Authored by Bengt Kallen, professor emeritus in embryology at Lund University in Sweden. The subject of this book is to describe the occurrence of congenital malformations among children born and what risk factors exist. Population data are presented for a number of malformations, ascertained with the use of data from the Swedish national health registers for the period 1998-2010 corresponding to some 1.3 million births, together with prospectively collected information on a group of exposures of possible interest. The structure of the analysis is such that it excludes studies of, for instance, nutrition, alcohol or street drug use and many other lifestyle factors where prospective information or independent register information is difficult or impossible to obtain. Epidemiology of Human Congenital Malformations culminates with a discussion on how the presence of malformations can be explained and various possibilities for the prevention of birth defects. Moreover, it will include a series of instructions on how to read epidemiological literature in this field making it an essential resource both for those currently working in the field of reproductive epidemiology or those intending to enter it. It will additionally be useful for doctors working with malformations, either as obstetricians, neonatologists or pediatricians.

JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.

Psychology's recent immersion in risk research has introduced a new variant in which the focus is "not" solely on disease, but also on the effects and consequences produced by the multiple aspects of "risk" on individual adaptation. Variations in such patterns of adaptation signal the entrance of "protective factors" as an added element to the clinical and research focus in the prediction of positive versus negative outcomes under the duress of stressful experiences.
Given psychology's investment in the entire range of human adaptation--embracing severe disorder at one extreme and strong positive adaptations at the other--it is not surprising to find this new element of compensatory protective factors as a reshaping factor in the field of risk research. It is one that recognizes and studies the relevance of risk influences on disorder, but also focuses on recovery from disorder or the absence of disorder despite the presence of risk. This latter element implicates the notion of "resilience." It is this opening of the field of risk research that seems to bear the heavy and welcome imprint of psychology. Fundamental to the study of protective factors in development, however, is a broad knowledge base focused on risk factors that often contain the healthy development of infants and children.
This volume reflects a continuation of the concerns of the Institute of Child Development with the nature and content of development in multiple contexts. It comes at a most welcome point since the Institute--in collaboration with the University of Minnesota's Department of Psychology--now participates in a jointly shared graduate training program in clinical psychology which stimulates and supports the growth of a newly emergent "developmental psychopathology." For this field to advance will require a broad perspective and acceptance of the significance of the diversity of risk factors that extends throughout the life span and results in developmental trajectories that implicate various biological, psychological, and sociocultural risk elements.

The treatment of children with medicinal products is an important scientific area. It is recognized that many medicines that are used extensively in pediatric patients are either unlicensed or off-label. This textbook will help pediatric health professionals effectively treat children with the most appropriate medicine with minimal side effects.

The first book of its kind, this reference describes current diagnostic and treatment strategies for acute and chronic heart failure in the fetus, neonate, child, and young adult-encompassing every aspect of pediatric heart failure including historical perspectives, the latest technologies in mechanical circulatory support, and recent information on the psychosocial aspects of heart failure in children.

This book focuses on predictive, preventative and personalized medicine (PPPM) and how it is related to the healthcare of rare diseases. Readers will discover how advanced rare diseases healthcare provides an excellent "proof-of-principles" for the personalisation of healthcare systems on a global scale. Chapters look at national plans for rare disease, at biobanking, gene identification, rare cancers, virus gene therapy , induced pluripotency for cell therapy amongst other topics. There is a chapter dedicated to personalized medicine for hereditary deafness and another exploring the complexity of genotype-phenotype correlations. Specific diseases such as Fabry's, Gauchers and mitochondrial cytopathies are highlighted and we look at enzyme replacement therapy in lysosomal storage diseases. This work is part of a series, produced with the involvement of the European Association for Predictive, Preventive and Personalised Medicine. The series focusses on the concept of an integrative medical approach by PPPM. This volume is dedicated to all aspects related to the prediction, prevention and personalised treatments of rare diseases, and in doing so it explores developments relevant to all medical branches. The authors cover ethical considerations, the creation of a robust platform for professional communication, synergies with patient organisations, "doctor-patient" collaboration and a new philosophy of integrative medicine by PPPM. This volume serves as a reference source for scientific and medical centres in the field and can be used both at medical curricula and graduate level in the life sciences. Those who place a special emphasis on healthcare promotion and innovations intended to combat rare diseases, save the affected lives and enhance life quality will all find this book of great value.

Publications on aesthetic rejuvenation often start with the treatment-such as fillers or lasers-and then work back to the patient problem. Comprehensive Aesthetic Rejuvenation: A Regional Approach starts from the perspective of what the patient perceives as the problem region of the body. It then moves to the appropriate range of treatments that can be offered and discusses how outcomes can be improved. Topics include: The new growth agent for eyelashes Multimodal approaches to healthy skin Aesthetic considerations in ethnic skin Hair loss and transplantation New developments in less invasive fat and cellulite treatments Body contouring surgery Enhanced with more than 200 color illustrations, this volume is an essential resource for all aesthetic and plastic surgeons.

JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.

JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.

Pediatric Intensive Care offers clinicians and trainees a concise, easy-to-carry resource on pediatric critical care medicine, designed for frequent and quick reference at the bedside, providing solutions to questions and situations encountered in practice. The book is sized to fit in a pocket and contains focused text, bulleted lists, tables, and figures. The book facilitates the delivery of critical care by a range of practitioners, from residents to generalists in settings where CCM expertise is not readily available, to intensivists.

JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.

This book provides an in-depth, practical, and cutting-edge summary of psychotherapy for immigrant children and adolescents. This text integrates practical therapeutic methods with current empirical knowledge on the unique life stressors and mental health concerns of immigrant youth, proving essential for all who seek to address the psychological needs of this vulnerable and under-served population. Specific chapters are devoted to trauma, refugees and forced displacement, cognitive-behavioral therapy, psychopharmacological issues, school-based treatment, family. Each chapter includes specific cultural concerns and treatment techniques for immigrant groups from various regions of the world. In-depth case examples illustrate case formulation, how and when to use specific techniques, challenges faced in the treatment of immigrant youth, and responses to common obstacles. With detailed theory and practice guidelines, Psychotherapy for Immigrant Youth is a vital resource for psychologists, psychiatrists, social workers, and other practitioners.

JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.

Selected as a Doody's Core Title for 2022! Essential for ob/gyn physicians, primary care physicians, and any health care provider working with pregnant or postpartum women, Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, 12th Edition, puts must-know information at your fingertips in seconds. An easy A-to-Z format lists more than 1,400 of the most commonly prescribed drugs taken during pregnancy and lactation, with detailed monographs designed to provide the most essential information on possible effects on the mother, embryo, fetus, and nursing infant. Each templated monograph includes: Generic US name (trade names in index) Risk factors Pharmacologic class Pregnancy and breastfeeding recommendations Pregnancy, fetal risk, and breastfeeding summaries Updated references NEW in the 12th Edition: 100 new drugs, with thorough updates of all existing drugs Subheadings with each review for faster reference List of cross-referenced combination drugs List of drugs contraindicated in breastfeeding women List of drugs contraindicated in pregnancy List of drugs that affect human development Quarterly updates, available online, to keep you at the forefront of the field Greatly improved eBook searchability Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

Our uncertain times are hard enough for adults to navigate. For all too many young people-even many who appear to possess good coping skills-the challenges may seem overwhelming. More and more, resilience stands as an integral component in prevention programs geared to children and adolescents, whether at risk or not. Resilience Interventions for Youth in Diverse Populations details successful programs used with children and teens in a wide range of circumstances and conditions, both clinical and non-clinical. New strength-based models clarify the core aspects of resilience and translate them into positive social, health, educational, and emotional outcomes. Program descriptions and case examples cover diverse groups from homeless preschoolers to transgender youth to children with autism spectrum disorders, while interventions are carried out in settings as varied as the classroom and the clinic, the parent group and the playground. This unique collection of studies moves the field toward more consistent and developmentally appropriate application of the science of resilience building. Among the empirically supported programs featured: Promoting resilience in the foster care system. Developing social competence through a resilience model. Building resilience in young children the Sesame Street way. School-based intervention for resilience in ADHD. Girls Leading Outward: promoting resilience in at-risk middle school girls. Resiliency in youth who have been exposed to violence. Resilience Interventions for Youth in Diverse Populations is an essential resource for researchers, professionals/practitioners, and graduate students in clinical child and school psychology, social work, educational psychology, child and adolescent psychiatry, developmental psychology, and pediatrics.

This textbook covers the classification, causes, treatment and prevention of psychological disorders in the infant through the adolescent years. Chapters balance the social and historical context of psychopathology with the physiological roots of abnormal behavior, leading students to a comprehensive understanding of child psychopathology. The book is totally up-to-date, including coverage of the DSM-5 and criticisms of it. In four parts, this textbook describes the empirical bases of child psychopathology as well as the practice of child psychologists, outlining the classification and causes of disorders in addition to methods of assessment, intervention and treatment. Students will be able to evaluate the treatments used by professionals and debunk popular myths about atypical behavior and its treatment. Complementing the lively writing style, text boxes, clinical case studies and numerous examples from international cultures and countries add context to chapter material. Study questions, diagrams and a glossary offer further learning support.

Examining children presents unique challenges for trainees and new doctors in paediatrics. Paediatric patients vary greatly in age and development, often find it difficult to describe their symptoms, and can behave unpredictably in clinical settings. Clinical Examination Skills in Paediatrics helps MRCPCH candidates and other practitioners learn effective history taking and fundamental examination techniques. Clear and concise chapters-with contributions from a team of paediatric specialists-demonstrate the clinical examination and questioning techniques used in daily practice. Emphasis on the intellectual processes involved in decision making assists both trainees preparing for a formal examination as well as new clinicians faced with a difficult diagnostic problem. Topics include cardiovascular and respiratory examination, examining a child with a neuromuscular disorder, musculoskeletal examination, and taking history from a child with diabetes and a rheumatological condition. Includes access to a companion website containing high-quality videos that demonstrate techniques, procedures and approaches Features commentary by experienced practitioners which offer observations and deductions at each stage of the examination process Offers tips for communicating effectively with the patients using appropriate lay terms Helps translate the symptoms and signs experienced by patients into medical-speak Covers all the skills tested in the MRCPCH Clinical exam Clinical Examination Skills in Paediatrics is the perfect study and reference guide for paediatrics trainees, MRCPCH candidates, foundation doctors, allied healthcare professionals, and anyone looking to improve their clinical and communication skills in paediatrics.

This book provides recommendations for evaluation and therapy in the area of acute pediatric neurology; these are presented didactically with frequent use of illustrations and algorithms. Chapters in the first part of the book discuss presenting symptoms of acute neurological conditions. The second part of the book covers major areas of acute pediatric neurology and each of these chapters has three key elements: description of presenting symptoms; recommended assessments; and recommended interventions. Acute Pediatric Neurology provides an accessible, clinically focused guide to assist physicians in the emergency ward or intensive care unit in decisions on diagnosis and therapeutic interventions in all major acute pediatric neurological diseases.

Until the 1990s, it was generally accepted that medicines were first developed for adults and their use in children was investigated later, if at all. One of the main tasks of hospital pharmacies was the manufacturing of child-appropriate formulations in a more or less makeshift way. The first change came in 1997 with U.S. legislation that rewarded manufacturers to do voluntary pediatric research. Ten years later, the European Union passed legislation that required manufacturers to discuss all pediatric aspects, including formulations, with the regulatory authorities as a condition of starting the registration procedure. In consequence, manufacturers must now cover all age groups, including the youngest ones. So far, pediatric formulations were more a focus for academic researchers. Through the changed regulatory environment, there is now a sudden high commercial demand for age-appropriate formulations. This book begins by highlighting the anatomical, physiological and developmental differences between adults and children of different ages. It goes on to review the existing technologies and attempts to draw a roadmap to better, innovative formulations, in particular for oral administration. The regulatory, clinical, ethical and pharmaceutical framework is also addressed.

JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.

Spinal Injuries and Conditions in Young Athletes provides a comprehensive, in-depth review of the mechanisms and management of back injuries and problems occurring in this ever-growing and active population. Led by Dr. Lyle Micheli and his co-editors, an award-winning group of orthopedists discusses and explores common adolescent spine injuries and procedures, in addition to breakthroughs in gene therapy, tissue engineering, and complex operations. As spine surgery is among the most complex and challenging procedures performed in orthopedics, special considerations and procedures are required in pediatric populations. Since many corrective surgeries run the risk of arthritis later in life, particular efforts must be made in young populations to prevent future injury in a child's adolescence and young adulthood while maximizing return-to-play potential. Chapters cover acute spinal injuries, concussions, overuse injuries, spinal malformations, tumors, infections and inflammatory diseases across the range of athletics, including swimming and combat sports. Spinal Injuries and Conditions in Young Athletes provides an immeasurable guide for back surgery in pediatric populations and will be a go-to resource for practitioners and residents in pediatric orthopedics and sports medicine.

The past few decades have seen major impacts of different pandemics and mass casualty events on health resource use in terms of rising healthcare costs and increased mortality. In this context, the development of acute respiratory failure in patients requires the use of mechanical ventilation, either invasive or noninvasive. Recently, noninvasive ventilation (NIV) has proved to be a valuable strategy to reduce mortality rates in patients. This is the first book to describe the clinical indications of NIV in patients who have been hospitalized with high-risk infections as well as in the prehospital management of mass casualty incidents, including chemical or biological disasters and pandemics. Compiled by internationally respected experts, it offers comprehensive coverage of all aspects of noninvasive mechanical ventilation in public health emergencies, such as equipment needs and guidelines for health organizations. Considering recent events (SARS, H1N1 influenza pandemic), the book concludes with a critical review of current studies and future prospects for the use of NIV, offering a valuable resource for all practitioners managing mass casualty incidents and disasters.

Although respiratory syncytial virus (RSV) has been a high priority for vaccine development for over 50 years now, still no vaccine is available and none has yet demonstrated sufficient promise to move to licensure. The success of RSV immune prophylaxis and the availability of ever more powerful tools to study the immune response and pathogenesis of disease, combined with the ability to construct a wide variety of vaccines using different vaccine platforms, give us grounds to believe that an RSV vaccine is within reach. This book brings together in one source what is currently known about the virus: its clinical and epidemiologic features; the host response and pathogenesis of the disease; vaccines, vaccine platforms, and treatment; and animal and tissue culture models of RSV infection. It is designed to organize the critical information relevant to RSV vaccine development, facilitate the assimilation of data, and speed progress toward producing a safe and effective vaccine.

Typically, manuals of pediatric hematology-oncology are written by specialists from high-income countries, and usually target an audience with a sub-specialist level of training, often assisted by cutting-edge diagnostic and treatment facilities. However, approximately 80% of new cases of cancer in children appear in mid- and low-income countries. Almost invariably, general practitioners or general pediatricians without special training in oncology will look after children with malignancies who enter the health care system in these countries. The diagnostic facilities are usually limited, as are the treatment options. The survival figures in these conditions are somewhere below 20%, while in high-income countries they are in the range of 80% for many childhood cancers. Pediatric Hematology-Oncology in Countries with Limited Resources is the only book of its kind to provide specific guidance applicable to limited resource settings and builds up from the foundation of general practitioner or general pediatrician competence. Written and edited by leaders in the field, this manual educates physicians on the essential components of the discipline, filtered through the experience of specialists from developing countries, with immediate applicability in the specific healthcare environment in these countries.

The Clinical Pocket Guide to Advanced Practice Palliative Nursing is a companion guide to Advanced Practice Palliative Nursing, the first text devoted to advanced practice nursing care of the seriously ill and dying. Each chapter of this pocket guide presents point-of-care guidance on palliative care issues for quick reference in daily practice. Edited by leaders in the field, this handbook provides consistency in the nursing process from assessment to management and evaluation of symptoms and various clinical situations. The Clinical Pocket Guide to Advanced Practice Palliative Nursing contains clinical pearls developed from the textbook and practical tools on pain and symptom assessment, functional status, and communication, making it an ideal resource for practicing APNs.