Immunology: A Short Course provides an overview of the physiology of the immune system and the pathophysiology of a broad range of immune-mediated diseases, offering accessible and comprehensive guidance to the basic concepts and clinical approaches in the discipline. Now in its eighth edition, this bestselling textbook has been fully updated to reflect our expanded knowledge of how the immune system develops and functions, and the ways in which these physiological phenomena can fail or be compromised. New chapters examine cells and organs of the immune system, organization and expression of lymphocyte antigen receptor genes, experimental systems and methods, and B- and T-cell development activation. Helping students gain an integrated understanding of immunology, this textbook: Offers substantial new and revised material, expanded clinical coverage, enhanced pedagogical features, and updated figures, tables, and references Features recent research advances and therapeutic successes in the field of immunology Includes a companion website containing multiple choice questions, electronic flashcards, downloadable figures, PowerPoint slides, and sample cases Can be supplemented with the Clinical Cases in Immunology companion book The eighth edition of Immunology: A Short Course is an ideal resource for life and health science students, dental and nursing students seeking a short course text, and basic scientists and clinical researchers looking to refresh their knowledge in the subject.

Biologics and Biosimilars: Drug Discovery and Clinical Applications is a systematic integration and evaluation of all aspects of biologics and biosimilars, encompassing research and development, clinical use, global regulation, and more. Biosimilars are biological therapeutic agents designed to imitate a reference biologic with high similarities in structure, efficacy, and safety, but also with potential clinical effective and cost-efficient options for the manufacturers, payers, clinicians, and patients. Most of the top-selling prescription drugs in the current market are biologics, which have revolutionized the treatment strategies and modalities for life-threatening and/or rare diseases. This book outlines the key processes and challenges in drug development, regulations, and clinical applications of biologics, biosimilars, and even interchangeable biosimilars. Global experts in the field discuss essential categories and prototype drugs of biologics and biosimilars in clinical practice such as allergenics, blood and blood components, cell treatment, gene therapy, recombinant therapeutic proteins or peptides, tissues, and vaccines. Additional features: Integrates the latest bench and bedside evidence of drug development and regulations of biologics and biosimilars Contains key study questions for each chapter to guide the readers, as well as drug charts for all therapeutic applications of biologics and biosimilars Presents detailed schematic illustrations to explain the drug development, clinical trials, regulations, and clinical applications of biologics and biosimilars This book is an invaluable tool for health care professional students, providers, and pharmaceutical and health care industries, as well as the public, providing readers with educational updates about the drug development and clinical affairs of biological medications and their similar drugs.

Cancer is a dreaded disease. One in two people will be diagnosed with cancer within their lifetime. Medical Statistics for Cancer Studies shows how cancer data can be analysed in a variety of ways, covering cancer clinical trial data, epidemiological data, biological data, and genetic data. It gives some background in cancer biology and genetics, followed by detailed overviews of survival analysis, clinical trials, regression analysis, epidemiology, meta-analysis, biomarkers, and cancer informatics. It includes lots of examples using real data from the author's many years of experience working in a cancer clinical trials unit. Features: A broad and accessible overview of statistical methods in cancer research Necessary background in cancer biology and genetics Details of statistical methodology with minimal algebra Many examples using real data from cancer clinical trials Appendix giving statistics revision.

Early Childhood Education and Care in a Global Pandemic is a book that highlights how the international early childhood education and care sector responded to the global COVID-19 pandemic. It shows the resiliency of the sector around the world as it grappled with a rapidly changing environment of uncertainty and complexity. Drawing on a diverse range of early childhood education and care contexts, the book captures real-life examples of how COVID-19 impacted children, educators and teachers, and families. Chapters present cases of the particular challenges that COVID-19 presented in a wide range of countries and then how they responded to these challenges - challenges that tested the resilience of children, educators and teachers, and families. By forward anchoring, each chapter examines the opportunities that arose from these challenges and how new local knowledge was produced as new ways were found to support children, educators and teachers, and families during this time. This book offers early childhood education and care a timely resource on lessons learnt from a once-in-a-lifetime event. It offers the sector a way forward to commit to developing new ways of thinking and working that stem from the lessons learnt during the COVID-19 pandemic.

Written by an immunologist, this book traces the concept of immunity from ancient times up to the present day, examining how changing concepts and technologies have affected the course of the science. It shows how the personalities of scientists and even political and social factors influenced both theory and practice in the field. With fascinating stories of scientific disputes and shifting scientific trends, each chapter examines an important facet of this discipline that has been so central to the development of modern biomedicine. With its biographical dictionary of important scientists and its lists of significant discoveries and books, this volume will provide the most complete historical reference in the field.
Written in an elegant style by long-time practicing immunologist
Discusses the changing theories and technologies that guided the field
Tells of the exciting disputes among prominent scientists
Lists all the important discoveries and books in the field
Explains in detail the many Nobel prize-winning contributions of immunologists"

Specialist yoga teacher Vicky Fox shows how to mitigate the side effects of cancer diagnosis and treatment using yoga ('breath-informed movement'), starting with A for Anxiety and working through to Z for ZZZZZZZZZ (sleep/insomnia) to help anyone diagnosed with any type of cancer cope with the symptoms and the symptoms of treatment. They won't have to read it from cover to cover but can dip into it at will to access information about a specific side effect or symptom relevant to them personally. The book takes readers through breathing exercises (pranayama), physical postures (asana), hand gestures (mudras) and sounds/meditations (mantras) that can support, ease and make life more comfortable.

As the COVID-19 crisis began to take shape, all eyes were on Italy, the first Western country to attempt a response to the deadly pandemic. For institutional decision makers and average citizens alike, it was a time of deep uncertainty. As scientists struggled to understand the nature of the virus and how it spread, the gradualness with which information became available caused only deeper uncertainty, as did the inevitable disagreements over which protective actions the government should put in place. Despite some initial delay in its response, the Italian government eventually implemented a nationwide lockdown, which helped control the spread of the disease but simultaneously created unintended consequences for vulnerable populations, like small business owners, women, the elderly, and workers living paycheck to paycheck. Drawing on data surveys conducted during the transition between the first lockdown and staged reopening, this book examines people's risk perception and their willingness to trust the sources and channels of information that were available to them. It also looks at their attitudes toward the protective behaviors they were asked to adopt and the ways in which their own cultural worldviews impacted their support for pandemic response policies. With remarkable depth and candor, respondents reflected on what a post-COVID-19 Italy might look like, filling out the book with the hopes and fears of real people who had stared death in the face and lived to tell about it. The book looks ahead to possibilities for future research, policy, and practice. COVID-19 in Italy elaborates and tests several aspects of the Protective Action Decision Model (PADM) in the Italian context, introducing the concept of ontological security and insecurity as an explanatory change factor to help interpret the Italian experience of responding to COVID-19.

Originally published in 1987 this textbook is a comprehensive introduction to the rapidly developing field of medical geography. It illustrates the ideas, methods and debates that inform contemporary approaches to the subject, demonstrating the potential of a social and environmental approach to illness and health. The central theme is the need to reject an exclusively biological approach to health. The authors examine both the geography of health care and outline a selection of health service planning initiatives in both North America and Europe.

Key features include: Details the role of plants for the treatment and management of cancer and diabetes Discusses the role of phytocompounds as ligands for cancer and diabetic targets Reviews plants and the potential of phytochemicals as antidiabetic and anticancer drugs Explores the green biosynthesis of nanoparticles and their treatment efficiency

A much-needed overview of the available information now accumulating to indicate that assisted reproductive technologies are generally safe for both babies and mothers. However, the literature abounds with reports of a higher risk of obstetric and perinatal complications; regarding the long term outcomes for both women and children, the data are still scarce. The chapters summarized in this book review the current knowledge on long term safety of assisted reproduction and indicate the need for continued research to cover the lack of data in some specific patient groups and for recently developed treatments that only have a short period of follow-up.

the generative and resistant value of human vulnerability the importance of vulnerability in motivating engagement with social networks and material ecologies for productive thinking, communication, and community how relational ethics emerge as important for social and communicative life

Viruses and plagues have constantly threatened the survival of humanity since the evolution of modern man. Medical advances, thanks to the application of remedial plants, have helped to fight back against some of the most nefarious bacterial and viral infections, giving humanity a fighting chance. This fourth volume in the Medicinal Plants in the Asia Pacific for Zoonotic Pandemics series provides an unprecedented, comprehensive overview of the pharmacological activity of more than 100 medicinal plants used for the treatment of microbial infections in Asia and the Pacific. The text discusses the actions of such plants against viruses and bacteria representing a threat of epidemic and pandemic diseases, including COVID-19, with an emphasis on the molecular basis and cellular pathways. Scientific names, botanical classifications and descriptions, medicinal uses, and chemical constituents are presented, along with chemical structures and a vast selection of bibliographical references. FEATURES Introduces the molecular mechanism of natural products from medicinal plants in Asia on bacteria and viruses Includes phylogenetic presentations of a selection of medicinal plants and a chemotaxonomical rationale of antiviral and antibacterial actions Discusses the chemical structure-activity relationship, pharmacokinetics, and bioavailability of antimicrobial principles This book is a useful research tool for postgraduates, academics, and the pharmaceutical, herbal, and nutrition industries looking forward to developing antiviral and antibacterial agents from medicinal plants in Asia. Medicinal Plants in the Asia Pacific for Zoonotic Pandemics is a critical reference for anyone involved in the discovery of leads for the treatment of pandemic viral, bacterial, and infections. "This book will be an important resource for scientists, as well as people passionate about helping to save these critical resources. Perhaps a new drug lead will be identified from at least one of these plants." -From the Foreword by Dr. Mark S. Butler, MSBChem Consulting, Brisbane, Australia

Cover simple modelling approaches as well as full Monte Carlo simulation of x-ray tubes Bremsstrahlung and characteristic contributions to the spectrum are discussed in detail Learning is supported by free open-source software and an online repository of code.

COVID-19 has brought unprecedented challenges in the care of older adults. During the first surge of the pandemic, governments all over the world struggled with high disease severity and increased mortality among older adults. This work documents the impact of the pandemic by collating information from different countries and by synthesizing inputs from several knowledge domains-Sociology, Gerontology, Geriatrics, Medicine and Public Health. The impact on older adults is examined primarily with respect to three main issues-pervasive ageism, spread of infections in care homes worldwide, and the unintended harm of public health measures on geriatric population in different care settings. The complex tensions between epidemic control and the need to respond to social and economic imperatives are investigated with respect to disadvantaged and vulnerable older adults. The book also critically examines international ageing policies with the intention of identifying gaps in pandemic response in particular, and approaches to older adult care in general. In the light of the evidence presented, lessons are drawn which might improve aged care and strengthen emergency preparedness. Finally, considering the evolving nature of the pandemic, new international responses to older adult care and pandemic management are presented as an epilogue. It is anticipated that the book would help nourish critical thinking and implement new solutions to older care during and beyond the pandemic

Originally published in 1987, this book examines the priorities of health policy in the late 20th Century and the varied approaches or strategies to foster the prevention or control of disease. Several chapters focus on specific diseases and conditions, but other areas of concern such as injuries, alcoholism, drug-abuse, occupational health and nutrition are also dealt with. The book illuminates how epidemiology can serve as a more effective basis for health policy and practice and will be of great value to students and lecturers of medical sociology, epidemiological medicine and health policy.

Key Features * Explains the background of the COVID-19 pandemic, the current progress in the development of treatments and prevention of COVID-19 including future aspects of dealing with pandemics. * Serves as a timely repository of knowledge on COVID-19 for researchers and medical professionals engaged in its management. * Features the patent aspects of COVID-19.

**A NEW YORK TIMES BOOK OF THE YEAR 2022** From the author of the prescient Spillover: Animal Infections and the Next Human Pandemic Breathless is the story of the scientific quest to decipher, control and fight Covid-19. Breathless traces SARS-CoV-2's fierce journey through the human population as seen by the scientists who study its origin, ever-changing nature and capacity to kill. It shows how strange viruses emerge as we disrupt wild ecosystems - sometimes causing global catastrophe - and suggests this coronavirus could be a 'forever virus' that's destined to bedevil us endlessly. Quammen also explains that experts saw this pandemic coming; that scientists warned 'the next big one' would be caused by a changeable new virus, but were ignored for political or economic reasons; and that while the origins of this virus may not be known for years, some suppositions are compelling and others can be dismissed. Breathless takes us inside the frantic international effort to control SARS-CoV-2 as if peering over the shoulders of the brilliant scientists who led the chase. Praise for Spillover: 'A frightening and fascinating masterpiece of science reporting' Walter Isaacson 'A real-life thriller with an outcome that affects us all' Elizabeth Kolbert

If you had a trillion dollars and a year to spend it for the good of the world and the advancement of science, what would you do? It's an unimaginably large sum, yet it's only around one per cent of world GDP, and about the valuation of Google, Microsoft or Amazon. It's a much smaller sum than the world found to bail out its banks in 2008 or deal with Covid-19. But what could you achieve with $1 trillion? You could solve the problem of the pandemic, for one, and eradicate malaria, and maybe cure all disease. You could end global poverty. You could settle on the Moon and explore the solar system. You could build a massive particle collider to probe the nature of reality like never before. You could build quantum computers, develop artificial intelligence, or increase human lifespan. You could even create a new life form. Or how about transitioning the world to clean energy? Or preserving the rainforests, or saving all endangered species? Maybe you could refreeze the melting Arctic, launch a new sustainable agricultural revolution, and reverse climate change? How to Spend a Trillion Dollars is the ultimate thought experiment but it is also a call to arms: these are all things we could do, if we put our minds to it - and our money.

This book investigates the role of religion in the context of the COVID-19 pandemic in Southern Africa. Building on a diverse range of methodologies and disciplinary approaches, the book reflects on how religion, politics and health have interfaced in Southern African contexts, when faced with the sudden public health emergency caused by the pandemic. Religious actors have played a key role on the frontline throughout the pandemic, sometimes posing roadblocks to public health messaging, but more often deploying their resources to help provide effective and timely responses. Drawing on case studies from African indigenous knowledge systems, Islam, Rastafari and various forms of Christianity, this book provides important reflections on the role of religion in crisis response. This book will be of interest to researchers across the fields of African Studies, Health, Politics and Religious Studies. The Open Access version of this book, available at http://www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.

Tumors/cancers are characterized by uncontrolled growths of abnormal cells that extend beyond their usual boundaries and disrupt the normal functions of affected organs and systems. While about 75%-80% of tumors/cancers arise sporadically without a family connection, 20%-25% appear to be familial (including 10%-15% nonhereditary familial tumors [or familial tumors] and 5%-10% hereditary familial tumors [or hereditary tumors]). As nonhereditary and hereditary familial tumors often show both tumor-related and non-tumor-related (or syndromic) symptoms, they are referred to as tumor syndromes (or cancer susceptibility syndromes). In comparison with sporadic tumors/cancers, tumor syndromes (>300 described so far) tend to occur at a younger age, involve multiple organs and systems, produce multiple (often in a distinct spectrum) and bilateral lesions, form multiple hamartomatous, benign, or precursor lesions; locate in specific site(s), display unique syndromic features, and affect multiple members/generations of a family. This book provides state-of-art and authoritative coverage of nearly 100 tumor syndromes, with chapters presenting overviews of individual tumor syndromes in relation to their biology, epidemiology, pathogenesis, clinical features, diagnosis, treatment, and prognosis. Featuring contributions from oncologists, clinicians, and specialists, the book offers a reliable, comprehensive reference on tumor syndromes for scholars and students of medicine, dentistry, pharmacology, nursing, public health, and other biomedical disciplines. Key Features Reviews the biology, epidemiology, pathogenesis, and clinical features of tumor syndromes Contains up-to-date information on the diagnosis and treatment of tumor syndromes Includes expert coverage from leading oncologists and clinicians Related Titles J. R. McIntosh, Understanding Cancer: An Introduction to the Biology, Medicine, and Societal Implications of This Disease (ISBN 978-0-8153-4535-0) P. S. T. Shanmugam, Understanding Cancer Therapies (ISBN 978-1-1381-9815-9) J. M. Baehring and J. M. Piepmeier, eds., Brain Tumors: Practical Guide to Diagnosis and Treatment (ISBN 978-0-3673-9022-8) D. Liu, Tumors and Cancers: Endocrine Glands - Blood - Marrow - Lymph (ISBN 978-1-4987-2975-8) Dongyou Liu, PhD, has worked at several research and clinical laboratories in Australia and the United States for the past three decades, with a focus on molecular characterization of microbial pathogens and detection of human genetic disorders and tumors/cancers. He is the primary author of more than 50 original research and review articles in various peer-reviewed international journals, the contributor of 197 book chapters, and the editor of more than 10 books.

Dopamine is a small molecule traditionally regarded as a brain-derived neuronal modulator implicated in many neurological and psychiatric disorders. Outside the brain, dopamine fulfills all the criteria of a circulating hormone which affects normal and abnormal functions of multiple organs and regulatory systems and is also involved in many aspects of cancer formation and progression. This book provides a much needed systematic account of dopamine as an endocrine and autocrine/paracrine hormone and fills a major gap in the overall understanding of the production, distribution and actions of this very important molecule. Key Features: Explores the many different faces of dopamine as autocrine, paracrine and endocrine molecule Documents the adverse effects of antipsychotics on dopamine functions Reviews the many ways dopamine affects the cardiovascular, renal and reproductive systems Provides updates on receptor oligomerization and signaling Examines the role of dopamine in tumorigenesis Related Titles Jones, S. ed. Dopamine - Glutamate Interactions in the Basal Ganglia (ISBN 978-0-3673-8197-4) Luo, L. Principles of Neurobiology (ISBN 978-0-8153-4494-0) Sidhu, A. et al., eds. Dopamine Receptors and Transporters (ISBN 978-0-8247-0854-2)

This book considers the change in rhetoric surrounding the treatment of AIDS from one of crisis to that of 'ending AIDS'. Exploring what it means to 'end AIDS' and how responsibility is framed in this new discourse, the author considers the tensions generated between the individual and the state in terms of notions such as risk, responsibility and prevention. Based on analyses public health promotions in the UK and the US, HIV prevention science and engaging with the work of Foucault, this volume argues that the discourse of 'ending AIDS' implies a tension-filled space in which global principles and values may clash with localised needs, values and concerns; in which evidence-based policies strive for hegemony over local, tacit and communal regimes of knowledge; and in which desires compete with national and international ideas about what is best for the individual in the name of 'ending AIDS' writ large. As such, it will appeal to scholars of sociology and media studies with interests in the sociology of medicine and health, medical communication and health policy.

1) The first and only textbook solely about public health entomology, mapping onto new Certificate in Public Health Entomology courses in the U.S. Half the price of the nearest competitors, with the subject of Public Health Entomology rapidly becoming a hot topic in public health, this should be adopted as the "go-to" text for public health entomology. 2) Discusses the rationale for having public health entomology programs in state and federal health agencies. 3) Shows how to set up a public health program from scratch. 4) Compares and contrasts specific duties of a public health entomologist (and what are NOT the duties). 5) Includes a section about the primary public health arthropod vectors, their biology, distribution, disease potential, and control.

This timely interdisciplinary book brings together a wide spectrum of theoretical concepts and their empirical applications in relation to the COVID-19 pandemic, informing our understanding of the social and psychological bases of a global crisis. Written by an author team of psychologists and sociologists, the volume provides comprehensive coverage of phenomena such as fear, risk, judgement and decision making, threat and uncertainty, group identity and cohesion, social and institutional trust, and communication in the context of an international health emergency.The topics have been grouped into four main chapters, focusing on the individual, group, social, and communication perspectives of the issues affecting or being affected by the pandemic, based on over 740 classic and current references of peer-reviewed research and contextualized with an epidemiological perspective discussed in the introduction. The volume finishes with two special sections, with a chapter on cultural specificity of the social impact of pandemics, focusing specifically on both Islam and Hinduism, and a chapter on the cross-national differences in policy responses to the current health crisis. Providing not just a reference for academic research, but also short-term and long-term policy solutions based on successful strategies to combat adverse social, cognitive, and emotional consequences, this is the ideal resource for academics and policymakers interested in social and psychological determinants of individual reactions to pandemics, as well as in fields such as economics, management, politics, and medical care.

For many residents of Western nations, COVID-19 was the first time they experienced the effects of an uncontrolled epidemic. This is in part due to a series of little-known regulations that have aimed to protect the global north from epidemic threats for the last two centuries, starting with International Sanitary Conferences in 1851 and culminating in the present with the International Health Regulations, which organize epidemic responses through the World Health Organization. Unlike other equity-focused global health initiatives, their mission—to establish "the maximum protections from infectious disease with the minimum effect on trade and traffic"—has remained the same since their founding. Using this as his starting point, Alexandre White reveals the Western capitalist interests, racism and xenophobia, and political power plays underpinning the regulatory efforts that came out of the project to manage the international spread of infectious disease. He examines how these regulations are formatted; how their framers conceive of epidemic spread; and the types of bodies and spaces it is suggested that these regulations map onto. Proposing a modified reinterpretation of Edward Said's concept of orientalism, White invites us to consider "epidemic orientalism" as a framework within which to explore the imperial and colonial roots of modern epidemic disease control.