Jada Patrice Howard captures the ups and downs of her life in "Through These Eyes," the second volume of her memoir. This heartfelt, personal tale recalls her journey through the life experiences she has had in recent years.

She recounts her joy at finally being chosen to attend a live taping of the Oprah Winfrey Show in Chicago. Follow her as she prepares for the trip of a lifetime, traveling from Washington, DC, to Chicago to attend the show; share her delight as she has the time of her life at Oprah's show.

She also shares tales of her work as a school bus driver, her brief move to North Carolina to help family members, and her attendance of Dr. Dorothy Height's funeral.

"Through These Eyes" explores the nature of people and their relationships and relates experiences of happiness, sadness, joy, and pain-life experiences that we can learn from.

"Annual Reports in Medicinal Chemistry" provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.
* Critical reviews of the previous year s literature in many topics of interest to medicinal chemists
* Highlights major developments in medicinal chemistry
* Includes a comprehensive set of cumulative indexes to easily locate topics in all published volumes"

MicroRNAs (miRNA) are tiny bits of genetic material that were unknown nearly 10 years ago but now represent an exciting field of study in biology. Upon their discovery, researchers revealed for the first time a new mechanism by which microRNA can stop the function of messenger RNA (mRNA) by literally cutting it in half, interfering with the normal function of specific messenger RNAs in gene expression.
This "expression" of genes that code for essential proteins is essentially what controls whether a cell turns into a liver, lung, or brain cell, for example. Understanding what activates this process - or stops it - is a key to understanding the biological process and builds a foundation for advances in medicine and other fields. This volume in Methods in Enzymology presents valuable methods for studying MicroRNA, with three sections covering identification of MicroRNAs and their targets; MicroRNA expression, maturation and functional analysis; and MicroRNAs and disease.

The integration of mobile technology into the medical industry has revolutionized the efficiency and delivery of healthcare services. Once limited by distance and physical barriers, health professionals can now reach patients and other practitioners with ease. M-Health Innovations for Patient-Centered Care is a pivotal reference source for the latest scholarly research on the incorporation of mobile telecommunication devices in the health field and how this technology has increased overall quality of care. Highlighting various types of available technologies, necessary support infrastructures, and alterations in business models, this publication is ideally designed for medical professionals, upper-level students, and e-health system designers interested in the effects of mobile technology on healthcare delivery.

Volume forty-four of the Advances in Clinical Chemistry series contains review articles of wide interest to clinical laboratory scientists and diagnostic adventurers. Articles in this volume cover such topics as Caspases in Myocardial Infarction; Deamidated Gliadin Peptides as Targets for Celiac Disease Specific Antibodies; Urokinase Receptor Variants in Tissue and Body Fluids; Proteomics in Cancer; Paraneoplastic Neurological Syndromes and Oncnerual Antibodies: Clinical and Immunological Aspects; Pathophysiologic Mechanisms of Angiogenesis; Bikunin (Urinary Trypsin Inhibitor): Structure, Biological Relevance and Measurement; and Gene Expression Assays.

RNA processing plays a critical role in realizing the full potential of a given genome. One means of achieving protein diversity is through RNA editing. A diverse array of editing events has been characterized, affecting gene expression in organisms from viruses and single cell parasites to humans and plants. The variety of editing mechanisms has required the development of many different experimental approaches, many of which are likely to be broadly applicable, particularly given the interplay between editing and other cellular processes, including transcription, splicing, and RNA silencing. This volume not only covers most of the principal methods employed in the field, but also offers innovative solutions to the significant challenges posed by these experimental systems.
* Presents newly developed methods
* Covers topics ranging from biochemistry to bioinformatics
* Includes innovative solutions to potential problems

Volume forty-three of the Advances in Clinical Chemistry series contains review articles of wide interest to clinical laboratory scientists and diagnostic adventurers. In this volume, the biochemistry of bilirubin, the endproduct of heme metabolism, is explored with respect to its potential beneficial role in preventing oxidative changes associated with a variety of pathological conditions including atherosclerosis, cancer, inflammatory, autoimmune and other degenerative diseases.

Healthcare Information Systems and Informatics: Research and Practices compiles estimable knowledge on the research of information systems and informatics applications in the healthcare industry. This book addresses organizational issues, including technology adoption, diffusion, and acceptance, as well as cost benefits and cost effectiveness, of advancing health information systems and informatics applications as innovative forms of investment in healthcare. Rapidly changing technology and the complexity of its applications make this book an invaluable resource to researchers and practitioners in the healthcare fields.

Thomas Addison, a physician from the North of England, was acutely ill, and he knew it. The profession of medicine had been his life. Students and patients flocked to Guy's Hospital in London because he taught and worked there. He had no rival in Britain during the early Victorian era.

Addison taught his students that most people resisted new ideas even when society benefitted from them and that people were unwilling to admit the merits of a great discovery. This would prove to be true particularly in the case of his own discoveries. Addison weathered five years of scorching criticism from his peers when he discovered that the adrenal glands were essential to life and that diseased adrenal glands could darken a white person's skin to mulatto hues. In the end, he experienced an unshakable depression that ultimately led to suicide.

Medical science subsequently validated Addison's ingenious discoveries, which led other investigators to isolate and identify epinephrine, the adrenocortical steroids, and even vitamin B12.

In this biography, author Margaret R. O'Leary, MD, presents Addison's life story, considering his reception during his lifetime and recognizing his profound contributions to modern medicine.

This issue of Heart Failure Clinics, guest edited by Antonio Cittadini and Hector O. Ventura, will cover key topics in Emerging Comorbidities in Heart Failure. This issue is one of four selected each year by our series consulting editor, Dr. Eduardo Bossone. Topics discussed in this issue will include: Anabolic deficiencies in Heart Failure, Thyroid Abnormalities in Heart Failure, The Gut Axis Involvement in Heart Failure: focus on trimethylamine N-oxide (TMAO), Chronic Obstructive Pulmonary Disease and Heart Failure, When Pulmonary Hypertension complicates Heart Failure, Sex and Gender-related Issues in Heart Failure, Cardiac Cachexia Revisited: The Role of Wasting in Heart Failure, Atrial Fibrillation in Heart Failure, The Impact of Obesity in Heart Failure, Sleep Breathing Disorders in Heart Failure, The Cardiorenal Syndrome in Heart Failure, Psychological Disorders in Heart Failure, Hypertension in Heart Failure, among others.

Advances in Anesthesia highlights the year's significant medical advances, providing one source to review the essential information updates for the Anesthesiologist in that year. The distinguished editorial board, led by Dr. Thomas McLoughlin, includes Drs. Richard Dutton, Laurence Torsher, and Francis Salinas. The board has assembled a first-rate volume for 2019."