This book covers the many ways humans benefit from interactions with other living species. By studying animals of all kinds and sizes, from microbial organisms to elephants and whales, we can learn about their adaptations to extreme conditions on the planet Earth, about the evolutionary development of specialized capabilities, and about their ways to defend themselves against predators and diseases. The authors discuss the strengths and weaknesses of Homo sapiens, and how the study of animals can make us stronger and healthier. To deepen our knowledge of genetics, molecular and cell biology, physiology and medicine, we need to study model organisms. To cure human disease, we can learn from animals how they have evolved ways to protect themselves. To improve human performance, we can study the animal kingdom's top performers and learn from their successes. Considering these important pointers, the authors review genetic engineering techniques that can translate our existing and future animal connections into benefits for human health and performance. Finally, they discuss the challenges associated with our animal connection: the history of pandemics caused by bacterial and viral pathogens demonstrates that there is a risk for transmission of diseases that can disrupt human societies. The recent COVID-19 outbreak is covered in detail as an example.

Artificial Intelligence (AI) has transformed many aspects of our daily activities. Health and well-being of humans stand as one of the key domains where AI has achieved significant progresses, saving time, costs, and potentially lives, as well as fostering economic resilience, particularly under the COVID-19 pandemic environments. This book is a sequel of the Handbook of Artificial Intelligence in Healthcare. The first volume of the Handbook is dedicated to present advances and applications of AI methodologies in several specific areas, i.e., signal, image, and video processing as well as information and data analytics. In this second volume of the Handbook, general practicality challenges and future prospects of AI methodologies pertaining to healthcare and related domains are presented in Part 1 and Part 2, respectively. It is envisaged that the selected studies will provide readers a general perspective on the issues, challenges, and opportunities in designing, developing, and implementing AI-based tools and solutions in the healthcare sector, bringing benefits to transform and advance health and well-being development of humans..

The book focuses on biomedical innovations related to the diagnosis and treatment of sleep apnea. The latest diagnostic tools are described, including sleep laboratory equipment, wearables, and even smartphone apps. Innovative medical devices for treatment are also covered, such as CPAP, Auto-PAP, hypoglossal nerve stimulation, phrenic nerve stimulation, acoustic brain stimulation and electrical brain stimulation. This is an ideal book for biomedical engineers, pneumologists, neurologists, cardiologists, physiologists, ENT physicians, pediatrics, and epidemiologists who are interested in learning about the latest technologies in treating and diagnosing sleep apnea.

Gait analysis is the study of the walking or running pattern of an individual. This can include spatial and temporal measurements such as step length, stride length and speed along with angular measurements of various joints and the interplay between various parts like the foot, hip, pelvis or spine when walking. Gait analysis can be used to assess clinical conditions and design effective rehabilitation; for example, following limb injury or amputation, or other disorders such as a stroke or Parkinson's diagnosis. It can be used to influence intervention decisions, such as whether a patient should undergo surgery, further physiotherapy, or begin a particular treatment regime. Gait analysis can also be used in sports science to monitor and review performance and technique. Gait can be recorded in a variety of ways, including pressure sensors, force plates, in-shoe pressure systems, through marker-based or marker-less systems using various cameras or sensors to calculate body positions in a set sequence of movements. This book focuses on both the hardware systems for collecting data as well as data visualisation and mathematical models for interpreting the data. It is written by a range of international researchers from academia, industry, and clinical settings, providing a complete overview of gait analysis technologies suitable for an audience of engineers in rehabilitation technologies or other biomedical engineering fields.

For more than a decade, the focus of information technology has been on capturing and sharing data from a patient within an all-encompassing record (a.k.a. the electronic health record, EHR), to promote improved longitudinal oversight in the care of the patient. There are both those who agree and those who disagree as to whether this goal has been met, but it is certainly evolving. A key element to improved patient care has been the automated capture of data from durable medical devices that are the source of (mostly) objective data, from imagery to time-series histories of vital signs and spot-assessments of patients. The capture and use of these data to support clinical workflows have been written about and thoroughly debated. Yet, the use of these data for clinical guidance has been the subject of various papers published in respected medical journals, but without a coherent focus on the general subject of the clinically actionable benefits of objective medical device data for clinical decision-making purposes. Hence, the uniqueness of this book is in providing a single point-of-capture for the targeted clinical benefits of medical device data--both electronic- health-record-based and real-time--for improved clinical decision-making at the point of care, and for the use of these data to address and assess specific types of clinical surveillance. Clinical Surveillance: The Actionable Benefits of Objective Medical Device Data for Crucial Decision-Making focuses on the use of objective, continuously collected medical device data for the purpose of identifying patient deterioration, with a primary focus on those data normally obtained from both the higher-acuity care settings in intensive care units and the lower-acuity settings of general care wards. It includes examples of conditions that demonstrate earlier signs of deterioration including systemic inflammatory response syndrome, opioid-induced respiratory depression, shock induced by systemic failure, and more. The book provides education on how to use these data, such as for clinical interventions, in order to identify examples of how to guide care using automated durable medical device data from higher- and lower-acuity care settings. The book also includes real-world examples of applications that are of high value to clinical end-users and health systems.

For more than a decade, the focus of information technology has been on capturing and sharing data from a patient within an all-encompassing record (a.k.a. the electronic health record, EHR), to promote improved longitudinal oversight in the care of the patient. There are both those who agree and those who disagree as to whether this goal has been met, but it is certainly evolving. A key element to improved patient care has been the automated capture of data from durable medical devices that are the source of (mostly) objective data, from imagery to time-series histories of vital signs and spot-assessments of patients. The capture and use of these data to support clinical workflows have been written about and thoroughly debated. Yet, the use of these data for clinical guidance has been the subject of various papers published in respected medical journals, but without a coherent focus on the general subject of the clinically actionable benefits of objective medical device data for clinical decision-making purposes. Hence, the uniqueness of this book is in providing a single point-of-capture for the targeted clinical benefits of medical device data--both electronic- health-record-based and real-time--for improved clinical decision-making at the point of care, and for the use of these data to address and assess specific types of clinical surveillance. Clinical Surveillance: The Actionable Benefits of Objective Medical Device Data for Crucial Decision-Making focuses on the use of objective, continuously collected medical device data for the purpose of identifying patient deterioration, with a primary focus on those data normally obtained from both the higher-acuity care settings in intensive care units and the lower-acuity settings of general care wards. It includes examples of conditions that demonstrate earlier signs of deterioration including systemic inflammatory response syndrome, opioid-induced respiratory depression, shock induced by systemic failure, and more. The book provides education on how to use these data, such as for clinical interventions, in order to identify examples of how to guide care using automated durable medical device data from higher- and lower-acuity care settings. The book also includes real-world examples of applications that are of high value to clinical end-users and health systems.

This book gathers selected, extended and revised contributions to the 17th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering and the 5th Conference on Imaging and Visualization (CMBBE 2021), held online on September 7-9, 2021, from Bonn, Germany. It reports on cutting-edge models, algorithms and imaging techniques for studying cells, tissues and organs in normal and pathological conditions. It covers numerical and machine learning methods, finite element modeling and virtual reality techniques, applied to understand biomechanics of movement, fluid and soft tissue biomechanics. It also reports on related advances in rehabilitation, surgery and diagnosis. All in all, this book offers a timely snapshot of the latest research and current challenges at the interface between biomedical engineering, computational biomechanics and biological imaging. Thus, it is expected to provide a source of inspiration for future research and cross-disciplinary collaborations.

This book covers topics related to medical practices from communications technology point of view. The book provides detailed inside information about the use of health informatics and emerging technologies for the well-being of patients. Each chapter in this book focuses on a specific development in the use of informatics in healthcare. In general, each chapter uses various emerging technologies such as Internet of Things (IoT), Big Data, Cloud computing, Wireless Body Area Networks (WBAN), for various health-related illness, such as tuberculosis, heart diseases, asthma and various epidemic outbreaks. The book is intended both for communications engineers with a healthcare focus and medical researchers.

The intimate relationship between form and function inherent in the design of animals is perhaps nowhere more evident than in the musculoskeletal system. This book, about how function determines form, addresses the role of mechanical factors in the development, adaptation, maintenance, aging, and repair of skeletal tissues. The authors refer to this process as mechanobiology and develop their theme within an evolutionary framework. They show how degenerative disorders such as arthritis and osteoporosis are regulated by the same mechanical processes that influence normal development and growth. Skeletal Function and Form bridges important gaps among disciplines, providing a common ground for a multidisciplinary understanding.

Mild traumatic brain injury (mTBI), directly related to chronic traumatic encephalopathy, presents a crisis in contact sports, the military, and public health. Mild Traumatic Brain Injury: A Science and Engineering Perspective reviews current understanding of mTBI, methods of diagnosis, treatment, policy concerns, and emerging technologies. It details the neurophysiology and epidemiology of brain injuries by presenting disease models and descriptions of nucleating events, characterizes sensors, imagers, and related diagnostic measures used for evaluating and identifying brain injuries, and relates emerging bioinformatics analysis with mTBI markers. The book goes on to discuss issues with sports medicine and military issues; covers therapeutic strategies, surgeries, and future developments; and finally addresses drug trials and candidates for therapy. The broad coverage and accessible discussions will appeal to professionals in diverse fields related to mTBI, students of neurology, medicine, and biology, as well as policy makers and lay persons interested in this hot topic. Features Summarizes the entire scope of the field of mTBI Details the neurophysiology, epidemiology, and presents disease models and descriptions of nucleating events Characterizes sensors, imagers, and related diagnostic measures and relates emerging bioinformatics analysis with mTBI markers Discusses issues with sports medicine and military issues Covers therapeutic strategies, surgeries, and future developments and addresses drug trials and candidates Dr Mark Mentzer earned his PhD in Electrical Engineering from the University of Delaware. He is a former research scientist at the US Army Research Laboratory where he studied mild traumatic brain injury and developed early-detection brain injury helmet sensors. He is a certified test director and contracting officer representative. He possesses two Level-III Defense Acquisition University Certifications in Science and Technology Management and in Test and Evaluation. During his career, he developed a wide range of sensors and instrumentation as well as biochemical processes to assess brain trauma. Mentzer currently teaches graduate systems engineering and computer science courses at the University of Maryland University College.

The book fills a void as a textbook with hands-on laboratory exercises designed for biomedical engineering undergraduates in their senior year or the first year of graduate studies specializing in electrical aspects of bioinstrumentation. Each laboratory exercise concentrates on measuring a biophysical or biomedical entity, such as force, blood pressure, temperature, heart rate, respiratory rate, etc., and guides students though all the way from sensor level to data acquisition and analysis on the computer. The book distinguishes itself from others by providing electrical circuits and other measurement setups that have been tested by the authors while teaching undergraduate classes at their home institute over many years. Key Features: * Hands-on laboratory exercises on measurements of biophysical and biomedical variables * Each laboratory exercise is complete by itself and they can be covered in any sequence desired by the instructor during the semester * Electronic equipment and supplies required are typical for biomedical engineering departments * Data collected by undergraduate students and data analysis results are provided as samples * Additional information and references are included for preparing a report or further reading at the end of each chapter Students using this book are expected to have basic knowledge of electrical circuits and troubleshooting. Practical information on circuit components, basic laboratory equipment, and circuit troubleshooting is also provided in the first chapter of the book.

The book offers unique insight into the modern world of wireless communication that included 5G generation, implementation in Internet of Things (IoT), and emerging biomedical applications. To meet different design requirements, gaining perspective on systems is important. Written by international experts in industry and academia, the intended audience is practicing engineers with some electronics background. It presents the latest research and practices in wireless communication, as industry prepares for the next evolution towards a trillion interconnected devices. The text further explains how modern RF wireless systems may handle such a large number of wireless devices. Covers modern wireless technologies (5G, IoT), and emerging biomedical applications Discusses novel RF systems, CMOS low power circuit implementation, antennae arrays, circuits for medical imaging, and many other emerging technologies in wireless co-space. Written by a mixture of top industrial experts and key academic professors.

Efficient mobile systems that allow for vital sign monitoring and disease diagnosis at the point of care can help combat issues such as rising healthcare costs, treatment delays in remote and resource-poor areas, and the global shortage of skilled medical personnel. Covering everything from sensors, systems, and software to integration, usability, and regulatory challenges, Mobile Point-of-Care Monitors and Diagnostic Device Design offers valuable insight into state-of-the-art technologies, research, and methods for designing personal diagnostic and ambulatory healthcare devices. Presenting the combined expertise of contributors from various fields, this multidisciplinary text: Gives an overview of the latest mobile health and point-of-care technologies Discusses portable diagnostics devices and sensors, including mobile-phone-based health systems Explores lab-on-chip systems as well as energy-efficient solutions for mobile point-of-care monitors Addresses computer vision and signal processing for real-time diagnostics Considers interface design for lay healthcare providers and home users Mobile Point-of-Care Monitors and Diagnostic Device Design provides important background information about the design process of mobile health and point-of-care devices, using practical examples to illustrate key aspects related to instrumentation, information processing, and implementation.

This timely overview of dose, benefit, and risk in medical imaging explains to readers how to apply this information for informed decision-making that improves patient outcomes. The chapters cover patient and physician perspectives, referral guidelines, appropriateness criteria, and quantifying medical imaging benefits. The authors have included essential discussion about radiologic physics in medical imaging, fundamentals of dose and image quality, risk assessment, and techniques for optimization and dose reduction. The book highlights practical implementation aspects with useful case studies and checklists for treatment planning. Clinicians, students, residents, and professionals in medical physics, biomedical engineering, radiology, oncology, and allied disciplines will find this book an essential resource with the following key features: Discusses risk, benefit, dose optimization, safety, regulation, radiological protection, and shared & informed decision-making. Covers regulatory oversight by government agencies, manufacturers, and societies. Highlights best practices for improving patient safety and outcomes. Gives guidelines on doses associated with specific procedures.

This book covers the essentials of drug delivery research and provides a unique forum for scientific experimental methods that are exclusively focused by the in-vitro, ex-vivo, and in-vivo methodologies of drug delivery research and felicitates translational research. The book includes recent and novel approaches in evaluation methods of transdermal, nasal, ocular, oral and intraoral, gastro-retentive, colon-targeted, and brain-targeted drug delivery systems. Providing up to date and comprehensive information, this text is invaluable to students, teachers, scientists, and others employed in the field of drug delivery.

A significant portion of biomedical applications necessitates the establishment of an interface between the cells of the patient and the components of the device. In many cases, such as in implants and engineered tissues, the interaction of the cells with the biomaterial is one of the main determinants of the success of the system. Cell and Material Interface: Advances in Tissue Engineering, Biosensor, Implant, and Imaging Technologies explores this interaction and its control at length scales ranging from the nano to the macro. Featuring contributions from leading molecular biologists, chemists, and material scientists, this authoritative reference: Presents practical examples of cell and material interface-based applications Reflects the interdisciplinary nature of bioengineering, covering topics such as biosensing, immunology, and controlled delivery Explains the role of the cell and material interface in the context of cardiac and skin tissue engineering, nanoparticles, natural polymers, and more Cell and Material Interface: Advances in Tissue Engineering, Biosensor, Implant, and Imaging Technologies addresses concepts essential to biomaterial production methods and cell and material interactions. The book provides a solid starting point for elucidating and exploiting the different aspects of cellular interactions with materials for biomedical engineering.

This title covers recent advances in a variety of biomedical applications of nanostructured materials, as the field evolves from prototype device to real-world application.It presentsthe main types of nanomaterial used in medical application today: semiconductor nanomaterials, Magnetic nanomaterials, metal nanoparticles, Carbon nanomaterials, Hydrogel nanocomposites, Liposomes, Dendrimers, Polymer nanocomposites, and Biodegradable polymers. Structurally the workis demarcated into the six most popular areas of research: (1) "biocompatibility" of nanomaterials with living organisms in their various manifestations (2) "nanobiosensors for clinical diagnostics," detecting biomolecules which are useful in the clinical diagnosis of genetic, metabolically acquired, induced or infectious disease (3) "targeted drug delivery" for nanomaterials in their various modifications (4) "nanomedical devices and structures" which are used in the development of implantable medical devices and structures such as nanorobots (5) "nanopharmacology," as novel nanoparticlesare increasingly engineered to diagnose conditions and recognize pathogens, identify ideal pharmaceutical agents to treat the condition or pathogens, fuel high-yield production of matched pharmaceuticals (potentially in vivo), locate, attach or enter target tissue, structures or pathogens; and dispense the ideal mass of matched biological compound to the target regions (6) "nanotoxicology and remediation," whichfocuses onfinished and on-going various toxicity evaluations on various nanomaterials that are used and currently being developed for medical applications
Discusses the most important biomedical applications and devices of nanomaterials: drug delivery, medical imaging, gene therapy, nanorobots, biosensors and diagnostics Focuses on current commercialized techniques and applications, ensuring the work is entirely relevant to a rapidly evolving fieldReviews the most recent studies on nanomaterial toxicity, thereby responding to the widescale private, policy and public interest in nanoscience"

The book covers the latest updates in the application of infrared to biomedical sciences, a non-invasive, contactless, safe and easy approach imaging of skin and tissue temperatures. Its diagnostic procedure allows practitioners to identify the locations of abnormal chemical and blood vessel activity such as angiogenesis in body tissue. Its non-invasive approach works by applying the technology of the infrared camera and state-of-the-art software, where high-resolution digital infrared imaging technology benefits highly from enhanced image production, standardized image interpretation protocols, computerized comparison and storage, and sophisticated image enhancement and analysis. The book contains contributions from global prominent scientists in the area of infrared applications in biomedical studies. The target audience includes academics, practitioners, clinicians and students working in the area of infrared imaging in biomedicine.

Composites in Biomedical Applications presents a comprehensive overview on recent developments in composites and their use in biomedical applications. It features cutting-edge developments to encourage further advances in the field of composite research. Highlights a completely new research theme in polymer-based composite materials Outlines a broad range of different research fields, including polymer and natural fiber reinforcement used in the development of composites for biomedical applications Discusses advanced techniques for the development of composites and biopolymer-based composites Covers fatigue behavior, conceptual design in ergonomics design application, tissue regeneration or replacement, and skeletal bone repair of polymer composites Details the latest developments in synthesis, preparation, characterization, material evaluation, and future challenges of composite applications in the biomedical field This book is a comprehensive resource for advanced students and scientists pursuing research in the broad fields of composite materials, polymers, organic or inorganic hybrid materials, and nano-assembly.

Bionics means learning from the nature for the development of technology. The science of "bionics" itself is classified into several sections, from materials and structures over procedures and processes until evolution and optimization. Not all these areas, or only a few, are really known in the public and also in scientific literature. This includes the Lotus-effect, converted to the contamination-reduction of fassades and the shark-shed-effect, converted to the resistance-reduction of airplanes. However, there are hundreds of highly interesting examples that contain the transformation of principles of the nature into technology. From the large number of these examples, 250 were selected for the present book according to "prehistory", "early-history", "classic" and "modern time". Most examples are new. Every example includes a printed page in a homogeneous arrangement. The examples from the field "modern time" are joint in blocks corresponding to the sub-disciplines of bionics.