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Nature's Gift to Neuroscience - A Tribute to Sydney Brenner and John Sulston (Hardcover)
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Nature's Gift to Neuroscience - A Tribute to Sydney Brenner and John Sulston (Hardcover)
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In the 1960s, Sydney Brenner proposed to use the nematode worm
Caenorhabditis elegans to discover the control mechanisms of animal
development and to reveal how a small number of neurons generate
different behaviours, giving birth to a vibrant community that uses
this animal model for their studies. Brenner was aided in his aim
by John Sulston, who mapped the C. elegans cell lineages - from a
single cell to the multicellular adult - which transformed the
field of developmental biology. As a tribute to these two men, this
book captures the perspectives of some of the early pioneers of the
worm community, from Martin Chalfie, Robert Waterston and Donald
Moerman to Catherine Rankin, Antony Stretton and John White. It
also includes contributions from subsequent generations of the
community, who explore the development and function of the C.
elegans nervous system. This book features how this animal has
become one of the best models for elucidating the biology of
different sensory modalities and their complex behavioural outputs,
or how this animal's survival strategies have contributed to our
understanding of ageing and neurodegeneration. Thus, this volume
documents the development of the C. elegans neuroscience field,
from infancy to maturity. The chapters in this book were originally
published as a special issue of the Journal of Neurogenetics.
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