Oxford Textbook of Clinical and Biochemical Disorders of the Skeleton 2 is a definitive reference providing comprehensive coverage of common polygenic and rare monogenic disorders, emphasizing new advances in bone cell biology and human skeletal disease. With an up-to-date account of common and rare metabolic disorders of the skeleton, including their causes, clinical aspects, and treatment, this book offers the reader clarity in the complex field of the molecular biology of the skeleton. Topics covered include bone biology and investigation, osteoporosis, osteomalacia and rickets, parathyroid bone disease, Paget disease, and the effects of malignancy on the skeleton. Newer metabolic bone disorders are also included, along with chapters on osteogenesis imperfecta, skeletal dysplasias, osteopetrosis and osteosclerosis, Marfan syndrome, Ehlers-Danlos syndrome, fibrous dysplasia, and ectopic mineralisation. Essential for postgraduates and clinicians, this accessible and highly illustrated book provides a clear authoritative account of metabolic bone diseases in their widest sense. Bringing together considerable advances in the field, it discusses molecular causes and personal experiences of all disorders, ensuring a comprehensive and didactic reference. Enriched with over 100 new illustrations and revised chapters to reflect a rapidly developing field, this second edition will be indispensable for those who look after patients with metabolic bone disease, including general physicians, rheumatologists, endocrinologists, and orthopaedic surgeons, along with paediatricians and geneticists. This print edition of The Oxford Textbook of Clinical and Biochemical Disorders of the Skeleton comes with a year's access to the online version on Oxford Medicine Online. By activating your unique access code, you can read and annotate the full text online, follow links from the references to primary research materials, and view, enlarge and download all the figures and tables. Oxford Medicine Online is mobile optimized for access when and where you need it.

Strategies for Collaborating With Children: Creating Partnerships in Occupational Therapy and Research applies client-centered and strengths-based theories to pediatric practice. The text is organized using a research-based conceptual model of collaboration. Within this text, there are detailed descriptions of how to engage and work with children aged 3 to 12 years, from the beginning to the end of therapy. Dr. Clare Curtin covers a variety of topics, such as how to interview children, involve them in defining the purpose of therapy, and develop self-advocacy. Similarly presented is the therapist’s role as a guide in setting respectful limits, teaching self-regulation, avoiding power struggles, and co-creating educational experiences that are challenging and fun. Strategies for Collaborating With Children: Creating Partnerships in Occupational Therapy and Research advocates for children's rights and participation in therapy and research. The United Nations Convention on the Rights of the Child, the new sociology of childhood, and childhood studies are discussed. Also included are children's perspectives on what therapists should know and what children said they might be thinking at each stage of therapy. The last chapter focuses on methods to enhance children’s participation in research, including adaptations for children with disabilities. Unique features:•Describes a new research-based model of collaboration with children •Incorporates children’s views and knowledge about therapy •Illustrates the use of client-centered and strengths-based theories as well as child-friendly approaches within pediatric practice •Provides over 1,600 practical strategies that are exemplified by stories with actual dialogue •Describes ways to involve children throughout the research process •Identifies verbal, visual, and activity-based participatory research methods for eliciting children's voices, including creative ways to involve children with different levels of abilities •Includes review questions at the end of each chapter Instructors in educational settings can visit www.efacultylounge.com for additional material to be used for teaching in the classroom. Strategies for Collaborating With Children: Creating Partnerships in Occupational Therapy and Research delivers a comprehensive resource for collaborating with children for the occupational therapist, occupational therapy assistant, or any other practitioner working with children in a therapeutic setting.

Dysfunction of the gastrointestinal tract in critically ill patients has recently become a focus of intensive research. This book, the first one on this topic, is a comprehensive overview of what is currently known about the role of the gut in patients requiring intensive care. The definitions and pathogenesis of intestinal dysfunction are critically evaluated. Currently available and potential new ways to monitor intestinal function in the intensive care setting are presented. Emphasis has been placed on the evaluation of therapeutic strategies in the prevention and treatment of gut dysfunction. Options for monitoring and treating gut dysfunction in critically ill patients are rapidly evolving. This volume provides state-of-the-art information for both clinicians and clinical researchers.

This groundbreaking book explores how the attachment- focused family therapy model works at a neural level. Investigation of the brain science of early childhood and developmental trauma offers clinicians new insights-and powerful new methods-to help neglected and insecurely attached children regain a sense of safety and security with caring adults.

JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.

The human foetus is separated from the maternal blood by the syncytiotrophoblast induced by endogeneous human retrovirus-encoded proteins. This barrier is a highly developed one, which suppors apical-basolateral transport of maternal idiotype and anti-idiotype IgG, IgG-virus complexes. The selective maternal-fetal transport of epitope- and paratope-bearing entities can influence the developping fetal immune system during pregnancy. The bidirectional maternal-fetal transfer of cells are of even more importance during pregnancy. Maternal cells with latent viruses transport viruses without impairment of fetal development. Cells with premaligant and malignant genetic transformation are also transported to the fetus. Fetal and neonatal tumours are initiated by such cells in spite of the antitumour potential of fetal organism. On the contary, the fetal cells repair maternal tissue injouries and survive in the organisms of the recipients for decades. These possess new consequences for the neonatal immunity and organ transplatation surgery.

Mental health problems and worries are common among infants, children and adolescents in every part of the world. This book is a practical manual for primary healthcare professionals, teachers and anyone who works with children - especially in places where specialist psychiatric care is not available. After giving the reader an overview of child mental health problems, the manual goes on to deal with the various developmental, behavioural and emotional problems that arise in as many as 10% of the youth population. For each problem it first provides a case study and then describes how to find out more about a child with this problem. It suggests what can be done to help the child and their family. It also examines the mental health aspects of childhood maltreatment and exposure to natural or man-made disasters. Covers problems that health workers and teachers in low- and middle-income countries often have to deal with. Written in simple language with many case examples and pictures. The only comprehensive book on mental healthcare in young people for those with no access to specialist medical advice. This book is intended for anyone who works with children or young people, but who does not have specialist training in mental health problems. This includes: primary care doctors and nurses, community health workers and teachers.

captured for the published proceedings. Nevertheless, the two Supplements to this Journal (also available together as a hard-backed book) do, over the years, embrace many of the major aspects of the study of inborn errors of metabolism and can, particularly with the Short Communications section, be used as a way into the literature on specific new topics. We hope that with judicious selection of material these supplements will continue to provide, as did the Society's earlier annual publications, a balanced record of the present state of the subject in all its facets, a record of interest to those working in allied fields as well as to the specialist. R. J. Pollitt G. M. Addison R. A. Harkness The papers listed below were also presented at the meeting. Scripts were not available by the time of publication. 1. Tangier disease and related disorders of apolipoprotein Al. G. Assmann, Munster. 2. Contribution to Ethics Symposium by M. E. Pembrey, London.

Diagnostic neuroradiology is undergoing such rapid change that standard texts are quickly becoming outdated in important respects. Recent Advances in Diagnostic Neuroradiology is designed to complement the general textbooks of neuroradiology by documenting and discussing the progress that has been achieved. Following six introductory chapters, 26 important topics in brain and spinal imaging are discussed in detail, with appropriate illustrations and a review of the most recent literature. Each of these topics has specifically been chosen in order to summarize recent developments and to document the state of the art in the field. This book, written by acknowledged experts in the field, will be of relevance and importance to all with an interest in neuroradiology.

In conventional partial resection of parenchymatous organs significant bleeding is one of the main problems, especially in neonates and infants. The patients rapidly lose considerable amounts of their small blood volume. Laser light leads to photo thermal effects in tissue and causes coagulation, drying up, carbonization and evaporization, depending on the temperature. The neodymium Y AG laser emits nonvisible light in the near infrared with a wavelength of l. 0611m. This wavelength implies a relatively deep penetration into the tissue. This laser system, properly a coagulation laser, achieves its cutting effect by its high power density [9]. Because of thermal radiation in all directions, both sides of the section plane are coagulated as a positive side effect. Thus, in parenchymatous organs a combination of resection and sealing of the cut vessels and ducts, up to a limited diameter, is obtained. Laser Instruments We use a neodymium-YAG laser mediLas 2 (MBB-Medizintechnik, D-8012 Ottobrunn, Federal Republic of Germany), wavelength l. 0611m, maximal power output around 110 W (Fig. 1). Normally we prefer to work without tissue contact, Fig. l. The Nd-YAG laser system mediLas 2 with maximal power output around 100 W The Neodymium Y AG Laser in Surgery of Parenchymatous Organs 25 Fig. 2. The focusing handpiece with focal distance of 50 mm 1cm Fig. 3.

JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.

Imaging in Pediatric Pulmonology is a definitive reference to imaging and differential diagnosis for pediatric pulmonology. Diseases and disorders seen in everyday clinical practice are featured, including infections, developmental disorders, airway abnormalities, diffuse lung diseases, focal lung diseases, and lung tumors. Organized to support the clinical thought process, the text begins with a series of clinical algorithms that provide a starting point for formulating a diagnosis. The physician will be able to identify the differentials by symptom complex and accordingly determine what test would be effective and how to proceed. The balance of the book is image-based and presents a comprehensive, multi-modality approach, with an emphasis on plain film and cross-sectional imaging. The imaging sections are correlated with pathology and clinical findings to help readers learn what the modality of choice can enable them to see. Edited by Robert H. Cleveland, MD, Professor of Radiology at Harvard Medical School and Chief of the Division of Diagnostic Radiology at Children's Hospital Boston, the book includes a talented group of associate editors and contributing authors who are noted experts in pathology, pulmonology, and radiology, making Imaging in Pediatric Pulmonology an ideal reference for all physicians involved in the diagnosis and treatment of pediatric pulmonary issues.

JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.

This book will provide both an evidence base and practical recommendations for the treatment of patients with congenital heart disease. It will be a resource to all health care providers, including pediatric cardiologists, pediatric intensivists, pediatric heart surgeons, fetal specialists, maternal fetal medicine specialists, neonatologists, nurses, advanced practice nurses, in addition to trainees in the field. It will summarize world knowledge on the topic of heart failure in patients with congenital heart disease. It will provide an in depth analysis of the current methods of diagnosis and treatment of heart failure. Now that surgical results are at record success rates, more patients with congenital heart disease are surviving, and thus at risk for sequelae from their disease, including heart failure. It will provide evidence based and practical recommendations to the practitioner for the management of heart failure signs and symptoms.

Increasingly, global humanitarian efforts are focusing on improving the lives of children. And among the developing world, the African nations are particularly affected by extreme weather conditions, devastating pandemics, and armed conflict. Neurocognitive science offers significant avenues toward bringing needed aid to the continent while creating a template for helping children worldwide. The studies in Neuropsychology of Children in Africa clearly illustrate how the brain develops and adjusts in the face of adversity. Contributors span assessment approaches and public health risk factors, and represent established topics and emerging lines of research, including biocultural constructs and genomic technologies. Together, these chapters argue for methodology that is culturally sensitive, scientifically rigorous, consistent, and sustainable. And although the focus is pediatric, the book takes a lifespan approach to prevention and intervention, modeling a universal framework for understanding neurocognitive development. Included in the coverage: Assessment of very young children in Africa in the context of HIV. Psychosocial aspects of malnutrition among African children. Assessment of neuropsychological outcomes in pediatric severe malaria. Neurodisability screening using the Ten Questions questionnaire. The neuropsychology of sickle cell disease in West African children. Computerized Cognitive Rehabilitation Thera py for African children. As a guide to current findings or a springboard for new studies, Neuropsychology of Children in Africa is a necessary reference for researchers, policymakers, and diverse professionals in global aid organizations, and across the discipline.

The molecular era ushered in the cloning of the growth hormone (GH) gene and the production of unlimited amounts of GH through recombinant technology. The continuing momentum of research from basic science to clinical evaluation has brought unprecedented advances to the understanding of GH biology for the clinical endocrinologist. Growth Hormone Related Diseases and Therapy: A Molecular and Physiological Perspective for the Clinician distills all the new information of relevance to the endocrinologist over the last 20 years by offering five sections: physiology, molecular genetics, GH deficiency, acromegaly and pharmacotherapy. The first section on physiology focuses on GH action. A review on the structure and function of the GH receptor is followed by a perspective on the regulatory role of ghrelin on GH secretion. The second section on genetics covers pituitary function and adenomas, including new and fascinating information on familial pituitary adenomas, their genotype and phenotype. The adult GH deficiency section spans the epidemiology and diagnosis of GH deficiency with a strong reminder for the clinician that the transition period represents a critical time of somatic maturation, which continues for years after cessation of liner growth. The section on acromegaly focuses on management, giving practical guides to the value of GH and IGF-1 measurements, the place of somatostatin analogues and of radiotherapy while reminding the reader as to why evaluating quality of life is an important part of management. Finally, the section on GH pharmacology takes the reader through innovative developments of long-acting GH formulations with some products on the threshold of clinical use. This section provides a balanced evidence based review of the effects of GH supplementation in aging and in sports where recent data indicates an enhancing effect on a selective aspect of performance. Growth Hormone Related Diseases and Therapy: A Molecular and Physiological Perspective for the Clinician integrates a wealth of information and will prove an invaluable reference for pediatric endocrinologists, adult endocrinologists, endocrine scientists and internists interested in the human biology of GH.

With Bridging Worlds, you will learn to uncover the roots of teenage problems - the causes behind symptoms such as self-destructiveness, anger, recklessness, and violence. Originally published in 1998, this title shows you how to develop treatment guidelines and thoughtful frames of reference that address the problems of teenage violence, pregnancy, truancy, and delinquency. It will help you detect when the reckless, even frightening, behaviour of adolescents is a cry for help and show you what you can do to defuse the situation, make authentic and meaningful connections, and offer valuable help.

Are you looking for concise, practical answers to those questions that are often left unanswered by traditional pediatric sleep disorder references? Are you seeking brief, evidence-based advice for complicated cases or controversial decisions? Curbside Consultation in Pediatric Sleep Disorders: 49 Clinical Questions provides quick answers to the tricky questions most commonly posed during a “curbside consultation” between pediatricians. Dr. Aaron Chidekel has designed this unique reference which offers expert advice, preferences, and opinions on tough clinical questions commonly associated with pediatric sleep disorders. The unique Q&A format provides quick access to current information related to pediatric sleep disorders with the simplicity of a conversation between two colleagues. Numerous images, diagrams, and references allow readers to browse large amounts of information in an expedited fashion. Some of the questions that are answered: • Why do we sleep and what is happening when children sleep? • How does sleep change from infancy to adulthood? • What are the latest recommendations for safe infant sleep and the prevention of SIDS? • What are some pearls or strategies to manage or even better, to prevent behavioral sleep disorders in young children? • What is obstructive sleep apnea syndrome? • What is narcolepsy and do children actually develop this condition? • Which of my patients should have a polysomnogram? Curbside Consultation in Pediatric Sleep Disorders: 49 Clinical Questions provides information basic enough for residents while also incorporating expert advice that even high-volume pediatricians will appreciate. Pediatricians, family practitioners, and pediatric residents will benefit from the user-friendly, casual format and the expert advice contained within.

Some engage in high-risk behaviors. Others need help with emotional skills. Many are affected by mental disorders. While every school has its share of students needing comprehensive mental health services, personnel struggle to address these needs effectively in an era of scarce resources and dwindling budgets. Preventive Mental Health at School gives school-based practitioners and researchers an accessible, nuanced guide to implementing and improving real-world proactive programs and replacing outmoded service models. Based firmly in systems thinking and an ecological-public health approach, the book outlines the skills needed for choosing evidence-based interventions that are appropriate for all students, and for coordinating prevention efforts among staff, educators, and administration. As schools become more and more diverse, school-based practitioners must become knowledgeable in regard to the critical racial and cultural differences that affect students, their families, and enrich our schools. Research currently available to help meet the needs of various groups of children and their families is included as each topic is addressed. In addition, the author provides a theoretical groundwork and walks readers through the details of assessing resources and needs, applying knowledge to practice, and evaluating progress. Instructive case examples show these processes in action, and further chapters address questions of adapting programs already in place for greater developmental or cultural appropriateness. Included in the coverage: Student engagement, motivation, and active learning. Engaging families through school and family partnerships. Evidence-based prevention of internalizing disorders. Social emotional learning. Adapting programs for various racial and ethnic populations. Adapting programs for young children. Preventive Mental Health at School offers solid guidance and transformative tools to researchers, graduate students, and professionals/practitioners/clinicians in varied fields including clinical child and school psychology, social work, public health and policy, educational policy and politics, and pediatrics.

In recent years, developments in ultrasound, computed tomography and magnetic resonance imaging have made important changes in the practice of diagnostic radio logy. Concomitantly, invasive radiology for both diagnostic and therapeutic purposes has grown into a rapidly evolving subspecialty. This text represents a landmark in paediatric radiology. The three authors are distinguished radiologists who, over the past two decades, have greatly contributed to paediatric hepatology. Their pioneering work in the area of splanchnic angiography and diagnostic as well as therapeutic cholangiography was facilitated by their close day-to-day interaction with the Paediatric Liver Disease Unit at Hoepital Bicetre. The contents and the format of this "atlas" are testimony to their knowledge of clinical hepatology and to their wide experience in invasive paediatric radiology. The out standing quality of the images is enhanced by appropriate clinical descriptions which will help the reader understand the indications for these procedures, their accuracy and limitations.

Readers of this book can update their knowledge in the fast-moving field of endocrinology and neurobiology. Topics concerning growth and development are extensively reviewed from both basic science and clinical viewpoints. Aspects related to growth development and to the control of cellular differentiation and multiplication are discussed. Further new information is provided on: synthetic recombinant human growth hormone (rHGH); potential diagnostic and therapeutic applications of the neuropeptide, growth hormone releasing hormone (GHRH); the physiology and physiopathology of the neural control of growth hormone secretion; the diagnosis and therapy of growth hormone deficiency or excess states; and the biology, function and possible utilization of growth factors. These important new findings are relevant to progress in pediatrics, pediatric and clinical endocrinology, neuroendocrinology and physiology.

The book presents a modern, psychoanalytically-informed chronological view of how the mind develops from infancy through young adulthood. It is a comprehensive work which integrates analytic theories and concepts with a contemporary systems model of development and draws on scholarly research from neighboring fields.

This book is a concise guide to ordering radiology tests for diagnosis and treatment and provides best practice guidelines for patients whose management depends on a clinical question that is best approached through imaging. Organized primarily by organ system, it outlines considerations in selecting the most efficacious imaging studies based on the clinical history, laboratory values, and physical findings to arrive cost-effectively at a correct diagnosis. It also explores the current limitations of each imaging modality and presents evidence-based information to insure that patient safety considerations are observed when ordering potentially dangerous examinations. Clinician's Guide to Diagnostic Imaging is a valuable resource for all physicians who regularly order imaging studies, including primary care physicians, family practitioners, internists, and surgeons alike. Further, this volume serves as an invaluable reference for medical students who are exposed to medical imaging for their first time or who are rotating through a radiology elective in medical school.

Originally published in 1959, this book was written to assist medical students in viewing their child patients within a social context. It provides a framework within which trainee doctors can understand the broader needs of the patient, encouraging a more complex view of the medical environment than one limited to academic detachment. The book is divided into ten chapters, the first five chapters are devoted to broader environmental concerns, whilst the remainder are based around the direct relationship between the physician and the child. It will be of value to anyone with an interest in the history of medicine, sociology or anthropology.