The second edition of Fascia: What It Is and Why It Matters, the first being the "must-have" book for everyone wanting to learn more about fascia as a tissue and a system, maintains the high standard of the first book while expanding on everything that made it so popular. By focusing first on the fundamentals of fascia as a tissue that surrounds, supports, and permeates all the muscle, bones, nerves, and organs, Lesondak takes the reader on a journey throughout their entire body from the perspective of the fascial system, making many stops along the way to make sure the reader understands what it is that's important and why it matters to the body. From the new rules of biomechanics, biotensegrity, cellular processes, musculoskeletal issues, proprioception, neuroscience and cognition, somatic dysfunction, and restoration-Lesondak deftly weaves it all together with a deep appreciation for the history of science, fine storytelling sensibilities, and a sense of humor as well as a sense of wonder.

The book provides an updated overview of molecular analysis of human tissues, and the impact this analysis has on diagnosis and prognosis of human diseases. Special emphasis is placed on human cancer and the future directions of the field. Methods of handling clinical tissue samples, including the impact of handling on subsequent molecular analysis, are also discussed. In addition, detailed protocols for molecular analysis of DNA, RNA and protein, with special emphasis on molecular analysis of highly complex human tissue samples containing mixtures of cell populations, are provided.

For centuries, humankind has sought to know itself through an understanding of the body, in sickness and in health, inside and out. This fascination left in its wake a rich body of artworks that demonstrate not only the facts of the human body, but also the ways in which our ideas about the body and its proper representation have changed over time. At times both beautiful and repulsive, illustrated anatomy continues to hold our interest today, and is frequently referenced in popular culture. Anatomica brings together some of the most striking, fascinating and bizarre artworks from the 16th through to the 20th century, exploring human anatomy in one beautiful volume.

During the past decade, great strides have been made in our un derstanding of the biochemistry and pharmacology of the alpha-l adrenergic receptor. The alpha-l adrenergic receptor plays a key role in biological function. This is evidenced by the fact that the alpha-l adrenergic receptor plays a prominent functional role in most organs of the body and in the key systems responsible for survival of the organism and maintenance of optimum biological activity. This is most apparent in the cardiovascular system, in which alpha-l adrenergic receptors are the single most important receptor involved in the maintenance of blood pressure and circu latory function. It is appropriate, therefore, that recent findings related to the pharmacology and biochemistry of the alpha-l adrenergic receptor be compiled, since this subject has not been reviewed in detail in recent years. It is the purpose of this book to present a series of reviews of key experimental findings that shed new light on the alpha-l adrenergic receptor and the manner in which it functions. Classically, most receptors have been characterized based on structure-activity relationships obtained for selective agonists and antagonists interacting with the receptor. Although there are many newer and more sophisticated approaches to receptor char acterization, structure-activity relationships still provide impor tant information regarding the chemical requirements made by the receptor for its occupation by ligands and its subsequent acti vation by those ligands possessing intrinsic efficacy and, there fore, agonist activity."

1) Classic anatomical atlases 2) Detailed labeling of the earliest phases of prenatal neurological development 3) Appeals to neuroanatomists, developmental biologists and clinical practitioners. 4) Persistent relevance - brain development is not going to change

Despite extensive physiological, biochemical, and structural studies, the mechanisms of muscle contraction operating in living muscle fibres are still not clearly understood. This book aims to describe and assess various experimental methods currently used in the field of muscle research. For
each method discussed, there is a comprehensive description of its advantages, problems, and limitations. Each chapter also contains a summary of the central results to have been obtained using each method. Comprehensively written by experts in their respective fields, this book will be of interest
to all investigators in muscle physiology.

In this issue of Neuroimaging Clinics, guest editor Dr. Tarik F. Massoud brings his considerable expertise to the topic of Neuroimaging Anatomy, Part 2: Head, Neck, and Spine. Anatomical knowledge is critical to reducing both overdiagnosis and misdiagnosis in neuroimaging. This issue is part two of a two-part series on neuroimaging anatomy that focuses on the head, neck, and spine. Each article addresses a specific area such as the orbits, sinonasal cavity, temporal bone, pharynx, larynx, and spinal cord. Contains 14 relevant, practice-oriented topics including anatomy of the orbits; maxillofacial skeleton and facial anatomy; temporal bone anatomy; craniocervical junction and cervical spine anatomy; anatomy of the spinal cord, coverings, and nerves; and more. Provides in-depth clinical reviews on neuroimaging anatomy of the head, neck, and spine, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

This book explores how daily and seasonal rhythmicity is generated, how these rhythms are synchronised by our environment, and how they regulate the neuroendocrine systems that impact our physiology and behaviour. The constraints of surviving in a seasonal environment have shaped human evolution and migration, have shaped our societies and cultures, and continue to influence our everyday lives, health and wellbeing. Identifying the mechanisms whereby seasonal rhythmicity is generated and regulates the brain and body is not only important for understanding the natural world and relevant to animal production, it also offers many insights into the human condition. Each chapter is written by an international expert in the field of chronobiology. A historical perspective on how research into photoperiodism and rhythmicity progressed is initially provided, but the main focus of this book is on the remarkable studies in the last few decades that have unravelled the molecular and cellular machinery underpinning circadian and circannual timing. Topics covered include the role of melatonin in communicating seasonal information to the brain and pituitary gland, the neuroanatomical pathways in mammals, birds and fish by which changes in photoperiod reach the hypothalamus, the role of glial cells (tanycytes) and thyroid hormone in seasonal rhythmicity, neuroplasticity across seasons, effects of changing day length on mood, regulation of "clock" gene expression, and the role of the suprachiasmatic nucleus. This book will appeal to all students and researchers who wish to learn about current and past research on daily and seasonal rhythmicity. This is the tenth volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series (Volumes 1-7 published by Wiley) that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology.

First published in 1967, Human Guinea Pigs is a report by a consultant physician on the implications of medical research on both the medical profession and on the men, women and children who are the subjects of medical experiments. It suggests that there are limits to the permissibility of experiments on humans. It points out how it has become a common occurrence for medical investigators to take risks with patients of which the patients themselves are frequently unaware, and to submit them to mental and physical distress and possible hazards which in no way are necessitated by or have connection with the treatment of the disease from which are suffering. The author describes a number of experiments which, in his opinion, raise important problems. In his view, medical research must go on, but there must be acknowledged and observed safeguards for patients. This book will be of interest to students of medicine, ethics, law, politics and social work.

1) Classic anatomical atlases 2) Detailed labeling of the earliest phases of prenatal neurological development 3) Appeals to neuroanatomists, developmental biologists and clinical practitioners. 4) Persistent relevance - brain development is not going to change.

1) Classic anatomical atlases 2) Detailed labeling of the earliest phases of prenatal neorological development 3) Appeals to neuroanatomists, developmental biologists and clinical practioners. 4) Persistent relevantce - brain development is not going to change.

In this book, experts in the field provide comprehensive descriptions of the neuroanatomy of the hypothalamic neuroendocrine systems. The book begins with an extensive discussion on the structural components of the neuroendocrine systems. The reader will be introduced to the anatomy and biology of the hypothalamus and the pituitary. The human hypothalamus is presented in particular detail using state-of-the-art imaging techniques. In the next section, the neuroanatomy of traditional hypothalamo-hypophyseal systems is highlighted, with chapters describing magnocellular neuroendocrine cells and discussing the respective types of hypothalamic neurons that regulate various pituitary hormones. Following this detailed structural and anatomical description of the neuroendocrine system, the book's final section focuses on the hypothalamic control of neuroendocrine functions. This includes the control of circadian rhythm, metabolism and appetite via specific peptidergic circuits. This book provides essential information on the neuroanatomy and control of neuroendocrine systems, addresses cutting-edge research questions posed by recent advances in the development of potent neuroanatomical tools, and highlights the latest technologies used in neuroendocrinology research, making it a valuable reference guide for students, trainees and established researchers alike. This is the twelfth volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series, which aims to illustrate the highest standards and to encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology.

Kaufman's Atlas of Mouse Development: With Coronal Sections continues the stellar reputation of the original Atlas by providing updated, in-depth anatomical content and morphological views of organ systems.The publication offers written descriptions of the developmental origins of the organ systems alongside high-resolution images for needed visualization of developmental processes. Matt Kaufman himself has annotated the coronal images in the same clear, meticulous style of the original Atlas. Kaufman's Atlas of Mouse Development: With Coronal Sections follows the original Atlas as a continuation of the standard in the field for developmental biologists and researchers across biological and biomedical sciences studying mouse development.

This monograph offers a cross-system exchange and cross-modality investigation into brain-heart interplay. Brain-Heart Interplay (BHI) is a highly interdisciplinary scientific topic, which spreads from the physiology of the Central/Autonomous Nervous Systems, especially Central Autonomic Network, to advanced signal processing and modeling for its activity quantification. Motivated by clinical evidence and supported by recent findings in neurophysiology, this monograph first explores the definition of basic Brain-Heart Interplay quantifiers, and then moves onto advanced methods for the assessment of health and disease states. Non-invasive use of brain monitoring techniques, including electroencephalogram and function Magnetic Resonance Imaging, will be described together with heartbeat dynamics monitoring through pulseoximeter and ECG signals. The audience of this book comprises especially of biomedical engineers and medical doctors with expertise in statistics and/or signal processing. Researchers in the fields of cardiology, neurology, psychiatry, and neuroscience in general may be interested as well.

1) Classic anatomical atlases 2) Detailed labelling of the earliest phases of prenatal neurological development without abbreviations 3) Appeals to neuroanatomists, developmental biologists and clinical practioners 4) Persistent relevance - brain development is not going to change, but this Atlas offers updated terminology for primordial neural structures.

This third of 15 short atlases reimagines the classic 5-volume Atlas of Human Central Nervous System Development. This volume presents serial sections from specimens between 15 mm and 18 mm with detailed annotations, together with 3D reconstructions. An introduction summarizes human CNS development by using high-resolution photos of methacrylate-embedded rat embryos at a similar stage of development as the human specimens in this volume. The accompanying Glossary gives definitions for all the terms used in this volume and all the others in the Atlas. Features Classic anatomical atlas Detailed labeling of structures in the developing brain offers updated terminology and the identification of unique developmental features, such as germinal matrices of specific neuronal populations and migratory streams of young neurons Appeals to neuroanatomists, developmental biologists, and clinical practitioners A valuable reference work on brain development that will be relevant for decades

Completely revised and updated, The Human Body in Health & Disease, 8th Edition makes it easier to understand how the body works, both in typical conditions and when things change. Its easy-to-read writing style, more than 500 full-color illustrations, and unique Clear View of the Human Body transparencies keep you focused on the principles of anatomy, physiology, and pathology. Key features are Connect It! with bonus online content, concept maps with flow charts to simplify complex topics, and chapter objectives and active learning sections. From noted educator Kevin Patton, this book presents A&P in a way that lets you know and understand what is important. More than 500 full-color photographs and drawings illustrate the most current scientific knowledge and bring difficult concepts to life. The beautifully rendered illustrations are unified by a consistent color key and represent a diversity of human identity. A conversational writing style is paired with "chunked" content, making it easy to read and comprehend. UNIQUE! Creative page design uses color backgrounds to organize information in a more inviting, accessible, and motivating way to enhance learning. UNIQUE! The full-color, semi-transparent Clear View of the Human Body permits the on-demand virtual dissection of typical male and female human bodies along several body planes. This 22-page insert contains a series of transparencies that allows you to peel back the layers of the body anterior-to-posterior and posterior-to-anterior. Language of Science/Language of Medicine word lists at the beginning of chapters present key terms, pronunciations, and word-part translations to help you become familiar with new and complex terminology. Animation Direct feature throughout the text guides you to state-of-the-art animations on the companion Evolve website to provide dynamic visual explanations of key concepts. Active Concept Maps offer animated, narrated walk-throughs of concept maps to clarify the text narrative and provide you with clear examples of how to build your own concept maps.

The Geometric Induction of Bone Formation describes new biomimetic biomaterials that offer mechanistic osteogenic surfaces for the autonomous and spontaneous induction of bone formation without the addition of osteogenic soluble molecular signals of the transforming growth factor- supergene family. The chapters frame our understanding of regenerative medicine in primate species, including humans. The goal is to unravel the fundamental biological mechanisms of bone formation unique to non-human and human primates. The broad target audience dovetails with several disciplines both in the academic and private biotech sectors primarily involved in molecular biology, tissue biology, tissue engineering, biomaterial science, and reconstructive, orthopedic, plastic, and dental surgery. Key Features Includes outstanding images of undecalcified whole mounted sections Summarizes non-human primate research - ideal for clinical translation Reviews methods for creating devices capable of making bone autonomously, i.e. an intrinsically osteo-inductive bioreactor and/or biomaterial Describes the spontaneous induction of bone formation including a whole spectrum of tissue biology, from basic molecular biology to clear-cut morphology and pre-clinical application in non-human primate species Intended for audiences in both academic research and the biotech industry

This book brings together current advances in high-technology visualisation and the age-old but science-adapted practice of drawing for improved observation in medical education and surgical planning and practice. We begin this book with a chapter reviewing the history of confusion around visualisation, observation and theory, outlining the implications for medical imaging. The authors consider the shifting influence of various schools of philosophy, and the changing agency of technology over time. We then follow with chapters on the practical application of visualisation and observation, including emerging imaging techniques in anatomy for teaching, research and clinical practice - innovation in the mapping of orthopaedic fractures for optimal orthopaedic surgical guidance - placental morphology and morphometry as a prerequisite for future pathological investigations - visualising the dural venous sinuses using volume tracing. Two chapters explore the use and benefit of drawing in medical education and surgical planning. It is worth noting that experienced surgeons and artists employ a common set of techniques as part of their work which involves both close observation and the development of fine motor skills and sensitive tool use. An in-depth look at police identikit construction from memory by eyewitnesses to crimes, outlines how an individual's memory of a suspect's facial features are rendered visible as a composite image. This book offers anatomy educators and clinicians an overview of the history and philosophy of medical observation and imaging, as well as an overview of contemporary imaging technologies for anatomy education and clinical practice. In addition, we offer anatomy educators and clinicians a detailed overview of drawing practices for the improvement of anatomical observation and surgical planning. Forensic psychologists and law enforcement personnel will not only benefit from a chapter dedicated to the construction of facial composites, but also from chapters on drawing and observation.

This book brings together a cross-fertilization of ideas between human molecular genetics, developmental biology, tissue biology and the biochemistry of cell signalling pathways, in order to create new insights into the mechanisms of normal and abnormal skeletogenesis. This broad perspective is essential in order to understand the aetiology of genetic diseases affecting skeletal development at all levels from genotype to phenotype, i.e. from mutation to syndrome.
The book encompasses normal and abnormal skeletogenesis process by process, beginning with the signalling pathways that control early patterning events, then the molecular control of osteoblast, chondrocyte and osteoclast differentiation, joint formation and finally osteoclast activity. Each step takes into consideration the results of mouse gene cloning and knockout studies, human molecular genetics, and new mouse studies stimulated by the human information. Such an integrated approach is essential if this new understanding is to be applied for future therapeutic strategies.

This informative and fun coloring book with 32 flash cards teaches anatomy through classic yoga poses.

With a primary focus on the bones, joints, and muscles involved in yoga, this unique adult coloring book presents a wealth of information in an accessible manner—making it the perfect gift for medical students and yoga enthusiasts alike!

Features:

• Helpfully organized, starting with an introduction to essential anatomical terms and overview of the systems of the body, followed by the skeletal system, joints, and connective tissue, and the muscular system with its structure and function.
• Each anatomical feature is beautifully illustrated with a black-and-white drawing depicting a yoga posture (asana); coloring each in will foster a deeper understanding of the bones and muscles involved and a better recall of their names.
• Contains 60 original illustrations to color, along with fun facts about anatomy, practice tips for yogis, pose names in both English and Sanskrit, and a detailed glossary.
• Sewn layflat binding makes for an easier coloring and learning experience.
• 32 press-out flashcards in the back of the book enable readers to quiz themselves and study yoga anatomy on the go.

Immerse yourself in this captivating blend of education and creativity, as you unlock the secrets of anatomy for yoga practitioners and instructors alike. Let seasoned yoga instructor, licensed massage therapist, and anatomy teacher Kelly Solloway be your guide as you embark on an illuminating journey through the human body, demystifying yoga's connection to anatomy in an engaging and memorable way.

Lysosomes are key subcellular organelles that regulate the cell function. Many of the essential activities of the cell are dependent on lysosomes. Dysfunction is linked to multiple diseases - storage disorders, neurodegeneration, immunological diseases and cancer. This book discusses concepts and methods used to study lysosome ion and small molecule transport. The contents will not only attract accomplished investigators in need of a broad review and synthesis of this important subject but will also appeal to young investigators and trainees needing to acquire comprehensive knowledge and technical skills working with lysosomal ion channels and small molecule transporters. Key selling features: Summarizes the endocellular role that lysosomes play with respect to cellular waste disposal Reviews essential cellular functions of lysosomes Explores how lysosome dysfunction is the cause of many metabolic disorders Examines how lysomes are involved in storage diseases Describes various technologies and methods used in lysosome research