In this book, the author provides expert analysis on naturally occurring iridoids, their chemistry and their distribution in plants and insects. Particular attention is given to the pharmacology of iridoids and their prospective applications in pharmaceutical and agricultural industries. Iridoids are found in a wide variety of plants and some insects, and they are structurally derived from monoterpenoid natural products. In the first two chapters of this book, the author describes the iridoids classification, occurrence and distribution in plants and insects. The following chapters cover different chromatographic and spectroscopic techniques that can be used to identify and quantify iridoids in herbal formulations, and also the biosynthesis of iridoids, in which the reader will discover a metabolomics and transcriptomics analysis to identify the genes involved in the biosynthesis. The final chapters provide insights on several pharmacological activities of iridoids, their physiological role in insects, pharmacokinetics in mammals, insects and microorganisms, and their applications in medicine and agriculture. This book will engage students and researchers interested in the chemistry of natural products, and it will also appeal to medicinal chemists and practitioners working in the design of new herbal drugs with bioactive pure iridoids.

Ion Channels Down Under, Volume 79 provides up-to-date information on ion channel pharmacology, their pharmacological modulators, and their role in a diverse range of poorly treated medical conditions. This new volume covers specific topics relating to Receptors and the Diversity in their Structure and Pharmacology, Acid-Sensing Ion Channel Pharmacology, Past, Present and Future, Sodium Channels and Venom Peptide Pharmacology, the Role of Non-Neuronal TRPV4 Signaling in Inflammatory Processes, and Genetically Encoded Calcium Indicators as Probes to Assess the Role of Calcium Channels in Disease and for High-Throughput Drug Discovery. Contributors in this series include prominent scientists and highly-recognized experts with major accomplishments in the field of ion channel pharmacology. Topics covered include the role of ion channels in health and disease, ion channels as therapeutic targets and the molecular pharmacology of ion channels.

Immunopharmacology represents the boundary between the immune system and chemical mediators of the inflammatory and neuroendocrine responses. The subject as applied to the respiratory system embraces most of the common non-malignant lung diseases of which asthma and allied disorders are the most prevalent. An understanding of the underlying mechanisms of the disorders provides rationale for prevention and drug treatment as well as creating opportunities for novel drug development. This volume embraces all of these principles and should enable the reader to become rapidly updated in an area of medical importance.
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* Focuses on aspects of disease pathogenesis that are common to a variety of lung disorders.
* Includes coverage of the mechanisms of asthma - origin, progression, and novel therapeutic interventions.
* This volume is another in the "Systems" section of the Handbook of Immunopharmacology.

This book presents formulations for over-the-counter (OTC) or nonprescription drugs. The phrase "over-the-counter" implies that the product may be purchased by the consumer without the need for a physician's prescription. The terms "nonprescription" and "OTC" are synonymous.

The OTC drug formulations in this book are organized according to their therapeutic effect. There are 19 categories of OTC drugs included. Each category is presented in a single chapter that consists of two parts; Part I presents the composition of brand name products, and Part II presents starting or prototype formulations contributed by suppliers of raw materials for OTC drugs.

The brand name products are listed alphabetically in Part I of each chapter, followed by the name of the manufacturer, the type and concentration of the active ingredient(s) and the product form(s). It is also customary, but not required, for the manufacturer to list the so-called "inactive ingredients" on the label of the product.

Part II of each chapter (except Chapter 17) includes starting formulations, developed by a number of raw material suppliers. Those formulations that are included, contain not only the concentration of the active ingredients but also the concentration of the other ingredients and, in most cases, a recommended procedure for mixing the formulation.

This book includes 559 brand name formulations of 63 manufacturers and 270 supplier's suggested formulations for a total of 829 formulations.

Protein pharmaceuticals form a fast-growing category in the arsenal of drugs. This book explores the nature of different analytical techniques and the way in which they are related to pharmaceutical proteins. In addition to serving the analytical chemist, this book is needed by the formulation scientist who is responsible for design and formulation of a pharmaceutical protein that can be monitored during production and over time.

This textbook provides a comprehensive overview of the currently used concepts, approaches and technologies in the discovery and development of new treatments for the full spectrum of disorders of the central nervous system. It guides the reader through all essential steps, from finding an innovative idea, to the registration of a new drug. Divided into four sections, the book starts by presenting a broad perspective on current approaches in central nervous system (CNS) drug discovery. The second section addresses the generation of ideas for the identification of targets and novel treatment strategies; covers core functions in early discovery, and provides an example of a novel treatment paradigm: brain stimulation. The third section highlights strategies and technologies in translational CNS drug discovery. In an effort to bridge the gap between discovery and clinical development, it also covers brain imaging, EEG and cognitive testing approaches. The fourth section extensively discusses the clinical phase of drug development, covering the basics of early clinical testing for psychopharmacological drugs. The book's final chapter addresses the registration for newly developed drugs. Written by experts from academia and industry, the book covers important basics and best practices, as well as recent developments in drug discovery. Offering in-depth insights into the world of drug development, it represents essential reading for early researchers who want to prepare for a career in drug discovery in academia or industry.

This issue of Hematology/Oncology Clinics is devoted to New Anticoagulant and Antithrombotic Agents and will include articles such as: Development and Pharmacology; Post Orthopedic Joint Replacement Surgery VTE Prophylaxis; Use for Afib; Treatment of Acute VTE; Extended Treatment of VTW; Bleeding Risks: Use in Special Poplulations; Monitoring Anticoagulant Effect, and many more articles surrounding this important title.

Vascular Pharmacology: Smooth Muscle provides up-to-date information on the structure, function, signaling, and development of vascular smooth muscle. Contributors include prominent scientists and highly-recognized experts with major accomplishments in the field of vascular smooth muscle research.

A comprehensive and clearly written book on pharmacy calculations, which covers all the calculations that students of pharmacy need to know in relation to pharmacy practice and clinical pharmacy. It includes a large number of self-testing questions at the end of each chapter as well as some 'mock' UK registration exam papers. The self-testing aspect is important and is in line with the educational premise that it is only through practice of calculations that true competence is achieved. The book will be especially useful for anyone preparing for registration exams in pharmacy, in particular those based on the UK exam. It will be an invaluable tool in developing the critical skills necessary for student and prereg pharmacists, and will also be a useful reference during subsequent practice. Contains self-study questions and answers, many with worked examples Includes 'mock' registration exam papers Ideal for exam preparation and as a reference for later practice Includes a chapter on pharmacokinetics Serves as a useful reference during practice

The "Side Effects of Drugs Annual" was first published in 1977. It has been continually published since then, as a yearly update to the voluminous encyclopedia "Meyler's Side Effects of Drugs." Each new Annual continues to provide clinicians and medical investigators with a reliable and critical yearly survey of new data and trends in the area of Adverse Drug Reactions and Interactions. An international team of specialists has contributed to the informative, by critically interpreting it, and by pointing to whatever is misleading.
Provides a critical yearly survey of new data and trends in the side effects of drugs.
Each drug article contains case histories.
Contains detailed information on drug-drug interactions.

One of the first major theoretical reviews of schizophrenia since the publication of the 5th edition of the APA's Diagnostic and Statistical Manual, the DSM-5, this volume is a landmark in the history of schizophrenia research. It assembles recent groundbreaking developments in research on schizophrenia and reaffirms its central place in the mental health research agenda. Significantly, this volume reflects the paradigmatic shift in schizophrenia research applied in parallel to new approaches in psychiatric diagnosis. New models and findings from across disciplines in recent years reflect a new and greater understanding of the workings of the brain, which, in turn, helps develop our knowledge of the neuro and psychological processes in schizophrenia. Consequently, this volume illustrates a historical convergence of psychology, psychopathology and the neurosciences in schizophrenia. World-renowned leaders of the schizophrenia research community in fields such as neuroscience, p sychiatry, neuropsychology, and clinical psychology offer clear suggestions for further advances in psychological and medical interventions, assessment, prevention strategies, and research. And in keeping with other titles in the Nebraska Symposium on Motivation series, these papers are noteworthy for their depth of detail, scientific rigor, and clinical relevance. Included among the topics: Cognitive organization as a dimension of individual differences and psychopathology. Neurodevelopmental genomic strategies in the study of the psychosis spectrum. Multimodal brain and behavior indices of psychosis risk. The NIMH Research Domain Criteria Project: new approaches to classifying psychotic spectrum disorders. The Neuropsychopathology of Schizophrenia is one of the most forward-thinking and engaging treatments of the field in recent years, and is an i ndispensable text for all researchers, academics, and clinicians who treat or study mental illness, especially psychiatrists, psychologists, mental health practitioners, and neuroscientists specializing in schizophrenia.

This incisive book offers an epidemiological study of road users' consumption of psychoactive substances in Nigeria. It examines psychoactive drug screening and the use of driving simulators to evaluate skills impairment after drinking alcoholic beverages. Portable electronic digital screening devices such as "Oral Screen," along with other screening devices were used to establish the prevalence of substances of abuse amongst road users in some selected cities in Nigeria. Blood, saliva, urine, and other biological fluids were screened. Skills impairment, characterized by unsafe driving actions based on the level of blood alcohol concentration (BAC), was evaluated using a driving simulator. The findings were validated by application of a Field Impairment Test (FIT) or modified clinical test of impairment. The implication of the results on everyday highway utilization and the best approach for research into screening for psychoactive drugs are highlighted, along with several recommendations to enhance highway safety. Edeaghe Ehikhamenor is a senior lecturer at the University of Benin, Benin City, Nigeria, and the founder/national coordinator of Save Accident Victims Association of Nigeria (SAVAN) (www.savan.org). He has a bachelor of dental surgery, (BDS) a master's in pharmacology, and a Ph.D. in pharmacology and toxicology from the University of Benin. He has extensive research experience on digital screening of alcohol and other psychoactive drugs with saliva and biological fluids to establish skills impairment on a driving simulator. Hope Obianwu is a professor of pharmacology and toxicology who has served as past dean of pharmacy at the University of Benin and the department head at Niger Delta University in Nigeria. He is on the editorial board of several national and international journals, and has mentored several Ph.D. and master's graduates in pharmacology. Publisher's website: http: //sbprabooks.com/EdeagheEhikhamenorandHopeObianwu

This book addresses chemical and biological aspects related to sesquiterpene lactones (STLs). Experts in different fields have been invited to contribute on this class of compound's chemistry, isolation and identification, biological activities (antibacterial, antifungal, antiviral, antitrypanosomal, antileishmanial,antiplasmodial, antiproliferative and antiinflammatory), synthesis, biosynthesis, derivatization and QSAR analysis. Taxonomic and chemotaxonomic aspects related to the Asteraceae family are also contributed. The book begins by describing the chemical characteristics of STLs, their classification in different skeleton types, synthesis, distribution in nature and their most important biological properties. An overview of the group's main representatives, based on their importance for human health, as well as an update of the most recently isolated STLs, follow. The authors also provide an overview of the most common methods described in the literature for the extraction, purification, identification and structure elucidation of STLs, while also highlighting more recently developed methods. Furthermore, experts in the field provide an in-depth discussion of the most commonly employed in vitro and in vivo antiprotozoal assays against the different stages of parasites, as well as STLs' properties as anticancer agents in numerous cancer cell lines and animal models. Lastly, the book presents examples of the in vitro and in vivo activity of STLs and their mechanism of antiprotozoal action, together with an analysis of ultrastructural alterations, observed using TEM techniques. The book is aimed at scientists working on natural products: both those investigating this particular group of compounds and those who wish to further explore its potential as new drugs for medical conditions such as protozoal diseases and cancer.

Expanding from the classic use of immunosuppressants in transplantation and rejection, this current overview highlights their new roles in clinical medicine. Immunosuppressants are at the forefront of new treatment modalities. Individual chapters focus on their use not only in prevention or treatment of transplant rejection, but also on their use in immune-complex and autoimmune diseases, including rheumatoid arthritis; on combination therapies to achieve synergy in immunosuppression; on new drugs, low molecular weight chemicals, the use of antibodies and gene therapy; on immunological tolerance to prevent or inhibit transplant rejection; and how data derived from transplant studies can be applied to other avenues of immunosuppression. Clinicians and researchers will appreciate the scope of the work and the presentation of new approaches in the rapidly developing field of immunosuppression.