During the last 40 years, the study of the biological basis of aging has progressed tremendously, and it has now become an independent and respectable field of study and research.

This volume on "Aging of Organs and Systems," is an attempt to bring understanding to both the aging process and the disease processes of old age. Bringing together contributions from an international team of authors, it will be of interest to graduates and postgraduates in the fields of medicine and nursing, researchers of different aspects of biogerontology and those in the pharmaceutical, cosmeceutical, nutriceutical and health-care industry.

The fourth edition of "Human Reproductive Biology" emphasizes the biological and biomedical aspects of human reproduction, explains advances in reproductive science and discusses the choices and concerns of today. Generously illustrated in full color, the text provides current information about human reproductive anatomy and physiology. This expansive text covers the full range of topics in human reproduction, from the biology of male and female systems to conception, pregnancy, labor and birth. It goes on to cover issues in fertility and its control, population growth and family planning, induced abortion and sexually transmitted diseases. This is the ideal book for courses on human reproductive biology, with chapter introductions, sidebars on related topics, chapter summaries and suggestions for further reading.
Beautifully redrawn full-color illustrations complement completely updated material with the latest research results, and clear, logical presentation of topics Covers the basic science of reproduction - endocrinology, anatomy, physiology, development, function and senescence of the reproductive system - as well as applied aspects including contraception, infertility and diseases of the reproductive system New companion website features full-color illustrations as PPT and jpeg files for both professors and students to use for study and presentations

Why do the best-known examples of evolutionary change involve the alteration of one kind of animal into another very similar one, like the evolution of a bigger beak in a bird? Wouldn't it be much more interesting to understand how beaks originated? Most people would agree, but until recently we didn't know much about such origins. That is now changing, with the growth of the interdisciplinary field evo-devo, which deals with the relationship between how embryos develop in the short term and how they (and the adults they grow into) evolve in the long term. One of the key questions is: can the origins of structures such as beaks, eyes, and shells be explained within a Darwinian framework? The answer seems to be yes, but only by expanding that framework. This book discusses the required expansion, and the current state of play regarding our understanding of evolutionary and developmental origins.

Mammary Development: Growth and Growth Factors: The Environment of the Mammary Secretory Cell (C.H. Knight). Role of Bovine Placental Lactogen in Intercellular Signalling during Mammary Growth and Lactation (R.J. Collier et al.). Expression of Hox Genes in Normal and Neoplastic Mouse Mammary Gland (Y. Friedmann, C.W. Daniel). Apoptosis in Mammary Gland Involution: Isolation and Characterization of Apoptosisspecific Genes (W. Bielke et al.). Mammary Development: Differentiation and Gene Expression: Extracellular Matrix Dependent Gene Regulation in Mammary Epithelial Cells (C. Schmidhauser et al.). Regulation of Milk Secretion and Composition by Growth Hormone and Prolactin (D.J. Flint). Basement Membrane in the Control of Mammary Gland Function (C.H. Streuli). Heterogeneous Expression and Synthesis of Human Serum Albumin in the Mammary Gland of Transgenic Mice (I. Barash et al). Milk Secretion: Autocrine Control of Milk Secretion: Development of the Concept (M. Peaker). Endocrine and Autocrine Strategies for the Control of Lactation in Women and Sows (P.E. Hartmann et al.). Autocrine Control of Milk Secretion: From Concept to Application (C.J. Wilde et al.). A Role for Mediumchain Fatty Acids in the Regulation of Lipid Synthesis in Milk Stasis? (D.H. Williamson et al.). 41 additional articles. Appendix. Index.

This book is about morphogenesis as the genesis of forms. It is not restricted to plants growing from seed or animals developing from an embryo (although these do supply the most abundant examples) but also addresses kindred processes, from inorganic to social to biomorphic technology. It is about our morphogenetic universe: unplanned, unfair and frustratingly complicated but benevolent in allowing us to emerge, survive, and inquire into its laws.

Morphogenesis is the set of processes that generate shape and form in the embryo--an important area within developmental biology. An exciting and up-to-the-minute account of the very latest research into the factors that create biological form, "Mechanisms of Morphogenesis," second edition is a text reference on the mechanisms of cell and tissue morphogenesis in a diverse array of organisms, including prokaryotes, animals, plants and fungi.

By combining hard data with computer modeling, "Mechanisms of Morphogenesis," second edition equips readers with a much broader understanding of the scope of modern research than is otherwise available. The book focuses on the ways in which the genetic program is translated to generate cell shape, to direct cell migration, and to produce the shape, form and rates of growth of the various tissues. Each topic is illustrated with experimental data from real systems, with particular reference to gaps in current knowledge and pointers to future
* Includes over 200 four-color figures
* Offers an integrated view of theoretical developmental biology and computer modelling with laboratory-based discoveries
* Covers experimental techniques as a guide to the reader
* Organized around principles and mechanisms, using them to integrate discoveries from a range of organisms and systems

Section I Selected Aquatic Plant Organisms.- Dasycladaceae: A Family of Giant unicellular Algae Ideal for Research.- Acetabularia: A Giant Unicellular Organism for Studying Polarity.- Model Algal System to Study Plant Development.- Section II Selected Aquatic Animal Organisms.- Experimental Analysis of Developmental Processes in Marine Hydroids.- Reproduction and Development in Ctenophores.- Descriptive and Experimental Embryology of the Turbellaria: Present Knowledge, Open Questions and Future Trends.- Growth, Degrowth and Regeneration as Developmental Phenomena in Adult Freshwater Planarians.- Genealogy, Geometry and Genes: Experimental Embryology of Caenorhabditis elegans.- Gap Junctional Communication and Cell Cycle Duration in the Early Molluscan Embryo.- In vitro Preparation of the Early Squid Blastoderm.- On the Establishment of Polarity in Polychaete Eggs.- Experimental Embryology in Leeches: Cellular and Molecular Approaches.- Practical Approaches to the Study of Nervous System Development in Hirudinid Leeches.- Starfish Oocytes and Sea Urchin Eggs as Models to Study the Intracellular Mechanisms Controlling the Cell Division Cycle.- Morphogenesis in the Sea Urchin Embryo: Mechanism of Gastrulation.- Fertilization in Aquatic Animals.- Patterns of Gene Expression during Ascidian Development.- Some Contributions of Research on Early Teleost Embryogenesis to General Problems of Development.- Gastrulation in the Zebrafish Brachydanio rerio (Teleostei) as seen in the Scanning Electron Microscope.- Section III Historical and Conceptual Aspects of "Causal Embryology".- L'Epigenese et la Preformation a l'Epoque de l'Embryologie Causale.- Section IV Contributions of General Value to Embryological Research.- The Role of Retinoic Acid in Vertebrate Limb Morphogenesis.- Physiological Approach to the Early Embryogenesis.- Environmental Pollution and Embryonic Development: Relevance of Standardized Toxicological Tests.- Participants Photo.- Author Index.

Orangutans, together with chimpanzees and gorillas, are our closest living relatives. Photographic and Descriptive Musculoskeletal Atlas of Orangutans, the first photographic and descriptive musculoskeletal atlas of the genus Pongo, adopts the same format as the photographic atlases of Gorilla, Pan and Hylobates previously published by the same authors. These four books are part of a series of monographs that will set out the comparative and phylogenetic context of the gross anatomy and evolutionary history of the soft tissue morphology of modern humans and their closest relatives. The present atlas, which includes detailed high-quality photographs of musculoskeletal structures from most anatomical regions of the body as well as textual information about the attachments, innervation, function and weight of the respective muscles, is based on dissections of five orangutans and on an extensive review of the literature. It provides an updated review of the anatomical variations within orangutans as well as an extensive list of the synonyms used in the literature to designate the structures we discuss. It will be of interest to students, teachers and researchers studying primatology, comparative anatomy, functional morphology, zoology, and physical anthropology and to medical students, doctors and researchers who are curious about the origin, evolution, homology and variations of the musculoskeletal structures of modern humans.

Biology of Sharks and Their Relatives is an award-winning and groundbreaking exploration of the fundamental elements of the taxonomy, systematics, physiology, and ecology of sharks, skates, rays, and chimera. This edition presents current research as well as traditional models, to provide future researchers with solid historical foundations in shark research as well as presenting current trends from which to develop new frontiers in their own work. Traditional areas of study such as age and growth, reproduction, taxonomy and systematics, sensory biology, and ecology are updated with contemporary research that incorporates emerging techniques including molecular genetics, exploratory techniques in artificial insemination, and the rapidly expanding fields of satellite tracking, remote sensing, accelerometry, and imaging. With two new editors and 90 contributors from the US, UK, South Africa, Portugal, France, Canada, New Zealand, Australia, India, Palau, United Arab Emirates, Micronesia, Sweden, Argentina, Indonesia, Cameroon, and the Netherlands, this third edition is the most global and comprehensive yet. It adds six new chapters representing extensive studies of health, stress, disease and pathology, and social structure, and continues to explore elasmobranch ecological roles and interactions with their habitats. The book concludes with a comprehensive review of conservation policies, management, and strategies, as well as consideration of the potential effects of impending climate change. Presenting cohesive and integrated coverage of key topics and discussing technological advances used in modern shark research, this revised edition offers a well-rounded picture for students and researchers.

This book presents recent scientific investigations in microbial ecology and systematics. Advanced microbial science investigations employ the latest technologies for research in microbiology and microbial applications. The book has complete information on classical microbiology techniques for assessment of the composition of microbial diversity assessment, advancement in next-generation technology, advantages of microbial products in sustainable developments and their application for societal benefits. Current research on microorganisms is presented as a perfect book for studies on "Microbial Systematics". This book will serve as an important resource for practising research and review for the scientific community.

Neural Crest Induction and Differentiation, written by an international panel of recognized leaders in the field, discusses all aspects of modern neural crest biology from its evolutionary significance, to its specification, migration, plasticity and contribution to multiple lineages of the vertebrate body, to the pathologies associated with abnormal neural crest development and function. Each chapter provides an invaluable resource for information on the most current advances in the field, with discussion of controversial issues and areas of emerging importance.

Plant tissue culture (PTC) is basic to all plant biotechnologies and is an exciting area of basic and applied sciences with considerable scope for further research. PTC is also the best approach to demonstrate the totipotency of plant cells, and to exploit it for numerous practical applications. It offers technologies for crop improvement (Haploid and Triploid production, In Vitro Fertilization, Hybrid Embryo Rescue, Variant Selection), clonal propagation (Micropropagation), virus elimination (Shoot Tip Culture), germplasm conservation, production of industrial phytochemicals, and regeneration of plants from genetically manipulated cells by recombinant DNA technology (Genetic Engineering) or cell fusion (Somatic Hybridization and Cybridization). Considerable work is being done to understand the physiology and genetics of in vitro embryogenesis and organogenesis using model systems, especially Arabidopsis and carrot, which is likely to enhance the efficiency of in vitro regeneration protocols. All these aspects are covered extensively in the present book. Since the first book on Plant Tissue Culture by Prof. P.R. White in 1943, several volumes describing different aspects of PTC have been published. Most of these are compilation of invited articles by different experts or proceedings of conferences. More recently, a number of books describing the Methods and Protocols for one or more techniques of PTC have been published which should serve as useful laboratory manuals. The impetus for writing this book was to make available a complete and up-to-date text covering all basic and applied aspects of PTC for the students and early-career researchers of plant sciences and plant / agricultural biotechnology. The book comprises of nineteen chapters profusely illustrated with self-explanatory illustrations. Most of the chapters include well-tested protocols and relevant media compositions that should be helpful in conducting laboratory experiments. For those interested in further details, Suggested Further Reading is given at the end of each chapter, and a Subject and Plant Index is provided at the end of the book.

1) Classic anatomical atlases 2) Detailed labeling of the earliest phases of prenatal neorological development 3) Appeals to neuroanatomists, developmental biologists and clinical practioners. 4) Persistent relevance - brain development is not going to change.

Since the publication of the first edition of Regenerative Biology and Medicine in 2006, steady advances have been made in understanding the origin and characteristics of stem cells in epithelia, skeletal muscle, and bone, and in the niche signals that regulate the activities of these cells. Simultaneously, breakthroughs including the creation of iPSCs and transdifferentiation have created a momentum for regenerative biology with implications in regenerative biology that are far-reaching.

This book highlights these advances in the field to embrace a vast audience of investigators in chemistry, computer science, informatics, physics and mathematics as well as graduate students, clinical physicians, and biologists who are realizing the importance of the fields of regenerative biology and medicine in practice. Organized in three parts - biology of regeneration, regenerative medicine, and perspectives - this second edition creates a framework for integrating old and new data in this progressive field.
Includes coverage odskin, hair, teeth, cornea, and central neural tissuesProvides description of regenetive medicine indigestive, respiratory, urogenital, musculoskeletal, and cardiovascular systemsIncludes amphibians as powerful research models with discussion ofappendage regeneration in amphibians and mammals"

This wide-ranging and accessible book serves as a fascinating guide to the strategies and concepts that help us understand the boundaries between physics, on the one hand, and sociology, economics, and biology on the other. From cooperation and criticality to flock dynamics and fractals, the author addresses many of the topics belonging to the broad theme of complexity. He chooses excellent examples (requiring no prior mathematical knowledge) to illuminate these ideas and their implications. The lively style and clear description of the relevant models will appeal both to novices and those with an existing knowledge of the field.

Chaetomium genus was established by Gustav Kunze in 1817. According to Index Fungorum Partnership, there are 273 Chaetomium species accepted till now. Members of the genus Chaetomium are capable of colonizing various substrates and are well-known for their ability to degrade cellulose and to produce a variety of bioactive metabolites. More than 200 compounds have been reported from this genus. A huge number of new and bioactive secondary metabolites associated with unique and diverse structural types, such as chaetoglobosins, epipolythiodioxopiperazines, azaphilones, depsidones, xanthones, anthraquinones, chromones, and steroids, have been isolated and identified. Many of the compounds have been reported to possess significant biological activities, such as antitumor, antimalarial, cytotoxic, enzyme inhibitory, antimicrobial, phytotoxic, antirheumatoid and other activities. Chaetomium taxa are frequently reported to be cellulase and ligninase producers with the ability to degrade cellulosic and woody materials. This is the first, comprehensive volume covering Chaetomium genus in detail. It includes the latest research, methods, and applications, and was written by scholars working directly in the field. The book also contains informative illustrations and is fully referenced for further reading.

Key Features 1) Detailed summary of every recorded variation and anomaly for each muscle in the human body 2) Information on comparative anatomy of each muscle (e.g., how each human muscle may appear in our closest living relatives, the apes). 3) Schematic illustrations of the variations and anomalies for easy visualization 4) Comprehensive literature review resulting in the most accurate prevalence information for each variation and anomaly 5) Diverse group of co-authors from various academic and cultural backgrounds

In the 1960s, Sydney Brenner proposed to use the nematode worm Caenorhabditis elegans to discover the control mechanisms of animal development and to reveal how a small number of neurons generate different behaviours, giving birth to a vibrant community that uses this animal model for their studies. Brenner was aided in his aim by John Sulston, who mapped the C. elegans cell lineages - from a single cell to the multicellular adult - which transformed the field of developmental biology. As a tribute to these two men, this book captures the perspectives of some of the early pioneers of the worm community, from Martin Chalfie, Robert Waterston and Donald Moerman to Catherine Rankin, Antony Stretton and John White. It also includes contributions from subsequent generations of the community, who explore the development and function of the C. elegans nervous system. This book features how this animal has become one of the best models for elucidating the biology of different sensory modalities and their complex behavioural outputs, or how this animal's survival strategies have contributed to our understanding of ageing and neurodegeneration. Thus, this volume documents the development of the C. elegans neuroscience field, from infancy to maturity. The chapters in this book were originally published as a special issue of the Journal of Neurogenetics.

This title includes a number of Open Access chapters. Embryology is the study of embryos. It is the branch of biological science that deals with the formation and early development of an individual organism, from fertilization of the egg (ovum) to birth. This collection includes articles on some of the most important topics in embryology today, such as cryopreservation of human embryos, in vitro generation of neurons from embryonic stem cells, embryonic transfer, transcriptional profiling, and more.

Human Microanatomy is a comprehensive histology text that analyzes human structure and function from the subcellular to organ level of organization. In addition to emphasizing medically relevant information, each chapter considers developmental and evolutionary aspects of microanatomy while also using celebrity medical histories to help provide real-world context for accompanying descriptions of normal histology. The book is richly illustrated with over 1400 full-color micrographs and drawings assembled into cohesive groupings with detailed captions to help elucidate key histological concepts. Text illustrations are further supplemented by hundreds of other light and electron micrographs available in a free digital atlas covering a broad spectrum of microanatomy. Each text chapter also includes a preview, pictorial summary, and self-study quiz to highlight and review essential elements of histology. By incorporating features like medical histories, biological correlates, and various study aids, Human Microanatomy provides an appealing and informative treatment of histology for readers who are interested in the structural bases of cell, tissue, and organ functioning. KEY FEATURES: Uses celebrity medical histories to help provide context for descriptions of normal histology Supplements medically relevant information with developmental and evolutionary correlates of microanatomy Contains 1400+ full-color micrographs and drawings that illustrate a wide range of histological features Offers free access to an ancillary online atlas with hundreds of additional light and electron micrographs Includes helpful study aids such as chapter previews, pictorial summaries, and self-study quizzes Presents a novel and comprehensive account of the structure and function of human cells, tissues, and organs

Human Microanatomy is a comprehensive histology text that analyzes human structure and function from the subcellular to organ level of organization. In addition to emphasizing medically relevant information, each chapter considers developmental and evolutionary aspects of microanatomy while also using celebrity medical histories to help provide real-world context for accompanying descriptions of normal histology. The book is richly illustrated with over 1400 full-color micrographs and drawings assembled into cohesive groupings with detailed captions to help elucidate key histological concepts. Text illustrations are further supplemented by hundreds of other light and electron micrographs available in a free digital atlas covering a broad spectrum of microanatomy. Each text chapter also includes a preview, pictorial summary, and self-study quiz to highlight and review essential elements of histology. By incorporating features like medical histories, biological correlates, and various study aids, Human Microanatomy provides an appealing and informative treatment of histology for readers who are interested in the structural bases of cell, tissue, and organ functioning. KEY FEATURES: Uses celebrity medical histories to help provide context for descriptions of normal histology Supplements medically relevant information with developmental and evolutionary correlates of microanatomy Contains 1400+ full-color micrographs and drawings that illustrate a wide range of histological features Offers free access to an ancillary online atlas with hundreds of additional light and electron micrographs Includes helpful study aids such as chapter previews, pictorial summaries, and self-study quizzes Presents a novel and comprehensive account of the structure and function of human cells, tissues, and organs

The importance of molecular approaches for comparative biology and the rapid development of new molecular tools is unprecedented. The extraordinary molecular progress belies the need for understanding the development and basic biology of whole organisms. Vigorous international efforts to train the next-generation of experimental biologists must combine both levels - next generation molecular approaches and traditional organismal biology. This book provides cutting-edge chapters regarding the growing list of marine model organisms. Access to and practical advice on these model organisms have become a conditio sine qua non for a modern education of advanced undergraduate students, graduate students and postdocs working on marine model systems. Model organisms are not only tools they are also bridges between fields - from behavior, development and physiology to functional genomics. Key Features Offers deep insights into cutting-edge model system science Provides in-depth overviews of all prominent marine model organisms Illustrates challenging experimental approaches to model system research Serves as a reference book also for next-generation functional genomics applications Fills an urgent need for students Related Titles Jarret, R. L. & K. McCluskey, eds. The Biological Resources of Model Organisms (ISBN 978-1-1382-9461-5) Kim, S.-K. Healthcare Using Marine Organisms (ISBN 978-1-1382-9538-4) Mudher, A. & T. Newman, eds. Drosophila: A Toolbox for the Study of Neurodegenerative Disease (ISBN 978-0-4154-1185-1) Green, S. L. The Laboratory Xenopus sp. (ISBN 978-1-4200-9109-0)

The evolution of segmentation is one of the central questions in evolutionary developmental biology. Indeed, it is one of the best case studies for the role of changes in development in the evolution of body plans. Segmented body plans are believed to have appeared several times in animal evolution, and to have contributed significantly to the evolutionary success of the taxa in which they are present. Because of the centrality of the subject, and the continuing interest in understanding segmentation, this book offers an often overlooked focus on the cellular aspects of the process of segmentation, providing an invaluable reference for students of evolutionary developmental biology at all levels. Key Features Explores the role that segmentation has played in the diversity of animals Documents the diverse cellular mechanisms by which segmentation develops Reviews the independent evolutionary origins of segmentation Provides insight into the general patterns of serial homology at the cellular level Related Titles Lynne Bianchi. Developmental Neurobiology (ISBN 978-0-8153-4482-7). Jonathan Bard. Principles of Evolution: Systems, Species, and the History of Life (ISBN 978-0-8153-4539-8). Gerhard Scholtz. Evolutionary Developmental Biology of Crustacea (ISBN 978-9-0580-9637-1). Dr. Ariel D. Chipman is Associate Professor in the Department of Ecology, Evolution & Behavior of the Silberman Institute of Life Sciences at The Hebrew University of Jerusalem. He is the author or co-author of dozens of peer reviewed scientific journal articles. His research focuses upon the evolution of animal body plans with a focus on arthropod segmentation, integrating comparative embryology, the fossil record and genome evolution.

The Vertebrata is one of the most speciose groups of animals, comprising more than 58,000 living species. This book provides a detailed account on the comparative anatomy, development, homologies and evolution of the head, neck, pectoral and forelimb muscles of vertebrates. It includes hundreds of illustrations, as well as numerous tables showing the homologies between the muscles of all the major extant vertebrate taxa, including lampreys, elasmobranchs, hagfish, coelacanths, dipnoans, actinistians, teleosts, halecomorphs, ginglymodians, chondrosteans, caecilians, anurans, urodeles, turtles, lepidosaurs, crocodylians, birds, and mammals such as monotremes, rodents, tree-shrews, flying lemurs and primates, including modern humans. It also provides a list of more than a thousand synonyms that have been used by other authors to designate these muscles in the literature. Importantly, it also reviews data obtained in the fields of evolutionary developmental biology, molecular biology and embryology, and explains how this data helps to understand the evolution and homologies of vertebrate muscles. The book will useful to students, teachers, and researchers working in fields such as functional morphology, ecomorphology, evolutionary developmental biology, zoology, molecular biology, evolution, and phylogeny. As the book includes crucial information about the anatomy, development, homologies, evolution and muscular abnormalities of our own species, Homo sapiens, it will also be helpful to physicians and medical students.

This volume examines cells set aside during development for use later in ontogeny or in adult life. There is no single term for such cells. The cells explored fall within several major categories - stem cells, set-aside cells (in echinoderm larvae), imaginal discs in insects such as Drosophila, meristems (plants), blastemata (regeneration in amphibians), neoblasts (regeneration in planarians). The book compares and contrasts these cell types and the environments (niches) in which they operate with the aim of unravelling any relationships between them, between their activation in development, and in their evolution. Key Features Explores the nature of deferred-use cells in evolutionary and developmental context. Reviews the mechanisms of development of set-aside cells, such as stem cells, meristems, and imaginal discs. Provides phylogenetic overview of different types of deferred-use cells. Compares and contrasts different theories on the origin of deferred-use cells. Related Titles Calegari, F. & C. Waskow, eds. Stem Cells: From Basic Research to Therapy (ISBN 978-1-4822-0775-0) Cabral, J. M. S. & C. L. da Silva, eds. Bioreactors for Stem Cell Expansion and Differentiation (ISBN 978-1-4987-9590-6) Kong, H., A. J. Putnam, & L. B. Schook, eds. Stem Cells and Revascularization Therapies (ISBN 978-1-4398-0323-3) Schaffer, D., J. D. Bronzino, & D. R. Peterson, eds. Stem Cell Engineering: Principles and Practices (ISBN 978-1-4398-7204-8)