RNA processing plays a critical role in realizing the full potential of a given genome. One means of achieving protein diversity is through RNA editing. A diverse array of editing events has been characterized, affecting gene expression in organisms from viruses and single cell parasites to humans and plants. The variety of editing mechanisms has required the development of many different experimental approaches, many of which are likely to be broadly applicable, particularly given the interplay between editing and other cellular processes, including transcription, splicing, and RNA silencing. This volume not only covers most of the principal methods employed in the field, but also offers innovative solutions to the significant challenges posed by these experimental systems.
* Presents newly developed methods
* Covers topics ranging from biochemistry to bioinformatics
* Includes innovative solutions to potential problems

This issue of Cardiology Clinics, guest edited by Drs. Marie-Annick Clavel and Philippe Pibarot, focuses on Aortic Valve Disease. Articles in this issue include, but are not limited to: Pathophysiology of Aortic Stenosis and future perspectives for medical therapy, Assessment of Aortic Stenosis Severity, Assessment of Cardiac Damage in Aortic stenosis, Aortic Stenosis with Other Concomitant Valvular Disease (AR, MR, TR), Biomarker in Aortic Stenosis, Aortic stenosis guidelines: evidence gaps and changing concepts, Heart Valve Clinics and Heart Valve Centers, Frailty and Multi-Comorbidities in Aortic Stenosis, Procedures and Outcomes of Surgical Aortic Valve Replacement, Patient selection and Work-up for Transcatheter Aortic Valve Replacement, Procedures and Outcomes of Transcatheter Aortic Valve Replacement, Sex differences in the Pathophysiology, Diagnosis, and Management of Aortic Stenosis, Implications of Aortic stenosis in Pregnancy and Non-Cardiac Surgery.

Volume forty-three of the Advances in Clinical Chemistry series contains review articles of wide interest to clinical laboratory scientists and diagnostic adventurers. In this volume, the biochemistry of bilirubin, the endproduct of heme metabolism, is explored with respect to its potential beneficial role in preventing oxidative changes associated with a variety of pathological conditions including atherosclerosis, cancer, inflammatory, autoimmune and other degenerative diseases.

Healthcare Information Systems and Informatics: Research and Practices compiles estimable knowledge on the research of information systems and informatics applications in the healthcare industry. This book addresses organizational issues, including technology adoption, diffusion, and acceptance, as well as cost benefits and cost effectiveness, of advancing health information systems and informatics applications as innovative forms of investment in healthcare. Rapidly changing technology and the complexity of its applications make this book an invaluable resource to researchers and practitioners in the healthcare fields.

This issue of Heart Failure Clinics, guest edited by Antonio Cittadini and Hector O. Ventura, will cover key topics in Emerging Comorbidities in Heart Failure. This issue is one of four selected each year by our series consulting editor, Dr. Eduardo Bossone. Topics discussed in this issue will include: Anabolic deficiencies in Heart Failure, Thyroid Abnormalities in Heart Failure, The Gut Axis Involvement in Heart Failure: focus on trimethylamine N-oxide (TMAO), Chronic Obstructive Pulmonary Disease and Heart Failure, When Pulmonary Hypertension complicates Heart Failure, Sex and Gender-related Issues in Heart Failure, Cardiac Cachexia Revisited: The Role of Wasting in Heart Failure, Atrial Fibrillation in Heart Failure, The Impact of Obesity in Heart Failure, Sleep Breathing Disorders in Heart Failure, The Cardiorenal Syndrome in Heart Failure, Psychological Disorders in Heart Failure, Hypertension in Heart Failure, among others.

"I found it (the story) at first sad and tragic, all the more to be uplifted by its outcome. What better ever proof of a miracle, of the value of family support, of the power of faith, of the hand of God, of the unpredictability of life. All in all it's a wonderful piece to read. What's more, you make readers care, because the woman (Jane Williams) and her family, including the convincing and articulate narrator, Dr. Henry, become real people in readers' minds, people they know well enough to worry about, to cheer for. I came to feel, thanks to Dr. Joel Hilaire's sharp and rich writing, that I was one of those people, close to the family, involved in every down-and-up event. To my mind you achieved exactly what you were after with this extensive true-to-life story."--Lou Fisher, from Long Ridge Writers Group

Behavioral-developmental pediatrician Lawrence Diller continues his investigation into the widespread use of psychiatric drugs for children in America, an investigation that began with his first book, Running on Ritalin. In this work at hand, Diller delves more deeply into the factors that drive the epidemic of children's psychiatric disorders and medication use today, questioning why these medications are being sought, and why Americans use more of these drugs with children than is used in any other country in the world. There is relentless pressure for performance and success on children as young as three, Diller acknowledges, but his analysis goes further, and his conclusion is both surprising and ironic. In the name of preserving children's self esteem, American society has become intolerant of minor differences in children's behavior and performance. We worry so much about how our children feel about themselves that struggles once within the realm of normal are now considered abnormal - indicative of a psychiatric or brain disorder, requiring diagnosis and treatment wth psychiatric drugs, often for years. The Last Normal Child also addresses the role of drug companies in the advertising and promotion of both disorders and drugs. The pharmaceutical industry has garnered incredible profits and power in influencing the way we view children today. Diller illustrates through vivid and poignant stories of real patients, how he, together with families, make informed decisions about using psychiatric drugs for children. Parents, educators, pediatric and mental health professionals will gain valuable insights, tips and tools for navigating what has become a truly perilous trip of childhoodfor children in America today.

Author Dr. Nelly Maseda often wonders how she became successful, but her brothers didn't. She wonders how she survived a childhood raised by a single Dominican mother on public assistance who suffered from severe mood swings, rage, promiscuous sexual behavior, and cycles of depression. While Maseda pursued her degree at Cornell University, her brothers and cousins entered into a world of substance abuse and its related criminal activities and violence.

In Strangers in the Night, Maseda looks inside the dynamics of a family and describes the life of her mother, Nena-her early years in the Dominican Republic, immigration to the United States in 1959, her new life in New York City, and raising her children against the backdrop of rage, depression, and a questionable home life. She also shares the trajectory of her two brothers' lives to show that lessons can be learned from their experiences.

Maseda tells her mother's story from the perspective of her profession as a pediatrician to communicate to patients and others that we now live in a time where help exists to undo the damage that negative, early life experiences can do to minds and lives.

Jada Patrice Howard captures the ups and downs of her life in "Through These Eyes," the second volume of her memoir. This heartfelt, personal tale recalls her journey through the life experiences she has had in recent years.

She recounts her joy at finally being chosen to attend a live taping of the Oprah Winfrey Show in Chicago. Follow her as she prepares for the trip of a lifetime, traveling from Washington, DC, to Chicago to attend the show; share her delight as she has the time of her life at Oprah's show.

She also shares tales of her work as a school bus driver, her brief move to North Carolina to help family members, and her attendance of Dr. Dorothy Height's funeral.

"Through These Eyes" explores the nature of people and their relationships and relates experiences of happiness, sadness, joy, and pain-life experiences that we can learn from.

As a new physician, you face numerous questions: How do you decide what type of medicine to practice? How should you prepare for your residency interview? Where do you want to settle after your training? Dr. Rashed Hasan, a pediatrician, knows that it's not always easy to answer that question. He offers advice that can help you decide what's right for you, answering the questions above and also providing insights on

determining the right time to buy a home;

negotiating contracts with hospitals;

building a sound financial life;

deciding whether to open your own practice or join a group; and

navigating the tax code to maximize earnings.

He includes practical information for new and established physicians on a variety of topics, such as improving leadership skills, maintaining health, responding to malpractice claims, and preparing for retirement. Hasan also explores the ramifications of recent changes to the health care system, including the Affordable Care Act.

While it isn't perfect, the medical profession can be everything you dreamed it would be when you learn how to build your future today.

This issue of Veterinary Clinics: Food Animal Practice, guest edited by Dr. Christopher Chase in collaboration with Consulting Editor Dr. Robert Smith, focuses on Ruminant Immunology. Article topics include: Herd immunity: an epidemiologist's view; Genetics of immunoresponsive and correlates of immunity; Microbiome and immunity: an evolving field; Vaccine administration dos and don'ts (endotoxin stacking; delayed MLV); Mycoplasma bovis: interations with the immune system and failure to generate an immune response; Nutriceuticals and their effect on immune response; Adjuvants; Immunology of maximizing passive transfer; Mucosal immunity and common mucosal response; Vaccinating in the face of maternal immunity; and Gamma Delta T cells in ruminants: their role, function, and importance.

Patient providers need to continue to stay abreast of the advances in the care of patients with advanced liver disease. They will continue to be exposed to a greater number of patients with cirrhosis, a reflection of the increasing burden of liver disease in patients where non-alcoholic steatohepatitis and even hepatitis C mature to cirrhosis. Although the hepatitis C viral infection can be eliminated, the natural history of the disease will not be necessarily completely altered. For this issue on Portal Hypertension, recognized authorities in these areas stress the relevance, utility, and novelty in their clinical review articles so that they can be used by practicing providers, quoted in the medical literature, and referenced in lectures. Topics addressed are Portal Hypertension, Sarcopenia, Hepatic Encephalopathy, Varices, Ascites and Hepatorenal Syndrome, Pulmonary Complications, Pharmacologic Management, Non-Cirrhotic Portal Hypertension, and Surgery in the Portal Hypertension Patient.

Before the integration of expert systems in biomedical science, complex problems required human expertise to solve them through conventional procedural methods. Advancements in expert systems allow for knowledge to be extracted when no human expertise is available and increases productivity through quick diagnosis. Expert System Techniques in Biomedical Science Practice is an essential scholarly resource that contains innovative research on the methods by which an expert system is designed to solve complex problems through the automation of decision making through the use of if-then-else rules rather than conventional procedural methods. Featuring coverage on a broad range of topics such as image processing, bio-signals, and cognitive AI, this book is a vital reference source for computer engineers, information technologists, biomedical engineers, data-processing specialists, medical professionals, and industrialists within the fields of biomedical engineering, pervasive computing, and natural language processing.