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Books > Medicine > Clinical & internal medicine > Diseases & disorders
This book offers comprehensive coverage of both basic and clinical aspects of immune reactions responsible for infertility. It has four sections focusing on Sperm antigens, Antisperm antibodies (ASAs), Clinical impact of ASAs, and Immune contraception, and include contributions from leading experts in these fields. This new edition of the book offers a comprehensive update that reflects the very significant advances in reproductive immunology that have been achieved over the past five years, especially related to the sperm proteome, sperm-egg binding/fusion proteins, gene knockout studies, and immunocontraception. Reproductive immunology continues to be a fast-growing discipline in which new knowledge is emerging almost every day. Immune Infertility is a model source of vital and reliable information on the latest scientific developments in the field. It will be of value for clinicians, scientists, students, residents, and fellows working in reproductive biology, obstetrics and gynecology, and urology.
Stresses molecular and biochemical studies of opportunistic and
frank fungal pathogens
Cells are by nature compelled to live in groups. They develop dependence over signaling cues received from their microenvironment, in particular from other cells, whether of their own "kind" or of a different type. Therefore, communicating with these cells is a critical aspect of their behavior and fate, as they live and die normally or as they undergo disease-related pathological changes, with dramatic repercussions. In this book, we have asked expert researchers in the field of Intercellular Communication in Cancer to provide chapters on different aspects of interaction between neighboring cells, in the context of cancer diseases. We have specifically focused our efforts on membrane-to-membrane contact-based rather than growth factors-mediated modes of intercellular communications. The contributing authors provide an extensive overview of their respective area of specialization, with an in-depth discussion of the molecular mechanisms of cell-cell interactions, the impact on tumor progression and response to therapies, as well as the cancer diagnostic value of this scientific information. This book aims to introduce essential aspects of the normal and pathological cellular fate and homeostasis to both scientists and clinicians, and also to provide established researchers with an update on the novelties and future directions this expanding field is witnessing.
The role of the cytokine macrophage migration inhibitory factor (MIF) in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well-established. Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, metabolism, and cellular stress responses. MIF's molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. New family members, such as D-dopachrome tautomerase, or MIF-2, and the closely homologous genes encoding by parasites have been defined and are being functionally characterized. MIF directed therapies also are entering clinical testing and ultimately may be applied in a pharmacogenomics manner. This book provides a comprehensive synthesis of the state-of-the-art of MIF science. The intended audience are post-graduate students and researchers in inflammation, innate immunity, immunology, and immunopathology.
Fish Vaccines: Health Management for Sustainable Aquaculture is a timely reference book that highlights the role of vaccination in the fast-growing aquaculture industry. It discusses topics such as vaccine formulation, vaccine delivery and enhancing the immune response of fish using nanoparticles. Information related to vaccine safety, ethical approval and regulations is also discussed, together with dissemination of vaccines to fish farms across the globe. This cutting-edge book presents novel strategies to meet the growing demand for vaccines in finfish aquaculture. The book is useful to students, academics, clinicians, and professionals in the field of fisheries sciences, aquaculture, and veterinary sciences.
The management of liver tumors is a nexus of interactions among multiple medical specialties, including radiation oncology. A multitude of liver-directed therapies are available for patients, ranging from surgery and liver transplantation to intra-arterial therapies, thermal ablation procedures, systemic therapies, and radiation treatments. With the introduction of hypofractionated irradiation, particle therapy, and radioembolization, there is growing interest in the use of radiation as a treatment for liver malignancies. This book examines basic principles of the management of liver tumors. The evolving roles of x-ray and particle therapies as well as radioembolization in the treatment of liver tumors is the main focus. A theme of multidisciplinary management is also emphasized, as surgical, interventional and systemic therapies are reviewed. A unique resource that discusses the role of radiation treatment in the context of other liver-directed therapies, Radiation Therapy for Liver Tumors is of broad interest to radiation oncologists, surgeons, hepatologists, medical oncologists, and radiologists.
This text provides a comprehensive overview of the essential concepts and malignancies of hematology. Now in its second edition, the book reviews every major hematologic disorder and disease entity in thorough detail, from incidence and prevalence to patient and treatment-related issues. Formatted in an organized and easy-to-read outline style to facilitate rapid learning and information processing, the book allows readers to easily locate topics of immediate interest without wading through entire sections to obtain the desired data. Written by a diverse range of experts in the field, Concise Guide to Hematology, Second Edition is a valuable resource for clinicians, residents, trainees, and entry-level fellows who work in or are just entering the field of hematology.
Like the successful first edition, this improved, updated and expanded second edition covers the presentation of the common orofacial disorders and a wide range of less common and some rare disorders. It also now includes treatment recommendations for the most common oral diseases, tailored to the pediatric age group. Any health professional called upon to diagnose and treat children who have orofacial problems will benefit from the wealth of material offered here.
This handbook is a concise, thorough, and portable reference guide to the multitude of complex chemotherapy protocols and other frequently utilized medications in the field of Hematology/Oncology. Its inclusion of commonly used oncology regimens, guidelines for supportive care during administration and sections on pain control, antibiotic use and antiemesis guidelines set it apart from other "chemotherapy handbooks". The authors have prepared this book with the intention of improving the care of those suffering from cancer.
This volume presents information on both the basic and clinical aspects of sphingolipid-metabolizing enzymes in various cancers. The volume also includes discussions of the innovative techniques and approaches for quantitative analysis and imaging that could significantly impact the general understanding of this topic, and the potential benefit of targeting sphingolipid enzymes to develop novel cancer therapeutics. As well, the volume includes a critical examination of the specific pathways and pathobiologies associated with the altered regulation of sphingolipid metabolism as a contributor to the development and/or maintenance of pathological conditions such as cancer.
Encyclopedia of Cancer, Third Edition, Three Volume Set provides a comprehensive, up-to-date overview of the multiple facets of the disease, including research, treatment and societal impact. This new edition comprises 180 contributions from renown experts who present the latest in Mechanisms, Hallmarks of Cancer, Causes of Cancer, Prevention and Control, Diagnosis and Therapy, Pathology and the Genetics of specific Cancers. Readers will find a comprehensive overview of the main areas of oncology, including etiology, mechanisms, prevention, and treatments, from basic science to clinical applications and public health, all set alongside the latest advances and hot topics that have emerged since the previous edition. Topics of interest in the field, including genomics and epigenomics, our understanding of the causes of cancer and the approaches to preventing it (e.g., HPV vaccination, role of obesity and nutrition, molecular markers of environmental exposures), new screening techniques (e.g., low-dose CT for lung cancer) and improvements in the treatment of many cancers (e.g., breast cancer, lung adenocarcinoma) are comprehensively and authoritatively presented.
Immunology: An Illustrated Outline is both a guide to the essential principles of immunology and a concise dictionary of immunological terms. The book can be used to consolidate understanding in preparation for course exams and medical licensing exams, or as a refresher when immunology is encountered in related life sciences, such as microbiology, virology, and zoology. The book is organized into five sections that represent the major topics in basic and clinical immunology. The Sixth Edition has been comprehensively revised to highlight the latest understanding of the field, particularly in the areas of innate immune defenses and antibody-based therapeutics. Concise explanations of immunological terms Full-color illustrations and micrographs to reinforce the text Each topic is set out in single- or double-page spreads Tables collate and summarize detailed information
Contains key theory and copious clinical material * Subject poorly covered in the existing literature * Focus on work with cancer patients, but insights also applicable to many other serious conditions
Melioidosis is an endemic tropical disease and is fast becoming an emerging global concern. Its clinical mimicry with several other common diseases has made its diagnosis and treatment difficult. This book identifies a gap in the literature and represents the management and diagnosis of this fatal but curable disease. It provides detailed coverage of its history, epidemiology, the latency of the agent, pathogenesis, manifestations, clinical clues for detection, microbiological diagnosis, treatment, prevention, and environmental aspects. This book is for clinicians, infectious disease specialists, microbiologists, and public health professionals, in countries where melioidosis is endemic. Key Features: * Provides practical guidance on clinical diagnosis, management, and prevention of melioidosis. * Features high quality radiological and clinical photographs for clinicians and professionals. * Explores the latest techniques and advancements in laboratory diagnosis.
This book covers classic epidemiological designs that use a reference/control group, including case-control, case-cohort, nested case-control and variations of these designs, such as stratified and two-stage designs. It presents a unified view of these sampling designs as representations of an underlying cohort or target population of interest. This enables various extended designs to be introduced and analysed with a similar approach: extreme sampling on the outcome (extreme case-control design) or on the exposure (exposure-enriched, exposure-density, countermatched), designs that re-use prior controls and augmentation sampling designs. Further extensions exploit aggregate data for efficient cluster sampling, accommodate time-varying exposures and combine matched and unmatched controls. Self-controlled designs, including case-crossover, self-controlled case series and exposure-crossover, are also presented. The test-negative design for vaccine studies and the use of negative controls for bias assessment are introduced and discussed. This book is intended for graduate students in biostatistics, epidemiology and related disciplines, or for health researchers and data analysts interested in extending their knowledge of study design and data analysis skills. This book Bridges the gap between epidemiology and the more mathematically oriented biostatistics books. Assembles the wealth of epidemiological knowledge about observational study designs that is scattered over several decades of scientific publications. Illustrates the performance of methods in real research applications. Provides guidelines for implementation in standard software packages (Stata, R). Includes numerous exercises, covering simple mathematical proofs, consideration of proposed or published designs, and practical data analysis.
This book covers a wide range of topics relating to the health and wellbeing of the construction workforce. Based on more than a decade of work examining various aspects of workers' health and wellbeing, the book addresses a key topic in construction management: how the design of work environments, construction processes and organisation of work impact upon construction workers' physical and psychological health. Occupational health is a significant problem for the construction industry. However, the subject of health is usually treated as an afterthought in other books which emphasise safety issues. Traditional management approaches (focused on the prevention of accidents and injuries) are arguably ill-suited to addressing issues of workers' health and wellbeing. The evidenced informed approach in this book provides a rich analysis of how construction workers' health and wellbeing are impacted by working in the construction industry, and critical information about how organisations (and decision-makers within them) can create workplaces and practices that are supportive and enable construction workers to maintain healthy and productive working lives. Including chapter summaries and discussion questions to encourage student readers to reflect on and formulate their own viewpoints about the issues raised in each chapter, the book has the potential to be used as a textbook in undergraduate or postgraduate occupational health and safety, or construction management courses dealing with occupational health and safety. It could also be used as supplementary, recommended reading in undergraduate or postgraduate programs in architecture, engineering or management.
* A highly illustrated guide and reference for haematologists, oncologists and clinical scientists * Guiding investigation, differential diagnosis, prognosis and treatment options Meeting the needs of haematologists, oncologists and clinical scientists for an up-to-date reference, this handbook provides a visual presentation of lymphoproliferative disorders, lymphoid leukaemias and plasma cell neoplasms. Each malignancy is surveyed based on molecular and cellular changes, including histochemistry, cytochemistry and relevant radiographs. Pertinent clinical information relating to clinical presentation, differential diagnosis and prognostic indicators are concisely outlined, using numerous graphics and citing key references in the field.
Make sense out of confusing HIV/AIDS terminology Finally, here is a reference work that contains clear and useful definitions of words, phrases, and medical terms associated with HIV/AIDS The Encyclopedic Dictionary of AIDS-Related Terminology is an easy-to-understand guide to all of the mainstream jargon surrounding this epidemic. This user-friendly volume brings you a number of essential features, such as: popular and scientific names of conditions and medicines listings of addresses and contact information for organizations and government agencies that are concerned with HIV/AIDS definitions of historical terms, abbreviations, and acronyms related to HIV/AIDS details of corporate and organizational involvement with HIV/AIDS research, prevention, and interventionThe Encyclopedic Dictionary of AIDS-Related Terminology also includes entries that describe and relate to legal, social, psychological, and religious issues, not just medical terms, to give readers a complete source that will meet all of their needs. With this single resource, you will be able to easily and thoroughly understand the sometimes complex jargon associated with HIV/AIDS. For librarians, AIDS service organizations, people living with AIDS, and the general public, the Encyclopedic Dictionary of AIDS-Related Terminology is a comprehensive guide to conditions and medical terms associated with HIV/AIDS. Dates, histories, addresses, telephone numbers, and Web site addresses are included with many entries.Including words specific to the epidemic as well as related psychosocial phrases, this essential volume offers you definitions of HIV/AIDS medications and listings of organizations and government agencies that are concerned with the disease.
Learn to handle the problems that Parkinson's patients face
Make sense out of confusing HIV/AIDS terminology!Finally, here is a reference work that contains clear and useful definitions of words, phrases, and medical terms associated with HIV/AIDS! The Encyclopedic Dictionary of AIDS-Related Terminology is an easy-to-understand guide to all of the mainstream jargon surrounding this epidemic. This user-friendly volume brings you a number of essential features, such as: popular and scientific names of conditions and medicines listings of addresses and contact information for organizations and government agencies that are concerned with HIV/AIDS definitions of historical terms, abbreviations, and acronyms related to HIV/AIDS details of corporate and organizational involvement with HIV/AIDS research, prevention, and intervention The Encyclopedic Dictionary of AIDS-Related Terminology also includes entries that describe and relate to legal, social, psychological, and religious issues, not just medical terms, to give readers a complete source that will meet all of their needs. With this single resource, you will be able to easily and thoroughly understand the sometimes complex jargon associated with HIV/AIDS. For librarians, AIDS service organizations, people living with AIDS, and the general public, the Encyclopedic Dictionary of AIDS-Related Terminology is a comprehensive guide to conditions and medical terms associated with HIV/AIDS. Dates, histories, addresses, telephone numbers, and Web site addresses are included with many entries.Including words specific to the epidemic as well as related psychosocial phrases, this essential volume offers you definitions of HIV/AIDS medications and listings of organizations and government agencies that are concerned with the disease.
Advances in Immunology, Volume 140, the latest in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology.
This book is a detailed guide to image interpretation in patients with spine and spinal cord tumors that will enable clinicians and residents to improve their diagnostic abilities. The book opens by introducing basic concepts in the imaging of spinal tumors, namely the compartmental approach and the histologic basis for the different imaging appearances. These concepts are explained with the aid of representative cases and schematic illustrations. The second part of the book represents a "training step" in which various spinal tumors are described in detail, focusing on the imaging findings. Representative cases are presented with radiographic, CT, and MR images; in addition, schematic illustrations and pathologic or operative images are included in selected cases. The third part is a "practice step" describing tips for correct imaging diagnosis. Individual chapters in this part focus on incidence-, age-, location-, and imaging pattern-based approaches to bone, extradural, intradural extramedullary, intramedullary, and pediatric spinal tumors. The presented cases will enhance the reader's understanding of the different tumor patterns and assist in solving diagnostic problems that may be encountered in daily practice.
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