An Introduction to Hypergeometric, Supertigonometric, and Superhyperbolic Functions gives a basic introduction to the newly established hypergeometric, supertrigonometric, and superhyperbolic functions from the special functions viewpoint. The special functions, such as the Euler Gamma function, the Euler Beta function, the Clausen hypergeometric series, and the Gauss hypergeometric have been successfully applied to describe the real-world phenomena that involve complex behaviors arising in mathematics, physics, chemistry, and engineering.

This book gathers revised selected papers from the 3rd International Workshop on Gerontechnology, IWoG 2020, held on October 5-6, 2020, in Evora, Portugal. They reports on cutting-edge technologies and optimized workflows for promoting active aging and assisting and elderly people at home, as well as in healthcare centers. It discusses the main challenges in the development, use and delivery of health care services and technologies. Not only they proposes solutions for improving in practice the monitoring and management of health parameters and age-related diseases, yet they also describes improved approaches for helping seniors in their daily tasks and facilitating their communication and integration with assistive technologies, thus improving their quality of life, as well as their social integration. The book provides health professionals, researchers, and service providers with extensive information on the latest trends in the development and practical application of gerontechnology in elderly care.

In recent years there has been rapid progress in the development of signal processing in general, and more specifically in the application of signal processing and pattern analysis to biological signals. Techniques, such as parametric and nonparametric spectral estimation, higher order spectral estimation, time-frequency methods, wavelet transform, and identifi cation of nonlinear systems using chaos theory, have been successfully used to elucidate basic mechanisms of physiological and mental processes. Similarly, biological signals recorded during daily medical practice for clinical diagnostic procedures, such as electroen cephalograms (EEG), evoked potentials (EP), electromyograms (EMG) and electrocardio grams (ECG), have greatly benefitted from advances in signal processing. In order to update researchers, graduate students, and clinicians, on the latest developments in the field, an International Symposium on Processing and Pattern Analysis of Biological Signals was held at the Technion-Israel Institute of Technology, during March 1995. This book contains 27 papers delivered during the symposium. The book follows the five sessions of the symposium. The first section, Processing and Pattern Analysis of Normal and Pathological EEG, accounts for some of the latest developments in the area of EEG processing, namely: time varying parametric modeling; non-linear dynamic modeling of the EEG using chaos theory; Markov analysis; delay estimation using adaptive least-squares filtering; and applications to the analysis of epileptic EEG, EEG recorded from psychiatric patients, and sleep EEG."

In general, every problem of science and engineering is governed by mathematical models. There is often a need to model, solve and interpret the problems one encounters in the world of practical problems. Models of practical application problems usually need to be handled by efficient computational models. New Paradigms in Computational Modeling and Its Applications deals with recent developments in mathematical methods, including theoretical models as well as applied science and engineering. The book focuses on subjects that can benefit from mathematical methods with concepts of simulation, waves, dynamics, uncertainty, machine intelligence, and applied mathematics. The authors bring together leading-edge research on mathematics combining various fields of science and engineering. This perspective acknowledges the inherent characteristic of current research on mathematics operating in parallel over different subject fields. New Paradigms in Computational Modeling and Its Applications meets the present and future needs for the interaction between various science and technology/engineering areas on the one hand and different branches of mathematics on the other. As such, the book contains 13 chapters covering various aspects of computational modeling from theoretical to application problems. The first six chapters address various problems of structural and fluid dynamics. The next four chapters include solving problems where the governing parameters are uncertain regarding fuzzy, interval, and affine. The final three chapters will be devoted to the use of machine intelligence in artificial neural networks.

This book explores Autonomic Nervous System (ANS) dynamics as investigated through Electrodermal Activity (EDA) processing. It presents groundbreaking research in the technical field of biomedical engineering, especially biomedical signal processing, as well as clinical fields of psychometrics, affective computing, and psychological assessment. This volume describes some of the most complete, effective, and personalized methodologies for extracting data from a non-stationary, nonlinear EDA signal in order to characterize the affective and emotional state of a human subject. These methodologies are underscored by discussion of real-world applications in mood assessment. The text also examines the physiological bases of emotion recognition through noninvasive monitoring of the autonomic nervous system. This is an ideal book for biomedical engineers, physiologists, neuroscientists, engineers, applied mathmeticians, psychiatric and psychological clinicians, and graduate students in these fields. This book also: Expertly introduces a novel approach for EDA analysis based on convex optimization and sparsity, a topic of rapidly increasing interest Authoritatively presents groundbreaking research achieved using EDA as an exemplary biomarker of ANS dynamics Deftly explores EDA's potential as a source of reliable and effective markers for the assessment of emotional responses in healthy subjects, as well as for the recognition of pathological mood states in bipolar patients

This book presents and discusses recent scientific progress on Cell and Stem Cell Engineering. It predominantly focuses on Biological, Physical and Technical Basics, and features new trends of research reaching far into the 21st century.

This book relates to the analysis and the development of methods to for a nerve-machine interface. Peripheral nerves, both somatic and autonomic, carry signals related to control and the status of the organs. Nerves are made up of many fascicles, each surrounded by protective membranes. The goal is to provide a theoretical and experimental understanding of how one can recover neural signals from the various fascicles or selectively control the activation of these fascicles.

This book presents a comprehensive framework for model-based electrical stimulation (ES) controller design, covering the whole process needed to develop a system for helping people with physical impairments perform functional upper limb tasks such as eating, grasping and manipulating objects. The book first demonstrates procedures for modelling and identifying biomechanical models of the response of ES, covering a wide variety of aspects including mechanical support structures, kinematics, electrode placement, tasks, and sensor locations. It then goes on to demonstrate how complex functional activities of daily living can be captured in the form of optimisation problems, and extends ES control design to address this case. It then lays out a design methodology, stability conditions, and robust performance criteria that enable control schemes to be developed systematically and transparently, ensuring that they can operate effectively in the presence of realistic modelling uncertainty, physiological variation and measurement noise.

This book reports on the latest advances in concepts and further developments of principal component analysis (PCA), addressing a number of open problems related to dimensional reduction techniques and their extensions in detail. Bringing together research results previously scattered throughout many scientific journals papers worldwide, the book presents them in a methodologically unified form. Offering vital insights into the subject matter in self-contained chapters that balance the theory and concrete applications, and especially focusing on open problems, it is essential reading for all researchers and practitioners with an interest in PCA.

In the age of data science, the rapidly increasing amount of data is a major concern in numerous applications of computing operations and data storage. Duplicated data or redundant data is a main challenge in the field of data science research. Data Deduplication Approaches: Concepts, Strategies, and Challenges shows readers the various methods that can be used to eliminate multiple copies of the same files as well as duplicated segments or chunks of data within the associated files. Due to ever-increasing data duplication, its deduplication has become an especially useful field of research for storage environments, in particular persistent data storage. Data Deduplication Approaches provides readers with an overview of the concepts and background of data deduplication approaches, then proceeds to demonstrate in technical detail the strategies and challenges of real-time implementations of handling big data, data science, data backup, and recovery. The book also includes future research directions, case studies, and real-world applications of data deduplication, focusing on reduced storage, backup, recovery, and reliability.

This book takes the notions of adaptivity and learning from the realm of engineering into the realm of biology and natural processes. It introduces a Hebbian-LMS algorithm, an integration of unsupervised Hebbian learning and supervised LMS learning in neural networks, as a mathematical representation of a general theory for synaptic learning in the brain, and adaptation and functional control of homeostasis in living systems. Written in a language that is able to address students and scientists with different backgrounds, this book accompanies readers on a unique journey through various homeostatic processes in living organisms, such as body temperature control and synaptic plasticity, explaining how the Hebbian-LMS algorithm can help understand them, and suggesting some open questions for future research. It also analyses cell signalling pathways from an unusual perspective, where hormones and hormone receptors are shown to be regulated via the principles of the Hebbian-LMS algorithm. It further discusses addiction and pain, and various kinds of mood disorders alike, showing how they can be modelled with the Hebbian-LMS algorithm. For the first time, the Hebbian-LMS algorithm, which has been derived from a combination of Hebbian theory from the neuroscience field and the LMS algorithm from the engineering field of adaptive signal processing, becomes a potent model for understanding how biological regulation works. Thus, this book is breaking new ground in neuroscience by providing scientists with a general theory for how nature does control synaptic learning. It then goes beyond that, showing that the same principles apply to hormone-mediated regulation of physiological processes. In turn, the book tackles in more depth the concept of learning. It covers computer simulations and strategies for training neural networks with the Hebbian-LMS algorithm, demonstrating that the resulting algorithms are able to identify relationships between unknown input patterns. It shows how this can translate in useful ideas to understand human memory and design cognitive structures. All in all, this book offers an absolutely, unique, inspiring reading for biologists, physiologists, and engineers, paving the way for future studies on what we could call the nature's secret learning algorithm.

Digital Health: Mobile and Wearable Devices for Participatory Health Applications is a key reference for engineering and clinical professionals considering the development or implementation of mobile and wearable solutions in the healthcare domain. The book presents a comprehensive overview of devices and appropriateness for the respective applications. It also explores the ethical, privacy, and cybersecurity aspects inherent in networked and mobile technologies. It offers expert perspectives on various approaches to the implementation and integration of these devices and applications across all areas of healthcare. The book is designed with a multidisciplinary audience in mind; from software developers and biomedical engineers who are designing these devices to clinical professionals working with patients and engineers on device testing, human factors design, and user engagement/compliance.

This book constitutes the proceedings of the third international conference AsiaHaptics 2018, held in Songdo, Korea. It presents the state-of-the-art of the diverse haptics (touch)-related research, including perception and illusion, development of haptics devices, and applications to a wide variety of fields such as education, medicine, telecommunication, navigation and entertainment. This book is a valuable resource not only for active haptics researchers, but also for general readers wishing to understand the status quo in this interdisciplinary area of science and technology.

Tens of thousands of different animal species live on this planet, having survived for millions of years through adaptation and evolution, which has given them a vast variety of structures and functions. Biomechanical studies of animals swimming and flying can aid understanding of the mechanisms that enable them to move effectively and efficiently in fluids . Based on such understandings and analyses, we can aim to develop environmentally friendly machines that emulate these natu ral movements. The Earth Summit in Rio de Janeiro in 1992 agreed major treaties on biological diversity, addressing the comb ined issues of environmental protection and fair and equitable economic development. With regard to coastal environments, increasing biological diversity has begun to play an important role in reestablishing stable and sustainable ecosystems. This approach has begun to influence research into the behavior of aquatic species, as an understanding of the history of an individual aquatic species is indispensable in constructing an environmental assessment mod el that includes the physical, chemical, and biological effects of that species . From an engineering viewpoint, studying nature's biological diversity is an opportunity to reconsider mechanical systems that were systematically constructed in the wake of the Industrial Revolution. We have been accumulating knowledge of the sys tems inherent in biological creatures and using that knowledge to create new, envi ronmentally friendly technologies.

Wearable Sensors: Fundamentals, Implementation and Applications has been written by a collection of experts in their field, who each provide you with an understanding of how to design and work with wearable sensors. Together these insights provide the first single source of information on wearable sensors that would be a fantastic addition to the library of any engineers working in this field. Wearable Sensors covers a wide variety of topics associated with development and applications of wearable sensors. It also provides an overview and a coherent summary of many aspects of wearable sensor technology. Both professionals in industries and academic researchers need this package of information in order to learn the overview and each specific technology at the same time. This book includes the most current knowledge on the advancement of light-weight hardware, energy harvesting, signal processing, and wireless communications and networks. Practical problems with smart fabrics, biomonitoring and health informatics are all addressed, plus end user centric design, ethical and safety issues. The new edition is completely reviewed by key figures in the field, who offer authoritative and comprehensive information on the various topics. A new feature for the second edition is the incorporation of key background information on topics to allow the less advanced user access to the field and to make the title more of an auto-didactic book for undergraduates.

The development of a bio-engineered pacemaker is of substantial clinical and also scientific interest because it promises to overcome several limitations of electronic pacemakers. Moreover it may answer the longstanding question of whether the complex structure of the sinus node is indeed a prerequisite for reliable pacemaking, or simpler structures might work as well.

This book gives an overview of the current state-of-the-art of creating a bio-engineered pacemaker. It shows the approaches to develop of genetic and cell-based engineering methods suitable to implement them with safety and stability. It also illuminates the problems that need to be solved before bio-pacemaking can be considered for clinical use.

The research areas as well as the knowledge gained for the practical use of robots are growing and expanding beyond manufacturing and industrial automation, making inroads in sectors such as health care and terrain sensing, as well as general assistive systems working in close interaction with humans. In a situation like this, it is necessary for future robot systems to become less stiff and more specialized by taking inspiration from the mechanical compliance and versatility found in natural materials and organisms. At present, a new discipline is emerging in this area, called "Soft Robotics". It particularly challenges the traditional thinking of engineers, as the confluence of technologies, ranging from new materials, sensors, actuators and production techniques to new design tools, will make it possible to create new systems whose structures are almost completely made of soft materials, which bring about entirely new functions and behaviors, similar in many ways to natural systems. These Proceedings focus on four main topics: * Soft Actuators and Control * Soft Interactions * Soft Robot Assistants: Potential and Challenges * Human-centered "Soft Robotics".

This book offers an impressive collection of contributions on the epistemology of international biolaw and its applications, both in the legal and ethical fields. Bringing together works by some of the world's most prominent experts on biolaw and bioethics, it constitutes a paradigmatic text in its field. In addition to exploring various ideologies and philosophies, including European, American and Mediterranean biolaw traditions, it addresses controversial topics straight from today's headlines, such as genetic editing, the dual-use dilemma, and neurocognitive enhancement. The book encourages readers to think objectively and impartially in order to resolve the ethical and juridical dilemmas that stem from biotechnological empowerment and biomedical techniques. Accordingly, it offers a valuable resource for courses on biolaw, law, bioethics, and biomedical research, as well as courses that discuss law and the biosciences at different professional levels, e.g. in the courts, biomedical industry, pharmacological companies and the public space in general.

The book set develops a bridge between physiologic mechanisms and diagnostic human engineering. While the first volume is focused on the interface between physiologic mechanisms and the resultant biosignals, this second volume is devoted to the interface between biosignals and biomedical sensors. That is, in the first volume, the physiologic mechanisms determining biosignals are described from the basic cellular level up to their advanced mutual coordination level. This second volume, considers the genesis of acoustic and optic biosignals and the associated sensing technology from a strategic point of view. As a novelty, this book discusses heterogeneous biosignals within a common frame. This frame comprises both the biosignal formation path from the biosignal source at the physiological level to biosignal propagation in the body, and the biosignal sensing path from the biosignal transmission in the sensor applied on the body up to its conversion to a, usually electric, signal. Some biosignals arise in the course of the body's vital functions while others map these functions that convey physiological data to an observer. It is highly instructive how sound and light beams interact with biological tissues, yielding acoustic and optic biosignals, respectively. Discussed phenomena teach a lot about the physics of sound and physics of light (as engineering sciences), and, on the other hand, biology and physiology (as live sciences). The highly interdisciplinary nature of biosignals and biomedical sensors is obviously a challenge. However, it is a rewarding challenge after it has been coped with in a strategic way, as offered here. The book is intended to have the presence to answer intriguing "Aha!" questions.

This book describes a comprehensive framework for hardware/software co-design, optimization, and use of robust, low-cost, and cyberphysical digital microfluidic systems. Readers with a background in electronic design automation will find this book to be a valuable reference for leveraging conventional VLSI CAD techniques for emerging technologies, e.g., biochips or bioMEMS. Readers from the circuit/system design community will benefit from methods presented to extend design and testing techniques from microelectronics to mixed-technology microsystems. For readers from the microfluidics domain, this book presents a new design and development strategy for cyberphysical microfluidics-based biochips suitable for large-scale bioassay applications. * Takes a transformative, "cyberphysical" approach towards achieving closed-loop and sensor feedback-driven biochip operation under program control; * Presents a "physically-aware" system reconfiguration technique that uses sensor data at intermediate checkpoints to dynamically reconfigure biochips; * Enables readers to simplify the structure of biochips, while facilitating the "general-purpose" use of digital microfluidic biochips for a wider range of applications.

Biomedical signals provide unprecedented insight into abnormal or anomalous neurological conditions. The computer-aided diagnosis (CAD) system plays a key role in detecting neurological abnormalities and improving diagnosis and treatment consistency in medicine. This book covers different aspects of biomedical signals-based systems used in the automatic detection/identification of neurological disorders. Several biomedical signals are introduced and analyzed, including electroencephalogram (EEG), electrocardiogram (ECG), heart rate (HR), magnetoencephalogram (MEG), and electromyogram (EMG). It explains the role of the CAD system in processing biomedical signals and the application to neurological disorder diagnosis. The book provides the basics of biomedical signal processing, optimization methods, and machine learning/deep learning techniques used in designing CAD systems for neurological disorders.

Plastic is one of the widely used polymers around the globe since its discovery. It is highly impossible to think the ease of life without the aid of plastic. Every year billion tons of plastic waste gets accumulated in the environment and leads to death of both marine and terrestrial animals. Plastic is very durable and needs around 1000 years to degrade under the natural environment. The present book illustrates the importance and significance of the bioremediation to tackle the problem of plastic waste. Previously, we have reported elite rhizobacterial isolates (Lysinibacillus fusiformis strain VASB14/WL and Bacillus cereus strain VASB1/TS) of Avicennia marina Vierh (Forsk.) from the West Coast of India with the potential to degrade plastic (polythene). The present book attempted to address the bioremediation scenario of plastic waste (including micro plastic) using microbes with bacteria in particular. Various strategies used to tackle with the plastic waste were highlighted with case studies of plastic waste management, including in vitro, in situ and ex situ with a special reference to biodegradation technology. After the biodegradation of the plastic using microbes, the generated plastic (polythene) degradation products (PE-DPs) were also documented using GC-MS technique followed by their deleterious effect on both animal and plant systems. The book also enhances the awareness of the plastic-free society and also suggests some alternative materials to be used instead of plastic. Lastly, the book suggests/recommends the strategies to be followed by the lawmakers in the government organizations/non-government organizations/social organizations to frame the regulations and guidelines to implement at mass level to reduce the generation of plastic waste.

The book provides an overview of bio-manufacturing techniques for the production, purification, characterization and modification of chito/chitin oligosaccharides and their monomers. In addition, it explores potential applications in the food, biomedical and agricultural industry on the basis of their bioactivities and biomaterial properties. Lastly, it shares a range of cutting-edge insights to help solve problems in industrial processes and promote further academic investigation. Given its scope, it offers a valuable resource for researchers and graduate students in the fields of bioengineering, food science, biochemistry, etc.

This book explores a sampling of the most powerful and enterprising efforts to achieve biotechnological goals by means of various interdisciplinary approaches. From the fabrication of extremely small units to achieve specific objectives through nano-bio-technology, to devices with artificial intelligence, gene therapy for cerebrovascular anomalies, biodegradable plastics, the use of phyto-stem cells in cosmetology, CarT cell immune therapy, targeted therapies for cancer, 3D printed bones developed by the University of Wollongong in Australia, the sickle cell chip developed by IIT Bombay, and innovative sustainable energy solutions, the book includes a colorful spectrum of reviews on current and future biotech products. Gathering contributions by an international team of researchers, this book offers its audience, and particularly younger readers, revealing information on current and upcoming smart technologies.

Proceedings of the Light-Activated Tissue Regeneration and Therapy II Conference covers issues such as the latest advances in the field and measurements including the determination of the mechanisms of light-activated tissue regeneration and therapy. Light sources, narrow and broadband, as well as the metrology and medical outcomes they produce, will be discussed. This book discusses the following topics: Laser therapy; Mechanism; Photodynamic therapy; Cardiovascular; Pain; Neuroscience/Progenitor and Stem cells; Wound healing; Unusual Sources; Electrical Fields, Optical Fields and Other fields; Dentistry; Diabetes. This book is the first to present the mechanism which explains why light is an effective treatment for so many illnesses and diseases. Proceedings of the Light-Activated Tissue Regeneration and Therapy II Conference not only explains this mechanism, but also describes uses for the mechanism, as well as what new work is planned and what changes will be seen in FDA regulations.