This new title in the Fast Facts series, full of up-to-date and authoritative information, is a critical resource for all health care professionals working with children and adolescents.Psychiatrists, prescribing psychologists, psychotherapists, pediatricians, family practice physicians, pediatric neurologists, nurse practitioners, allied mental health professionals, and trainees in these professions are provided with: General introductory reviews of the principles of pediatric psychopharmacology and related patient assessment issues; Detailed discussions of psychiatric medications organized by drug class; A comprehensive review of child and adolescent psychiatric disorders. Rich background information and clear explanations of clinical directions for the prescriber and nonprescriber alike.

Authored by two child and adolescent psychiatrists, Pediatric Psychopharmacology provides empirically-based, state-of-the-art knowledge as well as clear practical guidance regarding assessment, prescription, monitoring, and discontinuation of medications.

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A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, 4th Edition "features the latest ideas and research about the application of pharmacology to the process of drug discovery to equip readers with a deeper understanding of the complex and rapid changes in this field. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for all those involved in drug discovery. This edition has been thoroughly revised to include material on data-driven drug discovery, biased signaling, structure-based drug design, drug activity screening, drug development (including pharmacokinetics and safety Pharmacology), and much more. With more color illustrations, examples, and exercises throughout, this book remains a top reference for all industry and academic scientists and students directly involved in drug discovery, or pharmacologic research.

Highlights changes surrounding the strategy of drug discovery to provide you with a comprehensive reference featuring advances in the methods involved in lead optimization and more effective drug discoveryIncludes a new chapter on data-driven drug discovery in terms of the optimal design of pharmacological experiments to identify mechanism of action of new moleculesIllustrates the application of rapid inexpensive assays to predict activity in the therapeutic setting, showing data outcomes and the limitations inherent in interpreting this data

This authoritative volume explores advances in the techniques used to measure percutaneous penetration of drugs and chemicals to assess bioavailability and bioequivalence and discusses how they have been used in clinical and scientific investigations. Seven comprehensive sections examine topics including in vitro drug release, topical drugs products, clinical studies, and guidelines and workshop reports, among others. The book also describes how targeted transdermal drug delivery and more sophisticated mathematical modelling can aid in understanding the bioavailability of transdermal drugs. The first edition of this book was an important reference guide for researchers working to define the effectiveness and safety of drugs and chemicals that penetrated the skin. This second edition contains cutting-edge advances in the field and is a key resource to those seeking to define the bioavailability and bioequivalence of percutaneously active compounds to improve scientific and clinical investigation and regulation.

Volumes in this widely revered series present comprehensive reviews of drug substances and additional materials, with critical review chapters that summarize information related to the characterization of drug substances and excipients. This organizational structure meets the needs of the pharmaceutical community and allows for the development of a timely vehicle for publishing review materials on this topic.
The scope of the Profiles series encompasses review articles and database compilations that fall within one of the following six broad categories: Physical profiles of drug substances and excipients; Analytical profiles of drug substances and excipients; Drug metabolism and pharmacokinetic profiles of drug substances and excipients; Methodology related to the characterization of drug substances and excipients; Methods of chemical synthesis; and Reviews of the uses and applications for individual drug substances, classes of drug substances, or excipients.

Key features:

* Contributions from leading authorities * Informs and updates on all the latest developments in the field

The "Side Effects of Drugs Annual" was first published in 1977. It has been continually published since then as a yearly update to the voluminous encyclopedia, "Meyler's Side Effects of Drugs." Each new Annual continues to provide clinicians and medical investigators with a reliable and critical yearly survey of new data and trends in the area of adverse drug reactions and interactions. An international team of specialists has contributed to the informative Annual by critically interpreting it and by pointing to whatever is misleading.
Provides a critical yearly survey of new data and trendsSpecial reviews in this Annual include, among other topics, epidemiology of the use of ecstasy, paracetamol and the risk of asthma, combination vaccines/multiple immunizations, interactions of herbal medicines with warfarin, and tyrosine kinase inhibitors

International Cooperation, Convergence and Harmonization of Pharmaceutical Regulations: A Global Perspective provides the current status of the complex and broad phenomenon of cooperation, convergence and harmonization in the pharmaceutical sector (Part I), thoroughly evaluates its added value and its critical parameters and influencing factors (Part II) in order to recommend actions and measures to support the next steps for cooperation, convergence and harmonization (Part III). All of these recommendations in the book support the establishment of a better coordinated global pharmaceutical system which represents the best realistic alternative to fulfill the objective to establish a global coalition of regulators and to respond to an increased demand to further cooperation in the pharmaceutical sector. This proposed framework, which leverages all of the ongoing positive cooperation initiatives and uses as foundations all of the numerous harmonization projects developed over the years, presents advantages for all stakeholders and would definitively have significant added value to the promotion and protection of global public health.
The status of all major worldwide harmonization and cooperation initiatives (at bilateral, regional, and global levels)The value of cooperation in the pharmaceutical sector and the driving factors behind harmonizationThe proposition of a structure for the global pharmaceutical system and timely recommendations for enhancing international cooperation, as well as further discussion and policy changes in this area

This book continues as volume 7 of a multi-compendium on Edible Medicinal and Non-Medicinal Plants. It covers plant species with edible flowers from families Acanthaceae to Facaceae in a tabular form and seventy five selected species from Amaryllidaceae, Apocynaceae, Asclepiadaceae, Asparagaceae, Asteraceae, Balsaminaceae, Begoniaceae, Bignoniaceae, Brassicaceae, Cactaceae, Calophyllaceae, Caprifoliaceae, Caryophyllaceae, Combretaceae, Convolvulaceae, Costaceae, Doryanthaceae and Fabaceae in detail. This work will be of significant interest to scientists, medical practitioners, pharmacologists, ethnobotanists, horticulturists, food nutritionists, botanists, agriculturists, conservationists, lecturers, students and the general public. Topics covered include: taxonomy; common/English and vernacular names; origin and distribution; agroecology; edible plant parts and uses; botany; nutritive/pharmacological properties, medicinal uses, nonedible uses; and selected references.

This issue of Interventional Cardiology Clinics reviews pharmacologic agents currently used to treat patients in the cath lab. All the pharmaceutical knowledge an interventionalist needs is summarized in this handy reference.

Prescription drugs are a basic and invaluable part of society today, but there is debate surrounding the methods of testing new drugs, the possible misuse of prescription drugs, and the economics of drug production and use. This book examines the evolution of prescription drugs in the United States, as well as the formation of the pharmaceutical industry. It begins with a history of prescription drugs, dating back to their origins, then moves through the Industrial Revolution and into the present day. It also delves into the issues and controversies related to prescription drugs, such as drug costs, regulations, prescription drug abuse, insurance complications, and more. Both implemented and proposed solutions are also discussed. One of the most valuable aspects of the book is that it surveys the history of prescription drugs in a manner that helps the reader identify key issues in an easy-to-understand fashion. Finally, the perspectives chapter allows a broad range of voices to be heard, allowing crucial, diverse perspectives to round out the author's expertise. Provides readers with an understanding of the various types of drugs and how they differ in their effects and possible applications Introduces a detailed review of the steps involved in the preclinical, clinical, and post-clinical stages of testing of a new prescription drug Outlines some major issues in the way experimental drugs are tested, such as gender, age, and racial bias Reviews the current status of prescription drug abuse in the United States Explains issues involved in the pricing of prescription drugs and issues involved in over-pricing

This volume of "International Review of Neurobiology" brings together cutting-edge research on advances in the neurochemistry and neuropharmacology of Tourette syndrome. It reviews current knowledge and understanding, provides a starting point for researchers and practitioners entering the field, and includes important topics regards tics, neurotransmitters, pharmacology and emerging treatments.

This volume of brings together research on tourettes synrdrome. It reviews current knowledge and understanding on the neurochemistry and neuropharmacology of tourettes syndrome.

Volumes in this widely revered series present comprehensive reviews of drug substances and additional materials, with critical review chapters that summarize information related to the characterization of drug substances and excipients. This organizational structure meets the needs of the pharmaceutical community and allows for the development of a timely vehicle for publishing review materials on this topic.
The scope of the Profiles series encompasses review articles and database compilations that fall within one of the following six broad categories: Physical profiles of drug substances and excipients; Analytical profiles of drug substances and excipients; Drug metabolism and pharmacokinetic profiles of drug substances and excipients; Methodology related to the characterization of drug substances and excipients; Methods of chemical synthesis; and Reviews of the uses and applications for individual drug substances, classes of drug substances, or excipients.

Key features:

* Contributions from leading authorities * Informs and updates on all the latest developments in the field

This volume looks at modern computational strategies and techniques used in GPCR drug discovery including structure and ligand-based approaches and cheminformatics. The chapters in this book describe how these approaches can be applied to address key drug discovery issues, such as receptor structure modelling, function and dynamics, prediction of protein-water-ligand interactions and binding kinetics, free energy of binding, interconversion between agonists and antagonists, deorphanization of GPCRs, and the discovery of biased and allosteric modulators. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary software and tools, step-by-step, readily reproducible modelling protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and unique,Computational Methods for GPCR Drug Discovery is a valuable resource for structural and molecular biologists, computational and medicinal chemists, pharmacologists, and drug designers.

Emerging approaches to treating addictions and minimizing relapse are spotlighted in this idea-packed volume, as alternatives or adjuncts to standard psychological and pharmacological therapies. Its biopsychosocial perspective delves into the causes and processes of chemical dependence, and the clinical characteristics it shares with other addictions (e.g., food, sex, gambling, online activities), to identify client needs that substance abuse may fulfill. Accordingly, the diverse modalities featured here address substance addiction on multiple levels, offering clients physical or mental stimulation and/or emotional relief as well as affording different degrees of autonomy. Methods can be mixed and matched to reinforce treatment goals, and clinicians can tailor treatment to individual issues and interests to assure clients nuanced and meaningful care. Included in the coverage: * Use of herbal medicine to treat drug addiction. * EMDR therapy and the treatment of substance abuse and addiction. * Evaluating the change processes in drug users' interventions. * Web-based interventions for substance abuse. * Physical exercise and treatment of addiction. * Mindfulness to reduce the anxiety during the abstinence * Neurofeedback to deal with craving and anxiety symptoms Psychologists, psychiatrists, clinical social workers, and addiction counselors and educators will find Innovations in the Treatment of Substance Addiction a valuable sourcebook for understanding addiction-and intervention-in its wider context.

Updated to include a succinct yet thorough review of the most recent evidence-based information and data-driven best treatment practices in child and adolescent psychiatry, this fourth edition of the Clinical Manual of Child and Adolescent Psychopharmacology not only examines the evidence for treating mental health disorders in younger patients but also illuminates how clinical trials of various methodologies can inform different aspects of clinical practice. Organized by DSM-5-TR diagnosis rather than drug class, this clinically accessible volume offers an exhaustive analysis of the use of psychotropic agents in disorders that include • Attention-deficit/hyperactivity disorder • Depressive disorders • Autism spectrum disorder • Early schizophrenia and psychotic illnesses • Eating disorders Comprehensive medication tables allow for easy reference of dosing, side effects, and tips for management. Additionally, key points at the conclusion of each chapter summarize essential information for treating clinicians. With a depth of information unmatched by any other guide, this new edition of the Clinical Manual of Child and Adolescent Psychopharmacology is an indispensable desktop reference for clinicians working with young patients.

Ibuprofen is one of the most successful drugs used worldwide for the treatment of mild to moderate pain and various inflammatory conditions. Over the past 40 years, ibuprofen has been proven to be as safe or even safer and also as effective as the established non-steroidal anti-inflammatory drugs (NSAIDs) and the coxibs. This well-written book reviews the pharmacology, clinical uses and the various adverse effects of Ibuprofen, the disposition and unique modes of action in relation to clinical effects of the drug as well as various formulations. The use of combinations with other drugs (e.g. paracetamol, codeine, caffeine) are critically assessed and the impact of natural products and Chinese Medicines on the safety of ibuprofen.

Leading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.

Innovative approach to drug design that's more likely to result in an approvable drug product Retrometabolic drug design incorporates two distinct drug design approaches to obtain soft drugs and chemical delivery systems, respectively. Combining fundamentals with practical step-by-step examples, Retrometabolic Drug Design and Targeting gives readers the tools they need to take full advantage of retrometabolic approaches in order to develop safe and effective targeted drug therapies. The authors, both pioneers in the fields of soft drugs and retrometabolic drug design, offer valuable ideas, approaches, and solutions to a broad range of challenges in drug design, optimization, stability, side effects, and toxicity. Retrometabolic Drug Design and Targeting begins with an introductory chapter that explores new drugs and medical progress as well as the challenges of today's drug discovery. Next, it discusses: * Basic concepts of the mechanisms of drug action * Drug discovery and development processes * Retrometabolic drug design * Soft drugs * Chemical delivery systems Inside the book, readers will find examples from different pharmacological areas detailing the rationale for each drug design. These examples set forth the relevant pharmacokinetic and pharmacodynamic properties of the new therapeutic agents, comparing these properties to those of other compounds used for the same therapeutic purpose. In addition, the authors review dedicated computer programs that are available to support and streamline retrometabolic drug design efforts. Retrometabolic Drug Design and Targeting is recommended for all drug researchers interested in employing this newly tested and proven approach to developing safe and effective drugs.

Written by a leading researcher in the field, "Transporters in Drug Discovery and Development "provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant polymorphism; drug transporter related pharmacokinetic, pharmacodynamics and toxicity; in vitro/in vivo probes of drug transport studies; the practical methodologies of industrial transporter screening and translational aspect in drug discovery and developments.
A comprehensive overview of drug transporter families and their clinical relevance in drug discovery and developmentBalanced coverage of molecular biology aspects and functional outcomesState of art knowledge related to transporter-mediated DDI and the clinical relevance in pharmacokinetics, dynamics, and toxicity

"Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation" includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives. Each chapter presents an overview of the potential or opportunity within the areas discussed and also outlines foreseeable challenges and limitations in moving pharmacogenomics into drug development and direct therapeutic applications. This edited book contains review questions for a more in-depth analysis of the implications of pharmacogenomics and discussion points to generate ideas on best to move the field forward. Clinical pearls and case studies are used to illustrate real-life experiences and both successful and unsuccessful applications. Tables, figures, and annotations are included throughout the book to facilitate understanding and further reference.
Multi-contributed book and chapters are written by contributors who are experts in their fieldProvides perspectives from those involved in all aspects of pharmacogenomics-including academic, regulatory, economic, industry and medical-to illustrate how all of the pieces fit together and where the challenges may beIncludes case studies of both successful and unsuccessful applications so readers can consider the potential and challenges in moving the science into drug development and direct therapeutic applicationsChapters contain discussion questions and clinical pearls and enable readers to reflect on how to move pharmacogenomics forward and apply these observations and useful tips to their own work and research

A companion website offers an elaboration on key points and discussion questions and provides patient case scenarios that illustrate how pharmacogenomics may be applied to a clinical setting