This book highlights the impact of nutrients on early placentation processes and their relevance for fetal growth and pregnancy outcome. The role of maternal nutrition on fetal growth and development has been evidenced in many epidemiological studies that included infamous Dutch famine, Helsinki Birth cohort and others. Fetal programming hypothesis states that the nutritional and other environmental conditions under which an individual develops from pre-conception to birth has a major impact on the future health of the newborn child. The developmental environment of the fetus is primarily dependent on two major factors that are maternal nutritional state (excess/low/imbalance) and placental function. Placentation is characterized by the extensive remodeling of the maternal uterine vasculature producing low-resistance blood vessels that facilitate the exchange of nutrients and wastes between the mother and the fetus. Cellular and molecular mechanisms involved in human placental blood vessel formation, which are now well established, are discussed.

Extensive reviews have been published on the mor aspects, anatomy, ultrastructure, physiology, bio phology, anatomy, and physiology of the mam chemistry, endocrinology, pharmacology, and physiopathology of the mammalian ovary. The malian ovary. However, little attention has been given to the gaps between the physiological, endo contributors, who prepared their chapters metic ulously, are recognized experts in their respective crine and histochemical parameters of the ovary as disciplines and their writings reflect extensive per it relates to clinical aspects. There is a wealth of sonal experience and unpublished data of both publications concerning the biology of the ovary: basic and clinical sciences. Without the assistance of the purpose of this volume is to integrate this information with emphasis on modern concepts in good friends and permission to draw extensively microanatomy, physiology, methodology, clinical from investigations, this volume would not have complications, and therapeutic approaches. An been possible. attempt is made to place fundamental research in Thanks are due to G. F. Franchitto, F. Barberini, clear perspectives. P. Stoops. Lori Rust and J. Squiers for their editorial It is hoped that this volume will fulfil a long skills and for checking the references to the original standing need and serve as an important source for sources. Thanks are particularly due to 1. K. Smith investigators and clinicians concerned with the of Martinus Nijhoff Publishers BV for his excellent physiopathology of the ovaries for years to come. It cooperation during the production of the book."

The last decade has seen significant advances in the study of tubal physiology using novel methods, and our understanding of the involvement of Fallopian tubes in the development of ovarian cancer has changed fundamentally. At the same time success rates of IVF have improved significantly, with the aid of better understanding of tubal function. This volume will present a fully comprehensive update of Fallopian tube physiology and provide a practical guide to the clinical aspects related to them. The first part of the book will consist of chapters on basic science of the Fallopian tubes, which will explain how specific aspects relate to infertility and contraception. In the second half, assessment of tubal function, conditions that compromise tubal function, surgical and non-surgical management approaches to various types of tubal pathology, fertility control (contraception) and future aspects of tubal research will be covered in chapters written by world-renowned experts in these fields. Fallopian Tube: Physiology and Clinical Aspects will be of tremendous interest and utility to both basic scientists and clinicians who are involved in the management of infertility and contraception.

This book presents expert opinions on a variety of key topics related to the management of breast cancer, with a focus on the implications of recent advances and research findings for clinical practice. It also explores the controversy regarding mammography screening and reviews the contribution of new imaging modalities. Considerable attention is paid to developments in surgical procedures, including the potential for the safe and effective use of sentinel lymph node dissection alone-even in patients with positive nodes-and to the advantages and contraindications of new radiotherapy techniques. Genetic aspects are discussed in detail, including an assessment of the role of genetic testing and the potential impact of genetic signatures on breast cancer management. New systemic strategies, such as anti-HER2 therapy, endocrine agents, and agents to reverse endocrine resistance, are considered, and the optimal use of chemotherapy for early-stage and advanced-stage disease is addressed. In closing, the book shares important new insights into lifestyle risk factors, risk reduction strategies, and survivor issues, including sexual dysfunction and fertility maintenance.

This volume comprehensively focuses on polycystic ovary, metabolic syndrome and obesity and their impact on women's health, reproduction and quality of life from adolescence to old age. PCOS is analyzed form the early origins - highlighting the importance of diagnosis, management and treatment starting from the high-risk period of adolescence - throughout infertility PCOS-related issues, pregnancy and menopause transition. All aspects of this syndrome are covered also in relation with endocrine and metabolic features that affects women's health. This book is a very useful tool for gynecologists, endocrinologists, obstetricians, reproductive medicine and general practitioners and is an important resource for all physicians involved in women's health.

The book provides detailed information on breast cancer and covers all the aspects of this rapidly spreading disease, such as applied anatomy and physiology, causative factors, various Investigations to reach a concise, definitive and complete diagnosis. The management of breast cancer involves multi-modality treatment and the book describes all the modalities in a very clear manner. It also discusses in a very lucid and practical way. the multi-prong treatment that the patient requires . Additionally, the book covers lesser-known areas of the subject like rehabilitation, management of lymphoedema, Extravasation of chemo-Infusion, organization of breast cancer management group, breast cancer awareness and patient education, follow up of the patient, and psychological support to these patients who have undergone mutilation of their organ. Edited by experts the chapters are contributed by renowned onco-sugeons from high volume and reputed centers in India such as, PGIMER, Chandigarh, AIIMS, New Delhi, and TMH, Mumbai among others. The book serves as a useful resource for surgeons, medical oncologists, radiotherapists, pathologists, radiologists and many other specialists interested in the field of breast cancer and actively working in this area. It is useful for practitioners and residents as well as for those who want to learn the different aspects of this disease.

This easy-to-understand pocketbook in the highly respected Clark's stable of diagnostic imaging texts is an invaluable tool for students, sonographers and other ultrasound practitioners, providing practical guidance on clinical ultrasound procedures, summarising current relevant literature and professional body guidelines. The content is arranged by anatomical system and organ for ease of reference, with each section comprising a short introduction, the indications for the procedure, patient preparation, the imaging procedure itself, along with an image analysis, supported throughout by positioning photographs and clinical images. Clark's Essential Guide to Clinical Ultrasound is ideal for all users of clinical ultrasound at both undergraduate and postgraduate level and will also provide a convenient distillation of the latest best practice and guidelines for sonographers, midwives, vascular technologists, ECG technologists, medical doctors, sports injury specialists, paramedics, and other health professionals.

Maha Nasrallah-Babenko presents a culturally sensitive and uniquely accessible guide that equips clinicians, student sex therapists, and female clients with the tools to confidently treat genito-pelvic pain and penetration disorders (GPPPD). Addressing the issue from an integrated approach, the book provides evidence-based information and sensate, solo and partner practical exercises derived from the author's experience to help clinicians support women in redefining their relationship with sex, their bodies, and their partners. With a special focus on those from conservative and religious backgrounds, this beautifully illustrated text emphasizes the psychological, emotional, and relational factors that may increase shame and fear surrounding sex. The book defines GPPPD before outlining the author's ABCs approach, awareness, body, control, and safety, where she examines topics such as sexual abuse, how to communicate with you partner, sexual beliefs and messages, the importance of arousal, vulnerability and assertiveness, and shifting the significance of penetration for an enjoyable sex life. This book is essential reading for training and established sex therapists, family therapists, and couple therapists looking to support those struggling with sexual intimacy, as well as the couples seeking their help.

Meningitis and Encephalitis are associated with high rates of mortality and neurological sequelae. The differential diagnosis includes a wide spectrum of infectious and non-infectious etiologies, some requiring urgent therapy for survival. The current management challenges in patients with meningitis and encephalitis include a low sensitivity of meningeal signs, overutilization of unnecessary screening cranial imaging, delays in diagnosis of urgent treatable causes, a large proportion of unknown etiologies, low sensitivity of current microbiological techniques especially in the setting of previous antibiotic therapy, underutilization of available molecular diagnostic tests, and empiric antibiotic therapy and hospitalization for viral meningitis cases. Even though there are published guidelines, compliance with them is not optimal and physicians do not follow standardized algorithms in their empirical approach. As meningitis and encephalitis is associated with high rates of adverse clinical outcomes, prevention, when feasible is of upmost importance. Adherence to protocols to prevent health-care associated meningitis and ventriculitis are effective but compliance with them is not uniformly performed. This book seeks to improve outcomes for meningitis and encephalitis cases handled by physicians who may or may not be thoroughly trained for these challenges. The text introduces the current guidelines but also discusses the gaps that leave clinicians struggling to implement the most appropriate approaches for these particular neurological infections. Each chapter delivers the tools necessary to identify and adhere to the most appropriate diagnostic technique, management protocols, and prevention approach for each situation. All chapters conclude with discourse on future directions in research and quality improvement. Written by experts in infectious diseases, the book covers topics that are the most devastating, including healthcare-acquired infections, autoimmune encephalitis, and infections as they present in HIV patients. Meningitis and Encephalitis is a well-rounded resource for all medical professionals encountering these neurological syndromes, including infectious disease specialists, neurologists, primary care physicians, and immunologists.

Endometriosis is a complex gynecological disorder with multifactorial etiology. An estrogen-dependent condition, it affects 6% to 10% of women in the general population, and in 35% to 50% of these women often experience pain, and sometimes infertility. Exploring this benign but chronic disease, the book covers the different aspects of endometriosis from basic to advanced levels, including diagnoses, management, treatment modalities, complications, and fertility. Features Provides an overview of the guidelines, expert opinions, and ethical dilemmas involved with endometriosis. Covers the various complications that these women can experience Presents informative illustrations that complement the text discussion An overview of surgery, hormone therapy, and other options is provided In-depth coverage of novel treatments, including alternative medicine, diet, nutrition, and lifestyle modifications

Recurrent pregnancy loss (RPL) includes recurrent first- and second-trimester abortions and recurrent preterm delivery, second- or third-trimester intrauterine fetal death, intrapartum stillbirth, and early neonatal death. This book includes protocols for case scenarios of early and late pregnancy loss as well as instances of poor obstetric history. Key Features Explores the management of different clinical presentations of RPL Includes preeclampsia, intrahepatic cholestasis of pregnancy, and hypertension-related disorders in pregnancy Includes clinical protocols with flowcharts Features tip boxes with learning points for easy reference

Pelvic Organ Prolapse, or POP, is a little talked about female health issue that half of all childbearing women will experience late in life. There are more than 300,000 surgeries for POP annually. Due to various causes such as menopause, estrogen loss, genetics, childbirth or heavy lifting, a woman's pelvic organs can shift or drop. This can lead to POP symptoms, including some painful and embarrassing ones, as well as impacting a woman's sexuality. The condition has probably always existed, but has received little press or public acknowledgement so women could learn about the condition and treatment options. This book on POP fills an unfortunate void in women's health awareness. Sherrie Palm writes about her own personal experiences in Pelvic Organ Prolapse: The Silent Epidemic. She had never heard about the condition until she needed surgery for it. Palm explores the subject from all angles, providing the information women need to recognize the symptoms of POP and to become advocates for their own health. Pelvic Organ Prolapse: The Silent Epidemic named the winner for Women's Health in the USA Book News National "BEST BOOKS 2009" Awards. http://www.usabooknews.com/2009bestbooksawards. html More information about Sherrie Palm, and how she is creating awareness for this women's health issue can be found on her website: http://sherriepalm.com/home About the Author: First-time author Sherrie Palm is a retired business owner. She lives in Wisconsin with her significant other; she has four children and seven grandchildren. Palm plans to conduct educational seminars on POP. She is also actively involved with the local Special Olympics and will donate a portion of the book's proceeds to the group.

This second edition offers an expanded and updated history of the field of fetal and neonatal development, allowing readers to gain a comprehensive understanding of the biological aspects that contribute to the wellbeing or pathophysiology of newborns. In this concluding opus of a long and prominent career as a clinical scientist, Dr. Longo has invited new contributions from noted colleagues with expertise in various fields to provide a historical perspective on the impact of how modern concepts emerged in the field of fetal physiology and contributed to the current attention paid to the fetal origins of diseases in adults. In addition to new chapters on maternal physiology and complications during pregnancy, others trace the history of the Society for Reproductive Investigation, governmental funding of perinatal research, and major initiatives to support training in the new discipline of maternal fetal medicine, including the Reproductive Scientist Development program. The extensive survey provided by the author, who personally knew most of the pioneers in the field, offers a unique guide for all clinical and basic scientists interested in the history of - and future approaches to diagnosing and treating - pathologies that represent the leading causes of neonatal mortality and, far too often, life-long morbidity.

The book provides a reference for years to come, written by world-renowned expert investigators studying sex differences, the role of sex hormones, the systems biology of sex, and the genetic contribution of sex chromosomes to metabolic homeostasis and diseases. In this volume, leaders of the pharmaceutical industry present their views on sex-specific drug discovery. Many of the authors presented at the Keystone Symposium on "Sex and gender factors affecting metabolic homeostasis, diabetes and obesity" to be held in March 2017 in Lake Tahoe, CA. This book will generate new knowledge and ideas on the importance of gender biology and medicine from a molecular standpoint to the population level and to provide the methods to study them. It is intended to be a catalyst leading to gender-specific treatments of metabolic diseases. There are fundamental aspects of metabolic homeostasis that are regulated differently in males and females, and influence both the development of diabetes and obesity and the response to pharmacological intervention. Still, most preclinical researchers avoid studying female rodents due to the added complexity of research plans. The consequence is a generation of data that risks being relevant to only half of the population. This is a timely moment to publish a book on sex differences in diseases as NIH leadership has asked scientists to consider sex as a biological variable in preclinical research, to ensure that women get the same benefit of medical research as men.

Chronic Pelvic Pain: Evaluation and Management presents a clinically oriented, multi-disciplinary approach to the diagnosis, treatment, and management of chronic pelvic pain in women -- one of the most common problems encountered in the practice setting. The editors present this challenging and often vexing subject in a practical, user-friendly, highly illustrated text, including chapters on: physiology of pain; pain associated with endometriosis; pain associated with fibroids; surgical management; the role of office based surgery; the role of the psychiatrist in pain management; pelvic pain of urinary origin; pelvic pain of gastrointestinal origin. Designed to be incorporated into the every day practice, this book is a must for all clinicians in obstetrics-gynecology as well as for any physician involved in the health care of women.

This volume summarizes advances in the optimal clinical management of preterm labour, using the best available evidence of the time. The contributors (mostly practising clinicians) are all actively involved in research into the mechanisms, aetiology, treatment and associated outcomes of preterm labour. The chapters are based on common clinical scenarios and each provides a comprehensive literature review followed by evidence-based recommendations on appropriate management. A summary of the pathophysiology of parturition is provided, and the obstetric scenarios cover management of threatened preterm labour, management of preterm premature ruptured membranes and management of preterm labour with specific complications (such as intrauterine growth restriction). Other chapters include the epidemiology, prediction and prevention of preterm labour. Anaesthetic and paediatric issues are explored in depth, and there are chapters on the legal and organizational issues surrounding preterm labour.

Titles in the Pocket Tutor series give practical guidance on subjects that medical students and foundation doctors need help with 'on the go', at a highly-affordable price that puts them within reach of those rotating through modular courses or working on attachment. Topics reflect information needs stemming from today's integrated undergraduate and foundation courses: Common presentations Investigation options (e.g. ECG, imaging) Clinical and patient-orientated skills (e.g. examinations, history-taking) The highly-structured, bite-size content helps novices combat the 'fear factor' associated with day-to-day clinical training and provides a detailed resource that students and junior doctors can carry in their pocket. Key points Logical, building-block approach to content: initial chapters outline the basic approach to gynaecological history and examination, and essential pelvic anatomy Subsequent chapters describe physiology and pathology of women at all stages of life from puberty, to reproductive age, to menopause; and associated disorders such as congenital disorders, menstrual disorders, genital diseases, and pelvic organ prolapse Concludes with chapter on gynaecological oncology Disorders are accompanied by medical images, examination photos and practical artworks Focuses on the conditions medical students and junior doctors are most likely to see

Combining detailed descriptions of pelvic anatomy with easy-to-follow instructions for gynecologic procedures, Atlas of Pelvic Anatomy and Gynecologic Surgery, 5th Edition, is a comprehensive, up-to-date atlas that reflects current practices in this fast-changing field. Pelvic anatomy and surgical operations are depicted through full-color anatomic drawings, correlative surgical artwork with step-by-step photographs, and computer-assisted hybrid photo illustrations. Complete coverage of both conventional and endoscopic surgeries helps you master the full spectrum of surgical procedures. Covers all frequently performed gynecologic operations including laparotomy, laparoscopic, robotic, hysteroscopic, vaginal, vulvar, and cystoscopic procedures. Includes expanded sections on gender reassignment surgery and vulvar and cervical surgery, as well as a new chapter devoted to laparoscopic techniques. Contains a revised anatomic section with updated figures, plus high-quality artwork and clinical photographs throughout-now entirely in full color. Features numerous videos of surgeries and cadaver dissection. Ideal for practicing obstetricians-gynecologists, obstetrics-gynecology residents, general surgeons, subspecialists, nurses, and medical students with an interest in gynecology. Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices.

Originally published in 1977 and as a second edition in 1988, this book introduces the reader to the women at the top of the midwifery profession up until the 17th Century who attended the aristocracy and Royalty. The author shows how their successors were gradually driven out of the better paid work until in the middle of the 19th Century it appeared that attendance on childbearing women would inevitably become the male monopoly it has virtually become in North America. This downward trend was reversed, thanks to efforts to preserve for women the choice of female attendance in childbirth and also to the labour of philanthropists to improve maternity services to the poor. However, the drive for the institutionalization and mechanization of childbirth during the 20th Century as well as a chronic shortage of midwives, has once again shone a spotlight on the profession. This unique history of developments in midwifery will be of interest to students of medical politics, 19th Century social history, the sociology of the professions and gender studies.

Originally published in 1986, this book examines the history of midwifery, concentrating on 19th and 20th Century Britain. It shows how the evolution of the midwife has been influenced by cultural waves which started in the Near East and Egypt in pre-classical times and slowly spread Northwards and Eastwards over Europe. The authors emphasize the effects of specialization and professionalization upon midwifery and also the influence of male authority and interest group politics. The evolution of the educated qualified midwife of the 20th Century is recorded, leading up to the ongoing debates about high technology birth vis-a-vis natural birth and home deliveries.

The authors address in particular the role of hormones and their links with other maternal environmental mediators in developmental programming. The crucial nature of the placenta as an interface and target between maternal and foetal environments is addressed. Emphasis is made on the emerging science of epigenetics as a potential explanation for how environmental events that occur during brief windows of development may exert effects that impact upon somatic cells through many rounds of mitosis for much of the life span of the subsequent organism.

Modern imaging methods have made it possible to detect breast cancer at an earlier stage than in the past. Nevertheless, a large majority of suspicious findings at screening subsequently prove to be benign. It is therefore important to be able to identify benign lesions in a manner that is reliable, tissue sparing, patient friendly, and cost-effective. More than 70% of breast biopsies can now be performed using minimally invasive procedures that meet these criteria. This book examines in detail vacuum-assisted minimally invasive breast biopsy systems (ATEC, EnCor, Intact, Mammotome and Vacora), stereotactic systems, MRI-guided procedures, and ductoscopy. Further chapters are devoted to the pathology of the breast tissue obtained using these procedures, their limitations, the implications of recent advances in breast imaging, and the results of cost-benefit analyses. The closing chapter provides a systematic review and meta-analysis of recent data.

This book presents the contemporary history and dynamics of Mexican midwifery - professional, (post)modern or autonomous, traditional and Indigenous - as profoundly political and embedded in differing societal stratifications. By situated politics, the authors refer to various networks, spaces and territories, which are also constructed by the midwives. By politically situated, the authors refer to various intersections, unsettled relations and contexts in which Mexican midwives are positioned. Examining Mexican midwiferies in depth, the volume sharpens the focus on the worlds in which midwives are profoundly immersed as agents in generating and participating in movements, alliances, health professions, communities, homes, territories and knowledges. The chapters provide a complex panorama of midwives in Mexico with an array of insights into their professional and political autonomy, (post)coloniality, body-territoriality, the challenges of defining midwifery, and above all, into the ways in which contemporary Mexican midwiferies relate to a complex set of human rights. The book will be of interest to a range of scholars from anthropology, sociology, politics, global health, gender studies, development studies, and Latin American studies, as well as to midwives and other professionals involved in childbirth policy and practice.

Infertility Comics and Graphic Medicine examines women's graphic memoirs on infertility, foregrounding the complex interrelationship between women's life writing, infertility studies, and graphic medicine. Through a scholarly examination of the artists' use of visual-verbal codes of the comics medium in narrating their physical ordeals and affective challenges occasioned by infertility, the book seeks to foreground the intricacies of gender identity, embodiment, subjectivity, and illness experience. Providing long-overdue scholarly attention on the perspectives of autobiographical and comics studies, the authors examine the gendered nature of the infertility experience and the notion of motherhood as an ideological force which interpolates socio-cultural discourses, accentuating the potential of graphic medicine as a creative space for the infertile women to voice their hitherto silenced perspectives on childlessness with force and urgency. This interdisciplinary volume will be of interest to scholars and students in comics studies, the health humanities, literature, and women's and gender studies, and will also be suitable for readers in visual studies and narrative medicine.

In this issue of Obstetrics and Gynecology Clinics of North America, guest editor Dr. Catherine Stika brings her considerable expertise to the topic of Drugs in Pregnancy. The use of medications during pregnancy can be difficult to manage because not only is research lagging in this area, but typically drugs are not studied for use in pregnant women. In this issue, key experts provide a state-of-the-art review on clinical pharmacology in pregnancy, with a look at commonly prescribed medications as well as over-the-counter medications. Contains 17 practice-oriented topics including obstetrical pharmacology; over-the-counter medications in pregnancy; antibiotic use in pregnancy; opioids in pregnancy; mood disorder medications in pregnancy; and more. Provides in-depth clinical reviews on drugs in pregnancy, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.