This volume examines cells set aside during development for use later in ontogeny or in adult life. There is no single term for such cells. The cells explored fall within several major categories - stem cells, set-aside cells (in echinoderm larvae), imaginal discs in insects such as Drosophila, meristems (plants), blastemata (regeneration in amphibians), neoblasts (regeneration in planarians). The book compares and contrasts these cell types and the environments (niches) in which they operate with the aim of unravelling any relationships between them, between their activation in development, and in their evolution. Key Features Explores the nature of deferred-use cells in evolutionary and developmental context. Reviews the mechanisms of development of set-aside cells, such as stem cells, meristems, and imaginal discs. Provides phylogenetic overview of different types of deferred-use cells. Compares and contrasts different theories on the origin of deferred-use cells. Related Titles Calegari, F. & C. Waskow, eds. Stem Cells: From Basic Research to Therapy (ISBN 978-1-4822-0775-0) Cabral, J. M. S. & C. L. da Silva, eds. Bioreactors for Stem Cell Expansion and Differentiation (ISBN 978-1-4987-9590-6) Kong, H., A. J. Putnam, & L. B. Schook, eds. Stem Cells and Revascularization Therapies (ISBN 978-1-4398-0323-3) Schaffer, D., J. D. Bronzino, & D. R. Peterson, eds. Stem Cell Engineering: Principles and Practices (ISBN 978-1-4398-7204-8)

This book, first published in English in 1932, serves as an introduction to experimental embryology. This title, while covering in-depth the field of investigation, presents the general issues surrounding this particular study rather than just providing an analysis of particular results. This title will be of interest to students of introductory biology and the history of science.

This book focuses on human anatomy and medicine and specifically on both muscular and skeletal birth defects in humans with trisomy. Moreover, this book also deals with Down syndrome, which is one of the most studied human syndromes and, due to its high incidence and the fact that individuals with this syndrome often live until adulthood, is of special interest to the scientific and medical community. This new line of inquiry is addressed to a wide audience, including medical researchers, physicians, surgeons, medical and dental students, pathologists, and pediatricians, among others, while also being of interest to developmental and evolutionary biologists, anatomists, functional morphologists, and zoologists.

Bees are flying insects of the order Hymenoptera closely related to wasps and ants. The ancestors of bees are assumed to be predatory wasps, which switched to pollen consumption. Further, bees co-evolved with flowering plants and divided into several species according to climatic conditions. Widely known bees are western bees Apis mellifera, and eastern bees Apis cerana. This book sheds light on features of evolution, phylogenesis, speciation, adaptation to environment, and taxonomy of bees. It will be of particular relevance to evolutionists, geneticists, taxonomists, ecologists, population geneticist, and breeders.

Gap junction channels are a group of intercellular channels expressed in tissues and organs to synchronize many physiological processes. A gap junction channel is formed by the docking of two hemichannels, and each hemichannel is a hexamer of connexins. The field of gap junction channel and hemichannel research has recently exploded and became one of the most active areas of cell biology. Numerous novel approaches and techniques have been developed, but there is no single book dedicated to the unique techniques and protocols employed for the research on these large pore channels. This book fills the gap and focuses on protocols, approaches and reviews of gap junction channels and connexin hemichannels. It will be a useful reference for graduate students, postdoctoral fellows and researchers. Anyone with an interest in gap junction channels and hemichannels will need this summary of state-of-the-art techniques and protocols.

Most vertebrate cranial sense organs arise from placodes. These placodes give rise to sensory neurons that transmit information to the brain and neurosecretory cells. This book reviews the evolutionary origin of the sensory and neurosecretory cell types. It summarizes our current understanding of vertebrate evolution, clarifies conceptual issues relating to homology and evolutionary innovation of cell types, compares the sensory and neurosecretory cell types with similar cell types in other animals, and addresses the question of how cranial placodes evolved as novel structures in vertebrates by redeploying pre-existing and sometimes evolutionarily ancient cell types.

This volume explores the diverse ways in which the evolution of human behaviour can be investigated, and confronts the most challenging aspects of the subject.

There has been an increasing interest in the application of dynamical systems to the study of development over the last decade. The explosion of the dynamical systems framework in the physical and biological sciences has opened the door to a new Zeitgeist for studying development. This appeal to dynamical systems by developmentalists is natural given the intuitive links between the established fundamental problems of development and the conceptual and operational scope of nonlinear dynamical systems. This promise of a new approach and framework within which to study development has led to some progress in recent years but also a growing appreciation of the difficulty of both fully examining the new metaphor and realizing its potential. Divided into 4 parts, this book is a result of a recent conference on dynamical systems and development held at Pennsylvania State University. The first 3 parts focus on the content domains of development that have given most theoretical and empirical attention to the potential applications of dynamical systems--physical growth and movement, cognition, and communication. These parts show that a range of nonlinear models have been applied to a host of developmental phenomena. Part 4 highlights two particular methodological issues that hold important implications for the modeling of developmental phenomena with dynamical systems techniques.

There is increasing interest in the biology of domestic animals ranging from genomics, transcriptomics, metabolomics, nutritional physiology, and systems biology. This book touches on all of these, with a particular focus on topics such as domestic animals as comparative models to humans, molecular regulation of growth, metabolic efficiency, reproduction, and the impact of stress on growth and development. The book concludes with a discussion on the current and future directions for researchers.

Morphodynamics is defined as the unique interaction among environment, functional morphology, developmental constraints, phylogeny, and time-all of which shape the evolution of life. These fabricational patterns and similarities owe their regularity not to a detailed genetic program, but to extrinsic factors, which may be mechanical, chemical, or biological in nature. These self-organizing mechanisms are the focus of Morphodynamics. Illustrated by numerous examples from across the biological spectrum, this book embodies the foundation of noted paleontologist Adolf Seilacher's thinking on the study of morphodynamics. It represents his unique approach of presenting paleontology from an ecological and constructional perspective, rather than a purely taxonomic one. The hallmark of Seilacher's storied career has been a constructional and functional focus. He begins by discussing the basic principles-form, pattern formation, ecology and evolution, as well as the factors that override those processes. Next, he examines how morphodynamic principles are implemented in various invertebrates including single-celled protists, Ediacarans, sponges, coelenterates, shelled organisms, worms, arthropods, and echinoderms. The final chapter explores how morphogenetic principles may apply to clonal colonial organisms. Summarizing seventy years of research into the interactions of form, function, and evolution, the book is copiously illustrated with the author's own distinctive drawings and an abundance of photos. It provides a framework for readers to pose their own questions and sharpen their interpretive skills on this fascinating topic.

The first 1,000 days, from conception to two years of age, is a critical period of growth and development. Exposures to dietary, environmental, hormonal, and other stressors during this window have been associated with an increased risk of poor health outcomes, some of which are irreversible. The book addresses this crucial interval of early life across biological disciplines, linking concepts related to all biological fields to outcomes during the first 1,000 days (e.g. fetal growth and pregnancy outcomes) and beyond (e.g. gut microbiome and cardiovascular disease later in life). The strength of this book lies in its cross-disciplinary nature.

Orangutans, together with chimpanzees and gorillas, are our closest living relatives. Photographic and Descriptive Musculoskeletal Atlas of Orangutans, the first photographic and descriptive musculoskeletal atlas of the genus Pongo, adopts the same format as the photographic atlases of Gorilla, Pan and Hylobates previously published by the same authors. These four books are part of a series of monographs that will set out the comparative and phylogenetic context of the gross anatomy and evolutionary history of the soft tissue morphology of modern humans and their closest relatives. The present atlas, which includes detailed high-quality photographs of musculoskeletal structures from most anatomical regions of the body as well as textual information about the attachments, innervation, function and weight of the respective muscles, is based on dissections of five orangutans and on an extensive review of the literature. It provides an updated review of the anatomical variations within orangutans as well as an extensive list of the synonyms used in the literature to designate the structures we discuss. It will be of interest to students, teachers and researchers studying primatology, comparative anatomy, functional morphology, zoology, and physical anthropology and to medical students, doctors and researchers who are curious about the origin, evolution, homology and variations of the musculoskeletal structures of modern humans.

Pathology of the Developing Mouse provides, in so far as feasible, one complete reference on the design, analysis, and interpretation of abnormal findings that may be detected in developing mice before and shortly after birth. In particular, this book is designed specifically to be not only a "how to do" manual for developmental pathology experimentation in mice but, more importantly, a "how to interpret" resource for pathologists and other biomedical scientists faced for the first or hundredth time with defining the significance of distorted features in some fantastic murine developmental monstrosity. The topics covered in this volume include a full range of subjects encountered when building and wielding a developmental pathology tool kit: baseline anatomic and physiologic traits of developing mice principles of good experimental design and statistical analysis for mouse developmental pathology studies procedures for anatomic pathology examinations, to evaluate structural changes at the macroscopic (gross), microscopic (cells and tissues), and ultrastructural (subcellular) levels, suing conventional autopsy-based or novel non-invasive imaging techniques; methods for clinical pathology testing, to assess the biochemical and cellular composition of tissues and fluids; options and protocols for in situ molecular pathology analysis, to undertake site-specific explorations of the various mechanisms responsible for producing adverse findings (i.e., "lesions") during development; and well-referenced and illustrated guides to the interpretation of anatomic pathology and clinical pathology changes in the animal (embryos, fetuses, neonates, and juveniles) and its support system (placenta).

Marine biogeography, the study of the spatial distribution of organisms in the world's oceans, is one of the most fascinating branches of oceanography. This book continues the pioneering research into the distributions of molluscan faunas, first studied by biologists over 160 years ago. It illustrates 1778 species of gastropods in full color, many of which are extremely rare and poorly known endemic species that are illustrated for the first time outside of their original descriptions. The spatial arrangements of malacofaunas shown in this book can be considered proxies for worldwide oceanic conditions and used as tools for determining patterns of global climate change. The book's documentation of evolutionary "hot spots" and geographically restricted endemic faunas can also be used as a base line for future studies on patterns of environmental deterioration and extinction in the marine biosphere. Documenting the evolution of the amazingly rich worldwide gastropod fauna, this book will appeal to physical and chemical oceanographers, systematic and evolutionary biologists, historical geologists, paleontologists, climatologists, geomorphologists, and physical geographers. The authors incorporate aspects of all of these disciplines into a new classification system for the nomenclature of biogeographical spatial units found in tropical, subtropical, and warm temperate seas.

Reproductive Biology and Phylogeny of Lizards and Tuatara is a remarkable compendium of chapters written by the world's leading experts from over four continents. The book begins with a chapter recounting historical discoveries in reproductive biology and a review of phylogenetics and up-to-date hypotheses concerning evolutionary relationships among lizards. Following these chapters are detailed reviews with additional new data concerning chemical communication, sexual selection, reproductive cues, female reproductive anatomy, female reproductive cycles, oogenesis, parthenogenesis, male reproductive anatomy, male reproductive cycles, spermatogenesis, reproductive investment, viviparity and placentation, multiple paternity, and parental care. The book culminates in two chapters on tuatara reproduction giving unique insight into evolutionary patterns in reproductive biology in squamates and tuatara. This is an essential resource for anyone studying reproduction in reptiles and/or vertebrates and offers a fascinating read for those interested in reproductive biology.

This new manual provides a convenient source of experimental procedures, including the most modern and frequently used molecular and cellular techniques. Experimental protocols have been carefully selected by developmental toxicologists for developmental toxicologists. The most important new trends, such as evaluation of the safety of therapeutic antisense oligonucleotides, studies of the role of cell death in abnormal development, and the identification of sparingly expressed developmental control genes are featured. This is the perfect manual for scientists trained in classical developmental toxicology who want to add molecular and cellular methods to their research.

This book presents recent scientific investigations in microbial ecology and systematics. Advanced microbial science investigations employ the latest technologies for research in microbiology and microbial applications. The book has complete information on classical microbiology techniques for assessment of the composition of microbial diversity assessment, advancement in next-generation technology, advantages of microbial products in sustainable developments and their application for societal benefits. Current research on microorganisms is presented as a perfect book for studies on "Microbial Systematics". This book will serve as an important resource for practising research and review for the scientific community.

Crustaceans adapt to a wide variety of habitats and ways of life. They have a complex physiological structure particularly with regard to the processes of growth (molting), metabolic regulation, and reproduction. Crustaceans are ideal as model organisms for the study of endocrine disruption and stress physiology in aquatic invertebrates. This book is an overview of the extensive research that has taken place over the recent years on issues of crustacean reproduction.

Regenerative Engineering and Developmental Biology: Principles and Applications examines cutting-edge developments in the field of regenerative engineering. Specific attention is given to activities that embrace the importance of integrating developmental biology and tissue engineering, and how this can move beyond repairing damage to body parts to instead regenerate tissues and organs. The text furthermore focusses on the five legs of the field of regenerative engineering, including: materials, developmental biology, stem cells, physics, and clinical translation. This book was written by leading developmental biologists; each chapter examines the processes that these biologists study and how they can be advanced by using the tools available in tissue engineering/biomaterials. Individual chapters are complete with concluding remarks and thoughts on the future of regenerative engineering. A list of references is also provided to aid the reader with further research. Ultimately, this book achieves two goals. The first encourages the biomedical community to think about how inducing regeneration is an engineering problem. The second goal highlights the discoveries with animal regeneration and how these processes can be engineered to regenerate body parts. Regenerative Engineering and Developmental Biology: Principles and Applications was written with undergraduate and graduate-level biomedical engineering students and biomedical professionals in mind.

High pressure biology is an old, fascinating and stimulating field of research. One of the major reasons for the interest in studying high pressure is that this environmental factor also plays an important role in thermodynamics and consequently in biology. Pressure, from a biological perspective, has a bearing on all living creatures. The book presents a panoramic view of this subject from molecules to the overall organism, via the cells and unicellular species, invertebrates and vertebrates, ectotherms and endotherms. This book provides not only the more recent results in each of its chapters but also suggests new directions for research. The intended readership is postgraduate students and research scientists in various fields.

This book is a synopsis of the key facts and concepts of human development. It is intended for students who are taking a human embryology course. The book includes the underlying mechanisms involved in clinically important congenital anomalies that will prove useful to medical and nursing.

The Vertebrata is one of the most speciose groups of animals, comprising more than 58,000 living species. This book provides a detailed account on the comparative anatomy, development, homologies and evolution of the head, neck, pectoral and forelimb muscles of vertebrates. It includes hundreds of illustrations, as well as numerous tables showing the homologies between the muscles of all the major extant vertebrate taxa, including lampreys, elasmobranchs, hagfish, coelacanths, dipnoans, actinistians, teleosts, halecomorphs, ginglymodians, chondrosteans, caecilians, anurans, urodeles, turtles, lepidosaurs, crocodylians, birds, and mammals such as monotremes, rodents, tree-shrews, flying lemurs and primates, including modern humans. It also provides a list of more than a thousand synonyms that have been used by other authors to designate these muscles in the literature. Importantly, it also reviews data obtained in the fields of evolutionary developmental biology, molecular biology and embryology, and explains how this data helps to understand the evolution and homologies of vertebrate muscles. The book will useful to students, teachers, and researchers working in fields such as functional morphology, ecomorphology, evolutionary developmental biology, zoology, molecular biology, evolution, and phylogeny. As the book includes crucial information about the anatomy, development, homologies, evolution and muscular abnormalities of our own species, Homo sapiens, it will also be helpful to physicians and medical students.

Fish accomplish most of their basic behaviors by swimming. Swimming is fundamental in a vast majority of fish species for avoiding predation, feeding, finding food, mating, migrating and finding optimal physical environments. Fish exhibit a wide variety of swimming patterns and behaviors. This treatise looks at fish swimming from the behavioral and ecological perspectives rather than from the more traditional biomechanics, ecomorphology and physiological perspectives used in studies of fish swimming. The book is therefore largely integrative by its own nature, and it includes considerations related to fisheries, conservation and evolution. It is aimed at students and researchers interested in fish swimming from any organismal background, be it biomechanics, ecomorphology, physiology, behavior or ecology.

To cope with the abiotic stress-induced osmotic problems, plants adapt by either increasing uptake of inorganic ions from the external solution, or by de novo synthesis of organic compatible solutes acting as osmolytes. Of the osmoregulants and protectants discussed in this volume, trehalose, fructans, ectoine and citrulline, which are generated in different species, in osmotically ineffective amounts, mitigate the stress effects on cells/plants and improve productivity. There are several pieces of encouraging research discussed in this volume showing significant improvement in stress tolerance and in turn productivity by involving genetic engineering techniques.

Health and welfare issues of brachycephalic (flat-faced) animals are one of the most pressing problems facing companion animals right now. Dogs, in particular, are suffering from a 'brachycephalic crisis' resulting from a perfect storm where predispositions to an array of health issues are amplified by a population boom for certain brachycephalic breeds such as the French Bulldog and Pug. But yet, for many owners, these dogs represent the perfect companion: endearing personas and cute looks in a socially desirable package. So where is the truth in all of this? This book will equip veterinary professionals, animal welfare scientists, breeders and owners with the fuller story about brachycephalic health and welfare. The first half of the book provides the context of how and why we are in this crisis, offering in-depth historical, social, ethical, communication, nursing, welfare, epidemiological, genetics and international perspectives. The second half shifts towards the clinical arena, with chapters that cover the background, diagnosis, treatment and prevention of the many unique healthcare needs of brachycephalic animals. Cutting-edge knowledge is shared on a range of disciplines including respiratory disease, ophthalmology, dermatology, dentistry, neurology, obesity, reproduction and anesthesia. With twenty chapters written by world-leading experts, lifetimes of experience and knowledge are condensed into the first book dedicated exclusively to brachycephaly in companion animals. This essential reference resource will inform, challenge and stimulate; it will open your mind to new opportunities for you to improve the welfare of brachycephalic animals by your personal and collective choices and actions. But prepare to be surprised: you may just find that your views on brachycephaly in companion animals will be changed forever.