JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.

This book describes the growing body of information on the epidemiology, clinical manifestations, transmission, pathogenesis, diagnosis, and treatment of Kingella kingae infections in young children. In addition, it covers experimental methods that have been developed to study the microbiology, genetics, and virulence factors of K. kingae, information that provides the foundation for new approaches to treatment and prevention of K. kingae disease. With this content in mind, excerpts from the book will be of relevance for clinicians who care for pediatric patients, for clinical microbiologists who are involved in detecting organisms in clinical specimens, and for scientists who are studying K. kingae in an effort to develop novel targets for antimicrobial therapy and new approaches to prevention. First isolated in the 1960s by Elizabeth O. King, a bacteriologist at the CDC, Kingella kingae was largely ignored over the next two decades as a human pathogen because of its uncommon recovery from patients with disease. However, in recent years K. kingae has been increasingly recognized as a clinically important pathogen in young children, and is currently recognized as the leading cause of osteoarticular infections in young children in a growing number of countries. Research into this organism has grown tremendously over the past 15 years, resulting in a better appreciation of the importance of K. kingae in pediatric patients and of the molecular mechanisms of disease.

The book provides a comprehensive summary of the best known and most highly respected well-controlled long-term prospective follow-up studies in ADHD. These studies followed children with ADHD and matched controls into young adulthood (mean age 20-25 years) and middle-age (mean age 41 years). They explore a wide variety of outcome areas, e.g. education, occupation, emotional and psychiatric functioning, substance use and abuse, sexual behavior, as well as legal problems. One chapter focuses particularly on the outcome of girls with ADHD. Outcome areas explored are thus comprehensive and clinically very relevant. The book also explores the possible predictors of adult outcome. A whole chapter is devoted to treatment (medication and psychosocial) as a predictor of outcome. In addition to treatment, predictors explored include characteristics of the child (e.g., IQ, severity of initial ADHD symptoms, initial comorbidity characteristics of the family, e.g., socioeconomic status, single parenthood, parental pathology, and family functioning. In a summary chapter, the impact and importance of these various predictors in different outcome areas, e.g. education, occupation, emotional/social functioning, antisocial behavior, substance use and abuse and risky sexual and driving behaviors are explored. In summary, the book provides a comprehensive view of the prognosis, e.g., long-term outcome of ADHD and key factors which can influence this outcome. Professionals and the general public will thus get a clear view of what can happen to children with ADHD as they proceed through adolescence and adulthood and address important prognostic and predictive factors in their treatment approaches to ensure better long-term outcome in patients with ADHD.

Like the ground-breaking first edition, "Pediatric Psycho-oncology, Second edition" puts the child at the centre of medical and psychological care. It broadens the focus beyond treatment and cure to consider the quality of life of the child and their family. Written by an international group of pediatric oncologists and psychologists/psycho-oncologists brought together by an expert editorial team, it focuses on the real-life practical aspects of children undergoing treatment for cancer.

This edition has been restructured and opens with a major section on Active treatment, which includes chapters addressing quality of life, pain, psychosocial aspects of treatment and interventions, art therapy and different fantasy-based techniques, palliative care, communication and education, as well as a new chapter on psychopharmacology. Shorter sections then discuss survivorship and care of the dying child, including a new chapter on bereavement. The final section comprises new chapters on ethical considerations and on addressing the emotional needs of children whose parents have cancer, as well as a case study on international collaboration. An appendix provides a comprehensive overview of tools for evaluation and assessment in pediatric psychooncology.

This book is a highly practical resource that will be invaluable for all health care professionals looking after children and adolescents with cancer.

JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.

For over thirty years, the Oxford Handbook of Clinical Specialties has guided students and junior doctors through their clinical placements, renowned for providing all the information needed for both practice and revision in a deceptively small package. Now in its eleventh edition, the Handbook has been revitalized by an expanded team of specialty experts and junior doctors to guide readers through each of the specialties encountered through medical school and Foundation Programme rotations, while remaining true to the humanity and patient focus of the original edition. Updated with the latest advice and clinical guidelines, packed full of high-quality illustrations, boxes, tables, and classifications, and with a brand new chapter on how to survive your junior doctor years and beyond, this handbook is ideal for both study and use at direct point of care. Each chapter is clear and concise and filled with medical gems, with features including ribbons to mark your most-used pages and mnemonics to help you memorize and retain key facts. With reassuring and friendly advice throughout, this is the ultimate guide and revision tool for every medical student and junior doctor for each clinical specialty placement. This well-loved Handbook remains the perfect companion to the Oxford Handbook of Clinical Medicine, together encompassing the entire spectrum of clinical medicine and unmatched by any competitor in their class, helping you become the doctor you want to be.

This clinical casebook presents a comprehensive review of common sleep problems in adolescents in a concise, easy-to-read format. Each chapter thoroughly addresses a unique sleep disorder in teenagers through illustrative cases, reviews of relevant literature, and pearls of wisdom for both the practicing sleep specialist and other practitioners involved in the care of adolescents. Early chapters address various sleep disorders in detail: parasomnias, narcolepsy, obstructive sleep apnea, and delayed sleep-wake phase disorder, providing clear treatment considerations. Later chapters address sleep when complicated by issues of major depression, PTSD, epilepsy, and Traumatic Brain Injury. In-depth discussions and differential diagnosis engage the reader, and offer a multitude of research-based and clinically guided recommendations for the evaluation and treatment of sleep disorders in the adolescent. An ideal, practical resource for clinicians at all levels, Sleep Disorders In Adolescents provides a valuable contribution to adolescent care.

Focusing on the essential information you need to know when caring for children in the hospital, ICU, emergency department, or subspecialty outpatient clinic, Dr. Andrew J. White's Washington Manual (R) of Pediatrics, 3rd Edition, provides concise, high-yield content that reflects recent advances in the field. This practical volume in the Lippincott Manual series presents brief, logical approaches to the diagnosis and treatment of common inpatient pediatric problems, as well as evidence-based references where they are available. It addresses common challenges faced by residents, interns, pediatric hospitalists, and medical students, plus offers practical solutions and expert guidance - all in one portable and user-friendly resource. Includes new chapters on Newborn Nursery, Immunodeficiency, Night Curriculum (how to answer cross-covering calls), Infection Prevention, Child Psychiatry, and Palliative Care Covers growth and nutrition, emergencies, poisonings, newborn medicine, critical care, surgery, adolescent medicine, child maltreatment, allergy and immunology, radiology, sedation, genetic diseases, and much more Contains numerous tables, algorithms, and evidence-based references that keep you up to date Written by interns, residents, chief residents, subspecialty fellows, and faculty at St. Louis Children's Hospital and Washington University in St. Louis The Washington Manual (R) is a registered mark belonging to Washington University in St. Louis to which international legal protection applies. The mark is used in this publication by Wolters Kluwer Health under license from Washington University. Enrich Your eBook Reading Experience Read directly on your preferred device(s),such as computer, tablet, or smartphone. Easily convert to audiobook,powering your content with natural language text-to-speech.

The past few decades have seen major impacts of different pandemics and mass casualty events on health resource use in terms of rising healthcare costs and increased mortality. In this context, the development of acute respiratory failure in patients requires the use of mechanical ventilation, either invasive or noninvasive. Recently, noninvasive ventilation (NIV) has proved to be a valuable strategy to reduce mortality rates in patients. This is the first book to describe the clinical indications of NIV in patients who have been hospitalized with high-risk infections as well as in the prehospital management of mass casualty incidents, including chemical or biological disasters and pandemics. Compiled by internationally respected experts, it offers comprehensive coverage of all aspects of noninvasive mechanical ventilation in public health emergencies, such as equipment needs and guidelines for health organizations. Considering recent events (SARS, H1N1 influenza pandemic), the book concludes with a critical review of current studies and future prospects for the use of NIV, offering a valuable resource for all practitioners managing mass casualty incidents and disasters.

This second, updated edition of Inflammatory Diseases of the Brain provides a comprehensive overview of the field from a neuroradiological point of view. In order to ensure a standardized approach throughout, each disease-oriented chapter is again subdivided into three principal sections: epidemiology, clinical presentation, and therapy; imaging; and differential diagnosis. A separate chapter addresses technical and methodological issues and imaging protocols. An important focus of the book is the current role of advanced MR imaging techniques, such as diffusion and perfusion MRI and MR spectroscopy, in the differentiation of inflammatory and other brain diseases. All of the authors are recognized experts, and the numerous high-quality and informative illustrations include some not contained in the first edition. This book will be of great value not only to neuroradiologists but also to neurologists, neuropediatricians, and general radiologists.

Sine syndromes (SSs) represent atypical forms of inflammatory rheumatic diseases, the courses of which are often severe. While the diagnosis of rheumatic diseases can be determined according to an established set of diagnostic criteria based on clinical characteristics and laboratory parameters, Sine Syndromes do not fulfill the standard criteria used to assist in the classification of patients with rheumatological disorders. This concise book gives an overview of atypical courses in common inflammatory rheumatic diseases such as Wegener's granulomatosis, systemic sclerosis, Sjoegren's syndrome, or systemic lupus erythematosus. Each chapter reviews similar cases reported in the literature and presents current data on treatment options. Drawing on their vast clinical experience, the editors provide a series of detailed case reports in order to illustrate the different types of disease. The book is intended to facilitate early diagnosis and effective therapy in patients where a schematic approach may not prove sufficient. Sine Syndromes in Rheumatology will serve as a useful and easily accessible reference for specialists in rheumatology as well as for practitioners in the fields of internal medicine, pediatrics, and orthopedics.

There are growing questions regarding the safety, quality, risk management, and costs of PCC teams, their training and preparedness, and their implications on the welfare of patients and families. This innovative book, authored by an international authorship, will highlight the best practices in improving survival while paving a roadmap for the expected changes in the next 10 years as healthcare undergoes major transformation and reform. An invited group of experts in the field will participate in this project to provide the timeliest and informative approaches to how to deal with this global health challenge. The book will be indispensable to all who treat pediatric cardiac disease and will provide important information about managing the risk of patients with pediatric and congenital cardiac disease in the three domains of: the analysis of outcomes, the improvement of quality, and the safety of patients.

As the worldwide prevalence of morbid obesity among adolescents continues to rise, recent years have seen a large increase in the performance of adolescent bariatric surgery. While surgical intervention often becomes necessary when conservative weight-loss therapies have failed, no standards regarding the post-operative regimen and long-term management of adolescent patients have been established. Thus, the treatment of obesity and its co-morbidities requires a multidisciplinary approach, taking into account epidemiological, clinical, nutritional and genetic aspects of morbid obesity in the pediatric age group. This volume discusses both conventional therapy and surgical options for morbid obesity in the pediatric age group. In the first part, obesity-related diseases, genetics and psychological factors are analyzed. The second part focuses on current bariatric surgery procedures, including dietary restrictions and guidelines to prevent nutritional deficiencies common after surgery. Therefore, the book will prove an invaluable resource for pediatricians, surgeons, nutritionists, dieticians and all other health professionals who treat adolescent obesity.

JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.

In Sleep Disorders in Women: A Guide to Practical Management, 2nd Edition, a multidisciplinary panel of eminent researchers and practicing clinicians comprehensively updates the multifaceted aspects of sleep disorders in women at different stages of life, illuminating the unique impact that each reproductive and endocrine stage has on both normal sleep and sleep disorders. This title not only introduces primary care physicians and health care providers to the discipline of sleep disorders in women, it also will appeal to a broader set of specialists as it summarizes the latest, cutting-edge research and presents it in a succinct and clinically relevant manner. The goal of this book is to help physicians recognize the symptom patterns of sleep disorders in their female patients, guide them in diagnosing and treating these patients in a timely fashion, and help in the elimination of gender bias in sleep medicine research and care. An invaluable addition to the literature, Sleep Disorders in Women: A Guide to Practical Management, 2nd Edition again fills an important niche by being an accessible, comprehensive, multidisciplinary review on sleep disorders in women.

While brain injury can be a potentially devastating childhood medical condition this book explores the developing field of neuropsychology to suggest it is not inevitable. It draws together contributions from leading international clinicians and researchers to provide an authoritative guide to help children with brain injury using neuropsychology.

Primary immunodeficiency diseases (PIDs) are a heterogeneous group of inherited disorders characterized by different defects in the development and function of the immune system. This book aims to increase the clinical awareness and knowledge of practicing clinicians regarding the diagnosis and management of PIDs. In order to achieve this goal, about 90 cases drawn from real life are presented, along with approximately 300 related questions. The selected case reports are the result of the invaluable cooperation of more than 40 scientists in the field of immunodeficiency. They focus both on the presenting features of patients with PIDs and on the required further investigation and management. Each of the numbered cases is followed by the questions, their answers, and additional discussion. Each question focuses on a particular aspect of the PID under consideration, and the topics covered include clinical diagnosis, laboratory findings, molecular mechanisms, and therapy.

Advances in the biomedical sciences, especially genomics, proteomics, and metabolomics, taken together with the expanding use of electronic health records, are radically changing the IT infrastructure and software applications needed to support the transfer of knowledge from bench to bedside. Pediatric Biomedical Informatics: Computer Applications in Pediatric Research describes the core resources in informatics necessary to support biomedical research programs and how these can best be integrated with hospital systems to receive clinical information that is necessary to conduct translational research.The focus is on the authors' recent practical experiences in establishing an informatics infrastructure in a large research-intensive children's hospital. This book is intended for translational researchers and informaticians in pediatrics, but can also serve as a guide to all institutions facing the challenges of developing and strengthening informatics support for biomedical research. The first section of the book discusses important technical challenges underlying computer-based pediatric research, while subsequent sections discuss informatics applications that support biobanking and a broad range of research programs. Pediatric Biomedical Informatics provides practical insights into the design, implementation, and utilization of informatics infrastructures to optimize care and research to benefit children. Dr. John Hutton is the Vice President and Director of Biomedical Informatics at Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. He is also Professor of Pediatrics and Associate Dean for Information Services at the University of Cincinnati College of Medicine.

Oxford Textbook of Clinical and Biochemical Disorders of the Skeleton 2 is a definitive reference providing comprehensive coverage of common polygenic and rare monogenic disorders, emphasizing new advances in bone cell biology and human skeletal disease. With an up-to-date account of common and rare metabolic disorders of the skeleton, including their causes, clinical aspects, and treatment, this book offers the reader clarity in the complex field of the molecular biology of the skeleton. Topics covered include bone biology and investigation, osteoporosis, osteomalacia and rickets, parathyroid bone disease, Paget disease, and the effects of malignancy on the skeleton. Newer metabolic bone disorders are also included, along with chapters on osteogenesis imperfecta, skeletal dysplasias, osteopetrosis and osteosclerosis, Marfan syndrome, Ehlers-Danlos syndrome, fibrous dysplasia, and ectopic mineralisation. Essential for postgraduates and clinicians, this accessible and highly illustrated book provides a clear authoritative account of metabolic bone diseases in their widest sense. Bringing together considerable advances in the field, it discusses molecular causes and personal experiences of all disorders, ensuring a comprehensive and didactic reference. Enriched with over 100 new illustrations and revised chapters to reflect a rapidly developing field, this second edition will be indispensable for those who look after patients with metabolic bone disease, including general physicians, rheumatologists, endocrinologists, and orthopaedic surgeons, along with paediatricians and geneticists. This print edition of The Oxford Textbook of Clinical and Biochemical Disorders of the Skeleton comes with a year's access to the online version on Oxford Medicine Online. By activating your unique access code, you can read and annotate the full text online, follow links from the references to primary research materials, and view, enlarge and download all the figures and tables. Oxford Medicine Online is mobile optimized for access when and where you need it.

Multiauthored book dealing comprehensively with the various aspects of imaging of pediatric musculoskeletal trauma. The work is subdivided in three main sections: Overview of lesions; Imaging of traumatic injuries according to body region; typical traumatic injuries of early infancy. The third section includes also legal aspects of child abuse (battered child) and will indicate current international medical-legal guidelines. The didactical approach and the wide-ranging account of the subject makes the book particularly valuable to practitioners from various disciplines, involved in diagnosis and management of trauma of pediatric bone and joint

JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.

Trauma can be defined as exposure to a shocking, distressing, or emotionally painful event that can result in negative mental and physical health effects. Due to its interference with development, childhood trauma is particularly detrimental and can result in symptoms including posttraumatic stress disorder, anxiety disorders, depression, dissociation, externalizing behavioral problems, and suicidal ideation. It can increase the risk of substance use, school disengagement, and academic difficulties, and it has been associated with attentional impairment, cognitive performance, and the development of self-regulation. Cue-Centered Therapy for Youth Experiencing Posttraumatic Symptoms presents a psychosocial treatment approach for children and adolescents who have been exposed to chronic traumatic experiences. Cue-Centered Therapy (CCT) derives its name from its focus on the conditioning process that results in sensitivity towards trauma-related cues. CCT addresses four core domains: cognition, behavior, emotions, and physiology, through a combination of empirically supported and CCT-specific interventions. This structured and flexible Therapist Guide focuses on helping the youth develop insight into his/her own patterns of behaviors and emotions. Rather than having youth attempt to "unlearn" maladaptive responses conditioned to cues, CCT focuses on creating new connections and behavioral responses. The treatment manual offers guidelines on conducting each of the sessions while respecting the individual therapist's own strengths. Through the use of visual icons, forms, and figures, the manual facilitates teaching relevant lessons. The therapy reduces negative cognitions, allows for emotional expression, identifies and changes trauma-related responses, empowers with knowledge and skills, and strengthens the relationship between the caregiver and his/her child.

Indispensable for continuous education and advanced training All editors with international reputation and contributing authors with great expertise in their topic Well-structured text and design, quick and easy to read Bridges the gap between primary literature and daily practice Every 2nd year each subject is covered with timely information about new developments in the specialised field

Pediatric Injury Biomechanics: Archive and Textbook consolidates and describes the current state of the art in pediatric injury biomechanics research in the automotive crash environment. Written by the most respected scientists in the field, the objective of this ground-breaking project is to provide a comprehensive archive and analysis of pediatric injury biomechanics research; to be the go-to reference for the epidemiology of motor vehicle related childhood injury data, pediatric anthropometry, pediatric biomechanical properties, tissue tolerance, and computational models. This book provides essential information needed by researchers working in the field of pediatric injury including those involved in rulemaking activities, injury criteria development, child dummy development, and child injury interventions development. In addition to the text, a companion archive will include valuable information and tools to assist in the identification of gaps in research and future research directions.This living document will be regularly updated with current research and advancements in pediatric injury biomechanics.

Strategies for Collaborating With Children: Creating Partnerships in Occupational Therapy and Research applies client-centered and strengths-based theories to pediatric practice. The text is organized using a research-based conceptual model of collaboration. Within this text, there are detailed descriptions of how to engage and work with children aged 3 to 12 years, from the beginning to the end of therapy. Dr. Clare Curtin covers a variety of topics, such as how to interview children, involve them in defining the purpose of therapy, and develop self-advocacy. Similarly presented is the therapist’s role as a guide in setting respectful limits, teaching self-regulation, avoiding power struggles, and co-creating educational experiences that are challenging and fun. Strategies for Collaborating With Children: Creating Partnerships in Occupational Therapy and Research advocates for children's rights and participation in therapy and research. The United Nations Convention on the Rights of the Child, the new sociology of childhood, and childhood studies are discussed. Also included are children's perspectives on what therapists should know and what children said they might be thinking at each stage of therapy. The last chapter focuses on methods to enhance children’s participation in research, including adaptations for children with disabilities. Unique features:•Describes a new research-based model of collaboration with children •Incorporates children’s views and knowledge about therapy •Illustrates the use of client-centered and strengths-based theories as well as child-friendly approaches within pediatric practice •Provides over 1,600 practical strategies that are exemplified by stories with actual dialogue •Describes ways to involve children throughout the research process •Identifies verbal, visual, and activity-based participatory research methods for eliciting children's voices, including creative ways to involve children with different levels of abilities •Includes review questions at the end of each chapter Instructors in educational settings can visit www.efacultylounge.com for additional material to be used for teaching in the classroom. Strategies for Collaborating With Children: Creating Partnerships in Occupational Therapy and Research delivers a comprehensive resource for collaborating with children for the occupational therapist, occupational therapy assistant, or any other practitioner working with children in a therapeutic setting.