Introduces an assortment of powerful command line utilities that can be combined to create simple, yet powerful shell scripts for processing datasets. The code samples and scripts use the bash shell, and typically involve small datasets so you can focus on understanding the features of grep, sed, and awk. Companion files with code are available for downloading from the publisher.

This volume explores the latest available wet-lab techniques and computational methods to study in-cell small-molecule behavior and interactions with their targets. The chapters in this book discuss topics such as disease-relevant models for chemical biology studies, target engagement using cellular thermal shift assay or bioluminescence resonance energy transfer; visualization of bio-active small molecules Raman microscopy; (phospho-)proteomics and transcriptomics for mode-of-action studies, CRISPR/Cas9-based chemogenomic profiling in mammalian cells; predicting drug interactions using computational approaches; comparison of compound-induced profiles using high-content imaging or cancer cell line panels and web-based tools for polypharmacology prediction. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Systems Chemical Biology: Methods and Protocols is a valuable resource for novice or expert scientists and researchers trying to initiate or continue their chemical biology studies at a systems level.

In today's modernized environment, a growing number of software companies are changing their traditional engineering approaches in response to the rapid development of computing technologies. As these businesses adopt modern software engineering practices, they face various challenges including the integration of current methodologies and contemporary design models and the refactoring of existing systems using advanced approaches. Applications and Approaches to Object-Oriented Software Design: Emerging Research and Opportunities is a pivotal reference source that provides vital research on the development of modern software practices that impact maintenance, design, and developer productivity. While highlighting topics such as augmented reality, distributed computing, and big data processing, this publication explores the current infrastructure of software systems as well as future advancements. This book is ideally designed for software engineers, IT specialists, data scientists, business professionals, developers, researchers, students, and academicians seeking current research on contemporary software engineering methods.

Social media has redefined the way marketers communicate with their customers, giving consumers an advantage that they did not have previously. However, recent issues in online communication platforms have increased the challenges faced by marketers in developing and retaining their customers. Practitioners need to develop effective marketing communication programs that incorporate the meaningful forms of sociality into a customer-driven marketing program. Leveraging Computer-Mediated Marketing Environments discusses the nature of heightened interaction between marketers and consumers in the evolving technological environments, particularly on the central nature of online communities and other emerging technologies on dialogic engagement. Additionally, it aims to examine the relevant roles of online communities and emerging technologies in creating and retaining customers through effective dialogue management. Highlighting brand strategy, e-services, and web analytics, it is designed for marketers, brand managers, business managers, academicians, and students.

Innovation is a time-consuming process that involves invention as a beginning and a marketable service or product as an end. But innovation itself, once concluded, is not necessarily a constructive act as some innovations yield positive and some negative results. The way we recognize and develop innovation - so often a serendipitous and almost invisible act in its beginning - is thus a matter of primary importance in today's world where new thoughts and products play such a crucial role in economies across the globe. Nowhere is the general support structure required for success in innovation more starkly illuminated than in the fields of science and medicine, where human well-being is so manifestly at stake. In this work, which draws together the perspectives of a multidisciplinary group of professionals - medical doctors, innovation policy analysts, and academics in business management - Shantha Liyanage and his colleagues provide a thorough examination of the technology innovation process, and display its critical links with organizational functions, so the innovative capacities of organizations can be better prepared to meet the rapid changes of our age.

The exponential digitization of medical data has led to a transformation of the practice of medicine. This change notably raises a new complexity of issues surrounding health IT. The proper use of these communication tools, such as telemedicine, e-health, m-health the big medical data, should improve the quality of monitoring and care of patients for an information system to "human face". Faced with these challenges, the author analyses in an ethical angle the patient-physician relationship, sharing, transmission and storage of medical information, setting pins to an ethic for the digitization of medical information. Drawing on good practice recommendations closely associated with values, this model is developing tools for reflection and present the keys to understanding the decision-making issues that reflect both the technological constraints and the complex nature of human reality in medicine .

Computational Methods for Agricultural Research: Advances and Applications brings computing solutions to ancient practices and modern concerns, sowing the seeds for a sustainable, constant food supply. This book treats subjects as old modeling flood patterns and predicting potential climates to distinctly 21st century topics such as pesticide leaching models and the impact of agricultural policy. All of these studies utilize cutting-edge computational techniques of interest to both academics and practitioners in agriculture but also computational modeling researchers, creating a reference practical significance.

Applications and Developments in Grid, Cloud, and High Performance Computing provides insight into the current trends and emerging issues by investigating grid and cloud evolution, workflow management, and the impact new computing systems have on the education fields as well as the industries. This book is practical for both researchers and IT professionals.

The utilization of information and communication technologies in almost all spheres of modern society has changed the social picture in significant ways while simultaneously leading to tensions with regard to traditional ethical and legal practices-particularly given the global context of its application. Where these technologies impact on the practice and implementation of healthcare, it is vital to recognize the extent and nature of the ethical and social impact both at the level of professional practice and the patient. Ethical, Legal and Social Issues in Medical Informatics presents a fundamental compendium of research on the ethical, social, and legal issues facing the healthcare industry as it adopts information technologies to provide fast, efficient, and cost effective healthcare. An essential resource for every reference library, this comprehensive book offers a multidisciplinary perspective, drawing from the expertise of a wide variety of global industries including law, ethics, medicine, philosophy, and computer science.

The association of personal time management research with calendar applications has remained a relatively under-researched area due to the complexity and challenges it faces. ""Temporal Structures in Individual Time Management: Practices to Enhance Calendar Tool Design"" covers the latest concepts, methodologies, techniques, tools, and perspectives essential to understanding individual time management experiences. Emphasizing personal temporal structure usage involving calendar tools, this book provides both qualitative and quantitative evidences and insights valuable for researchers and practitioners in enhancing current electronic calendar systems design and implementation.

Discrete event simulation environments have desirable features and components now driving researchers to develop and enhance existing environments. ""The Handbook of Research on Discrete Event Simulation Environments: Technologies and Applications"" provides a comprehensive overview of theory and practice in simulation systems. A leading publication in this growing field, this Handbook of Research offers researchers, academicians, and practitioners progressive findings in simulation methodologies, modeling, standards, and applications.

This book comprises the proceedings of the 4th International Conference on Computational Engineering (ICCE 2017), held in Darmstadt, Germany on September 28-29, 2017. The conference is intended to provide an interdisciplinary meeting place for researchers and practitioners working on computational methods in all disciplines of engineering, applied mathematics and computer science. The aims of the conference are to discuss the state of the art in this challenging field, exchange experiences, develop promising perspectives for future research and initiate further cooperation. Computational Engineering is a modern and multidisciplinary science for computer-based modeling, simulation, analysis, and optimization of complex engineering applications and natural phenomena. The book contains an overview of selected approaches from numerics and optimization of Partial Differential Equations as well as uncertainty quantification techniques, typically in multiphysics environments. Where possible, application cases from engineering are integrated. The book will be of interest to researchers and practitioners of Computational Engineering, Applied Mathematics, Engineering Sciences and Computer Science.

There is a broad consensus amongst law firms and in-house legal departments that next generation "Legal Tech" - particularly in the form of Blockchain-based technologies and Smart Contracts - will have a profound impact on the future operations of all legal service providers. Legal Tech startups are already revolutionizing the legal industry by increasing the speed and efficiency of traditional legal services or replacing them altogether with new technologies. This on-going process of disruption within the legal profession offers significant opportunities for all business. However, it also poses a number of challenges for practitioners, trade associations, technology vendors, and regulators who often struggle to keep up with the technologies, resulting in a widening regulatory "gap." Many uncertainties remain regarding the scope, direction, and effects of these new technologies and their integration with existing practices and legacy systems. Adding to the challenges is the growing need for easy-to-use contracting solutions, on the one hand, and for protecting the users of such solutions, on the other. To respond to the challenges and to provide better legal communications, systems, and services Legal Tech scholars and practitioners have found allies in the emerging field of Legal Design. This collection brings together leading scholars and practitioners working on these issues from diverse jurisdictions. The aim is to introduce Blockchain and Smart Contract technologies, and to examine their on-going impact on the legal profession, business and regulators.

The interrelation of globalization, communication, and media has prompted many individuals to view the world in terms of a new dichotomy: the global "wired" (nations with widespread online access) and the global "tired" (nations with very limited online access). In this way, differing levels of online access have created an international rift - the global digital divide. The nature, current status, and future projections related to this rift, in turn, have important implications for all of the world's citizens. Yet these problems are not intractable. Rather, with time and attention, public policies and private sector practices can be developed or revised to close this divide and bring more of the world's citizens to the global stage on a more equal footing. The first step in addressing problems resulting from the global digital divide is to improve understanding, that is, organizations and individuals must understand what factors contribute to this global digital divide for them to address it effectively. From this foundational understanding, organizations can take the kinds of focused, coordinated actions needed to address such international problems effectively. This collection represents an initial step toward examining the global digital divide from the perspective of developing nations and the challenges their citizens face in today's error of communication-driven globalization. The entries in this collection each represent different insights on the digital divide from the perspectives of developing nations - many of which have been overlooked in previous discussions of this topic. This book examines globalization and its effects from the perspective of how differences in access to online communication technologies between the economically developed countries and less economically developed countries is affecting social, economic, educational, and political developments in the world's emerging economies. This collection also examines how this situation is creating a global digital divide that will have adverse consequences for all nations. Each of the book's chapters thus presents trends and ideas related to the global digital divide between economically developed countries and less economically developed nations. Through this approach, the contributors present perspectives from the economically developing nations themselves versus other texts that explore this topic from the perspective of economically developed countries. In this way, the book provides a new and an important perspective to the growing literature on the global digital divide. The primary audiences for this text would include individuals from both academics and industry practitioners. The academic audience would include administrators in education; researchers; university, college, and community college instructors; and students at the advanced undergraduate and graduate levels.

Significant research and development advancement has been achieved in enterprise computing, integration, and management. The results of this advancement stimulate the creation of a new class of mission-critical infrastructures, a new category of integration methods and software tools, and a new group of business platforms for cost-effectively exploiting, integrating, and managing business operations across enterprises. ""Enterprise Service Computing: From Concept To Deployment"" presents the emerging service computing, or service-enabled computing, technologies currently preferably used in integrating enterprise-wide and cross-enterprise applications. The topics covered range from concept development, system design, modeling, and development technologies, to the final deployment, providing both theoretical research results and practical applications.

After a short description of the key concepts of big data the book explores on the secrecy and security threats posed especially by cloud based data storage. It delivers conceptual frameworks and models along with case studies of recent technology.

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