Offering a basis for further research into the interactions of hosts and pathogens, this work gathers up-to-date findings, and details basic structures, functions and immunology. It provides descriptions of a variety of experimental endotoxin neutralizing agents, as well as a guide to clinical research initiatives and the latest treatments.

HIV and AIDS information on the Internet can be very overwhelming. HIV/AIDS Internet Information Sources and Resources organizes the information on the Internet about HIV and AIDS so you don?t have to. Don?t allow access to the most up-to-date HIV and AIDS-related Web sites be an impossible challenge! With HIV/AIDS Internet Information Sources and Resources, you?ll know where to go to educate yourself and those you care about in an effort to stop the spread of this disease.HIV/AIDS Internet Information Sources and Resources is guaranteed to help you find the best Web sites to answer questions you may have regarding HIV and AIDS. Even if what you are searching for isn?t in the main recommended Web sites, you?ll be directed to discussion and support destinations tailored to suit your needs. HIV/AIDS Internet Information Sources and Resources reviews, evaluates, and categorizes all HIV and AIDS related Web sites according to who designed the Web site, the type of information within the Web site, and the Web site target audience. You?ll find the details of the best HIV/ AIDS information about: women, children, adolescents and minorities websites created by organizations such as the National Institute of Health (NIH) and the Center for Disease Control and Prevention (CDC) news sites general HIV and AIDS sites, a profile of HIV insite drug therapy sites, including one for alternative medicine medical management and Internet library resourcesSome newer Web sites use unusual terminology you may have never heard before. HIV/AIDS Internet Information Sources and Resources clarifies this new language so you?ll understand exactly what is meant. You?ll never have to waste your time reading scattered articles about HIV and AIDS information on the Internet after buying your own copy of HIV/AIDS Internet Information Sources and Resources.

Offers comprehensive coverage of currently available cancer predictors, the most recent research on carcinogenicity, and the design and interpretation of carcinogenicity experiments. Presents mouse, rat, and human carcinogenicity data for the liver, kidney, breast, cervix, prostate, hematopoietic system, colon, skin, urinary bladder, mouth, stomach, thyroid, and pancreas.

Sphingolipids in Cancer, Volume 140, the latest release in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research. Topics discussed in this updated volume include Mechanisms of ceramide-dependent cancer cell death, Sphingolipids as regulators of autophagy and endocytic trafficking, The role and function of sphingomyelin biosynthesis in the development of cancer, Neutral sphingomyelinases in cancer: Friend or foe?, Sphingolipid rendezvous at the crossroad of NAFLD and senescence, Ceramide signaling and p53 pathways, Sphingolipid regulation of RNA Biology in cancer phenotypes, The role of ceramide-1-phosphate in tumor cell survival and dissemination, and more.

Since nearly the beginning of the AIDS epidemic, activists have signaled the inadequacy of prevention strategies and drug protocols that have been developed from research done primarily on men. The latest C.D.C. figures prove they were right; for the first time since the beginning of the epidemic, AIDS cases among white men have fallen, yet the largest increases are among women.
Weaving together theoretical, critical, and practical perspectives, "Gendered Epidemic" is a collection of essays that questions the "add women and stir" model that governs most HIV/AIDS prevention and treatment efforts. The individual essays describe conflicts and contradictions, and pose new theories and practices. Written by HIV positive women, theorists, teachers, artists, policy makers and activists, it offers insights necessary to stem the spread of HIV.

Drug Injecting and HIV Infection is a comparative international study of drug injecting behaviour and HIV infection based on the World Health Organization's study of 13 cities as disparate as Athens, Bangkok, Glasgow and Rio de Janeiro. Using a standardized methodology for the collection of data, as well as central data management and analysis, this study represents the largest international project of its kind. It presents a comprehensive overview of what is currently known about drug injecting, HIV infection, epidemic dynamics and possibilities for prevention.
Stressing the importance of linking research to intervention and policy, the contributors emphasize the need to place HIV and policy issues on the international agenda. Written by experts in the field, this global study offers an in-depth and definitive analysis of the subject.

In The HIV-Negative Gay Man: Developing Strategies for Survival and Emotional Well-Being, you ll get instant access to some of the most recent information on the market today about remaining HIV-negative. You ll come in contact with a wealth of information concerning the psychosocial and psychosexual needs of HIV-negative gay men and discover strategies for staying uninfected and cultivating a meaningful way of life in the face of HIV/AIDS.Compiled by both professionals and peers, The HIV-Negative Gay Man goes to the front-lines of HIV prevention to help you understand the most beneficial and dependable ways of preserving the value of life and living it to the fullest. Radically reshaping and rehumanizing traditional HIV prevention efforts, these updated and personalized approaches will give you many individual strategies for survival in a world in which the link between sex and survival has been turned upside-down. You ll find new ways to expand and enrich your own coping repertoire as you explore these topics: how the HIV-negative gay man 's complex emotional reactions change what peer groups can do when creating and experimenting with new identities and roles when group work needs to be short-term or long-term why a sex life vocabulary needs to be built where Latino Men can learn critical thinking about internalized homophobia and transgression survival mechanisms changing attitudes as a result of the development of protease inhibitors and new drug therapies in HIV preventionIn The HIV-Negative Gay Man, you ll find that the road to survival is a long one but a road that can be travelled and enjoyed if the right strategies are applied. This book is a "road map" for survival. In it, you ll meet many brave professionals who are currently fighting on the front lines of HIV prevention and coming forward to share their own personal stories of survival. In turn, you ll learn from them and eventually tell your own survival story to someone else along the way.

Expanding on the highly successful first edition, this second edition of Proton Therapy Physics has been completely restructured and updated throughout, and includes several new chapters. Suitable for both newcomers in medical physics and more seasoned specialists in radiation oncology, this book provides an in-depth overview of the physics of this radiation therapy modality, eliminating the need to dig through information scattered across medical physics literature. After tracing the history of proton therapy, the book explores the atomic and nuclear physics background necessary for understanding proton interactions with tissue. The text then covers dosimetry, including beam delivery, shielding aspects, computer simulations, detector systems and measuring techniques for reference dosimetry. Important for daily operations, acceptance testing, commissioning, quality assurance and monitor unit calibrations are outlined. The book moves on to discussions of treatment planning for single- and multiple-field uniform doses, dose calculation concepts and algorithms, and precision and uncertainties for nonmoving and moving targets. Imaging for treatment guidance as well as treatment monitoring is outlined. Finally, the biological implications of using protons from a physics perspective are discussed. This book is an ideal practical guide for physicians, dosimetrists, radiation therapists, and physicists who already have some experience in radiation oncology. It is also an invaluable reference for graduate students in medical physics programs, physicians in their last year of medical school or residency, and those considering a career in medical physics. Features: Updated with the latest technologies and methods in the field, covering all delivery methods of proton therapy, including beam scanning and passive scattering Discusses clinical aspects, such as treatment planning and quality assurance Offers insight on the past, present, and future of proton therapy from a physics perspective

Contents:
Global perspectives on drug injecting; the social context of injectors' risk behaviour; health and social consequences of injecting drug use; drug injecting and HIV-1 infection - major findings from the multi-city study; new injectors and HIV-1 risk; the structure of stable seroprevalence HIV- 1 epidemics among injecting drug users; mobility and the diffusion of drug injecting and HIV infection; modelling the HIV-1 and AIDS epidemic among drug injectors; drug injecting and sexual safety - cross-national comparisons among cocaine and opioid injectors; cities responding to HIV- 1 epidemics among injecting drug users; prison and HIV-1 infection among drug injectors; preventing epidemics of HIV-1 among injecting drug users; overview - policies and interventions to stem HIV-1 epidemics associated with injecting drug use; appendix 1 - methodology of the World Health Organization multi-city study on drug injecting and risk of HIV infection; appendix 2 - city epidemics and contexts; appendix 3 - contributors and collaborating agencies in the World Health Organization multi-city study on drug injecting and risk of HIV infection.

Because of the individual and varying symptoms of chronic fatigue syndrome, medical guidelines encompassing the needs of every patient simply do not exist. Through proven research and recommendations for future treatment, Disability and Chronic Fatigue Syndrome: Clinical, Legal, and Patient Perspectives discusses the difficult subject of how to diagnose disability in chronic fatigue syndrome patients, how to determine the severity of a patient 's disability, and how new disability guidelines would make more chronic fatigue patients eligible to apply for disability benefits. From this information, you will gain a clearer understanding of chronic fatigue syndrome, enabling you to more accurately assess a patient 's condition or decide if your client is eligible for disability benefits. Essential for clinicians, lawyers, patients, and medical insurers, Disability and Chronic Fatigue Syndrome provides an outline of disability guidelines established by the Social Security Administration (SSA), the Veterans'Administration, and the American Medical Association, as well as federal guidelines. While gaining information on the different types of disability insurance available to chronic fatigue patients, such as the Long Term Disability (LTD) policy, you will also learn how standard procedures such as psychiatric evaluation, neuropsychological testing, and physical capacity measurement can both help and hinder the process of determining disability in a patient. In addition, Disability and Chronic Fatigue Syndrome provides insight into: the symptoms of chronic fatigue syndrome, such as inability to work and level of stamina, in accordance with medical and legal definitions disability guidelines set by the SSA how patients'varying symptoms and conflicting findings affect disability diagnosis in chronic fatigue syndrome patients by SSA standards plans by the Chronic Fatigue Immune Dysfunction Syndrome (CFIDS) Association of America to work with the SSA concerning strategies to dissolve barriers to Social Security Disability Income Benefits for patients and to advocate for up-to-date information on CFIDS in the SSA 's Listing of Impairments. tips on applying for SSA benefits claims that insurance companies have used misleading surveillance videos and fraud to discontinue disability benefits to patients in need of coverage Since the Social Security Administration does not currently consider a CFIDS diagnosis enough to win a disability claim, Disability and Chronic Fatigue Syndrome also contains many recommendations for improving federal disability guidelines, such as using results from functional evaluations, neuropsychological testing, and exercise endurance testing as evidence of impairment. For less severe cases, this book provides you with suggestions for rehabilitation of CFS patients before disability claims are made, including patient training and education, dependency counseling, muscular conditioning, and occupational therapy. Whether you are a patient, clinician, lawyer, or medical insurer, Disability and Chronic Fatigue Syndrome will guide you through the complex issues surrounding disability and this intricate disease.

Designed with academic vaccine researchers in mind, this book presents a road map of how a vaccine develops from an idea in a researcher's imagination, to the lab bench, through preclinical evaluation, and into the clinic for safety and immunogenicity. The result of the editors' own efforts to glean practical information on the steps necessary to manufacture, bottle, and test their vaccines for clinical trials, this book provides answers to researcher questions such as:
o How do I identify antigens that would produce effective vaccines?
o Can I produce a clinical lot of vaccine in my laboratory?
o How should a vaccine be bottled?
o Which FDA expectations must I meet?
o What is an IND application and how do I file it?
o Which CFRs apply to production of a vaccine?

Because of the individual and varying symptoms of chronic fatigue syndrome, medical guidelines encompassing the needs of every patient simply do not exist. Through proven research and recommendations for future treatment, Disability and Chronic Fatigue Syndrome: Clinical, Legal, and Patient Perspectives discusses the difficult subject of how to diagnose disability in chronic fatigue syndrome patients, how to determine the severity of a patient 's disability, and how new disability guidelines would make more chronic fatigue patients eligible to apply for disability benefits. From this information, you will gain a clearer understanding of chronic fatigue syndrome, enabling you to more accurately assess a patient 's condition or decide if your client is eligible for disability benefits. Essential for clinicians, lawyers, patients, and medical insurers, Disability and Chronic Fatigue Syndrome provides an outline of disability guidelines established by the Social Security Administration (SSA), the Veterans'Administration, and the American Medical Association, as well as federal guidelines. While gaining information on the different types of disability insurance available to chronic fatigue patients, such as the Long Term Disability (LTD) policy, you will also learn how standard procedures such as psychiatric evaluation, neuropsychological testing, and physical capacity measurement can both help and hinder the process of determining disability in a patient. In addition, Disability and Chronic Fatigue Syndrome provides insight into: the symptoms of chronic fatigue syndrome, such as inability to work and level of stamina, in accordance with medical and legal definitions disability guidelines set by the SSA how patients'varying symptoms and conflicting findings affect disability diagnosis in chronic fatigue syndrome patients by SSA standards plans by the Chronic Fatigue Immune Dysfunction Syndrome (CFIDS) Association of America to work with the SSA concerning strategies to dissolve barriers to Social Security Disability Income Benefits for patients and to advocate for up-to-date information on CFIDS in the SSA 's Listing of Impairments. tips on applying for SSA benefits claims that insurance companies have used misleading surveillance videos and fraud to discontinue disability benefits to patients in need of coverage Since the Social Security Administration does not currently consider a CFIDS diagnosis enough to win a disability claim, Disability and Chronic Fatigue Syndrome also contains many recommendations for improving federal disability guidelines, such as using results from functional evaluations, neuropsychological testing, and exercise endurance testing as evidence of impairment. For less severe cases, this book provides you with suggestions for rehabilitation of CFS patients before disability claims are made, including patient training and education, dependency counseling, muscular conditioning, and occupational therapy. Whether you are a patient, clinician, lawyer, or medical insurer, Disability and Chronic Fatigue Syndrome will guide you through the complex issues surrounding disability and this intricate disease.

A "brilliant" ("Fortune"), eye-opening history of the war on cancer, "The Truth in Small Doses" asks why we are losing this essential fight and charts a path forward.
Over the past half century, deaths from heart disease, stroke, and so many other killers have fallen dramatically. But cancer continues to kill with abandon. In 2013, despite a four-decade "war" against the disease that has cost hundreds of billions of dollars, more than 1.6 million Americans will be diagnosed with cancer and nearly six hundred thousand will die from it.
A decade ago, Clifton Leaf, a celebrated journalist and a cancer survivor himself, began to investigate why we had made such limited progress fighting this terrifying disease. The result is a gripping narrative that reveals why the public's immense investment in research has been badly misspent, why scientists seldom collaborate and share their data, why new drugs are so expensive yet routinely fail, and why our best hope for progress--brilliant young scientists--are now abandoning the search for a cure. "Through flowing prose Leaf delivers, alongside facts and data, stories on personalities involved in research, the fascinating process of solving an unusual and highly deadly cancer in Africa, and the heartbreaking realities of cancer treatment in children today. Leaf's extensively investigated treatise will resonate with researchers and patients frustrated by the bureaucratic woes he delineates. Public policy makers, grant reviewers, and pharmaceutical researchers alike must consider Leaf's indictment and proposed solutions" ("Publishers Weekly"). "The Truth in Small Doses" is that rare tale that will both outrage readers and inspire conversation and change.

In this startling new collection of case studies entitled HIV/AIDS and the Drug Culture: Shattered Lives, you ll take an eye-opening and informative look at the lifestyle and culture of the HIV/AIDS intravenous drug users (IVDUs). You ll see how health care providers and caregivers can update their methods and mindsets in order to meet the needs of this special cross-section of patients.In each chapter of HIV/AIDS and the Drug Culture, you ll gain instant access to full medical and psychosocial histories. You ll also find summaries of important events, clues to recognize, and strategies to safely manage each problematic situation that might arise, all of which will speed you on your way to more effectively and professionally administering to current and former intravenous drug users. Specifically, you ll read about: facts about needle exchange programs, injection drug use, and seroprevalence among IVDUs developing and assessing coping skills applying harm reduction models relapse prevention identifying and dealing with manipulative behaviorsBecause most health care providers only deal with a small number of HIV/AIDS IVDU cases, they lack the opportunity to construct valuable and viable plans for dealing with such patients. Now, finally, you have this guide to help you. So, if you re a nurse, social worker, health care provider, case manager, therapist, or someone interested in learning about the latest information regarding health care and intravenous drug use, let HIV/AIDS and the Drug Culture introduce you to the culture of the drug user and the best plans for meeting his or her health care needs. "

"Autologous Stem Cell Transplantation" integrates basic research and clinical aspects underlying the most recent results in those malignant diseases where progress is most effective.
Recent evidence shows that higher doses are better in inducing higher cure rates in hematological neoplasias, although myeloblation related to dose intensity can be a limiting factor. The toxicity can now be controlled with autologous marrow and peripheral blood progenitor cell transplantation, used with or without growth factors. The combination of high dose chemoradiotherapy followed by re-infusion of autologous stem cells constitute a dramatic advance in the treatment of refactory and relapse hematological neoplasias.

Nausea and vomiting are two of the most common side-effects of anti-cancer treatment, and the discovery and clinical application of 5-hydroxytryptamine3 receptor antagonists has transformed the management of these side effects, resulting in a much improved quality of life for cancer patients. This text presents a detailed overview of the management of cancer-treatment induced emesis in a number of different treatment settings, and focuses on the mechanisms and use of 5-HT3 receptor antagonists. Contributions are also included from the points of view of the nurse and the patient.

Activism and Marginalization in the AIDS Crisis shows readers how the advent of HIV-disease has brought into question the utility of certain forms of "activism" as they relate to understanding and fighting the social impacts of disease. This informative and powerful book is centrally concerned about the ways in which institutionally governed social constructions of HIV/AIDS affect policy and public images of the disease more so than activist efforts. It asserts that an accounting of the power institutional structures have over the dominant social constructions of HIV disease is fundamental to adequate forms of present and future AIDS activism. Chapters in Activism and Marginalization in the AIDS Crisis demonstrate how, despite what is thought of as the "successful activism" of the past decade, the claims of the HIV-positive are still being ignored, still being marginalized, and still being administratively "handled" and exploited even as the plight of those who find themselves HIV-positive worsens. Although chapters reject the assertion that activism has been a highly effective remedy to HIV-positive voicelessness, authors do not deny that activists have been vocal, but that they continue to be ignored despite their vocality.Contributors in Activism and Marginalization in the AIDS Crisis offer numerous examples of institutional control and demonstrate that institutional structures, and not activists, are controlling the public meaning of HIV-related issues. Readers learn how messages about HIV/AIDS are produced, negotiated, modified, and sustained through institutional mechanisms that serve mostly institutional interests rather than those of the HIV-positive. In gaining an understanding of these issues, readers will begin to learn how to modify and strengthen activist efforts with valuable insight on: the lack of HIV-positive voices in mainstream news portrayals of HIV/AIDS research on constructions of HIV-disease at the state government level social constructions and how they affect HIV/AIDS policy the political construction of AIDS and interest-based struggles the emergent "bio-politics" of HIV and homosexuality in the U.S. how institutional power works to govern public understanding of HIV diseaseInstitutional structures are defined in this book as groups engaged in and defined by the production of various "truths" which sustain them. Institutional power may be defined as the capacity to regulate, constrain, and disseminate versions of "truth." Activism and Marginalization in the AIDS Crisis reveals how HIV activist groups have been outmaneuvered when it comes to the production and dissemination of various "truths" about HIV/AIDS by institutional structures more deeply steeped in social legitimacy and which have a superior capacity for message dissemination.HIV/AIDS activists, HIV-positive persons and those with AIDS, HIV/AIDS educators, public and institutional policymakers, health professionals, and the general public will find this book essential to understanding the social constructions of HIV/AIDS, how these affect HIV/AIDS-related policy and public opinion, and how to begin to cipher through the plethora of information to find and promote the "truth."

This up-to-the-minute and comprehensive resource lucidly covers gene therapy for lung diseases from existing technologies delivering foreign DNA to the lungs via the airways or circulation to promising new approaches for the further development of safe and efficient gene delivery systems.

A 10th-century medical compendium. Reproduced here is the sixth book, which deals with sexual diseases. The text is given first in Arabic and then in English. Besides offering a glimpse into the history of medical practice, the work contains many quotations from ancient and medieval physicians and p

Advances in Applied Microbiology, Volume 102, the latest release in one of the most widely read and authoritative review sources in microbiology, contains comprehensive reviews of the most current research in applied microbiology. This latest release includes specific chapters on a variety of topics, most notably, Twenty-five Years of Investigating the Universal Stress Protein: Structure, function and applications, Fungal Genomes and Genotyping, Fungi in deep subsurface environments, Spore germination in pathogenic fungi, Host sensing by pathogenic fungi, Advances in the Microbial Ecology of Biohydrometallurgy, and The mycosphere and turnover of contaminants, amongst others.

Provides a detailed survey of new therapies for autoimmune diseases, exploring the rationale for their use and clinical data regarding their potential benefit. The book emphasizes biological interventions based on the pathogenesis of autoimmunity, ranging from altering tolerance to modifying cytokines and changing lymphocyte function.

In his trademark, revolutionary style, Dr. Goldstein uses his model of neural dysregulation to incorporate basic neuroscience research into pathophysiology and treatment. Betrayal by the Brain presents a comprehensive thesis that clearly defines the biological basis for many of the varied symptoms experienced by chronic fatigue syndrome patients. Dr. Goldstein provides a rationale for the use of symptomatic therapies that have worked in many CFS patients. Betrayal by the Brain is a valuable handbook to assist the medical professional in the diagnosis and treatment of the many patients afflicted with this illness. It is of great value to medical professionals as well as academic researchers in psychiatry, biobehavioral sciences, psychoneuroimmunology, and pain management.Dr. Goldstein has added layers of regulation to the limbic system that help further explain limbic dysfunction in neurosomatic disorders, and he suggests novel methods of remediation. Betrayal by the Brain represents integrative thinking and the latest research and discoveries by Dr. Goldstein on neurosomatic disorders--the most common group of illnesses for which patients consult physicians.

This study draws on feminist theory, cultural studies, the philosophy of science, and gay and lesbian studies to problematize the factual scientific discourse about AIDS, and interpret it as a political discourse. Waldby argues that much AIDS discourse relies on an implicit and unconscious equation between sexual health and heterosexual masculinity. In this equation, women, bisexual and gay men are the targets of preventative programmes, while heterosexual men tend to remain unaddressed by such programmes. Drawing upon examples of preventative policies from Australia, Britain and the USA, Waldby investigates the concept of public health and questions whose interests are represented in a "healthy society". It demonstrates the extent to which established ideas about the virus: the immune system, the HIV test and the epidemiology of the disease, rely upon unexamined, conservative assumptions about sexual identity and sexual difference.

First published in 1997. Routledge is an imprint of Taylor & Francis, an informa company.

Dr. Jay A. Goldstein 's Betrayal by the Brain can be a daunting treatise to the layperson as well as a challenge for the physician who is not versed in neurology, psychiatry, immunology, and endocrinology. Here, in A Companion Volume to Dr. Jay A. Goldstein 's Betrayal by the Brain: A Guide for Patients and Their Physicians, Author Katie Courmel, a longtime sufferer of chronic fatigue syndrome and fibromyalgia, presents in layperson 's terms the salient points of the book to lead readers to an understanding of Dr. Goldstein 's theory and methods of treatment. This guide provides CFS and FMS patients with an understanding of how their brains should function as opposed to how they are now dysfunctioning. It explains the proper role and function of each brain structure and neural assembly and the neurochemicals believed to be implicated in CFS and fibromyalgia along with the dysfunctions found in CFS/FMS patients. These dysfunctions, as a whole, form the basis of Dr. Goldstein 's unified theory behind the possible causes of CFS and FMS. Patients involved in or contemplating Dr. Goldstein 's treatment can use A Companion Volume to Dr. Jay A. Goldstein 's Betrayal by the Brain to gain an explanation of the process from a firsthand perspective and can follow along to learn why they are given particular drugs and what response Dr. Goldstein hopes to elicit from their bodies. This understanding gives patients a sense of control and helps them weather the ups and downs their bodies experience as a normal response to the treatment. The strength of A Companion Volume to Dr. Jay A. Goldstein 's Betrayal by the Brain lies in its ability to simplify without sacrificing the body of information that one must understand to make sense of the multitude of seemingly unrelated manifestations of these diseases of the brain. A thorough understanding will allow sufferers of CFS/FMS to approach Dr. Goldstein 's treatment method with an open mind and improve their chances for success. Specific questions answered for readers include: how safe is this protocol? should I go alone or take a companion? what should I expect during my initial consultation? what are the effects of so many drugs? why doesn t the same drug work for everyone? if my treatment is successful, how long will it last? what happens when I leave Dr. Goldstein 's care? A Companion Volume to Dr. Jay A. Goldstein 's Betrayal by the Brain prepares readers for a unique, sometimes scary, often perplexing, hopefully miraculous, leap-of-faith experience. It helps patients deal with the very natural sense of uneasiness they may be feeling and helps them understand, in layperson 's terms, what Dr. Goldstein 's protocol can accomplish and how it can be so successful.