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Books > Science & Mathematics > Biology, life sciences > Developmental biology
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Proteoglycans in Stem Cells - From Development to Cancer (Hardcover, 1st ed. 2021)
Loot Price: R4,912
Discovery Miles 49 120
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Proteoglycans in Stem Cells - From Development to Cancer (Hardcover, 1st ed. 2021)
Series: Biology of Extracellular Matrix, 9
Expected to ship within 12 - 17 working days
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This book provides a state-of-the-art compendium on the role of
proteoglycans and glycosaminoglycans during development and in
cancer. It also suggests directions for novel therapeutic and
biotechnological applications in stem cell biology. Proteoglycans
and glycosaminoglycans, as part of the extracellular matrix, are
multifunctional modulators of growth factor, cytokine, integrin and
morphogen signaling, which determine both self-renewal, senescence
and/or differentiation of stem cells during development. Since
proteoglycans modulate cell adhesion and migration they are
important organizers of the extracellular matrix within the proper
stem cell niche. A malfunctioning of proteoglycans and
glycosaminoglycans contributes to the cancer stem cell phenotype,
which is linked to therapeutic resistance and recurrence in
malignant disease. This book is essential reading for anyone
interested in the extracellular matrix and its role in development.
The series Biology of Extracellular Matrix is published in
collaboration with the American Society for Matrix Biology.
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