account the morphogenetic process, involving the concept of individuation proposed by Gilbert Simondon and Gilles Deleuze. The target audience primarily comprises experts in the field but the book may also be beneficial for graduate students. The challenge of the genesis and constitution of "units" has always been at the center of philosophical and scientific research. This ontogenetical issue is common to every discipline but it is articulated in different ways: in phenomenology of perception the constitution of perceptual units is at the base of gestalt field theories, in theoretical neuroscience synchronized neural assemblies are considered as correlates of conscious processes, in developmental embryogenesis the constitution of organs is the principle outcome of morphodynamic evolution while in social morphogenesis the constitution of coherent units is common to segmentary, gerarchic and functional differentiation.