Asymmetry of the brain and behaviour (lateralization) has traditionally been considered unique to humans. However, research has shown that this phenomenon is widespread throughout the vertebrate kingdom and found even in some invertebrate species. A similar basic plan of organisation exists across vertebrates. Summarising the evidence and highlighting research from the last twenty years, the authors discuss lateralization from four perspectives - function, evolution, development and causation - covering a wide range of animals, including humans. The evolution of lateralization is traced from our earliest ancestors, through fish and reptiles to birds and mammals. The benefits of having a divided brain are discussed, as well as the influence of experience on its development. A final chapter discusses outstanding problems and areas for further investigation. Experts in this field, the authors present the latest scientific knowledge clearly and engagingly, making this a valuable tool for anyone interested in the biology and behaviour of brain asymmetries.

Leo Buss expounds a general theory of development through a simple hierarchical extension of the synthetic theory of evolution. He perceives innovations in development to have evolved in ancestral organisms where the germ line was not closed to genetic variation arising during the course of ontogeny. Originally published in 1988. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

Cells in the developing embryo depend on signals from the extracellular environment to help guide their differentiation. An important mediator in this process is the extracellular matrix - secreted macromolecules that interact to form large protein networks outside the cell. During development, the extracellular matrix serves to separate adjacent cell groups, participates in establishing morphogenic gradients, and, through its ability to interact directly will cell-surface receptors, provides developmental clocks and positional information. This volume discusses how the extracellular matrix influences fundamental developmental processes and how model systems can be used to elucidate ECM function. The topics addressed range from how ECM influences early development as well as repair processes in the adult that recapitulate developmental pathways.

This advanced text, first published in 2006, takes a developmental approach to the presentation of our understanding of how vertebrates construct a retina. Written by experts in the field, each of the seventeen chapters covers a specific step in the process, focusing on the underlying molecular, cellular, and physiological mechanisms. There is also a special section on emerging technologies, including genomics, zebrafish genetics, and stem cell biology that are starting to yield important insights into retinal development. Primarily aimed at professionals, both biologists and clinicians working with the retina, this book provides a concise view of vertebrate retinal development. Since the retina is 'an approachable part of the brain', this book will also be attractive to all neuroscientists interested in development, as processes required to build this exquisitely organized system are ultimately relevant to all other parts of the central nervous system.

This volume discusses the current state of research findings related to healthy brain aging by integrating human clinical studies and translational research in animal models. Several chapters offer a unique overview of successful aging, age-related cognitive decline and its associated structural and functional brain changes, as well as how these changes are influenced by reproductive aging. Insights provided by preclinical studies in mouse models and advanced neuroimaging techniques in humans are also presented."

The Second Georgia Genetics Symposium was held color. Soon after, he joined the sta? of The Jackson in September 2000, and the development of this Laboratory in Bar Harbor, Maine. book took place over the nearly 4 years that ensued. Much of Bill's research at the lab was centered During this time, many advances in the Genome around investigating phenotypic variability within Project and mouse mutagenesis were made. In the highly inbred strains, and in that connection he book overview, we discuss the development of the developed the technique of ovarian transplanta- Genome Project (which is the context for the sym- tion (even using embryonic donors) and a genetic posium), the role the mouse was playing at that scheme whereby graft compatibility could be time, how that role has evolved, and how the combined with the ability to distinguish o?spring chapters of the book address issues in mouse func- from donor and regenerated host ovaries. His tional genetics. Many of the chapters in this book work was in?uenced by the second World War, will provide useful resources for years to come. ?rst because The Jackson Laboratory turned into Of greater impact, our keynote speaker, the a production colony for the military, primarily to mutagenesis pioneer William L. (Bill) Russell, produce mice for typhoid testing, and secondly, passed away on July 23, 2003.

The main objective of this book is to provide a comprehensive review on stem cells and their role in tissue regeneration, homeostasis and therapy. In addition, the role of cancer stem cells in cancer initiation, progression and drug resistance are discussed. The cell signaling pathways and microRNA regulating stem cell self-renewal, tissue homeostasis and drug resistance are also mentioned. Overall, these reviews will provide a new understanding of the influence of stem cells in tissue regeneration, disease regulation, therapy and drug resistance in several human diseases.

During the last decades a breakthrough in the understanding of the mechanisms controlling development has been achieved. This has been possible, in great part, by the use of various experimental approaches.
This book focuses on topics concerning some of the processes involved in development, the main emphasis being on the genetic and molecular mechanisms in the evolutionary context. "Drosophila "is used as an experimental model for the genetic approach to the understanding of behaviour.

Hedgehog-GLI Signaling in Human Disease represents the first compilation of up-to-date reviews by top-level scientists in this important field of research. The chapters cover a wide spectrum of related interests, from the molecular bases of morphogen function, to human genetics to cancer research. The aim of the book is to disseminate information on this exciting field, to allow students, scientists and the public in general to gain access current information from research leaders and to provide a book that encompasses different aspects of research showing the fusion of basic research in model systems and medicine. This is a timely primer on how a system of cell communication, Hedgehog-GLI signaling, plays a critical role in human disease and thus provides the background for the development of novel and rational therapies.

he biological sciences are dominated by the idea that cells are the functionally autonomous, physically separated, discrete units of life. TThis concept was propounded in the 19th century by discoveries of the cellular structuring of both plants and animals. Moreover, the ap parent autonomy of unicellular eukaryotes, as well as the cellular basis of the mammalian brain (an organ whose anatomy for a long while defied attempts to validate the idea of the cellular nature of its neurons), seemed to provide the final conclusive evidence for the completeness of *cell theory', a theory which has persisted in an almost dogmatic form up to the present day. However, it is very obvious that there are numerous observations which indicate that it is not the cells which serve as the basic units of biological life but that this property falls to some other, subcellular assemblage. To deal with this intricate problem concerning the fundamental unit of living matter, we proposed the so-called Cell Body concept which, in fact, devel ops an exceedingly original idea proposed by Julius Sachs at the end of the 19th century. In the case of eukaryotic cells, DNA-enriched nuclei are intimately associated with a microtubular cytoskeleton. In this configuration-as a Cell Body-these two items comprise the fundamental functional and struc tural unit of eukaryotic living matter. The Cell Body seems to be inherent to all cells in all organisms.

In this comprehensive and cutting-edge book, leading experts explore the parameters that define germline stem cells and the mechanisms that regulate the cell behavior in order to better isolate, characterize and maintain them. The volume begins by providing protocols for germline stem cell identification and regulation in model organisms, and concludes with detailed chapters covering current techniques involving in vitro culture and the applications of the cells.

Advances in morphological and molecular methods continue to uncover new information on the origin and evolution of bats. Presenting some of the most remarkable discoveries and research involving living and fossil bats, this book explores their evolutionary history from a range of perspectives. Phylogenetic studies based on both molecular and morphological data have established a framework of evolutionary relationships that provides a context for understanding many aspects of bat biology and diversification. In addition to detailed studies of the relationships and diversification of bats, the topics covered include the mechanisms and evolution of powered flight, evolution and enhancement of echolocation, feeding ecology, population genetic structure, ontogeny and growth of facial form, functional morphology and evolution of body size. The book also examines the fossil history of bats from their beginnings over 50 million years ago to their diversification into one of the most globally wide-spread orders of mammals living today.

Advances in morphological and molecular methods continue to uncover new information on the origin and evolution of bats. Presenting some of the most remarkable discoveries and research involving living and fossil bats, this book explores their evolutionary history from a range of perspectives. Phylogenetic studies based on both molecular and morphological data have established a framework of evolutionary relationships that provides a context for understanding many aspects of bat biology and diversification. In addition to detailed studies of the relationships and diversification of bats, the topics covered include the mechanisms and evolution of powered flight, evolution and enhancement of echolocation, feeding ecology, population genetic structure, ontogeny and growth of facial form, functional morphology and evolution of body size. The book also examines the fossil history of bats from their beginnings over 50 million years ago to their diversification into one of the most globally wide-spread orders of mammals living today.

Originally published during the early part of the twentieth century, the Cambridge Manuals of Science and Literature were designed to provide concise introductions to a broad range of topics. They were written by experts for the general reader and combined a comprehensive approach to knowledge with an emphasis on accessibility. The Life-Story of Insects by G. H. Carpenter was first published in 1913. The book contains an informative account of the facts and meanings of insect transformations, allowing scope for further entomological investigation in the field.

To aid in unraveling the complexities of the causation of congenital malformations, various influences on their frequency are considered in this book. And of course the known and possible environmental bases of their occurrence are fully described. An introductory record of the history of perinatal mortality in the last three centuries gives foundation for the discussion of death in contemporary decades.

Neuroscience has long been focused on understanding neural plasticity in both development and adulthood. Experimental work in this area has focused almost entirely on plasticity at excitatory synapses. A growing body of evidence suggests that plasticity at inhibitory GABAergic and glycinergic synapses is of critical importance during both development and aging. The book brings together the work of researchers investigating inhibitory plasticity at many levels of analysis and in several different preparations. This topic is of wide relevance across a number of different areas of research in neuroscience and neurology. Medical problems such as epilepsy, mental illness, drug abuse, and movement disorders can result from malfunctioning inhibitory circuits. Further, the maturation of inhibitory circuits may trigger the onset of critical periods of neural circuit plasticity, raising the possibility that such plastici periods could be reactivated for medical benefit by manipulating inhibitory circuitry.

Developmental biology attracts scientists from many different areas of biology, and the amphibian Xenopus holds a special place among the organisms studied as a model of vertebrate development. Until now, no recently published atlas existed to aid researchers and students coming to the Xenopus embryo for the first time.
The present book satisfies this need. With its synthesizing approach and its generous provision of beautiful scanning, transmission, and light microscopy images, this unique volume will be a standard reference not only for developmental biologists but for all students of embryology, histology, and comparative anatomy.

Fourteen years have passed since the publication of David Spencer Smith's Insect Cells: Their Structure and Function. Here the results of a decade of electronmicroscopic studies on insect cells were summarized in an organized and integrated fashion for the first time, and the ultrastructural characteristics of different specialized cells and tissues were abundantly illustrated in the 117 plates this monograph contained. In the intervening period great progress has been made in the field of Insect Ultrastructure. Organelles not even mentioned in Smith's book, such as synaptonemal complexes, clathrin baskets, fusomes, and retinular junc tions, have been identified and functions proposed for them. There have also been many technical advances that have profoundly influenced the direction of subsequent research. A spectacular example would be the development by Miller and Beatty of the chromosomal spreading technique which allowed for the first time ultrastructural studies on segments of chromosomes containing genes in various stages of replication and transcription. Then there is the freeze-fracture procedure first described by Moor and his colleagues. This technique permitted an analysis of intercellular junctions that was impossible with the conventional sectioning methods. The results greatly clarified our understanding of the channels for ion movement and the permeability barriers between cells and also the membrane changes that occur during the embryonic differentiation and metamorphosis of various types of insect cells."

This series was established to create comprehensive treatises on specific topics in developmental biology. Such volumes serve a useful role in developmental biology, since it is a very diverse field that receives contributions from a wide variety of disciplines. This series is a meeting-ground for the various practi tioners of this science, facilitating an integration of heterogeneous information on specific topics. Each volume is intended to provide the conceptual basis for a comprehen sive understanding of its topic as well as an analysis of the key experiments upon which that understanding is based. The specialist in any aspect of devel opmental biology should understand the experimental background of the field and be able to place that body of information in context to ascertain where additional research would be fruitful. At that point, the creative process gener ates new experiments. This series is intended to be a vital link in that ongoing process of learning and discovery."

How organisms come to possess adaptive traits is a fundamental question for evolutionary biology. Although it is almost impossible to demonstrate evolution in the laboratory, this issue can be approached by using an unusual organism, Dark-fly: "Drosophila melanogaster" kept in complete darkness for 57 years through 1,400 generations, which corresponds to 28,000 years in terms of human generations. Has Dark-fly adapted to an environment of total darkness? If so, what is the molecular nature of the adaptation? In "Evolution in the Dark," the remarkable findings from the Dark-fly project performed at Kyoto University are presented. It was found that Dark-fly did not have poor eyesight, but rather exhibited higher phototaxis ability and displayed lengthened bristles on the head that function as tactile receptors. Circadian rhythms were weakened but still retained in Dark-fly. With recent progress in genome science enabling researchers to perform whole genome sequencing for Dark-fly, a large number of mutations were identified including genes encoding a light receptor, olfactory receptors, and enzymes involved in neural development. The Dark-fly project is a simple but very long-term experiment. Combined with advanced techniques in genetics and genomics, it is a valuable tool for understanding the molecular nature of adaptive evolution."

Written by an international panel of recognized leaders in the field, Neural Crest Induction and Differentiation discusses all aspects of modern neural crest biology from its evolutionary significance to its specification, migration, plasticity and contribution to multiple lineages of the vertebrate body, to the pathologies associated with abnormal neural crest development and function. Abundant color figures enhance the text providing clear and attractive illustrations of central issues and concepts.

Molecular biology emerged from advances in biochemistry during the 1940s and 1950s, when the structure of the nucleic acids and proteins were elucidated. Beginning in the 1970s, with nucleic acid enzymology and the discovery of the restriction enzymes, the tools of molecular biology became widely available and applied in cell biology to study how genes are regulated. This new knowledge impacted endocrinology and reproductive biology since it was largely known that the secretion of the internal glands affected the phenotypes, and expression of genes. Modern reproductive biology encompasses every level of biological study from genomics to ecology, encompassing cell biology, biochemistry, endocrinology and general physiology. All of these disciplines require a basic knowledge, both as a tool and as an essential aid to a fundamental understanding of the principles of life in health and disease. Overall, molecular biology is central to scientific studies in all living matter, impacting disciplines such as medicine, related health sciences, veterinary, agriculture and environmental sciences. In this book, the basic biochemistry of nucleic acids and proteins are reviewed. Methodologies used to study signaling and gene regulation in the endocrine/reproductive system are also discussed. Topics include mechanisms of hormone action and several endocrine disorders affecting the reproductive system. Professionals in the medical, veterinary and animal sciences fields will find exciting and stimulating material enhancing the breadth and quality of their research.

Recent progress in recombinant DNA technology and the availability of a number of nonpeptide subtype-specific receptor antagonists and of specific antibodies to components of prorenin-renin-angiotensin system (PRAS) have led to rapid advances in the under standing of the multifaceted role of angiotensin II, classically known as a peptide hormone of cardiovascular homeostasis. Accumulating evidence sug responsible for the regulation gests that, in addition to its role in salt and water metabolism, PRAS may control other physiological functions including neurosecretion, cellular proliferation, hypertrophy and/or differentiation, angiogenesis and gonadal function. At the same time, it is becoming evident that the specialized functions of endocrine glands are not only regulated by trophic hormones but also by locally produced paracrine/autocrine factors. The concept is emerging that tissue PRAS is one such locally active regulatory system. With more and more reproductive and endocrine organs being added to the list of tissues that contain a local tissue PRAS, questions are being raised by the reproductive biologists and endocrinologists as to the role of such systems in the tissues of their interest. On the other hand, the cardiovascular and renovascular physiologists are wondering about the relevance of PRAS in various peripheral tissues compared to those of the classical cardiovascular organs. It appeared, therefore, that the time was ripe for a meeting to consider a merger of interest in these two important but heretofore distinct areas of physiology."

... an adult poet is simply an individual in a state of arrested development-in brief, a sort of moron. Just as all of us, in utero, pass through a stage in which we are tadpoles, ... so all of us pass through a state, in our nonage, when we are poets. A youth of seventeen who is not a poet is simply a donkey: his development has been arrested even anterior to that of the tadpole. But a man of fifty who still writes poetry is either an unfortunate who has never developed, intellectually, beyond his teens, or a conscious buffoon who pretends to be something he isn't-something far younger and juicier than he actually is. -H. 1. Mencken, High and Ghostly Matters, Prejudices: Fourth Series (1924) Where would evolution be, Without this thing, heterochrony? -M. L. McKinney (1987) One of the joys of working in a renascent field is that it is actually possible to keep up with the literature. So it is with mixed emotions that we heterochronists (even larval forms like myself) view the recent "veritable explosion of interest in heterochrony" (in Gould's words in this volume). On the positive side, it is ob viously necessary and desirable to extend and expand the inquiry; but one regrets that already we are beginning to talk past, lose track of, and even ignore each other as we carve out individual interests."

How do we understand and explain the apparent dichotomy between plasticity and robustness in the context of development? Can we identify these complex processes without resorting to 'either/or' solutions? Written by two leaders in the field, this is the first book to fully unravel the complexity of the subject, explaining that the epigenetic processes generating plasticity and robustness are in fact deeply intertwined. It identifies the different mechanisms that generate robustness and the various forms of plasticity, before considering the functional significance of the integrated mechanisms and how the component processes might have evolved. Finally, it highlights the ways in which epigenetic mechanisms could be instrumental in driving evolutionary change. Essential reading for biologists and psychologists interested in epigenetics and evolution, this book is also a valuable resource for biological anthropologists, sociobiologists, child psychologists and paediatricians.