Ribonucleic acid (RNA) binding proteins currently number in the thousands and defects in their function are at the heart of diseases such as cancer and neurodegeneration. RNA binding proteins have become implicated in the intricate control of surprisingly diverse biological settings, such as circadian rhythm, stem cell self-renewal, oncogenesis and germ cell development. This book surveys a range of genome-wide and systems approaches to studying RNA binding proteins, the importance of RNA binding proteins in development, cancer and circadian rhythm.

Aromatase Inhibitors (AIs) treat postmenopausal estrogen receptor positive tumours, which constitute the majority of breast cancer patients. This comprehensive volume brings together the current knowledge from different relevant areas, including molecular mechanisms and translational aspects of drug resistance in AIs. Topics covered include research, experimental , and clinical data specifically focused on AI resistance in breast cancer. The volume will include three sections. The first section covers general knowledge about aromatase inhibitors, including regulation of aromatase genes, and structure and function of aromatase protein. The second section provides the detailed mechanisms of resistance to AIs, while the third section explores prediction of resistance and potential strategies to overcome resistance. Breast cancer is the most common female cancer and AIs significantly improve treatments outcomes compatibly to previously used endocrine treatments. However 10-15% of post-operative patients develop a relapse during adjuvant treatment with AIs; about 25-50% of the patients do not respond to AIs in neo-adjuvant or metastatic setting, and the majority of metastatic patients who initially respond develop resistance within 3 years. There is an important need to understand these mechanisms of resistance in order to develop methods of preventing or overcoming the resistance to AIs, which will ensure a more successful outcome in treating breast cancer.

What happened along the evolutionary trail that made humans so unique? In his accessible style, Michael Gazzaniga pinpoints the change that made us thinking, sentient humans different from our predecessors. He explores what makes human brains special, the importance of language and art in defining the human condition, the nature of human consciousness, and even artificial intelligence.

Ataxia-telangiectasia (A-T) is a rare and severe genetic disorder affecting children. A-T is a multisystem disease characterized by progressive neurodegeneration, immunodeficiency and cancer predisposition. This detailed volume explores the ever expanding field of research into the ATM (ataxia-telangiectasia, mutated) gene and the role played by ATM kinase in DNA damage signaling and diverse cellular processes. What follows is a handy desktop reference for both seasoned A-T researchers and postgraduate students, as it demonstrates the breadth of recent developments in A-T studies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Both classic and cutting-edge techniques are described, including ATM gene mutation detection, assays for radiosensitivity and radioresistant DNA synthesis, new methods to measure ATM kinase activity by imaging microscopy and high content screening as well as proteomics, phosphoproteomics and bioinformatics approaches to decipher ATM-dependent signalling pathways. Additional methods include generation of patient-specific stem cells and approaches to study ATM functions in the nervous system. Comprehensive and practical, ATM Kinase: Methods and Protocols aims to ignite and attract the interest of colleagues from diverse fields to A-T research in an effort to bring their expertise and fresh ideas to resolve many A-T puzzles still waiting to be pieced together and to alleviate the suffering of A-T children and their families.

Designed specifically to meet the unique needs of students studying to become rehabilitation professionals - including physical therapists, occupational therapists, and chiropractors - this full-color dissection guide helps you connect discoveries in the dissection lab with function and pathology. With the necessary technical information you need - including content on applied anatomy, embryology, and structural histology - in 25 laboratory exploration chapters, this unique guide uses case studies and critical thinking exercises to encourage you to explore human anatomy, synthesize your findings, and apply your knowledge to clinical practice. Extensive coverage of the musculoskeletal and nervous system emphasizes the information on muscles, vertebral column, and the upper and lower extremities that you need as a rehabilitation health professional. Clinical cases, thought-provoking questions, clinical notes, and review exercises encourage you to explore through dissection and apply what you've learned to real-life practice. Sections on embryology and histology provide important insights into the origin and nature of adult anatomy and follow the national guidelines for physical therapy anatomy curricula. References to the most popular human anatomy atlases - Netter's, Gray's, Grant's, and Clemente's - allow for flexibility of use in any program. Emphasis on variations in anatomy reinforces the real-life diversity among patients. Over 200 full-color illustrations clearly demonstrate anatomy and dissection processes.

This book presents the anatomical systems that take part in the scientific and clinical study of emotional functions and neuropsychiatric disorders. It discusses the limbic system-the cortical and subcortical structures in the human brain involved in emotion, motivation, and emotional association with memory-at length and how this is no longer a useful guide to the study of psychiatric disorders. The book provides an understanding of brain anatomy, with an emphasis on the new anatomical framework which has emerged during the last quarter century. The goal is to help the reader develop an understanding of the gross anatomical organization of the human forebrain.
The book also includes an enlightening DVD describing the basic surface anatomy of the cerebral hemispheres, coronal and horizontal sections, and blunt dissection of the forebrain with special attention to clinical-anatomical correlations of interest to psychiatrists.
* A re-evaluation of brain anatomy, with an emphasis on the new anatomical framework which has emerged during the last quarter century
* A compellingly expanded conceptualization of Broca's famous limbic lobe
* Clinical and basic science boxes highlighting specific concepts, structures, or neuronal circuits from a clinical perspective
* DVD illustrating dissection of the human brain by one of the world's masters

This volume provides current methods and protocols for gene and protein delivery based on both lentivirus-generated and spontaneously released nanovesicles. Lentiviral Vectors and Exosomes as Gene and Protein Delivery Tools guides readers through methods on macromolecule delivery and chapters describe the LV-based protocols of gene engineering. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Lentiviral Vectors and Exosomes as Gene and Protein Delivery Tools aims to ensure successful results in the further study of this vital field.

This book discusses the molecular, biological, pathological, and clinical aspects of melanoma, with special emphasis in the new concepts of melanoma genetics. A multidisciplinary group of experts in Genetics, Dermatology, Pathology, and Melanoma Medical Oncology contribute state-of-the-art knowledge in melanoma research and clinical management, not only exposing the current status of knowledge of the topics but also providing their personal experiences and ideas about the future and potential practical application of the genetic aspects of melanoma. During the last few years we have witnessed an impressive amount of discoveries in the field of melanoma genetics which have changed our approach in understanding the pathogenesis and treatment of this lethal disease. Genetics of Melanoma is a practical approach to melanoma genetic mechanisms and their application in the diagnosis and treatment of this malignancy. It is an essential source of updated information and a powerful tool for clinicians, pathologists, and basic scientists who wish to understand, apply, and investigate the multiple new aspects of melanoma genetics.

This volume details protocols for genetic, molecular, cytological, and bioinformatic methods for determining haplotypes. Haplotyping: Methods and Protocols guides readers through methods that directly type haploid cells, difficult-to-resolve gene families, high-resolution, short range haplotyping for targeted loci, and long-range haplotyping for whole chromosomes or genomes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical Haplotyping: Methods and Protocols, aims to provide researchers with an overview of experimental methods for haplotyping.

The craniofacial musculature, including the extraocular muscles, muscles associated with the

auditory system, the masseter, the tongue, and the laryngeal and pharyngeal muscles, all

participate in functions that are critical to life: vision, intact of nutrition, breathing, and hearing.

Despite their critical importance, the majority of research on skeletal muscle basically has

ignored this collection of muscles. This is most likely due to their complexity in form,

development, fiber types, physiology, and disease profiles. All these make these muscles

extremely difficult to study.

Vision depends on voluntary and reflexive eye movements initiated by the oculomotor system.

The effector arm of this motor system includes the extraocular muscles and their motor neurons.

Mastication, and therefore food intake, depends on the complex movements of the masseter and

tongue musculature. The effector arm of this motor system includes the masseter and tongue

muscles and their motor neurons. Respiration, human phonation, as well as gestation, depend on

the laryngeal and pharyngeal musculature. The effector arm of these motor systems includes the

intrinsic and extrinsic laryngeal muscles and the pharyngeal muscles and their motor neurons.

Recently there has been a renewed interest in understanding the basic cell biology and

pathologies associated with these unusual skeletal muscles. This book will highlight novel

findings on the development of these muscles and their innervation, metabolic design, functional

consequences of their structural organization, and potential reasons for their differential response

to various neuromuscular diseases. In addition, critical areas for future studies will be identified.

Now in its fourteenth edition, this best-selling textbook has been honed over many years to provide a clear, straightforward introduction to the human body for students of nursing, allied health or biomedical and paramedical science. The book covers the core essentials of anatomy and physiology, including basic pathology and pathophysiology of important diseases and disorders. This new edition presents additional illustrations to enhance understanding of key concepts, including pathophysiology and diagnostics. Included for the first time is an introduction to surface anatomy, while other updating reflects current scientific knowledge and developments, including coronavirus. Enhanced learning features and an extensive online resource help you grasp all the important areas. Like millions of readers before you, you will treasure Ross & Wilson as a go-to resource that you will refer to time and again to support this critical aspect of your healthcare education. Clear and easy to read - suitable for students new to the area and anyone whose first language is not English Hundreds of stunning illustrations and images to make learning easy Helpful learning features such as Learning Outcomes boxes, colour coding and orientation icons to facilitate navigation Definitions of common prefixes, suffixes and roots, examples, glossary and an appendix of normal biological values Self-assessment activities in each chapter, including 'spot check' questions for each section and case studies with answers to develop understanding of key principles Accompanying website with animations, videos, audio-glossary and other self-assessment material Evolve Study Resources Online content offered with Ross & Wilson Anatomy and Physiology in Health and Illness 14th edition includes: New for this edition - a set of expert-narrated 3D videos summarizing key topics in the book, powered by Complete Anatomy: the world's most advanced 3D anatomy platform Over 120 animations clarifying underlying principles and make learning fun More than 1700 audio glossary entries Body Spectrum (c) online colouring and self-test software Self-assessment questions to help students test their knowledge

Powerful human anatomy desktop easel reference in 21 pages with more detailed illustrations and labeled parts per page than any other reference tool. Pages are laminated, making them rip and spill-proof and are spiral bound with an easel-stand making this a desktop reference that stands tall on your desk for hands-free reading. Simply flip pages to find the system you need to reference. Beautifully illustrated by award-winning anatomical artist Vincent Perez. There is no other source that offers this much anatomical reference in this amount of space and for this price. Systems covered include: Muscular System Origins & Insertions Skeletal System Joints & Ligaments Nervous System The Brain Cutaneous Innervation Circulatory System Heart Lymphatic System Digestive System & Viscera Respiratory & Urinary Systems Reproductive System Micro Anatomy Suggested uses: Students -- establish your core memory of human anatomy whether you will be a nurse, physical therapists, pre med, or even a massage therapist Medical Coders -- spiral reference stands upright on the desk for easy flip-through reference Medical Administration -- quick reference tool for the important roles on the other side of the medical profession

Bioinformatics as a discipline has come of age, and there are now numerous databases and tools that are widely used by researchers in the biomedical field. However, successful development of future bioinformatics applications will depend on an appropriately formalised representation of domain knowledge.

This book provides a timely and first-of-its-kind collection of contributed chapters on anatomy ontologies. It is interdisciplinary in its approach, bringing together relevant expertise from computing and biomedical studies, and covering both theoretical and applied aspects, with an emphasis on newer work relevant to the emerging Semantic Web.

Topics and Features:

a [ Provides a comprehensive discussion of the foundations of anatomical ontologies and the state of the art in existing computational tools and applications

a [ Considers a number of fundamental modelling principles

a [ Includes chapters about research on algorithms to systematically align anatomy ontologies and to mine data in the literature, using anatomy terms

a [ Explains recent efforts to develop a common anatomy reference ontology

a [ Discusses anatomy in the context of spatio-temporal biomedical atlases

a [ Describes systems and tools for linking anatomy ontologies with each other and with other on-line resources, such as the biomedical literature

a [ Highlights the challenges of dealing with anatomy-based information on the Semantic Web

Although primarily written for readers who will be involved in developing the next generation of IT applications in the areas of life sciences, biomedical sciences and health care, this unique volume will be of interest to anyone who will furtherdevelop anatomy ontologies, who will use them, and who will be involved in the actual development of relevant (semantic) web applications.

The first book to provide a detailed analysis of the body-trafficking networks of the dead poor that underpinned the expansion of medical education from Victorian times. With an even-handed approach to the business of anatomy, Hurren uses remarkable case histories which still echo a vibrant body-business on the internet today in a biomedical age.

Written for the UK's Access to Higher Education program, yet universally accessible, Access to HE: Anatomy and Physiology provides an easy-to-understand text with diagrams and straightforward notes explaining the human body's structure and systems. The broader issues of progress in disease control and the links between stress and health are also examined in this textbook. This vital introductory source will benefit students entering the health profession.

The revised fourth edition includes new chapters on medical ethics, embalming techniques and decomposition of body, back and vertebral column, ethical issues in medical genetics, attitude and communication skills, and x-rays. In each chapter, SAQs are arranged by topic. More than 700 new SAQs have been added in this edition. Useful for undergraduate students and students who are preparing for postgraduate entrance examinations. SAQs will also help the students to answer the MCQs on the same topic. In the Gross Anatomy section, in the beginning of each chapter SAQs on osteology are given, which are useful to the students for viva examinations More than 700 new SAQs have been added in this edition.

Hypoxia remains a constant threat throughout life. It is for this reason that the International Hypoxia Society strives to maintain a near quarter century tradition of presenting a stimulating blend of clinical and basic science discussions. International experts from many fields have focused on the state-of-the-art discoveries in normal and pathophysiological responses to hypoxia.

Topics in this volume include gene-environment interactions, a theme developed in both a clinical context regarding exercise and hypoxia, as well as in native populations living in high altitudes. Furthermore, experts in the field have combined topics such as skeletal muscle angiogenesis and hypoxia, high altitude pulmonary edema, new insights into the biology of the erythropoietin receptor, and the latest advances in cardiorespiratory control in hypoxia. This volume explores the fields of anatomy, cardiology, biological transport, and biomedical engineering among many others.

Gain the hands-on practice needed to understand anatomical structure and function! Anatomy & Physiology Laboratory Manual and eLabs, 11th Edition provides a clear, step-by-step guide to dissection, anatomy identification, and laboratory procedures. The illustrated, print manual contains 55 A&P exercises to be completed in the lab, with guidance including instructions, safety tips, and tear-out worksheets. Online, eight eLab modules enhance your skills with simulated lab experiences in an interactive 3-D environment. From noted educators Kevin Patton and Frank Bell, this laboratory manual provides you with a better understanding of the human body and how it works. Labeling exercises and coloring exercises make it easier to identify and remember critical structures examined in the lab and in lectures. Step-by-step "check-box" dissection instructions with accompanying illustrations and photos cover anatomical models and fresh or preserved specimens - and provide helpful guidance during dissection labs. Tear-out Lab Reports contain checklists, drawing exercises, and questions that help demonstrate your understanding of the labs you have participated in, and also allow instructors to check your progress. 250 illustrations include photos of cat, pig, and mink dissections, photos of various bones, microscopic and common histology slides, and depictions of proper procedures. Complete lists of materials for each exercise provide handy checklists for planning and setting up laboratory activities, allowing for easy and efficient preparation. Modern anatomical imaging techniques, such as computed tomography (CT), magnetic resonance imaging (MRI), and ultrasonography, are introduced to demonstrate how new technologies are changing and shaping health care. Review questions throughout the manual provide tools to reinforce and apply your knowledge of anatomy and function concepts. Eight eLabs improve the laboratory experience in an interactive digital environment. Convenient spiral binding allows for hands-free viewing in the lab setting. Hint boxes provide special tips on handling specimens, using equipment, and managing lab activities. Learning objectives at the beginning of each exercise offer a clear framework for learning. NEW! More photos of various types of bones help you learn skeletal anatomy. NEW! More microscope slide images, including "zooming in" at high-power magnification, help you learn microscopic anatomy. NEW! Updated lab tests align with what is currently in use in today's lab environment. NEW! Thorough revision of all chapters covers the latest anatomy and physiology lab exercises.

Further management strategies including clinimetry, cranio-cervical posture and 'psychological' management of chronic facial pain are described and discussed in relation to their integration in daily practice. Difficult clinical problems such as cervical headache, chronic ear pain in children, KISS syndrome, facial paralysis, tinnitus, craniomandibular dysfunction amongst others are described and discussed. A clinical reasoning approach to problem solving is emphasized throughout. This book is recommended for those interested in manual assessment and management of the craniofacial region including clinicians, physiotherapists, dentists, orthodontics, ENT-specialists, neurologists, maxillofacial surgeons, chiropractors and osteopaths. Foreword by Professor Mariano Racobado, Santiago, Chile. Contributors: HAJ Oudhof: Skull Growth in relation to mechanical stimulation Dr H Biedermann: Features of cranial tissue as a basis for clinical pattern recognition on management Dr med H Biederman: Primary and secondary cranial asymmetry in Kiss-children R Spermon-Marijne: Manual Therapy of the craniofacial region as therapeutic Dr J R Spermon: approach in children with long term ear disease P Westerhuis: Cervicogenic headache: a clinician's perspective and Cervicogenic Headache, physical examination and management David Butler: Experience of pain and the craniofacial region D Fitzgerald and Lynn Bryden: The influence of posture and alteration of function upon the cranio-cervical and craniofacial region M Jones: Clinical reasoning. A basis for examination and treatment in the cranial region F Winters: Pain management by patients with chronic craniofacial pain G Aufdemkampe: The relevance of clinimetrie by patients with cranial facial pain * Prestigious text with expert international contributors including acclaimed anatomists and cranial morphologists * Highly practical text with a page of text facing a page of high quality black and white photographs * Geoff Maitland has endorsed this text