A Beginners Guide to Data Agglomeration and Intelligent Sensing provides an overview of the Sensor Cloud Platform, Converge-casting, and Data Aggregation in support of intelligent sensing and relaying of information. The book begins with a brief introduction on sensors and transducers, giving readers insight into the various types of sensors and how one can work with them. In addition, it gives several real-life examples to help readers properly understand concepts. An overview of concepts such as wireless sensor networks, cloud platforms, and device-to-cloud and sensor cloud architecture are explained briefly, as is data gathering in wireless sensor networks and aggregation procedures. Final sections explore how to process gathered data and relay the data in an intelligent way, including concepts such as supervised and unsupervised learning, software defined networks, sensor data mining and smart systems.

Real-Time Data Analytics for Large-Scale Sensor Data covers the theory and applications of hardware platforms and architectures, the development of software methods, techniques and tools, applications, governance and adoption strategies for the use of massive sensor data in real-time data analytics. It presents the leading-edge research in the field and identifies future challenges in this fledging research area. The book captures the essence of real-time IoT based solutions that require a multidisciplinary approach for catering to on-the-fly processing, including methods for high performance stream processing, adaptively streaming adjustment, uncertainty handling, latency handling, and more.

The only book that covers in detail a broad range of cutting-edge topics within motor rehabilitation technology

Neural engineering is a discipline that uses engineering techniques to understand, repair, replace, enhance, or treat diseases of neural systems. This book describes state-of-the-art methods within this field, from brain-computer interfaces to spinal and cortical plasticity. Touching on electrode design, signal processing, the neurophysiology of movement, robotics, and much more, this innovative book presents the latest information for readers working in biomedical engineering.

Each section of "Introduction to Neural Engineering for Motor Rehabilitation "begins with an overview of techniques before moving on to provide information on the most recent findings. Topics include: INJURIES OF THE NERVOUS SYSTEM--including diseases and injuries of the central nervous system leading to sensory-motor impairment; peripheral and spinal plasticity after nerve injuries; and motor control modules of human movement in health and diseaseSIGNAL DETECTION AND CONDITIONING--including progress in peripheral neural interfaces; multi-modal, multi-site neuronal recordings for brain research; methods for non-invasive electroencephalograph detection; wavelet denoising and conditioning of neural recordingsFUNCTION REPLACEMENT (Prostheses and Orthosis)--including an introduction to upper limb prosthetics; controlling prostheses using peripheral nerve stimulation invasive interfaces for amputees; and exoskeletal robotics for functional substitutionFUNCTION RESTORATION--including methods for movement restoration; advanced user interfaces for upper limb functional electrical stimulation; and selectivity of peripheral neural interfacesREHABILITATION THROUGH NEUROMODULATION--including brain-computer interface applied to motor recovery after brain injury; functional electrical therapy of upper extremities; and robotic assisted neurorehabilitation

"Introduction to Neural Engineering for Motor Rehabilitation" is an important textbook and reference for graduate students and researchers in the fields of biomedical and neural engineering.

Biopolymer-Based Formulations: Biomedical and Food Applications presents the latest advances in the synthesis and characterization of advanced biopolymeric formulations and their state-of-the-art applications across biomedicine and food science. Sections cover the fundamentals, applications, future trends, environmental, ethical and medical considerations, and biopolymeric architectures that are organized in nano, micro and macro scales. The final section of the book focuses on novel applications and recent developments. This book is an essential resource for researchers, scientists and advanced students in biopolymer science, polymer science, polymer chemistry, polymer composites, plastics engineering, biomaterials, materials science, biomedical engineering, and more. It will also be of interest to R&D professionals, scientists and engineers across the plastics, food, biomedical and pharmaceutical industries.

Medical Data Sharing, Harmonization and Analytics serves as the basis for understanding the rapidly evolving field of medical data harmonization combined with the latest cloud infrastructures for storing the harmonized (shared) data. Chapters cover the latest research and applications on data sharing and protection in the medical domain, cohort integration through the recent advancements in data harmonization, cloud computing for storing and securing the patient data, and data analytics for effectively processing the harmonized data.

Drug Delivery Aspects reviews additional features of drug delivery systems, along with the standard formulation development, like preclinical testing, conversion into solid dosage forms, roles of excipients and polymers used on stability and sterile processing. There is a focus on formulation engineering and related large scale (GMP) manufacturing, regulatory, and functional aspects of drug delivery systems. A detailed discussion on biologics and vaccines gives insights to readers on new developments in this direction. The series Expectations and Realities of Multifunctional Drug Delivery Systems examines the fabrication, optimization, biological aspects, regulatory and clinical success of wide range of drug delivery carriers. This series reviews multifunctionality and applications of drug delivery systems, industrial trends, regulatory challenges and in vivo success stories. Throughout the volumes discussions on diverse aspects of drug delivery carriers, such as clinical, engineering, and regulatory, facilitate insight sharing across expertise area and form a link for collaborations between industry-academic scientists and clinical researchers. Expectations and Realities of Multifunctional Drug Delivery Systems connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stake holders. The wide scope of the book ensures it as a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about drug delivery systems.

This book is the first comprehensive overview of the emerging field of cuffless blood pressure monitoring. Increasing clinical evidence proves that longitudinal measurements of blood pressure allow for earlier detection and better management of multiple medical conditions and for superior prediction of cardiovascular events. Unfortunately, today's clinical and industry standards for blood pressure monitoring still require the inflation of a pneumatic cuff around a limb each time a measurement is taken. Over the last decades clinicians, scientists and device manufacturers have explored the feasibility of technologies that reduce or even completely eliminate the need of cuffs, initiating the era of cuffless blood pressure monitoring. Among the existing literature, this book is intended to be a practical guide to navigate across this emerging field. The chapters of the handbook have been elaborated by experts and key opinion leaders in the domain, and will guide the reader along the clinical, scientific, technical, and regulatory aspects of cuffless blood pressure monitoring.

The book reports on advanced topics in the areas of wearable robotics research and practice. It focuses on new technologies, including neural interfaces, soft wearable robots, sensors and actuators technologies, and discusses important regulatory challenges, as well as clinical and ethical issues. Based on the 4th International Symposium on Wearable Robotics, WeRob2018, held October 16-20, 2018, in Pisa, Italy, the book addresses a large audience of academics and professionals working in government, industry, and medical centers, and end-users alike. It provides them with specialized information and with a source of inspiration for new ideas and collaborations. It discusses exemplary case studies highlighting practical challenges related to the implementation of wearable robots in a number of fields. One of the focus is on clinical applications, which was encouraged by the colocation of WeRob2018 with the International Conference on Neurorehabilitation, INCR2018. Additional topics include space applications and assistive technologies in the industry. The book merges together the engineering, medical, ethical and political perspectives, thus offering a multidisciplinary, timely snapshot of the field of wearable technologies.

This book, written by key researchers in the field, provides a comprehensive analysis and overview of the state of the art of plasma-based cancer therapy. Recent progress in atmospheric plasmas has led to non-thermal or cold atmospheric plasma (CAP) devices with ion temperatures close to room temperature. In contrast to many existing anti-cancer approaches, CAP is a selective anti-cancer modality which has demonstrated significant potential in cancer therapy.Written by a global, cross-disciplinary group of leading researchers, this book covers basic theory, generation, diagnostics, and simulation of cold atmospheric plasma, as well as their clinical application in cancer therapy, immunotherapy, and future outlook, giving a complete picture of the field. It is meant for a broad audience, from students to engineers and scientists, who are interested in the emerging world of plasma medical applications. It presents recent advances, primary challenges, and future directions of this exciting, cutting-edge field.

High-Density Integrated Electrocortical Neural Interfaces provides a basic understanding, design strategies and implementation applications for electrocortical neural interfaces with a focus on integrated circuit design technologies. A wide variety of topics associated with the design and application of electrocortical neural implants are covered in this book. Written by leading experts in the field- Dr. Sohmyung Ha, Dr. Chul Kim, Dr. Patrick P. Mercier and Dr. Gert Cauwenberghs -the book discusses basic principles and practical design strategies of electrocorticography, electrode interfaces, signal acquisition, power delivery, data communication, and stimulation. In addition, an overview and critical review of the state-of-the-art research is included. These methodologies present a path towards the development of minimally invasive brain-computer interfaces capable of resolving microscale neural activity with wide-ranging coverage across the cortical surface.

Single-cell Omics, Volume 2: Advances in Applications provides the latest single-cell omics applications in the field of biomedicine. The advent of omics technologies have enabled us to identify the differences between cell types and subpopulations at the level of the genome, proteome, transcriptome, epigenome, and in several other fields of omics. The book is divided into two sections: the first is dedicated to biomedical applications, such as cell diagnostics, non-invasive prenatal testing (NIPT), circulating tumor cells, breast cancer, gliomas, nervous systems and autoimmune disorders, and more. The second focuses on cell omics in plants, discussing micro algal and single cell omics, and more. This book is a valuable source for bioinformaticians, molecular diagnostic researchers, clinicians and several members of biomedical field interested in understanding more about single-cell omics and its potential for research and diagnosis.

Data Democracy: At the Nexus of Artificial Intelligence, Software Development, and Knowledge Engineering provides a manifesto to data democracy. After reading the chapters of this book, you are informed and suitably warned! You are already part of the data republic, and you (and all of us) need to ensure that our data fall in the right hands. Everything you click, buy, swipe, try, sell, drive, or fly is a data point. But who owns the data? At this point, not you! You do not even have access to most of it. The next best empire of our planet is one who owns and controls the world's best dataset. If you consume or create data, if you are a citizen of the data republic (willingly or grudgingly), and if you are interested in making a decision or finding the truth through data-driven analysis, this book is for you. A group of experts, academics, data science researchers, and industry practitioners gathered to write this manifesto about data democracy.

Deep Learning Techniques for Biomedical and Health Informatics provides readers with the state-of-the-art in deep learning-based methods for biomedical and health informatics. The book covers not only the best-performing methods, it also presents implementation methods. The book includes all the prerequisite methodologies in each chapter so that new researchers and practitioners will find it very useful. Chapters go from basic methodology to advanced methods, including detailed descriptions of proposed approaches and comprehensive critical discussions on experimental results and how they are applied to Biomedical Engineering, Electronic Health Records, and medical image processing.

This book describes the future of microscopically small medical devices and how to locate a lab to start conducting your own do-it-yourself microelectromechanical systems (MEMS) research in one of the many national, international, government, and other regional open use facilities, where you can quickly begin designing and fabricating devices for your applications. You will learn specific, tangible information on what MEMS are and how a device is fabricated, including what the main types of equipment are in these facilities. The book provides advice on working in a cleanroom, soft materials, collaboration, intellectual property and privacy issues, regulatory compliance, and how to navigate other issues that may arise. This book is primarily aimed at researchers and students who work at universities without MEMS facilities, and small companies who need access to MEMS resources.

This book presents state-of-the-art experimental and modelling techniques for skin biophysics that are currently used in academic and industrial research. It also identifies current and future challenges, as well as a growing number of opportunities in this exciting research field. The book covers the basics of skin physiology, biology, microstructural and material properties, and progressively introduces the reader to established experimental characterisation protocols and modelling approaches. Advanced topics in modelling theories and numerical implementation are also presented. The book focusses especially on: 1. Basic physiology, molecular biology, microstructural and material properties of the skin. 2. Experimental characterisation techniques for the skin (including imaging): in vivo and in vitro techniques and combination of those with in silico approaches. 3. State-of-the-art constitutive models of the skin: elastic, anelastic and mechanobiological formulations (e.g. growth, ageing, healing). 4. Applications: mechanics, damage, biological growth, healing, ageing and skin tribology. This book is addressed to postgraduate students in biomedical/mechanical/civil engineering, (bio)physics and applied mathematics, postdoctoral researchers, as well as scientists and engineers working in academia and industry engaged in skin research, particularly, if at the cross-roads of physical experiments, imaging and modelling. The book is also be of interest to clinicians/biologists who wish to learn about the possibilities offered by modern engineering techniques for skin science research and, by so doing, provide them with an incentive to broaden their outlook, engage more widely with the non-clinical research communities and, ultimately, help cross-fertilising new ideas that will lead to better treatment plans and engineering solutions.

A Comprehensive Physically Based Approach to Modeling in Bioengineering and Life Sciences provides a systematic methodology to the formulation of problems in biomedical engineering and the life sciences through the adoption of mathematical models based on physical principles, such as the conservation of mass, electric charge, momentum, and energy. It then teaches how to translate the mathematical formulation into a numerical algorithm that is implementable on a computer. The book employs computational models as synthesized tools for the investigation, quantification, verification, and comparison of different conjectures or scenarios of the behavior of a given compartment of the human body under physiological and pathological conditions.

Biomechanics and Gait Analysis presents a comprehensive book on biomechanics that focuses on gait analysis. It is written primarily for biomedical engineering students, professionals and biomechanists with a strong emphasis on medical devices and assistive technology, but is also of interest to clinicians and physiologists. It allows novice readers to acquire the basics of gait analysis, while also helping expert readers update their knowledge. The book covers the most up-to-date acquisition and computational methods and advances in the field. Key topics include muscle mechanics and modeling, motor control and coordination, and measurements and assessments. This is the go to resource for an understanding of fundamental concepts and how to collect, analyze and interpret data for research, industry, clinical and sport.

Semi-empirical Neural Network Modeling presents a new approach on how to quickly construct an accurate, multilayered neural network solution of differential equations. Current neural network methods have significant disadvantages, including a lengthy learning process and single-layered neural networks built on the finite element method (FEM). The strength of the new method presented in this book is the automatic inclusion of task parameters in the final solution formula, which eliminates the need for repeated problem-solving. This is especially important for constructing individual models with unique features. The book illustrates key concepts through a large number of specific problems, both hypothetical models and practical interest.

Bioactive Materials for Bone Regeneration summarizes research advances on the topic, including sections on the characteristics of biomaterial-induced microenvironments, interactions of bioactive materials with stem cells and tissues, and the immunomodulatory microenvironment induced by biomaterials and its effects on osteogenesis. As the regeneration of large-size bone tissue defects represents a significant clinical challenge, this book demonstrates how new biomaterials with specific chemical and physical characteristics may interact with the host and create a unique micro-environment that actively facilitates stem cell differentiation along a specific lineage, thus stimulating tissue regeneration.

This book presents innovative solutions utilising informatics to deal with various issues related to the COVID-19 outbreak. The book offers a collection of contemporary research and development on the management of Covid-19 using health data analytics, information exchange, knowledge sharing, the Internet of Things (IoT), and the Internet of Everything (IoE)-based solutions. The book also analyses the implementation, assessment, adoption, and management of these healthcare informatics solutions to manage the pandemic and future epidemics. The book is relevant to researchers, professors, students, and professionals in informatics and related topics.

Applied Human Factors in Medical Device Design describes the contents of a human factors toolbox with in-depth descriptions of both empirical and analytical methodologies. The book begins with an overview of the design control process, integrating human factors as directed by AAMI TIR 59 and experienced practice. It then explains each method, describing why each method is important, its potential impact, when it's ideal to use, and related challenges. Also discussed are other barriers, such as communication breakdowns between users and design teams. This book is an excellent reference for professionals working in human factors, design, engineering, marketing and regulation.

Current Trends and Future Developments on (Bio-) Membranes: Reverse and Forward Osmosis: Principles, Applications, Advances covers the important aspects of RO, FO and their combination in integrated systems, along with their specific and well-established applications. The book offers an overview of recent developments in the field of forward and reverse osmosis and their applications in water desalination, wastewater treatment, power generation and food processing. General principles, membrane module developments, membrane fouling, modeling, simulation and optimization of both technologies are also covered. The book's ultimate goal is to support the scientific community, professionals and enterprises that aspire to develop new applications.

This book offers a comprehensive introduction to electron-based bioscience, biotechnology, and biocorrosion. It both explains the importance of electron flow during metabolic processes in microorganisms and provides valuable insights into emerging applications in various fields. In the opening section, readers will find up-to-date information on topics such as electron transfer reactions, extracellular electron transfer mechanisms, direct interspecies electron transfer, and electron uptake by sulfate-reducing bacteria. The focus then shifts to state-of-the-art advances and applications in the field of biotechnology. Here, the coverage encompasses e.g. progress in understanding electrochemical interactions between microorganisms and conductive particles, enzymatic reactions and their application in the bioproduction of useful chemicals, and the importance of redox balance for fatty acid production. In closing, the book addresses various aspects of the complex phenomenon of microbiologically induced corrosion, highlighting novel insights from the fields of electromicrobiology and electrochemistry and their implications.

This volume comprises the latest developments in both fundamental science and patient-specific applications, discussing topics such as: cellular mechanics, injury biomechanics, biomechanics of the heart and vascular system, algorithms of computational biomechanics for medical image analysis, and both patient-specific fluid dynamics and solid mechanics simulations. With contributions from researchers world-wide, Computational Biomechanics for Medicine: Measurments, Models, and Predictions provides an opportunity for specialists in the field to present their latest methodologies and advancements.

This book focuses on the latest fluorescent materials for cell imaging. Cell imaging is a widely used basic technique that helps scientists gain a better understanding of biological functions through studies of cellular structure and dynamics. In the past decades, the development of a variety of new fluorescent materials has significantly extended the applications of cellular imaging techniques. This book presents recently developed fluorescent materials, including semiconductor quantum dots, carbon dots, silicon nanoparticles, metal nanoclusters, upconversion nanoparticles, conjugated polymers/polymer dots, aggregation-induced emission (AIE) probes, and coordination compounds, used for various cellular imaging purposes. It will appeal to cell biologists and other researchers in academia, industry and clinical settings who are interested in the technical development and advanced applications of fluorescence imaging in cells, tissues and organisms to explore the mechanisms of biological functions and diseases.