This edited book designs the Cognitive Computing in Human Cognition to analyze to improve the efficiency of decision making by cognitive intelligence. The book is also intended to attract the audience who work in brain computing, deep learning, transportation, and solar cell energy. Due to this in the recent era, smart methods with human touch called as human cognition is adopted by many researchers in the field of information technology with the Cognitive Computing.

This book describes the use of modern micro- and nanofabrication technologies to develop improved tools for stimulating and recording electrical activity in neuronal networks. It provides an overview of the different ways in which the "nano-world" can be beneficial for neuroscientists, including improvement of mechanical adhesion of cells on electrodes, tight-sealed extracellular recordings or intracellular approaches with strongly reduced invasiveness and tools for localized electrical or optical stimulation in optogenetics experiments. Specific discussion of fabrication strategies is included, to provide a comprehensive guide to develop micro and nanostructured tools for biological applications. A perspective on integrating these devices with state-of-the-art technologies for large-scale in vitro and in vivo experiments completes the picture of neuronal interfacing with micro- and nanostructures.

This book focuses on important interfacial phenomena, such as interfacial potential and interfacial multi-functionality, responsible for determining the fate of nanoparticles inside the biological milieu. Additionally, this book explores the role of surface defects in photocatalytic nanoparticles in defining the nanoparticle interaction to biological membrane and cytotoxic propensity.The authors describe the interfacial assembly of peptide/protein on conformational/functional dynamics of the peptide/protein, which may be adopted as an approach to moderate the protein misfolding diseases.

This text is an introduction to electrophysiology, following a quantitative approach. The first chapter summarizes much of the mathematics required in the following chapters. The second chapter presents a very concise overview of the general principles of electrical fields and current flow, mostly es tablished in physical science and engineering, but also applicable to biolog ical environments. The following five chapters are the core material of this text. They include descriptions of how voltages come to exist across membranes and how these are described using the Nernst and Goldman equations (Chapter 3), an examination of the time course of changes in membrane voltages that produce action potentials (Chapter 4), propagation of action potentials down fibers (Chapter 5), the response of fibers to artificial stimuli such as those used in pacemakers (Chapter 6), and the voltages and currents produced by these active processes in the surrounding extracellular space (Chapter 7). The subsequent chapters present more detailed material about the application of these principles to the study of cardiac and neural electrophysiology, and include a chapter on recent developments in mem brane biophysics. The study of electrophysiology has progressed rapidly because of the precise, delicate, and ingenious experimental studies of many investigators. The field has also made great strides by unifying the numerous experimental observations through the development of increasingly accurate theoretical concepts and mathematical descriptions. The application of these funda mental principles has in turn formed a basis for the solution of many different electrophysiological problems."

This book explores computational fluid dynamics in the context of the human nose, allowing readers to gain a better understanding of its anatomy and physiology and integrates recent advances in clinical rhinology, otolaryngology and respiratory physiology research. It focuses on advanced research topics, such as virtual surgery, AI-assisted clinical applications and therapy, as well as the latest computational modeling techniques, controversies, challenges and future directions in simulation using CFD software. Presenting perspectives and insights from computational experts and clinical specialists (ENT) combined with technical details of the computational modeling techniques from engineers, this unique reference book will give direction to and inspire future research in this emerging field.

This handbook provides insights into becoming a better and more evolved athlete. It offers aspiring athletes, regardless of skill level, a better understanding of their bodies and how to unlock the unlimited potential of muscles without injury. It focuses on the "superhero" muscle: the iliopsoas, and also sheds light on Diamond-Corporation's new technology and elite athleticism, and how these can contribute to a healthier life. Lastly, the authors explore the mindset of success and provide exercises for remaining calm under pressure. This stand-alone book is the sequel to Paradigm Shift for Future Tennis and Enhancing Performance and Reducing Stress in Sport (2014, Springer). This book is written by scientists, whose expertise collectively spans the fields of biomechanics, clinical surgery, current and former elite athleticism, engineering and naturopath doctoral work. Together, they aim to inspire and educate athletes on how to improve their sports performance by using new technologies, world class biomechanics knowledge and ancient herbal medicines.

This book presents advances in biomedical imaging analysis and processing techniques using time dependent medical image datasets for computer aided diagnosis. The analysis of time-series images is one of the most widely appearing problems in science, engineering, and business. In recent years this problem has gained importance due to the increasing availability of more sensitive sensors in science and engineering and due to the wide-spread use of computers in corporations which have increased the amount of time-series data collected by many magnitudes. An important feature of this book is the exploration of different approaches to handle and identify time dependent biomedical images. Biomedical imaging analysis and processing techniques deal with the interaction between all forms of radiation and biological molecules, cells or tissues, to visualize small particles and opaque objects, and to achieve the recognition of biomedical patterns. These are topics of great importance to biomedical science, biology, and medicine. Biomedical imaging analysis techniques can be applied in many different areas to solve existing problems. The various requirements arising from the process of resolving practical problems motivate and expedite the development of biomedical imaging analysis. This is a major reason for the fast growth of the discipline.

This volume describes the state-of-knowledge in the study of the relationships between mechanical loading states in tissues and common pathophysiologies related to increase in mass of adipose tissues and/or hyperglycemia which eventually lead to obesity, diabetes, insulin resistance, hyperlipidemia, metabolic inflammations, certain types of cancer and other related diseases. There appears to be an interaction between the loading states in tissues and cells and these chronic conditions, as well as with factors such as age, gender and genetics of the individual. Bioengineering has made key contributions to this research field in providing technologies for cell biomechanics experimentation, microscopy and image processing, tissue engineering and multi-scale, multi-physics computational modeling. Topics at the frontier of this field of study include: the continuous monitoring of cell growth, proliferation and differentiation in response to mechanical factors such as stiffness of the extracellular matrix (ECM) and mechanical loads transferred through the ECM; mechanically-activated signaling pathways and molecular mechanisms; effects of different loading regimes and mechanical environments on differentiation fates of mesenchymal stem cells (MSCs) into myogenic and osteogenic versus adipogenic lineages; the interactions between nutrition and mechanotransduction; cell morphology, focal adhesion patterns and cytoskeletal remodeling changes in adipogenesis; activation of receptors related to diabetes by mechanical forces; brown and white adipose plasticity and its regulation by mechanical factors.

This two-volume set focuses on the interface between physiologic mechanisms and diagnostic human engineering. Today numerous biomedical sensors are commonplace in clinical practice. The registered biosignals reflect mostly vital physiologic phenomena. In order to adequately apply biomedical sensors and reasonably interpret the corresponding biosignals, a proper understanding of the involved physiologic phenomena, their influence on the registered biosignals, and the technology behind the sensors is necessary. The first volume is devoted to the interface between physiologic mechanisms and arising biosignals, whereas the second volume is focussed on the interface between biosignals and biomedical sensors. The physiologic mechanisms behind the biosignals are described from the basic cellular level up to their advanced mutual coordination level during sleep. The arising biosignals are discussed within the scope of vital physiologic phenomena to foster their understanding and comprehensive analysis.

Although somatosensory system works in tandem with the motor system in biology, the majority of the prosthetics research and commercial efforts had focused on accommodating movement deficits. With the development of neuroprostheses in the last 15 years, it has become evident that somatosensory input (mainly as touch and proprioception) is essential for motor control, manipulating objects, and embodiment, in addition to its primary role for sensory perception. Somatosensory Feedback for Neuroprosthetics covers all relevant aspects to facilitate learning and doing research and development in the field. To understand the properties of the body to create viable solutions, this book starts with chapters reviewing the basic anatomy, physiology, and psychophysics of the somatosensory system, sensorimotor control, and instrumentation. Some sections are dedicated to invasive (peripheral and central, mainly cortical) and noninvasive (vibrotactile, electrotactile, etc.) approaches. Final chapters cover future technologies such as novel sensors and electrodes, safety, and clinical testing, and help to make up future prospects for this field with an emphasis on development and end use. With contributions from renowned experts, the contents include their recent findings and technical details necessary to understand those findings.

"Smart Hydrogel Functional Materials" comprehensively and systematically describes our current understanding of smart or intelligent hydrogel functional materials with environmental stimuli-responsive functions. The contents range from hydrogels (including hydrogel-functionalized membranes) to microgels (including hydrogel-functionalized microcapsules) with various response properties, such as thermo-response, pH-response, pH-/thermo-dual-response, glucose-response, ethanol-response, ion-recognition, molecular-recognition, and so on. Most of the contents in this book represent the fresh achievements of the authors' group on smart hydrogel functional materials. While all chapters can be read as stand-alone papers, together they clearly describe the design concepts, fabrication strategies and methods, microstructures and performances of smart hydrogel functional materials. Vivid schematics and illustrations throughout the book enhance the accessibility of the theory and technologies involved.

This is an ideal reference book for a broad general readership including chemists, materials researchers, chemical engineers, pharmaceutical scientists and biomedical researchers, who are interested in designing and fabricating smart hydrogel functional materials for various application purposes.

Dr. Liang-Yin Chu is a professor at the School of Chemical Engineering, Sichuan University, China. He is a Distinguished Young Scholar of the National Natural Science Foundation of China and a Distinguished Professor of the "Chang Jiang Scholars Program" of the Ministry of Education of China.

This book reports on multidisciplinary research focusing on the analysis, synthesis and design of bionanomaterials. It merges the biophysicists', the biochemists' and bioengineers' perspectives, covering the study of the basic properties of materials and their interaction with biological systems, the development of new devices for medical purposes such as implantable systems, and new algorithms and methods for modeling the mechanical, physical or biological properties of biomaterials. The different chapters, which are based on selected contributions presented at the second edition of BIONAM, held on October 4-7, 2016, in Salerno, Italy, cover both basic and applied research. This includes novel synthetic strategies for nanomaterials, as well as the implementation of bio- and smart materials for pharmacological and medical purposes (e.g. drug delivery, implantable systems), environmental applications, and many others. The book provides a broad audience of academic and professionals with a comprehensive, timely snapshot of the field of biomaterials. Besides offering a set of innovative theories together with the necessary practical tools for their implementation, it also highlights current challenges in the field, thus fostering new discussions and possible future collaborations between groups with different backgrounds.

This book highlights recent advances in the field of biomaterials design and the state of the art in biomaterials applications for biomedicine. Addressing key aspects of biomaterials, the book explores technological advances at multi-scale levels (macro, micro, and nano), which are used in applications related to cell and tissue regeneration. The book also discusses the future scope of bio-integrated systems. The contents are supplemented by illustrated examples, and schematics of molecular and cellular interactions with biomaterials/scaffolds are included to promote a better understanding of the complex biological mechanisms involved in material-to-biomolecule interactions. The book also covers factors that govern cell growth, differentiation, and regeneration in connection with the treatment and recovery of native biological systems. Tissue engineering, drug screening and delivery, and electrolyte complexes for biomedical applications are also covered in detail. This book offers a comprehensive reference guide for multi-disciplinary communities working in the area of biomaterials, and will benefit researchers and graduate students alike.

This volume focuses on latest research in therapeutic devices for cardiovascular, i.e. vascular and valvular and cardiac diseases. In the area of vascular therapies, aspects covered relate to latest research in small-diameter tissue-regenerative vascular grafts, one of the greatest persisting challenges in cardiovascular therapies, stent grafts and endovascular stents for percutaneous arterial interventions. Contributions on valvular therapies focus on tissue engineered and tissue regenerative prosthetic heart valves and valvular prostheses for trans-apical implantation including the challenges posed on the prosthesis design. The section on cardiac diseases aims at covering therapeutic advances for myocardial infarction and prevention of heart failure and on in vivo biomechanics of implantable cardiac pacemaker devices. A further section complements these three areas by presenting constitutive modelling of soft biological tissues of the cardiovascular system, an area imperative for advanced numerical and computational modelling in the development and optimisation of cardiovascular devices and therapies.

There is a growing global awareness of the link between good diet and health. This fascinating book reviews various functional foods or nutraceuticals and the bio-active compounds they contain in order to identify the role of bioactive compounds such as nisin, micronutrients, and hydrocolloids in the diet in overall human health. It also provides up-to-date information on functional elements like antioxidants, dietary fibres, pre & probiotics, vitamins and mineral-enriched foods in the human diet. Consisting of fifteen chapters, the book offers a systematic review of the key factors in the preparation of functional foods from selected sources, and also describes the processing, preservation and packaging of a range of functional food products. This book is a valuable resource for students and researchers working in the field of food science, food technology, and nutrition, as well as for industry experts.

This thesis lays the groundwork for the automatic supervision of the laser incision process, which aims to complement surgeons' perception of the state of tissues and enhance their control over laser incisions. The research problem is formulated as the estimation of variables that are representative of the state of tissues during laser cutting. Prior research in this area leveraged numerical computation methods that bear a high computational cost and are not straightforward to use in a surgical setting. This book proposes a novel solution to this problem, using models inspired by the ability of experienced surgeons to perform precise and clean laser cutting. It shows that these new models, which were extracted from experimental data using statistical learning techniques, are straightforward to use in a surgical setup, allowing greater precision in laser-based surgical procedures.

A globalization of innovation has produced the most massive spurt in biotechnology in world history.  Businesses, universities, and non-governmental organizations are collaborating to produce a "science-industrial complex" in biotechnology.  Using case studies of stem cell research, cloning, genetically modified food, in-vitro fertilization, and chimeras in a number of Eastern and Western countries around the world, I argue that much of this biotech activity is global in nature and independent of state control.  This shift in the relative influence of state and non-state actors has led to the virtual deregulation of biotechnology and the liberation of innovation from geo-political constraints.  These trends post a number of interesting social, political, and ethical issues for the contemporary period and suggest the need to rethink how controversial moral issues are handled by the science-industrial complex.

The book Handheld Total Chemical and Biological Analysis Systems: Bridging NMR, Digital Microfluidics, and Semiconductors centers on the complete design of Nuclear Magnetic Resonance (NMR) microsystems for in vitro chemical and biological assays based on semiconductor chips and portable magnet. Different sensing mechanisms for CMOS in vitro assay are compared, key design criteria of the CMOS transceiver for NMR measurement are revealed, and system-level optimizations of the CMOS NMR platform utilizing digital microfluidic and diverse functions of the CMOS technology are discussed. Two CMOS NMR platforms are implemented, each of these focuses on different aspect of optimization.

This book describes 200 bio-polymers, including the most recent and advanced nanotechnology applications. The applications of various bio-medical and other future potential uses are covered and examined in depth. Systematic discussion of current leading natural polymers is also included.

The aim of this book is to present a range of analytical methods that can be used in formulation design and development and focus on how these systems can be applied to understand formulation components and the dosage form these build. To effectively design and exploit drug delivery systems, the underlying characteristic of a dosage form must be understood--from the characteristics of the individual formulation components, to how they act and interact within the formulation, and finally, to how this formulation responds in different biological environments. To achieve this, there is a wide range of analytical techniques that can be adopted to understand and elucidate the mechanics of drug delivery and drug formulation. Such methods include e.g. spectroscopic analysis, diffractometric analysis, thermal investigations, surface analytical techniques, particle size analysis, rheological techniques, methods to characterize drug stability and release, and biological analysis in appropriate cell and animal models. Whilst each of these methods can encompass a full research area in their own right, formulation scientists must be able to effectively apply these methods to the delivery system they are considering. The information in this book is designed to support researchers in their ability to fully characterize and analyze a range of delivery systems, using an appropriate selection of analytical techniques. Due to its consideration of regulatory approval, this book will also be suitable for industrial researchers both at early stage up to pre-clinical research.

This book presents an overview of the current state of research on ultrashort electric field pulses of high intensity and their use in biology and medicine. It examines in detail the most recent and exciting advances in how nanosecond and picosecond electric pulse research has grown and expanded into new areas of biology and medicine. Further, the book specifically focuses on electric pulses in the time domain, on intracellular effects as opposed to plasma membrane electroporation, and highlights the biological and medical applications of these unique pulse effects. Since the authors were initial innovators exploring nanosecond and picosecond pulses, their unique perspectives foreshadowed directions the research took, expanding into new areas that they continue to investigate today.

Nanobiotechnology is the convergence of existing and new biotechnology with the 1 ability to manipulate matter at or near the molecular level. This ability to manipulate matter on a scale of 100 nanometers (nm) or less is what constitutes the nanotechnology revolution occurring today, the potentially vast economic and social implications of which are yet to be fully understood (Royal Society, 2004). The most immediate way to understand the implications of nanobiotechnology for ethics is to consider the real life concerns of communities that are mobilizing within civil society. The conflicts and ethical debates surrounding nanotechnology will, almost by definition, emerge on the fault lines between different civil society actors, researchers and financial interests associated with nanobiotechnology, as well as (potentially) government regulators. These fault lines are all reflected within the concerns (as expressed d- cursively) of the communities mobilizing. This chapter will explore converging d- courses regarding converging technologies. Converging Technologies (CT) are already a familiar theme in the next gene- tion of biotechnology, nanotechnology, pharmacogenomics and proteomics research 2 and development. Nanobiotechnology means that previously separate disciplines (IT, physics, chemistry, and biology) are merging and converging to create new applications and even new life forms through converged technological platforms. Schummer (2004), and Glimell and Fogelberg (2003, p. 43), note the predominance of interdisciplinarity as a core theme of nano-discourse.

This book discusses the design of neural stimulator systems which are used for the treatment of a wide variety of brain disorders such as Parkinson's, depression and tinnitus. Whereas many existing books treating neural stimulation focus on one particular design aspect, such as the electrical design of the stimulator, this book uses a multidisciplinary approach: by combining the fields of neuroscience, electrophysiology and electrical engineering a thorough understanding of the complete neural stimulation chain is created (from the stimulation IC down to the neural cell). This multidisciplinary approach enables readers to gain new insights into stimulator design, while context is provided by presenting innovative design examples.

Non-Newtonian properties on bubble dynamics and cavitation are fundamentally different from those of Newtonian fluids. The most significant effect arises from the dramatic increase in viscosity of polymer solutions in an extensional flow, such as that generated about a spherical bubble during its growth or collapse phase. In addition, many biological fluids, such as blood, synovial fluid, and saliva, have non-Newtonian properties and can display significant viscoelastic behaviour. This monograph elucidates general aspects of bubble dynamics and cavitation in non-Newtonian fluids and applies them to the fields of biomedicine and bioengineering. In addition it presents many examples from the process industries. The field is strongly interdisciplinary and the numerous disciplines involve have and will continue to overlook and reinvent each others' work. This book helps researchers to think intuitively about the diverse physics of these systems, to attempt to bridge the various communities involved, and to convey the interest, elegance, and variety of physical phenomena that manifest themselves on the micrometer and microsecond scales.

The NATO Advanced Study Institute "Biomedical Optical Instrumentation and Laser Assisted Biotechnology" was held November 10-22, 1995 in Erice, Sicily. This was the 19 th conference organized by the International School of Quantum Electronics, under the auspices of the "Ettore Majorana" Center for Scientific Culture. The contributions presented at the Institute are written as extended, review-like papers to provide a broad and representative coverage of the fields of laser techniques, optoelectronics systems for medical diagnosis, and light and laser applications to Biology and Medicine. The aim of the Institute was to bring together some of the world's acknowledged scientists and clinicians that belong to different disciplines and consequently do not usually meet, but who have as a common link the use of optoelectronics instrumentation, techniques and procedures. Most of the lecturers attended all the lectures and devoted their spare hours to stimulating discussions. We would like to thank them all for their admirable contributions. The Institute also took advantage of a very active audience; most of the participants were active researchers in the field and contributed with discussions and seminars. Some of these seminars are also included in these Proceedings. The Institute was an important opportunity to discuss latest developments and emerging perspectives on the use of laser sources and optoelectronic techniques for diagnostic and therapeutic purposes."