AIDS and the virus that causes it have challenged the world's scientists, health care systems, and public health policies as much or more than any medical problem in recorded history. Perhaps this is so because this particular infirmity constitutes more than a merely medical problem: it is enmeshed in psychological, social, cultural, political, and economic contexts. This book examines the need for pragmatic and research-based suggestions on how to address some important problems related to these contexts. Although much basic research in virology and immunology can be accomplished within the biomedical domain, biobehavioral disciplines such as behavioral medicine offer more opportunities for the comprehensive approach necessary to confront the AIDS/HIV problem. The editors of this groundbreaking volume suggest that the very nature of this constantly evolving problem encourages an approach to research and intervention/prevention efforts that emphasizes flexibility of response to changing knowledge, patterns of the pandemic, new treatments, and shifts in public opinion and behavior. A major triumph in dealing with this phenomenon would include a bridging of the gap between research and applied efforts, which has been the largest obstacle for progress to date. In this book, such previously uncharted territory is explored, opening a host of new possibilities for dealing with the very real threat of AIDS.

Textiles and Their Use in Microbial Protection: Focus on COVID-19 and Other Viruses provides readers with vital information about disinfection mechanisms used in textile applications in the fight against dangerous microbes and viruses. KEY FEATURES: Introduces the basics of textile materials used for medical applications Features key information on virology, characterization, indication, and passivation of COVID-19 Describes UV, photocatalysis, photooxidation, application of TiO2, copper-based viral inhibition, and activated carbon Discusses antiviral finishes for the protection against SARS-CoV-2, particle penetration in dense cotton fabrics under swollen state, and the impact of moisture on face masks and their designs Aimed at textile and materials engineers as well as readers in medical fields, this text offers a comprehensive view of fundamentals and solutions in the use of textiles for microbial protection.

This work in the field of tropical medicine provides an in-depth review in the development of vaccines against some of the most debilitating tropical diseases. In this multi-contributed, three-part book, with clear and ample illustrations, the reader will gather useful data and guidance to further his study in the field.

This book provides an overview of background information on the epidemiology, biology, and pathophysiology of HIV infection. It presents the spectrum of HIV disease from acute infection to specific syndrome. The book reviews the management of specific opportunistic infections.

The aim of this comprehensively written volume is to provide a baseline of information on the normal microflora at various sites in the body. It focuses on the mouth, upper digestive tract, large intestine, skin, and urinogenital tract. Written in an easy-to-read format, this book highlights the level of detail available. For example, it explains that in the mouth and colon the data are extremely detailed and good quantitative information is available on large numbers of bacterial species. This work analyzes the similarities and differences between the microfloras of the various "internal" surfaces, and discusses the clear value of good taxonomy. It focuses on problems and extended research in the progress at other sites. Because this work researches the advances and discoveries made in specific areas of human microbial ecology, it is an ideal source for all who are involved in microbiology, bacteriology, and infectious diseases.

Delineating fundamental concepts of contemporary immunogenetics, this reference/text examines specific immunogenetic systems in terms of molecular biochemistry and immunophysiology. Covers material in diverse fields, including infectious diseases, cell biology, virology, molecular genetics. Comprise

Cancer is a major healthcare burden across the world and impacts not only the people diagnosed with various cancers but also their families, carers, and healthcare systems. With advances in the diagnosis and treatment, more people are diagnosed early and receive treatments for a disease where few treatments options were previously available. As a result, the survival of patients with cancer has steadily improved and, in most cases, patients who are not cured may receive multiple lines of treatment, often with financial consequences for the patients, insurers and healthcare systems. Although many books exist that address economic evaluation, Economic Evaluation of Cancer Drugs using Clinical Trial and Real World Data is the first unified text that specifically addresses the economic evaluation of cancer drugs. The authors discuss how to perform cost-effectiveness analyses while emphasising the strategic importance of designing cost-effectiveness into cancer trials and building robust economic evaluation models that have a higher chance of reimbursement if truly cost-effective. They cover the use of real-world data using cancer registries and discuss how such data can support or complement clinical trials with limited follow up. Lessons learned from failed reimbursement attempts, factors predictive of successful reimbursement and the different payer requirements across major countries including US, Australia, Canada, UK, Germany, France and Italy are also discussed. The book includes many detailed practical examples, case studies and thought-provoking exercises for use in classroom and seminar discussions. Iftekhar Khan is a medical statistician and health economist and a lead statistician at Oxford Unviersity's Center for Statistics in Medicine. Professor Khan is also a Senior Research Fellow in Health Economics at University of Warwick and is a Senior Statistical Assessor within the Licensing Division of the UK Medicine and Health Regulation Agency. Ralph Crott is a former professor in Pharmacoeconomics at the University of Montreal in Quebec, Canada and former head of the EORTC Health Economics Unit and former senior health economist at the Belgian HTA organization. Zahid Bashir has over twelve years experience working in the pharmaceutical industry in medical affairs and oncology drug development where he is involved in the design and execution of oncology clinical trials and development of reimbursement dossiers for HTA submission.

This book covers various aspects of cancer chemoprevention, including an overview of chemoprevention in the process of tumorigenesis; the roles of various phytochemicals, functional foods, and dietary interventions in disease prevention; and techniques such as cancer stem cell targeting, nano-formulations, and so forth. The nutrigenomic and epigenetic effects of natural products at the molecular and genetic levels are also covered alongside their potential for additive and synergistic effect, as well as overcoming drug resistance. The key selling features of the book are as follows: Discusses holistic and comprehensive areas of chemoprevention Includes diverse techniques, such as cancer stem cell targeting, nano-formulations, and nanotechnology-based drug delivery systems Introduces various mechanisms involved in prevention of the diseases, including targeting cancer stem cells Reviews various aspects which can reduce the toxicity and cost of treatment of diseases by alternative medicine Explores various sources, mechanisms, and ways to develop cancer chemopreventive agents with minimal toxicity compared to traditional cancer therapy drugs This book is focused on researchers and graduate students in drug delivery and formulation, nanobiotechnology, cancer chemoprevention, prevention, and therapeutics.

Both nutrition deficiency and overnutrition can have a significant effect on the risk of infection. Nutrition, Immunity, and Infection focuses on the influence of diet on the immune system and how altering one's diet helps prevent and treat infections and chronic diseases. This book reviews basic immunology and discusses changes in immune function throughout the life course. It features comprehensive chapters on obesity and the role of immune cells in adipose tissue; undernutrition and malnutrition; infant immune maturation; pre- and probiotics; mechanisms of immune regulation by various vitamins and minerals; nutrition and the aging immune system; nutrition interactions with environmental stress; and immunity in the global health arena. Nutrition, Immunity, and Infection describes the various roles of nutrients and other food constituents on immune function, host defense, and resistance to infection. It describes the impact of infection on nutritional status through a translational approach. Chapters bring together molecular, cellular, and experimental studies alongside human trials so that readers can assess both the evidence for the effects of the food component being discussed and the mechanisms underlying those effects. The impact of specific conditions including obesity, anorexia nervosa, and HIV infection is also considered. Chapter authors are experts in nutrition, immunity, and infection from all around the globe, including Europe, Australia, Brazil, India, and the United States. This book is a valuable resource for nutrition scientists, food scientists, dietitians, health practitioners, and students interested in nutrition and immunity.

How the Immune System Works has helped thousands of students understand what's in their hefty immunology textbooks. In this book, Dr. Sompayrac cuts through the jargon and details to reveal, in simple language, the essence of this complex subject: how the immune system fits together, how it protects us from disease and, perhaps most importantly, why it works the way it does. Featuring Dr. Sompayrac's hallmark lively prose and engaging analogies, How the Immune System Works has been rigorously updated for this sixth edition, including the latest information on subjects such as vaccines, immunological memory, and cancer. A highlight of this edition is a new chapter on immunotherapies - currently one of the hottest topics in immunology. Whether you are completely new to immunology, or require a refresher, How the Immune System Works will provide you with a clear and engaging overview of this fascinating subject.

Written by one of the very few pathologists who has real expertise in this field, this book is a comprehensive key for the identification of fungal infections in tissues. With updated terminology and presentation, all invasive mycoses-types are covered, detailing their epidemiology, pathology, histomorphology of fungal elements, and differential diagnoses. Each of the separate fungal groups has a good combination of text and high-quality illustrations which is a critical feature for clinicians to state the mycopathological diagnoses. Key Features: 1. Elaborates on the histological observations of both the pathological reaction and the histomorphology of fungal elements, guiding the reader in the right direction for obtaining a diagnosis of the infection. 2. Includes key observations that can be a game-changer for infectious diseases specialists and histopathologists studying the combination of fungal morphology and host response. 3. Follows a logical layout, structure, and organization with a wealth of high-quality illustrations of the various fungi in tissues elucidated by different stains.

This book is a valuable historical record of how counselling psychologists responded to the COVID-19 pandemic around the globe. Volume II presents 17 chapters that address four major topic areas. In the first, the chapters focus on training and supervision: during the pandemic, most on-site training and supervision had to be discontinued to prevent spread of the virus. However, many trainers and training programs found creative ways to continue to provide training opportunities to their trainees. The second focus is on the populations who may require specialty care during times of such upheaval, such as those with psychosis and serious mental illness. In the third part, the chapters speak to the pandemic across cultures, as well as its effects on clients from underrepresented groups. Finally, three chapters present research perspectives on the pandemic. Written by prominent researchers and clinicians in the field of counselling and psychotherapy, both the volumes together cover a wide range of perspectives and offer useful clinical recommendations related to effective telepsychotherapy practice. The chapters in these volumes were originally published as a special issue of Counselling Psychology Quarterly.

This title includes a number of Open Access chapters. Cell signaling is a field that studies how cells communicate to control basic activities and respond to their environment. When looking specifically at cancer cells, researchers can gain a better understanding of cancer on a cellular level, an understanding that may have implications for developing new treatments. The current volume provides an overview of the field and how various cell biology techniques are used to better understand cancer on a cellular level.Edited by a researcher from Florida Atlantic University, this easily accessible reference volume offers a comprehensive look at the field of cancer cell signaling.

This is guide for primary care doctors and nurses in treating and managing people with HIV infection at the primary care level. It will also be useful for counsellors, social workers, therapists, pharmacists and alternative health care professionals who are caring for or supporting people with HIV and AIDS.

This edition addresses the essential medical care for people infected with HIV, as well as issues relating to the epidemic in general, the HIV test, counselling, care of people who are dying. It also provides information on anti-retroviral therapy and common HIV-associated conditions. It covers AIDS and women and children, ethical and moral considerations, HIV risk and accidental exposure to health care workers, reducing mother to child transmission, TB and sexually transmitted infections.

It is ideal for those who are as yet unfamiliar or relatively new to clinical managing or caring for people with HIV/AIDS and to those on the "front line" of primary care. The title will also serve as a useful reference function in clinics and for health care personnel training.

How hype, money, and bias can mislead the public into thinking that many worthless or unproven treatments are effective. Each week, people read about new and exciting cancer drugs. Some of these drugs are truly transformative, offering major improvements in how long patients live or how they feel-but what is often missing from the popular narrative is that, far too often, these new drugs have marginal or minimal benefits. Some are even harmful. In Malignant, hematologist-oncologist Dr. Vinayak K. Prasad writes about the many sobering examples of how patients are too often failed by cancer policy and by how oncology is practiced. Throughout this work, Prasad illuminates deceptive practices which * promote novel cancer therapies long before credible data are available to support such treatment; and * exaggerate the potential benefits of new therapies, many of which cost thousands and in some cases hundreds of thousands of dollars. Prasad then critiques the financial conflicts of interest that pervade the oncology field, the pharmaceutical industry, and the US Food and Drug administration. This is a book about how the actions of human beings-our policies, our standards of evidence, and our drug regulation-incentivize the pursuit of marginal or unproven therapies at lofty and unsustainable prices. Prasad takes us through how cancer trials are conducted, how drugs come to market, and how pricing decisions are made, asking how we can ensure that more cancer drugs deliver both greater benefit and a lower price. Ultimately, Prasad says, * more cancer clinical trials should measure outcomes that actually matter to people with cancer; * patients on those trials should look more like actual global citizens; * we need drug regulators to raise, not perpetually lower, the bar for approval; and * we need unbiased patient advocates and experts. This well-written, opinionated, and engaging book explains what we can do differently to make serious and sustained progress against cancer-and how we can avoid repeating the policy and practice mistakes of the past.

Shocking new insider information that shows what really happened in Wuhan, China, at the start of the COVID-19 outbreak and in the ensuing cover-up. The day that Dr. Andrew G. Huff left his senior scientist and vice president role at EcoHealth Alliance was one of the happiest days of his life due to the corruption he had witnessed at the organization. However, he never thought working there would be of any great consequence to the future. He was wrong. Because, as an EcoHealth Alliance insider, Dr. Huff had had a ringside seat to one of the biggest cover-ups in history. The Truth about Wuhan contains new research and a breakdown of how and why the development of COVID-19 in the United States and China was supported by the US government to collect intelligence on laboratories in China. Dr. Huff, an expert in the fields of bioterrorism and bio warfare, is a whistleblower who will show why the reasons the lab leak was covered up are incorrect. He worked on the classified research side of the program as a US government scientist. He knows the real how and why COVID-19 emerged. Besides exposing the conspiracy and cover-up, Dr. Huff also puts forth policy solutions and recommendations to prevent a lab leak virus from plaguing the world again. The Truth about Wuhan simply explains the complexity of the system that led to COVID-19's emergence; how the medical industrial complex grew and became entrenched in gain of function work after 9/11; why EcoHealth Alliance was the (almost) perfect intelligence collection cover; the policy actions and decision-making process as to why the United States government engaged in the COVID cover-up; how and why the United States swapped biotechnology with China and biomedical corporations; and the incentives for each of the actors or governments to engage and coordinate a global cover-up of COVID-19 origins. The Truth about Wuhan also shows how and why Dr. Anthony Fauci is intricately involved in the COVID cover-up; how scientists like EcoHealth Alliance president and CEO Dr. Peter Daszak rose to power and used their influence to corrupt science and the COVID origin investigation; and how the intelligence community likely orchestrated the cover-up with Dr. Anthony Fauci. Dr. Huff also provides personal harrowing accounts of how the US government waged a psychological operation against him to prevent him from speaking out. COVID-19 is the biggest lie, scandal, and intelligence failure in US history, and Dr. Andrew G. Huff is stepping out of the shadows to share his insider story about this failure that led to millions of deaths around the world.

Multidisciplinary authors provide a holistic overview Details the key principles and models of cancer-related distress Guides through assessment and treatment Illustrated with case studies Printable tools for clinical use Psychosocial oncology is a health psychology specialty that focuses on the psychological, behavioral, emotional, and social challenges faced by patients with cancer and their loved ones. Cancer can cause significant distress, and psychosocial interventions are known to be effective for helping patients and families navigate the many issues that can arise at any stage of the cancer continuum. This volume provides psychologists, physicians, social workers, and other health care providers with practical and evidence-based guidance on the delivery of psychological interventions to patients with cancer. The multidisciplinary team of authors succinctly present the key principles, history, and theoretical models of cancer-related distress. They then move on to explore clinical assessment and interventions in cancer care, in particular psychological and psychiatric treatments, multidisciplinary care management, and complementary supportive interventions. Case vignettes give the reader insight into diagnostic processes and effective treatment planning. Practitioners will find the printable handout and screening tool for clients invaluable in their daily work.

This statistics textbook, with particular emphasis on radiation protection and dosimetry, deals with statistical solutions to problems inherent in health physics measurements and decision making.
The authors begin with a description of our current understanding of the statistical nature of physical processes at the atomic level, including radioactive decay and interactions of radiation with matter. Examples are taken from problems encountered in health physics, and the material is presented such that health physicists and most other nuclear professionals will more readily understand the application of statistical principles in the familiar context of the examples. Problems are presented at the end of each chapter, with solutions to selected problems provided online. In addition, numerous worked examples are included throughout the text.

In 2019 the world was struck with the Coronavirus (COVID-19) infecting major portions of the world's population. There were no vaccines or treatments available to help mitigate the disease or offer a cure. The world's health systems were inundated with massive numbers of patients with varying ranges of symptoms, acuity, and levels of criticality. The world's healthcare organizations soon found themselves in an unmanageable situation, directly impacting the ability to manage patients across the entire healthcare environment. Most healthcare institutions had plans for emergency preparedness and procedures to deal with temporary crises, none of which were effective against the impact of COVID-19. COVID-19 was a highly contagious disease, resulting in high volumes of admissions with long lengths of stay. The virus quickly overwhelmed institutions with large patient volumes, resulting in shortages of patient beds, medical equipment, personal protective devices, cleaning agents, and other critical supplies. Hospital operations were further impacted by staff shortages due to exposure, resulting contagion, the shutdown of transit systems, and responsibilities at home due to school and business closures. This timely and important book describes the impact on the hospital ability to provide patient care and how healthcare institutions leveraged diverse technology solutions to combat the impact of COVID-19 on providing patient care. The authors also discuss implementation of these technology solutions and the many lessons learned of how healthcare institutions can enhance their emergency preparedness in the future from the COVID experience. The authors would like to acknowledge, thank, and dedicate this book to the hundreds of thousands of healthcare workers around the world who spent countless hours and put their own lives and families lives at risk to help patients though this pandemic.

Outlining the unique psychosocial and development issues faced by young adults affected by cancer, this text draws on qualitative data from two pilot studies conducted in the United States to illustrate how the needs of this often-overlooked population can be effectively met via group therapy in clinical settings. Drawing on 25 years of experience as a licensed clinical social worker supporting pediatric and young adult cancer patients and their families, Kurker focuses on the role of the clinician in structuring support group sessions. Chapters draw on patient perspectives to demonstrate effective application of interventions to help adolescents work through trauma associated with a diagnosis of cancer, treatment, recovery and the impacts on their development. Outcomes from these studies also include strategies for selecting support group participants, structuring group activities and securing funding. Effective Group Therapies for Young Adults Affected by Cancer will be a valuable text for oncology social workers and clinicians involved in adolescent support services. In addition, researchers and postgraduate students with an interest in the fields of social work, psychology and adolescent development will find the book of interest.

This book considers Sweden's pandemic management which differed so significantly from much of the rest of the world: it provoked intense and wide-reaching interest, curiosity and criticism. Trans-disciplinary Swedish authors from the humanities, life sciences, social sciences, and cultural studies use a variety of tools to mine deeper into some of the central elements and dimensions in their country's pandemic management such as understandings of freedom, the execution of power, denialism, exceptionalism, patriotism, the role of expertise and trust in the national state to give a deeper understanding of Sweden's decisions, failures, successes, and the lessons to be learned. Aimed at readers with interest in global health and politics it will also be of interest in disciplines such as virology,epidemiology, history, cultural studies, ethics, media studies, medicine and economics. The Open Access version of this book, available at http://www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.

Positively influences career choices within public health Applies basic science to problems raised by the COVID-19 pandemic such as vaccine development and herd immunity Prepares readers with context and tactics for understanding future infectious disease outbreaks Successfully used in college senior health sciences seminar Engaging and balanced treatment of the politicization of public health issues, especially COVID-19

Originally published in 1997, Aids and Adolescents provided an insight into a wide range of adolescent issues which were rarely compiled in one volume at the time. Much of the HIV epidemic response had been at the individual level in the hope that this narrow focus would provide the key to containment and resolution of spread. However, over the ten years since the epidemic had taken hold, it was clear that paradigms were limited, input was uncritical and large cohorts were overlooked. In this text a series of contributions have been compiled to explore adolescent issues ranging from sexual behaviour and health education campaigns to HIV prevention and HIV/AIDS care. The chapters begin by giving an overview of adolescent problems, such as homelessness, pregnancy and gender, and explore why these problems are so often overlooked. We then move on to an examination of the facts and fictions associated with adolescent risk, challenging some of the basic current notions underpinning approaches to the subject at the time. Also included are particular focused studies of Australian adolescents' beliefs about HIV and STDs and also the American adolescents' perceptions of drug injection. Finally, the volume gives a focused view of those with HIV infection, with a review of findings of the time, neuropsychological and psychological factors. This overview provided some comments on merging issues and future directions. Today it can be read in its historical context.