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Books > Science & Mathematics > Biology, life sciences > Developmental biology
This book presents some of the most advanced experimental systems in which the role of forces has been dissected. It explores the physical principles accounting for how forces can affect soft matter such as our cells, and presents some of the methods used to measure or assess the role of forces. Presents some of the most advanced experimental systems in which
the role of forces has been dissected.
This volume of "Methods in Cell Biology, " the second of two parts
on the subject of zebrafish, provides a comprehensive compendium of
laboratory protocols and reviews covering all the new methods
developed since 1999.
In recent years, a number of molecular pathways and cellular processes that are essential for normal vertebrate development have been implicated in cancer initiation and progression. In this volume, leaders in the field of cancer genetics and developmental biology share recent insights into the importance of developmental pathways for tumorigenesis. These discoveries provide important avenues for innovative new approaches to treating some of the most challenging developmental tumors. Provides researchers an overview and synthesis of the latest
research findings and contemporary thought in the area
A subgroup of homeobox genes, which play an important role in the
developmental processes of a variety of multicellular organisms,
Hox genes have been shown to play a critical role in vertebrate
pattern formation. Hox genes can be thought of as general purpose
control genes that is, they are similar in many organisms and
direct the same processes in a variety of organisms, from mouse, to
fly, to human.
Understanding organogenesis is central to current efforts to direct stem cell differentiation and function in the context of a complex organ. Defects in organogenesis are often the major manifestations of human genetic disease syndromes. This volume describes the development of 10 major organ systems, reviewed by experts in each, to provide an up-to-date overview for researchers within and outside the field, students, teachers and clinicians.
Emphasizes up-to-date research relating to molecular control mechanisms Draws on a range of model vertebrates and contemporary experimental approaches, including lessons learnt from human developmental disease Distils common themes and differences for comparative studies Highlights key remaining questions and sets the agenda for future research
Advances in Genetics, Volume 108 provides the latest information on genetics, presenting new medical breakthroughs that are occurring as a result of advances in our knowledge of the topic. The book continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, with this new release including chapters on Clinical applications of cancer genetics and genomics, Epigenetic mutations in childhood tumors- the paradigm of Wilms tumor, Preventive population genomics-the model of BRCA related cancers, Recent advances of PARP inhibitors in medical oncology, Role of single cell and liquid biopsy in cancer research and clinical applications. Other chapters cover Recent advances and clinical utility of prostate cancer genomics, Recent advances in lung cancer genomics- applications in targeted therapy, and more.
Experimental Models of Infection, Inflammation and Injury, Volume 168 provides step-by-step protocols for scientific researchers to effectively utilize experimental model systems. Chapters in this new release include Induction and Evaluation of Murine T Cell Transfer Colitis, Modelling acute graft-versus-host disease (aGVHD) in murine bone marrow transplantation (BMT) models with MHC disparity, Mouse models of Graft-Versus-Host Disease, Preclinical Model of Multiple Sclerosis: Methods in Autoimmune Demyelination, Preclinical model of Multiple Sclerosis: focal, chemical or demyelination, Investigating demyelination, efficient remyelination and remyelination failure in organotypic cerebellar slice cultures: workflow and practical tips, and more. Other notable sections cover Rheumatoid Arthritis: Methods for Two Murine Models, Induction of Pancreatitis in Mice with Susceptibility to Pancreatic Cancer, Small Animal Models of Thermal Injury, Large Animal Models of Thermal Injury, Small animal models of localized heart irradiation, Methods for Induction and Assessment of Intestinal Permeability in Rodent Models of Radiation Injury, and more.
A subgroup of homeobox genes, which play an important role in the
developmental processes of a variety of multicellular organisms,
Hox genes have been shown to play a critical role in vertebrate
pattern formation. Hox genes can be thought of as general purpose
control genes-that is, they are similar in many organisms and
direct the same processes in a variety of organisms, from mouse, to
fly, to human.
The marriage of evolutionary biology with developmental biology has
resulted in the formation of a new field, evolutionary
developmental biology, or evo-devo. This volume reviews current
research findings and thought in the broad field of evo-devo,
looking at the developmental genetic mechanisms that cause
variation and how alterations of these mechanisms can generate
novel structural changes in a variety of plant and animal life.
Evolutionary developmental biology or evo-devo is a field of biological research that compares the underlying mechanisms of developmental processes in different organisms to infer the ancestral condition of these processes and elucidate how they have evolved. It addresses questions about the developmental bases of evolutionary changes and evolution of developmental processes. The book's content is divided into three parts, the first of which discusses the theoretical background of evo-devo. The second part highlights new and emerging model organisms in the evo-devo field, while the third and last part explores the evo-devo approach in a broad comparative context. To the best of our knowledge, no other book combines these three evo-devo aspects: theoretical considerations, a comprehensive list of emerging model species, and comparative analyses of developmental processes. Given its scope, the book will offer readers a new perspective on the natural diversity of processes at work in cells and during the development of various animal groups, and expand the horizons of seasoned and young researchers alike.
Biomolecular Interactions: Part A, Volume 166, the latest release in the Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics in cell biology. Each chapter is written by an international board of authors.
This handbook presents global research on health expectancies, a measure of population health that examines the interaction between quantity and quality of life. With data from Europe, North America, Asia, and beyond, it explains how to define and measure health and morbidity and how to integrate these measurements with mortality. Coverage first highlights long-term trends in longevity and health. It also considers variations across and within countries, inequalities, and social gaps as well as micro and macro-level determinants. Next, the handbook deals with the methodological aspects of calculating health expectancies. It compares results from different methods and introduces tools, such as decomposition tool for decomposing gaps, an attrition tool for attributing a medical cause to reported disability, and a tool for measuring policy impact on health expectancies. It introduces methods of forecasting health expectancies. The handbook then goes on to examine the synergies and/or trade-off between longevity and health as well as considers such topics as the compression versus the expansion of morbidity/disability and the health-survival paradox. The last section considers new concepts and dimensions of health and, more broadly, well being which can be used in summary measures of population health, including psychological factors. Researchers, clinicians, demographers, and health planners will find this handbook an essential resource to this increasingly important public health and social policy tool. It will help readers gain insight into changes in health over time as well as inequalities between countries, regions, and population subgroups.
This revised edition will continue to serve as the most complete
and up-to-date guide to the use of the avian embryo in studies of
vertebrate development. It will include new approaches to analysis
of the chick genome, gene knock-out studies using RNA interference,
morpholinos, and other cutting edge techniques. As with the
original edition, emphasis has been placed on providing practical
guidance, highlighting potentials and pitfalls of all key cell
biological and embryological techniques.
Stem cells, regenerative medicine, and translational medicine, are all areas of burgeoning basic research and clinical application. This dictionary includes the fundamental terminology of each of these areas, the major discoveries and significant scientists that comprise the history and current development of the field, as well as a number of concepts. The vocabulary is presented within the broader lexicon of developmental biology and embryology, which provides context for these three fields. Topics covered range from stem cells (embryonic, adult, and iPSCs) to teratology. The inclusion of extensive cross-referencing of the terms will enable readers to broaden their understanding of them. The Dictionary of Stem Cells, Regenerative Medicine, and Translational Medicine will provide both the basic background terminology needed by pre-health professions/biology major undergraduate students and early-stage graduate students, as well as being a valuable reference for university professors, researchers and peers in related disciplines.
This book highlights the ontogenetic development of larval T. ovatus, provides a comprehensive overview of larval rearing of this species. It focuses on the physiological and molecular changes during the early ontogeny of T. ovatus and hatchery and nursery practices. The first seven chapters update the recent development in the hatchery technology in T. ovatus, including feed and feeding, environmental manipulation, hatchery management, and fingerlings in transportation. Chapter eight and onwards decode the possible molecular mechanisms underlying fish development and response to environmental changes and discuss the transcription and expressions of growth and development-related genes in T. ovatus. The last chapters discuss the functional feed additives to the diet and antibiotic usage of T. ovatus juveniles. This book is a valuable resource for researchers, practitioners and students in the aquaculture industry and related fields.
Mathematical and computational biology is playing an increasingly
important role in the biological sciences. This science brings
forward unique challenges, many of which are, at the moment, beyond
the theoretical techniques available. Developmental biology, due to
its complexity, has lagged somewhat behind its sister disciplines
(such as molecular biology and population biology) in making use of
quantitative modeling to further biological understanding. This
volume comprises work that is among the best developmental modeling
available and we feel it will do much to remedy this
situation.
In 1993, Rolf Bodmer described a gene he named tinman that was
required for the formation of the dorsal aorta of the fly. Flies
without a functional tinman gene had no heart. Quickly, mammalian
counterparts of the tinman gene were identified and found to be
expressed by early cardiomyogenic precursors and by cardiomyocytes
throughout heart development. Since then, significant progress has
been made in the understanding of molecular and genetic
determinants of heart formation. An ever growing number of genes
have been identified that are required for cardiogenesis, as
evidenced by severe abnormalities in cardiac development produced
by inactivation in the mouse or inhibition of gene function in
other model organisms.
This serial provides a comprehensive survey of the major topics in
the field of developmental biology. These volumes are valuable to
researchers in animal and plant development, as well as to students
and professionals who want an introduction to cellular and
molecular mechanisms of development. The series has recently passed
its 30-year mark, making it the longest-running forum for
contemporary issues in developmental biology.
This serial provides a comprehensive survey of the major topics in
the field of developmental biology. These volumes are valuable to
researchers in animal and plant development, as well as to students
and professionals who want an introduction to cellular and
molecular mechanisms of development. The series has recently passed
its 30-year mark, making it the longest-running forum for
contemporary issues in developmental biology.
A superb compilation of reviews from leading experts in the field
of nuclear receptors, volume 16 in the Advances in Developmental
Biology series covers the role of different nuclear receptor
subfamilies in development, physiology and metabolism. This volume
brilliantly reviews how genetic defects in the function of nuclear
receptors leads to various developmental defects. Receptors
discussed include: thyroid receptors, peroxisome proliferators
activated receptors, and retinoic acid receptors. Additionaly, this
volume offers an indespesable chapter on the orphan receptors
Ftz-F1, COUPs, and RORs in embryonic and postnatal development.
Current Topics in Developmental Biology provides a comprehensive
survey of the major topics in the field of developmental biology.
These volumes are valuable to researchers in animal and plant
development, as well as to students and professionals who want an
introduction to cellular and molecular mechanisms of development.
The series has recently passed its 30-year mark, making it the
longest-running forum for contemporary issues in developmental
biology.
Current Topics in Developmental Biology provides a comprehensive
survey of the major topics in the field of developmental biology.
The volumes are valuable to researchers in animal and plant
development, as well as to students and professionals who want an
introduction to cellular and molecular mechanisms of development.
The series has recently passed its 30-year mark, making it the
longest-running forum for contemporary issues in developmental
biology.
Much effort has been devoted to developing theories to explain the
wide variation we observe in reproductive allocation among
environments. Reproductive Allocation in Plants describes why
plants differ in the proportion of their resources that they
allocate to reproduction and looks into the various theories. This
book examines the ecological and evolutionary explanations for
variation in plant reproductive allocation from the perspective of
the underlying physiological mechanisms controlling reproduction
and growth. An international team of leading experts have prepared
chapters summarizing the current state of the field and offering
their views on the factors determining reproductive allocation in
plants. This will be a valuable resource for senior undergraduate
students, graduate students and researchers in ecology, plant
ecophysiology, and population biology.
Current Topics in Developmental Biology provides a comprehensive
survey of the major topics in the field of developmental biology.
The volumes are valuable to researchers in animal and plant
development, as well as to students and professionals who want an
introduction to cellular and molecular mechanisms of development.
The series has recently passed its 30-year mark, making it the
longest-running forum for contemporary issues in developmental
biology.
In this authoritative three-volume reference work, leading
researchers bring together current work to provide a comprehensive
analysis of the comparative morphology, development, evolution, and
functional biology of the skull. |
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