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Books > Medicine > Clinical & internal medicine > Diseases & disorders

Pediatric and Adult MRI Atlas of Bone Marrow - Normal Appearances, Variants and Diffuse Disease States (Hardcover, 1st ed.... Pediatric and Adult MRI Atlas of Bone Marrow - Normal Appearances, Variants and Diffuse Disease States (Hardcover, 1st ed. 2016)
Hakan Ilaslan, Murali Sundaram
R6,460 Discovery Miles 64 600 Ships in 12 - 17 working days

This comprehensive atlas is unique in being devoted to the MRI appearances of bone marrow in the axial and appendicular skeleton of adults and children. Normal MRI findings, including common variants and degenerative changes, are first documented. MRI appearances in the entire spectrum of neoplastic and non-neoplastic infiltrative marrow disorders are then presented, with accompanying explanatory text. Among the conditions considered are multiple myeloma, the acute and chronic leukemias, diffuse metastases, diffuse lymphomas, the anemias, polycythemia vera, myelofibrosis, storage disorders, and infections. Characteristic changes to bone marrow following various forms of treatment are also displayed and discussed. The selected images reflect the use of a variety of sequences and techniques, such as fat suppression, chemical shift imaging, and contrast-enhanced imaging.

Particle Radiotherapy - Emerging Technology for Treatment of Cancer (Hardcover, 1st ed. 2016): Arabinda Kumar Rath, Narayan... Particle Radiotherapy - Emerging Technology for Treatment of Cancer (Hardcover, 1st ed. 2016)
Arabinda Kumar Rath, Narayan Sahoo
R4,272 Discovery Miles 42 720 Ships in 12 - 17 working days

The results of decades of research and development are providing compelling evidence about the efficacy of radiation therapy with proton and carbon ion beams to achieve superior complication free tumor control leading to a world-wide rapid growth in their clinical use. This book contains comprehensive reviews of the state of the art of the technology and physics of heavy charge particle therapy by the experts from the leading cancer centers of world that will be valuable as a practical guide for radiation therapy professionals interested in these modalities.

Immunotherapy of Cancer - An Innovative Treatment Comes of Age (Hardcover, 1st ed. 2016): Yoshiyuki Yamaguchi Immunotherapy of Cancer - An Innovative Treatment Comes of Age (Hardcover, 1st ed. 2016)
Yoshiyuki Yamaguchi
R5,500 Discovery Miles 55 000 Ships in 12 - 17 working days

This timely book, published just as cancer immunotherapy comes of age, summarizes the rationale, present status, and future perspective for cancer immunotherapy. Included are explanations of the constitution of the immune system and immunocheckpoints, the mechanism of antigen presentation and recognition, valuable modalities, clinical trials and guidance, personalization, and biomarkers, all of which are essential for understanding the success of cancer immunotherapy. This innovative therapy has been investigated worldwide as the fourth line of cancer treatment after the standard treatments of surgery, chemotherapy, and radiotherapy. The progress in fundamental understanding of tumor immunology and the recent advances in clinical trials have opened new avenues with a cancer vaccine in 2010 and immunocheckpoint modulation in 2011, with their approval already granted in the United States. Today, there are no doubts, even among experts in cancer chemotherapy and radiotherapy, that the immune system plays a vital role in tumor eradication. Following American approval, many clinical trials of cancer immunotherapy are being conducted. With this book the reader will readily understand the paradigm shift in cancer treatment and will realize the importance of cancer immunotherapy. The great value of immunotherapy will be obvious, not only for tumor shrinkage but for prolonging patient survival.

Mathematical and Statistical Modeling for Emerging and Re-emerging Infectious Diseases (Hardcover, 1st ed. 2016): Gerardo... Mathematical and Statistical Modeling for Emerging and Re-emerging Infectious Diseases (Hardcover, 1st ed. 2016)
Gerardo Chowell, James M. Hyman
R3,840 Discovery Miles 38 400 Ships in 12 - 17 working days

The contributions by epidemic modeling experts describe how mathematical models and statistical forecasting are created to capture the most important aspects of an emerging epidemic.Readers will discover a broad range of approaches to address questions, such as Can we control Ebola via ring vaccination strategies? How quickly should we detect Ebola cases to ensure epidemic control? What is the likelihood that an Ebola epidemic in West Africa leads to secondary outbreaks in other parts of the world? When does it matter to incorporate the role of disease-induced mortality on epidemic models? What is the role of behavior changes on Ebola dynamics? How can we better understand the control of cholera or Ebola using optimal control theory? How should a population be structured in order to mimic the transmission dynamics of diseases such as chlamydia, Ebola, or cholera? How can we objectively determine the end of an epidemic? How can we use metapopulation models to understand the role of movement restrictions and migration patterns on the spread of infectious diseases? How can we capture the impact of household transmission using compartmental epidemic models? How could behavior-dependent vaccination affect the dynamical outcomes of epidemic models? The derivation and analysis of the mathematical models addressing these questions provides a wide-ranging overview of the new approaches being created to better forecast and mitigate emerging epidemics. This book will be of interest to researchers in the field of mathematical epidemiology, as well as public health workers.

Thyroid Cancer - From Emergent Biotechnologies to Clinical Practice Guidelines (Hardcover): Angelo Carpi, Jeffrey I. Mechanick Thyroid Cancer - From Emergent Biotechnologies to Clinical Practice Guidelines (Hardcover)
Angelo Carpi, Jeffrey I. Mechanick
R3,810 R3,504 Discovery Miles 35 040 Save R306 (8%) Ships in 12 - 17 working days

The current age of clinical medicine is witnessing biotechnological innovation at an unprecedented pace. As a result, the recently popularized clinical practice guidelines (CPG), as a tool to assist clinical decision-making, have been struggling to keep up. Thyroid Cancer: From Emergent Biotechnology to Clinical Practice Guidelines rides the wave of medical innovation, analyzing current and future CPG, and providing an up-to-date and comprehensive treatise on thyroid cancer, its diagnosis, and treatment.

A synthesis of ideas by prominent world experts in the field of thyroid cancer research and clinical practice, Thyroid Cancer covers:

  • Technologically-advanced diagnostic procedures and therapeutic interventions
  • Diagnostic techniques employed in the detection and follow-up of thyroid cancer including ultrasound, needle aspiration techniques, CT, PET, PET-CT, and MRI
  • Basic principles of systems biology, molecular and translational medicine, CPG development, and risk stratification for thyroid cancer
  • How CPG contain knowledge gaps and produce uncertainty
  • Advances in the field, including new surgical techniques, molecular targeted therapies, external beam radiation therapy, and chemotherapy

A comprehensive, scientific description of current and future diagnostic and therapeutic modalities for the management of thyroid cancer, this treatise is an indispensible reference for both the specialist and referring physician.

Proteases in Physiology and Pathology (Hardcover, 1st ed. 2017): Sajal Chakraborti, Naranjan S. Dhalla Proteases in Physiology and Pathology (Hardcover, 1st ed. 2017)
Sajal Chakraborti, Naranjan S. Dhalla
R4,573 Discovery Miles 45 730 Ships in 10 - 15 working days

Using a multidisciplinary approach, this book describes the biochemical mechanisms associated with dysregulation of proteases and the resulting pathophysiological consequences. It highlights the role and regulation of different types of proteases as well as their synthetic and endogenous inhibitors. The role of proteases was initially thought to be limited to general metabolic digestion. However, we now know that the role of protein breakdown is much more complex, and proteases have multiple functions: they are coupled to turnover and can affect protein composition, function and synthesis. In addition to eliminating abnormal proteins, breakdown has many modulatory functions, including activating and inactivating enzymes, modulating membrane function, altering receptor channel properties, affecting transcription and cell cycles and forming active peptides. The ubiquity of proteases in nature makes them an important target for drug development. This in-depth, comprehensive is a valuable resource for researchers involved in identifying new targets for drug development. With its multidisciplinary scope, it bridges the gap between fundamental and translational research in the biomedical and pharmaceutical industries, making it thought-provoking reading for scientists in the field.

States of Plague - Reading Albert Camus in a Pandemic (Hardcover): Alice Kaplan, Laura Marris States of Plague - Reading Albert Camus in a Pandemic (Hardcover)
Alice Kaplan, Laura Marris
R530 R442 Discovery Miles 4 420 Save R88 (17%) Ships in 10 - 15 working days

States of Plague examines Albert Camus's novel as a palimpsest of pandemic life, an uncannily relevant account of the psychology and politics of a public health crisis. As one of the most discussed books of the COVID-19 crisis, Albert Camus's classic novel The Plague has become a new kind of literary touchstone. Surrounded by terror and uncertainty, often separated from loved ones or unable to travel, readers sought answers within the pages of Camus's 1947 tale about an Algerian city gripped by an epidemic. Many found in it a story about their own lives-a book to shed light on a global health crisis. In thirteen linked chapters told in alternating voices, Alice Kaplan and Laura Marris hold the past and present of The Plague in conversation, discovering how the novel has reached people in their current moment. Kaplan's chapters explore the book's tangled and vivid history, while Marris's are drawn to the ecology of landscape and language. Through these pages, they find that their sense of Camus evolves under the force of a new reality, alongside the pressures of illness, recovery, concern, and care in their own lives. Along the way, Kaplan and Marris examine how the novel's original allegory might resonate for a new generation of readers who have experienced a global pandemic. They describe how they learned to contemplate the skies of a plague spring, to examine the body politic and the politics of immunity. Both personal and eloquently written, States of Plague uncovers for us the mysterious way a novel can imagine the world during a crisis and draw back the veil on other possible futures.

Immune-based Cancer Treatment - The T Iymphocyte Response (Hardcover): Michael A. Alexander Immune-based Cancer Treatment - The T Iymphocyte Response (Hardcover)
Michael A. Alexander
R4,507 Discovery Miles 45 070 Ships in 12 - 17 working days

The culmination of 30 years of research and experience in T-cell-based cancer, this book highlights and evaluates new treatments that harness the power of the T cell to attack and kill all cancer cells in our bodies. It describes how the T cell immune system can be manipulated and redirected to kill resistant cancer cells by understanding and influencing the interaction of many different immune cells in the body. Citing current experimental trials, it examines the role and pathology of T-cells and suggests additional experimental approaches to the problem.

Genome Analysis and Human Health (Hardcover, 1st ed. 2017): Leena Rawal, Sher ?Ali Genome Analysis and Human Health (Hardcover, 1st ed. 2017)
Leena Rawal, Sher ?Ali
R2,896 Discovery Miles 28 960 Ships in 10 - 15 working days

This book highlights selected current data and its relevance in the human health care system, offering a fundamental primer on genetics and human health. With the advent of new high-throughput technologies (for the whole genome including exome sequencing), the conventional focus on genetics and individual genes is now shifting toward the analysis of complex genes, gene-gene interactions and the association between genes and environment, including epigenetics. The rapidly changing scientific research landscape, with the ever-growing influx of data on one hand and emergence of newer and more complicated diseases on the other, has created a dilemma for researchers and caregivers, who are still hopeful that advances in genetics and genomics will provide avenues for the understanding, prevention and possible cure of human diseases. The book focuses on the interactions between genes and proteins at both the transcriptome and proteome levels, which in turn affect the human genome and health. Additionally, it covers the domain that must be explored in order to understand the gene-gene and protein-protein interactions that contribute to human health. The book offers a valuable guide for all students and researchers working in the area of molecular genetics and genomics.

Leishmaniasis in Sri Lanka - A Research Review (Hardcover): Yamuna Deepani Siriwardana Leishmaniasis in Sri Lanka - A Research Review (Hardcover)
Yamuna Deepani Siriwardana
R1,501 Discovery Miles 15 010 Ships in 9 - 15 working days

Key Features: * Provides a comprehensive and complete resource on Leishmaniasis on various aspects of the disease, distilling credible information from available literature coupled with historical references. * Follows a model approach for handling emerging infectious diseases for the benefit of clinicians and front-line workers. * Discusses the unique problem of skin localizing visceral parasites and provides basic principles of management for other infectious diseases and vector-borne infections.

Distance, Equity and Older People's Experiences in the Nordic Periphery - Centering the Local (Hardcover): Paivi Naskali,... Distance, Equity and Older People's Experiences in the Nordic Periphery - Centering the Local (Hardcover)
Paivi Naskali, Shahnaj Begum, Minna Zechner, Joan R Harbison
R3,904 Discovery Miles 39 040 Ships in 12 - 17 working days

This book demonstrates how the largely neglected and multifaceted concept of distance can be used as a primary lens to expand and enrich our understandings of what older people say about their lives, needs, and wishes in diverse surroundings in the Northern periphery and beyond. It asks how physical, social and emotional distances shape older people's everyday lives and practices. Contributions from leading experts provides interdisciplinary investigations into the experiences and stories of older people in the Northern periphery. These insights demonstrate the utility of the concept distance when reflecting on the central aspects of contemporary ageing societies. The book explores key themes such as care, age politics, technology, intergenerational relations and migration, providing perspectives that are applicable across a variety of international geographical contexts. This innovative book offers a valuable theoretical and methodological contribution with critical new perspections on ageing in relation to distances. It will be of interest to students and scholars interested in sociology, human geography, health and social care, ageing and gerontological studies, gender studies and Arctic studies.

Management of Chemotherapy-Induced Nausea and Vomiting - New Agents and New Uses of Current Agents (Hardcover, 1st ed. 2016):... Management of Chemotherapy-Induced Nausea and Vomiting - New Agents and New Uses of Current Agents (Hardcover, 1st ed. 2016)
Rudolph M Navari
R2,478 R1,990 Discovery Miles 19 900 Save R488 (20%) Ships in 12 - 17 working days

This book provides a comprehensive review of new agents, a detailed description of new uses of current agents, and an integration of the available agents in clinical practice. A description of a detailed clinical approach provides clinical practitioners with the most up-to-date recommendations for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV) in various clinical settings. CINV is one of the most feared treatment related toxicities. Patient surveys for the past thirty years consistently demonstrate patients' perception of deterioration in quality of life due to chemotherapy treatments. The introduction of the antiemetics, serotonin 5-HT3 receptor antagonists and the neurokinin-1 receptor antagonists, have improved the control of chemotherapy-induced emesis, but the treatment of chemotherapy-induced nausea remains a significant clinical problem. Patients continue to have quality of life issues which prevent normal functioning during active treatment. New agents such as the second generation 5-HT3 receptor antagonist palonosetron and the new neuroknin-1 receptor antagonists rolapitant and netupitant are being introduced into clinical practice, and it is anticipated that these new agents will improve the control of CINV. Agents such as olanzapine (a FDA approved anti-psychotic), gabapentin (a FDA approved neuroleptic), and ginger (a food additive), which have been used primarily for other indications, are now being tested as potential, effective antiemetics. This work represents the first available comprehensive summary that details all new antiemetic agents and, particularly, their clinical role in treating patients; an important reference for practitioners seeking to improve the quality of life of patients undergoing chemotherapy.

The Arrhythmic Patient in the Emergency Department - A Practical Guide for Cardiologists and Emergency Physicians (Hardcover,... The Arrhythmic Patient in the Emergency Department - A Practical Guide for Cardiologists and Emergency Physicians (Hardcover, 1st ed. 2016)
Massimo Zecchin, Gianfranco Sinagra
R3,578 R3,315 Discovery Miles 33 150 Save R263 (7%) Ships in 12 - 17 working days

This book is a practical guide to the differential diagnosis and treatment of patients presenting in the Emergency Department with syncope or arrhythmias, including bradyarrhythmias, atrial fibrillation, narrow and wide QRS tachycardias. In addition, clear advice is provided on the management of patients with cardiac devices and possible dysfunction, electrical storm, or a requirement for urgent surgery. For each topic, a literature review of epidemiology, physiopathology, differential diagnosis, and treatment is conducted. Furthermore, practical suggestions are offered for short-term management, e.g., regarding the decision on when and where to hospitalize the patient; these proposals do not replace but rather summarize or integrate the current guidelines. The book is designed both for emergency physicians and cardiologists, who will be the first to evaluate and treat patients with arrhythmias or potentially arrhythmic problems in the emergency setting. It will also be a useful textbook for students and residents in Cardiology and Emergency Medicine.

Deadliest Enemy - Our War Against Killer Germs (Paperback): Mark Olshaker Deadliest Enemy - Our War Against Killer Germs (Paperback)
Mark Olshaker
R542 R347 Discovery Miles 3 470 Save R195 (36%) Ships in 9 - 15 working days
A Beginner's Guide to Targeted Cancer Treatments (Paperback): E Vickers A Beginner's Guide to Targeted Cancer Treatments (Paperback)
E Vickers
R1,261 Discovery Miles 12 610 Ships in 12 - 17 working days

Highly Commended in the category of Oncology at the British Medical Association Awards 2019 The accessible guide to the principles behind new, more targeted drug treatments for cancer Written for anyone who encounters cancer patients, cancer data or cancer terminology, but have no more than a passing knowledge of cell biology. A Beginner's Guide to Targeted Cancer Treatments provides an understanding of how cancer works and the many new treatments available. Using over 100 original illustrations, this accessible handbook covers the biology and mechanisms behind a huge range of targeted drug treatments, including many new immunotherapies. Dr Vickers translates a complex and often overwhelming topic into something digestible and easily understood. She also explains what cancer is, how it behaves and how our understanding of cancer has changed in recent years. Each chapter takes the reader through how new cancer drugs work and their benefits and limitations. With the help of this book, readers will be able to better understand more complex, in-depth articles in journals and books and develop their knowledge. This vital resource: Offers the latest insights into cancer biology Provides a broad understanding of how targeted cancer treatments work Describes many of the new immunotherapy approaches to cancer treatment, such as checkpoint inhibitors and CAR-modified T cells Helps readers feel confident discussing treatment options with colleagues and patients Provides an overview of which treatments are relevant to each of the most common solid tumours and haematological cancers, and the rationale behind them Demystifies the jargon - terms such as the EMT, cancer stem cells, monoclonal antibodies, kinase inhibitors, angiogenesis inhibitors etc. Explains the resistance mechanisms to many new treatments, including issues such as the way cancer cells diversify and evolve and the complex environment in which they live

Nano Drug Delivery Strategies for the Treatment of Cancers (Paperback): Awesh K. Yadav, Umesh Gupta, Rajeev Sharma Nano Drug Delivery Strategies for the Treatment of Cancers (Paperback)
Awesh K. Yadav, Umesh Gupta, Rajeev Sharma
R3,618 Discovery Miles 36 180 Ships in 12 - 17 working days

Nano Drug Delivery Strategies for the Treatment of Cancers discusses several current and promising approaches for the diagnosis and treatment of cancer by using the most recent developments in nanomedical technologies. The book presents introductory information about the biology of different types of cancer in order to provide the reader with knowledge on their specificities. In addition, it discusses various novel drug delivery systems, detailing their functionalities, expected outcomes and future developments in the field, focusing on brain, mouth and throat, breast, lung, liver, pancreas, stomach, colon, bool, skin and prostate cancers. The book is a valuable source for cancer researchers, oncologists, pharmacologists and nanotechnologists who are interested in novel drug delivery systems and devices for treatment of various types of cancer that take advantage of recent advances in this exciting field.

Deadly Outbreaks - How Medical Detectives Save Lives Threatened by Killer Pandemics, Exotic Viruses, and Drug-Resistant... Deadly Outbreaks - How Medical Detectives Save Lives Threatened by Killer Pandemics, Exotic Viruses, and Drug-Resistant Parasites (Paperback)
Alexandra M. Levitt; Foreword by Donald R. Hopkins
R476 R396 Discovery Miles 3 960 Save R80 (17%) Ships in 10 - 15 working days

CONTAINS IMPORTANT INFORMATION ABOUT THE CORONAVIRUS! "Portrays epidemiologists as disease detectives who tirelessly hunt for clues and excel at deductive reasoning. Even Sherlock Holmes would be proud of this astute group of professionals."-Booklist This updated edition features a brand new section detailing important facts about the coronavirus and tips for keeping yourself and your family safe. Despite advances in health care, infectious microbes continue to be a formidable adversary to scientists and doctors. Vaccines and antibiotics, the mainstays of modern medicine, have not been able to conquer infectious microbes because of their amazing ability to adapt, evolve, and spread to new places. Terrorism aside, one of the greatest dangers from infectious disease we face today is from a massive outbreak of drug-resistant microbes. Deadly Outbreaks recounts the scientific adventures of a special group of intrepid individuals who investigate these outbreaks around the world and figure out how to stop them. Part homicide detective, part physician, these medical investigators must view the problem from every angle, exhausting every possible source of contamination. Any data gathered in the field must be stripped of human sorrows and carefully analyzed into hard statistics. Author Alexandra Levitt, PhD, is an expert on emerging diseases and other public health threats. Here she shares insider accounts she's collected that go behind the alarming headlines we've seen in the media: mysterious food poisonings, unexplained deaths at a children's hospital, a strange neurologic disease afflicting slaughterhouse workers, flocks of birds dropping dead out of the sky, and drug-resistant malaria running rampant in a refugee camp. Meet the resourceful investigators-doctors, veterinarians, and research scientists-and discover the truth behind these cases and more.

Target Volume Definition in Radiation Oncology (Hardcover): Anca-Ligia Grosu, Carsten Nieder Target Volume Definition in Radiation Oncology (Hardcover)
Anca-Ligia Grosu, Carsten Nieder
R4,866 Discovery Miles 48 660 Ships in 12 - 17 working days

The main objective of this book is to provide radiation oncologists with a clear, up-to-date guide to tumor delineation and contouring of organs at risk. With this in mind, a detailed overview of recent advances in imaging for radiation treatment planning is presented. Novel concepts for target volume delineation are explained, taking into account the innovations in imaging technology. Special attention is paid to the role of the newer imaging modalities, such as positron emission tomography and diffusion and perfusion magnetic resonance imaging. All of the most important tumor entities treated with radiation therapy are covered in the book. Each chapter is devoted to a particular tumor type and has been written by a recognized expert in that topic.

Immunopharmacogenomics (Hardcover, 1st ed. 2015): Yusuke Nakamura Immunopharmacogenomics (Hardcover, 1st ed. 2015)
Yusuke Nakamura
R2,892 Discovery Miles 28 920 Ships in 10 - 15 working days

This book proposes immunogenomics, or immunopharmacogenomics, as the next-generation big science to uncover the role that the immune system plays in the pathogenesis of many diseases, by summarizing the importance of the deep sequencing of T-cell and B-cell receptors. Immunogenomics/immunopharmacogenomics, a genetic characterization of the immune system made possible by next-generation sequencing (NGS), will be important for the further understanding of the pathogenesis of various disease conditions. Abnormal immune responses in the body lead to development of autoimmune diseases and food allergies. Rejection of recipient cells and tissues, as well as severe immune reactions to donor cells, is also the result of uncontrolled immune responses in the recipient body. There have been many reports indicating that activated immune responses caused by the interaction of drugs and HLA are present in drug-induced skin hypersensitivity and liver toxicity. The importance of the host immune responses has been recognized in cancer treatments, not only for immunotherapy but also for cytotoxic agents and molecular targeted drugs. Hence, characterization of the T-cell receptor and B-cell receptor repertoire by means of NGS deep sequencing will ultimately make possible the identification of the molecular mechanisms that underlie various diseases and drug responses. In addition, this approach may contribute to the identification of antigens associated with the onset or progression of autoimmune diseases as well as food allergies. Although the germline alterations and somatic mutations have been extensively analyzed, changes or alterations of the immune responses during the course of various disease conditions or during various treatments have not been analyzed. It is also clear that computational analyses to draw meaningful inferences of functional recognition receptors on the immune cells remain a huge challenge.

Synthetic Peptide Vaccine Models - Design, Synthesis, Purification and Characterization (Paperback): Mesut Karahan Synthetic Peptide Vaccine Models - Design, Synthesis, Purification and Characterization (Paperback)
Mesut Karahan
R1,389 Discovery Miles 13 890 Ships in 9 - 15 working days

A new generation of technological vaccines protect against many infectious diseases. This book describes synthetic peptide-based vaccine prototypes - the future of vaccination. Production of peptides becomes simple using automatic synthesizers. Peptides are weak immunogen and need adjuvants to provide an effective autoimmune response, which is why peptide antigens are conjugated with biopolymers and loaded with nanoparticles. The book illustrates the use of peptides vaccine systems and makes predictions of future development not only for infectious diseases, but also for cancers and brain diseases such as Alzheimer, Parkinson and psychiatric diseases. Key Features Summarizes current studies on technological vaccines Describes the uses of vaccines for the prevention of brain diseases Reviews the ways different polymers are used to enhance vaccine efficacy

Lipoxygenases in Inflammation (Paperback, Softcover reprint of the original 1st ed. 2016): Dieter Steinhilber Lipoxygenases in Inflammation (Paperback, Softcover reprint of the original 1st ed. 2016)
Dieter Steinhilber
R3,715 Discovery Miles 37 150 Ships in 10 - 15 working days

Oxidation of polyunsaturated fatty acids by lipoxygenases leads to a variety of fatty acid metabolites which play important roles in physiology but also in pathophysiology. Data accumulated during the last decade point to the fact that lipoxygenase metabolites are involved in host defence reactions, cardiovascular system and contribute to the development of inflammatory and allergic diseases, cardiovascular disease and cancer. This PIR volume summarizes the physiological and pathophysiological functions of lipoxygenases.

Vaccine Efficacy Evaluation - The Gnotobiotic Pig Model (Paperback): Lijuan Yuan Vaccine Efficacy Evaluation - The Gnotobiotic Pig Model (Paperback)
Lijuan Yuan
R1,345 Discovery Miles 13 450 Ships in 9 - 15 working days

Testing the immunogenicity, protective efficacy and safety in animal models is a crucial step in vaccine development. Pigs raised in germ-free environments, called gnotobiotic (Gn) pigs, are one of the most useful animal models for testing vaccines. The Gn pig model is a widely accepted model for studying pathogenesis and immunity and an ideal model for pre-clinical testing for the safety and efficacy of enteric viral vaccines. Through these studies and others, the Gn pig model has been established as the most reliable animal model for pre-clinical evaluation of human rotavirus and norovirus vaccines. This book provides detailed information on establishing Gn pig models, determining a proper virus inoculum pool and challenge dose, measuring protection and calculating efficacy, and delineating intestinal and systemic immune responses associated with the protection. Key Features Provides a natural history of human rotavirus and norovirus infection in Gn pigs Establishes the optimal virus challenge doses in Gn pigs for vaccine evaluation Evaluates various candidate rotavirus and norovirus vaccines Discusses human gut microbiota transplanted Gn pig models Documents the role of probiotics and rice bran as prophylactics and vaccine adjuvants

Breast Cancer Screening and Diagnosis - A Synopsis (Hardcover, 2015 ed.): Mahesh K. Shetty Breast Cancer Screening and Diagnosis - A Synopsis (Hardcover, 2015 ed.)
Mahesh K. Shetty
R4,680 Discovery Miles 46 800 Ships in 10 - 15 working days

This book presents the current trends and practices in breast imaging. Topics include mammographic interpretation; breast ultrasound; breast MRI; management of the symptomatic breast in young, pregnant and lactating women; breast intervention with imaging pathological correlation; the postoperative breast and current and emerging technologies in breast imaging. It emphasizes the importance of fostering a multidisciplinary approach in the diagnosis and treatment of breast diseases. Featuring more than 800 high-resolution images and showcasing contributions from leading authorities in the screening, diagnosis and management of the breast cancer patient, "Breast Cancer Screening and Diagnosis" is a valuable resource for radiologists, oncologists and surgeons.

Handbook of Targeted Cancer Therapy and Immunotherapy (Paperback, 3rd edition): Daniel D. Karp, Gerald S. Falchook, JoAnn D. Lim Handbook of Targeted Cancer Therapy and Immunotherapy (Paperback, 3rd edition)
Daniel D. Karp, Gerald S. Falchook, JoAnn D. Lim
R1,497 Discovery Miles 14 970 Ships in 12 - 17 working days

Designed for quick, everyday reference, Handbook of Targeted Cancer Therapy and Immunotherapy, 3rd Edition, includes clinical trial results of more than 250 state-of-the-art targeted therapy and immunotherapy agents, providing a practical, intuitive, colorful overview of this rapidly advancing field. Comprehensive yet concise, this easy-access resource by Drs. Daniel D. Karp, Gerald S. Falchook, and JoAnn D. Lim, helps you navigate through the newest research reports and apply the most recent discoveries as they pertain to specific tumor types, actionable molecular targets, and clinical performance of investigational targeted agents and combinations of agents. This handbook presents information distilled by dozens of translational research clinicians and other healthcare experts with hundreds of years of cumulative experience in the revolutionary area of genomically based precision oncology. Covers cancer targets-phase 1, 2, and 3 trials and preliminary results, as well as approved therapies. Includes sections on Molecular Targets and Pathways, and Targeted and Immunotherapy Agents. Contains a section on Carcinogenesis from the Perspective of Targeted Therapy and Immunotherapy, with essential content on biology, immunology, and immunotherapy. Organizes information by tumor type, pathway, and drug name, so you can approach clinical challenges from any direction. Highlights FDA approvals throughout. Pocket-sized and color coded to help you find information quickly and easily. Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

Proteases in Human Diseases (Hardcover, 1st ed. 2017): Sajal Chakraborti, Tapati Chakraborti, Naranjan S. Dhalla Proteases in Human Diseases (Hardcover, 1st ed. 2017)
Sajal Chakraborti, Tapati Chakraborti, Naranjan S. Dhalla
R5,772 Discovery Miles 57 720 Ships in 10 - 15 working days

This book bridges the gap between fundamental research and biomedical and pharmacological applications on proteases. It represents a comprehensive overview of the multifaceted field of proteases in cellular environment and highlights the recently elucidated functions of complex proteolytic systems in different diseases. Several established investigators have elucidated the crucial role of proteases in biological processes, including how proteolytic function and regulation can be combined to develop new strategies of therapeutic interventions. Proteases form one of the largest and most diverse families of enzymes known. It is now clear that proteases are involved in every aspect of life functions of an organism. Under physiological conditions, proteases are regulated by their endogenous inhibitors; however, when the activity of proteases is not regulated appropriately, disease processes can result in. So, there is absolute need for a stringent control of proteolytic activities in cells and tissues. Dysregulation of proteases may cause derangement of cellular signalling network resulting in different pathophysiological conditions such as vascular remodelling, atherosclerotic plaque progression, ulcer and rheumatoid arthritis, Alzheimer disease, cancer metastasis, tumor progression and inflammation. Additionally, many infective microorganisms require proteases for replication or use proteases as virulence factors, which have facilitated the development of protease-targeted therapies for a variety of parasitic diseases.

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