The bioscience of immunology has given us a better understanding of human health and disease. Artificial intelligence (AI) has elevated that understanding and its applications in immunology to new levels. Together, AI for immunology is an advancing horizon in health care, disease diagnosis, and prevention. From the simple cold to the most advanced autoimmune disorders and now pandemics, AI for immunology is unlocking the causes and cures. Key features: A highly accessible and wide-ranging short introduction to AI for immunology Includes a chapter on COVID-19 and pandemics Includes scientific and clinical considerations, as well as immune and autoimmune diseases

Radiomics and Radiogenomics: Technical Basis and Clinical Applications provides a first summary of the overlapping fields of radiomics and radiogenomics, showcasing how they are being used to evaluate disease characteristics and correlate with treatment response and patient prognosis. It explains the fundamental principles, technical bases, and clinical applications with a focus on oncology. The book's expert authors present computational approaches for extracting imaging features that help to detect and characterize disease tissues for improving diagnosis, prognosis, and evaluation of therapy response. This book is intended for audiences including imaging scientists, medical physicists, as well as medical professionals and specialists such as diagnostic radiologists, radiation oncologists, and medical oncologists. Features Provides a first complete overview of the technical underpinnings and clinical applications of radiomics and radiogenomics Shows how they are improving diagnostic and prognostic decisions with greater efficacy Discusses the image informatics, quantitative imaging, feature extraction, predictive modeling, software tools, and other key areas Covers applications in oncology and beyond, covering all major disease sites in separate chapters Includes an introduction to basic principles and discussion of emerging research directions with a roadmap to clinical translation

"Taken together, the body of information contained in this book provides readers with a bird's-eye view of different aspects of exciting work at the convergence of disciplines that will ultimately lead to a future where we understand how immunity is regulated, and how we can harness this knowledge toward practical ends that reduce human suffering. I commend the editors for putting this volume together." -Arup K. Chakraborty, Robert T. Haslam Professor of Chemical Engineering, and Professor of Physics, Chemistry, and Biological Engineering, Massachusetts Institute of Technology, Cambridge, USA New experimental techniques in immunology have produced large and complex data sets that require quantitative modeling for analysis. This book provides a complete overview of computational immunology, from basic concepts to mathematical modeling at the single molecule, cellular, organism, and population levels. It showcases modern mechanistic models and their use in making predictions, designing experiments, and elucidating underlying biochemical processes. It begins with an introduction to data analysis, approximations, and assumptions used in model building. Core chapters address models and methods for studying immune responses, with fundamental concepts clearly defined. Readers from immunology, quantitative biology, and applied physics will benefit from the following: Fundamental principles of computational immunology and modern quantitative methods for studying immune response at the single molecule, cellular, organism, and population levels. An overview of basic concepts in modeling and data analysis. Coverage of topics where mechanistic modeling has contributed substantially to current understanding. Discussion of genetic diversity of the immune system, cell signaling in the immune system, immune response at the cell population scale, and ecology of host-pathogen interactions.

All radiotherapy students have to undertake clinical placements. These are daunting and challenging experiences: students have to deal with qualified staff, patients, and practices and equipment that will differ from what they have been taught in the classroom. This book gives students essential practical advice to help them in these placements. It is intended as a companion that students can carry and refer to; the format is small enough to fit into the pocket of a uniform, and there is a section for students to make their own notes. Written by a student who was the Society of Radiographers Student of the Year in 2013, this book is crammed with practical detail to help all students get to grips with their clinical placements.

This volume, Bioresponsive Polymers: Design and Application in Drug Delivery, focuses on recent advancements in bioresponsive polymers and their design, characterization, and applications in varied fields, such as drug delivery and gene delivery. It looks at several carriers for drug delivery and biological molecules using different bioresponsive polymers. To address the many difficulties in existing dosage forms, this book provides information on recent developments to overcome drawbacks of conventional forms of the drug delivery. The chapters cover most areas of bioresponsive polymers, starting with a basic introduction to bioresponsive polymers, followed by chapters on design, characterization, and mechanism of bioresponsive polymers; and applications of drug and gene delivery using bioresponsive polymers via oral, topical, nasal, ocular, and parenteral methods. The book also reviews recent advancements in bioresponsive polymers and advanced applications, such as engineering particulate moieties, biomedical applications, hydrogels as emerging therapy, and electrochemical responses, bioresponsive nanoparticles, and bioresponsive hydrogels.

This book explores the physics of CT dosimetry and provides practical guidance on best practice for medical researchers and practitioners. A rigorous description of the basic physics of CT dosimetry is presented and illustrates flaws of the current methodology. It also contains helpful (and rigorous) shortcuts to reduce the measurement workload for medical physicists. The mathematical rigor is accompanied by easily-understood physical explanations and numerous illustrative figures. Features: Authored by a recognised expert in the field and award-winning teacher Includes derivations for tube current modulation and variable pitch as well as stationary table techniques Explores abnormalities present in dose-tracking software based on CTDI and presents methods to correct them

Sickle cell disease (SCD) is a severe chronic illness and one of the world's most common genetic conditions, with 400,000 children born annually with the disorder, mainly in Sub-Saharan Africa, India, Brazil, the Middle East and in diasporic African populations in North America and Europe. Biomedical treatments for SCD are increasingly available to the world's affluent populations, while such medical care is available only in attenuated forms in Africa, India and to socio-economically disadvantaged groups in North America and Europe. Often a condition rendered invisible in policy terms because of its problematic association with politically marginalized groups, the social study of sickle cell has been neglected. This illuminating volume explores the challenges and possibilities for developing a social view of sickle cell, and for improving the quality of lives of those living with SCD. Tackling the controversial role of screening and genetics in SCD, the book offers a brief thematic history of approaches to the condition, queries the role of ethnicity and includes a discussion of how the social model of disability can be applied, as well as featuring chapters focusing on athletics, prisons and schools. Bringing together a wide range of original research conducted in the USA, the UK, Ghana and Nigeria, Sickle Cell and the Social Sciences is anchored in the discipline of sociology, but draws upon a diverse range of fields, including public health, anthropology, social policy and disability studies.

On-treatment verification imaging has developed rapidly in recent years and is now at the heart of image-guided radiation therapy (IGRT) and all aspects of radiotherapy planning and treatment delivery. This is the first book dedicated to just this important topic, which is written in an accessible manner for undergraduate and graduate therapeutic radiography (radiation therapist) students and trainee medical physicists and clinicians. The later sections of the book will also help established medical physicists, therapeutic radiographers, and radiation therapists familiarise themselves with developing and cutting-edge techniques in IGRT. Features: Clinically focused and internationally applicable; covering a wide range of topics related to on-treatment verification imaging for the study of IGRT Accompanied by a library of electronic teaching and assessment resources for further learning and understanding Authored by experts in the field with over 18 years' experience of pioneering the original forms of on-treatment verification imaging in radiotherapy (electronic portal imaging) in clinical practice, as well as substantial experience of teaching the techniques to trainees

Big Data in Radiation Oncology gives readers an in-depth look into how big data is having an impact on the clinical care of cancer patients. While basic principles and key analytical and processing techniques are introduced in the early chapters, the rest of the book turns to clinical applications, in particular for cancer registries, informatics, radiomics, radiogenomics, patient safety and quality of care, patient-reported outcomes, comparative effectiveness, treatment planning, and clinical decision-making. More features of the book are: Offers the first focused treatment of the role of big data in the clinic and its impact on radiation therapy. Covers applications in cancer registry, radiomics, patient safety, quality of care, treatment planning, decision making, and other key areas. Discusses the fundamental principles and techniques for processing and analysis of big data. Address the use of big data in cancer prevention, detection, prognosis, and management. Provides practical guidance on implementation for clinicians and other stakeholders. Dr. Jun Deng is a professor at the Department of Therapeutic Radiology of Yale University School of Medicine and an ABR board certified medical physicist at Yale-New Haven Hospital. He has received numerous honors and awards such as Fellow of Institute of Physics in 2004, AAPM Medical Physics Travel Grant in 2008, ASTRO IGRT Symposium Travel Grant in 2009, AAPM-IPEM Medical Physics Travel Grant in 2011, and Fellow of AAPM in 2013. Lei Xing, Ph.D., is the Jacob Haimson Professor of Medical Physics and Director of Medical Physics Division of Radiation Oncology Department at Stanford University. His research has been focused on inverse treatment planning, tomographic image reconstruction, CT, optical and PET imaging instrumentations, image guided interventions, nanomedicine, and applications of molecular imaging in radiation oncology. Dr. Xing is on the editorial boards of a number of journals in radiation physics and medical imaging, and is recipient of numerous awards, including the American Cancer Society Research Scholar Award, The Whitaker Foundation Grant Award, and a Max Planck Institute Fellowship.

This book provides a contemporary and comprehensive examination of cancer in everyday life, drawing on qualitative research with people living with cancer, their family members and health professionals. It explores the evolving and enduring affects of cancer for individuals, families and communities, with attention to the changing dynamics of survivorship, including social relations around waiting, uncertainty, hope, wilfulness, obligation, responsibility and healing. Challenging simplistic deployments of survivorship and drawing on contemporary and classical social theory, it critically examines survivorship through innovative qualitative methodologies including interviews, focus groups, participant produced photos and solicited diaries. In assembling this panoramic view of cancer in the twenty-first century, it also enlivens core debates in sociology, including questions around individual agency, subjectivity, temporality, normativity, resistance, affect and embodiment. A thoughtful account of cancer embedded in the undulations of the everyday, narrated by its subjects and those who informally and formally care for them, Survivorship: A Sociology of Cancer in Everyday Life outlines new ways of thinking about survivorship for sociologists, health and medical researchers and those working in cancer care settings.

This book explores the normalization of HIV and AIDS, reflecting upon the intended and unintended consequences of the multifarious "AIDS industry." The Normalization of the HIV and AIDS Epidemic in South Africa deals with the manner in which the HIV and AIDS epidemic has become such a well-known disease with such wide-ranging ramifications. With its focus on the "AIDS industry," this book examines issues such as the framing of the HIV and AIDS epidemic in a manner that greatly fostered notions of stigmatization and moralization. This book looks at the complexities of dealing with the epidemic in contemporary South Africa, examining the difficulties of addressing the social aspects of a disease in the context of increased focus on technological quick-fix solutions. De Wet explores these issues thoroughly, looking at the social determinants of the spread of the disease as well as the configuration and the nature of the responses to it, and their increasing marginalization as factors to address in an era of increased biomedicalization and concomitant normalization. This book will intrigue scholars and students of public health, global health care, medical sociology, and African Studies.

This book provides an overview of the current epidemiology of the HIV epidemic among young people in Eastern and Southern Africa (ESA) and examines the efforts to confront and reduce the high level of new HIV infections amongst young people. Taking a multi-dimensional approach to prevention, the contributors discuss the many challenges facing these efforts, in view of the slow progress in curbing the incidence of HIV amongst young people, focusing particularly on the structural and social drivers of HIV. Through an examination of these issues, chapters in this book provide valuable insights on how to mitigate HIV risk among young people and what can be regarded as the catalysts to mounting credible policy and programmatic responses required to achieve epidemic control in the region. The contributors draw on examples from a range of primary and secondary data sources to illustrate promising practices and challenges in HIV prevention, demonstrating links between conceptual approaches to prevention and lessons learnt from implementation projects in the region. Bringing together social scientists and public health experts who are actively engaged in finding effective solutions, the book discusses 'which interventions works', 'why they work', and the limitations and gaps in our knowledge to curb the pandemic amongst young people. As such it is an important read for researchers focusing on HIV/AIDS and public health. The Open Access version of this book, available at https://www.taylorfrancis.com/books/e/10.4324/9780429462818 has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.

Originally published in 1987, this book builds bridges between medical sociology and mainstream theory. It does so by demonstrating in new and important ways how selected theories of major thinkers like Marx, Durkheim, Weber, Freud, Parsons, Goffman, Foucault, Habermas and Offe stand to inform, and in turn be informed by the often highly focused and empirical studies of health, disease and health care found in contemporary medical sociology. The topics covered include doctor-patient interaction and the formation of health policy.

This book delves into this almost unchartered territory, documenting the lived experiences of sex workers in Bangladesh, considering the complex realities of their day-to-day lives and the ways they negotiate their working conditions and relationships. Despite being the most common form of female deviance and criminality globally, we know very little about sex work in Asia and the global south. Drawing on feminist frameworks, it shows that the experiences of sex workers vary widely depending on the ways they enter the sex trade, their modes of operation, and relationships with significant others. Towards a Southern Approach to Sex Work contributes to feminist scholarship on sex work, by offering a much needed southern perspective, drawing on culturally specific data. It argues that the lived experience of sex workers comprises both victimhood and agency, deception and resilience, and that it is the management of these relationships that enable sex works to avoid social marginalization and alienation. An accessible and compelling read, this will appeal to students and scholars of criminology, sociology, gender studies, south Asian studies, cultural studies, social theory and policy makers. In addition, it will engage all those interested in learning more about how the sex trade operates in Bangladesh.

Bayesian Approaches in Oncology Using R and OpenBUGS serves two audiences: those who are familiar with the theory and applications of bayesian approach and wish to learn or enhance their skills in R and OpenBUGS, and those who are enrolled in R and OpenBUGS-based course for bayesian approach implementation. For those who have never used R/OpenBUGS, the book begins with a self-contained introduction to R that lays the foundation for later chapters. Many books on the bayesian approach and the statistical analysis are advanced, and many are theoretical. While most of them do cover the objective, the fact remains that data analysis can not be performed without actually doing it, and this means using dedicated statistical software. There are several software packages, all with their specific objective. Finally, all packages are free to use, are versatile with problem-solving, and are interactive with R and OpenBUGS. This book continues to cover a range of techniques related to oncology that grow in statistical analysis. It intended to make a single source of information on Bayesian statistical methodology for oncology research to cover several dimensions of statistical analysis. The book explains data analysis using real examples and includes all the R and OpenBUGS codes necessary to reproduce the analyses. The idea is to overall extending the Bayesian approach in oncology practice. It presents four sections to the statistical application framework: Bayesian in Clinical Research and Sample Size Calcuation Bayesian in Time-to-Event Data Analysis Bayesian in Longitudinal Data Analysis Bayesian in Diagnostics Test Statistics This book is intended as a first course in bayesian biostatistics for oncology students. An oncologist can find useful guidance for implementing bayesian in research work. It serves as a practical guide and an excellent resource for learning the theory and practice of bayesian methods for the applied statistician, biostatistician, and data scientist.

A new generation of technological vaccines protect against many infectious diseases. This book describes synthetic peptide-based vaccine prototypes - the future of vaccination. Production of peptides becomes simple using automatic synthesizers. Peptides are weak immunogen and need adjuvants to provide an effective autoimmune response, which is why peptide antigens are conjugated with biopolymers and loaded with nanoparticles. The book illustrates the use of peptides vaccine systems and makes predictions of future development not only for infectious diseases, but also for cancers and brain diseases such as Alzheimer, Parkinson and psychiatric diseases. Key Features Summarizes current studies on technological vaccines Describes the uses of vaccines for the prevention of brain diseases Reviews the ways different polymers are used to enhance vaccine efficacy

Non-motor Parkinson's Disease is a burgeoning area of the movement disorders field, as patients increasingly live longer and encounter more late-stage symptoms. The spectrum of non-motor manifestations spans much of the body, with non-motor features occurring in all stages of the disease. Identification of symptoms is key for preserving quality of life and successful treatment. This is a practical manual on all aspects of pre-motor and non-motor manifestations of Parkinson's. The genetic causes of non-motor symptoms are detailed and methods of patient evaluation summarized. Topics such as autonomic and sexual dysfunction, mood disorders, and drug-induced symptoms of non-motor Parkinson's are covered in depth. This is an essential resource for movement disorder specialists, neurologists and other clinicians involved in caring for those with Parkinson's disease.

In the Psychological Insights for Understanding COVID-19 series, international experts introduce important themes in psychological science that engage with people's unprecedented experience of the pandemic, drawing together chapters as they originally appeared before COVID-19 descended on the world. This timely and accessible book brings together a selection of chapters offering insights into issues surrounding work and the COVID-19 pandemic. Featuring content on topics such as health and wellbeing, work-family, flexible hours, organisational communication, talent management, recovery from work, employee engagement and flourishing, burnout, and organisational interventions, the book includes a specially written introduction contextualising the chapters in relation to the COVID-19 crisis. Reflecting on how psychological research is relevant during a significant global event, the introduction examines the potential future impact of the pandemic on the practice and study of psychology and our lives more generally. Featuring theory and research on key topics germane to the global pandemic, the Psychological Insights for Understanding COVID-19 series offers thought-provoking reading for professionals, students, academics and policy makers concerned with the psychological consequences of COVID-19 for individuals, families and society.

In the Psychological Insights for Understanding COVID-19 series, international experts introduce important themes in psychological science that engage with people's unprecedented experience of the pandemic, drawing together chapters as they originally appeared before COVID-19 descended on the world. This book explores how COVID-19 has impacted our relationship with media and technology, and chapters examine a range of topics including fake news, social media, conspiracy theories, belonging, online emotional lives and relationship formation, and identity. It shows the benefits media and technology can have in relation to coping with crises and navigating challenging situations, whilst also examining the potential pitfalls that emerge due to our increasing reliance on them. In a world where the cyberpsychological space is constantly developing, this volume exposes the complexities surrounding the interaction of human psychology with media and technology, and reflects on what this might look like in the future. Featuring theory and research on key topics germane to the global pandemic, the Psychological Insights for Understanding COVID-19 series offers thought-provoking reading for professionals, students, academics and policy makers concerned with the psychological consequences of COVID-19 for individuals, families and society.

In the Psychological Insights for Understanding COVID-19 series, international experts introduce important themes in psychological science that engage with people's unprecedented experience of the pandemic, drawing together chapters as they originally appeared before COVID-19 descended on the world. This book explores how COVID-19 has impacted society, and chapters examine a range of societal issues including leadership and politics, community, social status, welfare, social exclusion and accountability. Addressing the social and psychological processes that structure, and are structured by, our social contexts, it shows not only how groups and individuals can come together to manage global crises, but also how these crises can expose weaknesses in our society. The volume also reflects on how we can work together to rebuild society in the aftermath of the pandemic, by cultivating a shared sense of responsibility through social integration and responsible leadership. Showcasing theory and research on key topics germane to the global pandemic, the Psychological Insights for Understanding COVID-19 series offers thought-provoking reading for professionals, students, academics and policy makers concerned with the psychological consequences of COVID-19 for individuals, families and society.

With specially commissioned introductions from international experts, the Psychological Insights for Understanding COVID-19 series draws together previously published chapters on key themes in psychological science that engage with people's unprecedented experience of the pandemic. This volume collects chapters that address prominent issues and challenges presented by the SARS-CoV-2 pandemic to families, parents, and children. A new introduction from Marc H. Bornstein reviews how disasters are known to impact families, parents, and children and explores traditional and novel responsibilities of parents and their effects on child growth and development. It examines parenting at this time, detailing consequences for home life and economies that the pandemic has triggered; considers child discipline and abuse during the pandemic; and makes recommendations that will support families in terms of multilevel interventions at family, community, and national and international levels. The selected chapters elucidate key themes including children's worry, stress and parenting, positive parenting programs, barriers which constrain population-level impact of prevention programs, and the importance of culturally adapting evidence-based family intervention programs. Featuring theory and research on key topics germane to the global pandemic, the Psychological Insights for Understanding COVID-19 series offers thought-provoking reading for professionals, students, academics, policy makers, and parents concerned with the psychological consequences of COVID-19 for individuals, families, and society.

With specially commissioned introductions from international experts, the Psychological Insights for Understanding COVID-19 series draws together previously published chapters on key themes in psychological science that engage with people's unprecedented experience of the pandemic. In this volume on health, Dominika Kwasnicka and Robbert Sanderman introduce chapters that explore the crucial topics of health behaviour change, wellbeing, stress, and coping. They highlight the key role digital health technologies can play in how we manage health conditions, and how we facilitate change to help individuals manage stressful situations such as physical isolation, job loss, and financial strain during the COVID-19 pandemic. The volume also offers an important overview of environmental and policy-based approaches to health behaviour change and addresses the highly relevant issues of identity and trust and how they shape the health of individuals, communities, and society. Highlighting theory and research on these key topics germane to the global pandemic, the Psychological Insights for Understanding COVID-19 series offers thought-provoking reading for professionals, students, academics, and policymakers concerned with psychological consequences of COVID-19 for individuals, families, and society.

This book is a collective journal of the COVID-19 pandemic. With first-hand accounts of the pandemic as it unfolded, it explores the social and the political through the lens of the outbreak. Featuring contributors located in India, the United States, Brazil, the United Kingdom, Germany, and Bulgaria, the book presents us with simultaneous multiple histories of our time. The volume documents the beginning of social distancing and lockdown measures adopted by countries around the world and analyses how these bore upon prevailing social conditions in specific locations. It presents the authors' personal observations in a lucid conversational style as they reflect on themes such as the reorganization of political debates and issues, the experience of the marginalized, theodicy, government policy responses, and shifts into digital space under lockdown, all of these under an overarching narrative of the healthcare and economic crisis facing the world. A unique and engaging contribution, this book will be useful to students and researchers of sociology, public health, political economy, public policy, and comparative politics. It will also appeal to general readers interested in pandemic literature.

"COVID-19 has transformed our everyday lives. It's as if another world has arrived in the blink of an eye. Yet life is not on pause. We still need to live. The pandemic, like any other time, is a moment both of opportunity as well as challenge. Healthy Faith in the Coronavirus Crisis is a briefing on how to thrive in a world of restrictions. Twenty leading Christian thinkers have come together to help you begin to navigate this strange reality. Each contributor writes on their area of expertise, and topics covered include prayer, loneliness, work, singleness, marriage, parenting, grief, death, imagination, conversations, humour, and much more. They offer practical advice as well as helpful perspective from Scripture. This is an essential resource for anyone looking to cultivate a healthy faith which infuses all areas of life during this disorienting time.

This book is a collective journal of the COVID-19 pandemic. With first-hand accounts of the pandemic as it unfolded, it explores the social and the political through the lens of the outbreak. Featuring contributors located in India, the United States, Brazil, the United Kingdom, Germany, and Bulgaria, the book presents us with simultaneous multiple histories of our time. The volume documents the beginning of social distancing and lockdown measures adopted by countries around the world and analyses how these bore upon prevailing social conditions in specific locations. It presents the authors' personal observations in a lucid conversational style as they reflect on themes such as the reorganization of political debates and issues, the experience of the marginalized, theodicy, government policy responses, and shifts into digital space under lockdown, all of these under an overarching narrative of the healthcare and economic crisis facing the world. A unique and engaging contribution, this book will be useful to students and researchers of sociology, public health, political economy, public policy, and comparative politics. It will also appeal to general readers interested in pandemic literature.