This book reports on the latest advances in complex and nonlinear cardiovascular physiology aimed at obtaining reliable, effective markers for the assessment of heartbeat, respiratory, and blood pressure dynamics. The chapters describe in detail methods that have been previously defined in theoretical physics such as entropy, multifractal spectra, and Lyapunov exponents, contextualized within physiological dynamics of cardiovascular control, including autonomic nervous system activity. Additionally, the book discusses several application scenarios of these methods. The text critically reviews the current state-of-the-art research in the field that has led to the description of dedicated experimental protocols and ad-hoc models of complex physiology. This text is ideal for biomedical engineers, physiologists, and neuroscientists. This book also: Expertly reviews cutting-edge research, such as recent advances in measuring complexity, nonlinearity, and information-theoretic concepts applied to coupled dynamical systems Comprehensively describes applications of analytic technique to clinical scenarios such as heart failure, depression and mental disorders, atrial fibrillation, acute brain lesions, and more Broadens readers' understanding of cardiovascular signals, heart rate complexity, heart rate variability, and nonlinear analysis

This new volume introduces the applications of microfluidic systems to facilitate biotechnological and biomedical processes. It provides an overview on cutting-edge technologies, summarizes traditional and modern fabrication methods and highlights recent advances regarding the application of lab-on-a-chip (LoC) systems for bioanalytical purposes. This book is ideal for research scientists and students interested at the cross-section between biotechnology, chemistry and chemical engineering.

This book highlights the recent advances in the field of microbial engineering and its application in human healthcare. It underscores the systemic and synthetic biology approaches for engineering microbes and discusses novel treatments for inflammatory bowel diseases based on engineered probiotics. The book also reviews the different options and methods for engineering microbes, ranging from recombinant DNA technology to designing microbes for targeting specific sites and delivering therapeutics. Further, it discusses genetically engineered microorganisms for smart diagnostics and describes current approaches in microbial gene editing using CRISPR-Cas9-based tools. Lastly, it summarizes the potential applications of human microbiome engineering in improving human health and explores potential strategies for scaling-up the production of engineered microbial strains for commercial purposes, as well as the challenges. Given its scope, this book is a valuable resource for students, researchers, academics and entrepreneurs interested in understanding microbial engineering for the production of commercial products.

This textbook provides a thorough introduction and overview of the design and engineering of state-of-the-art prosthetics and assistive technologies. Innovations in prosthetics are increasingly made by cross-disciplinary thinking, and the author introduces the application of biomedical, mechanical, electrical, computer, and materials engineering principles to the design of artificial limbs. Coverage includes the fundamentals of biomechanics, biomechanical modeling and measurements, the basics of anatomy and physiology of limb defects, and the historical development of prosthetic design. This book stimulates the innovative thinking necessary for advancing limb restoration, and will be essential reading for students, as well as researchers, professional engineers, and prosthetists involved in the design and manufacture of artificial limbs. Learning enhanced by the exercises, including physical modeling with MATLAB and Simulink; Includes appendices with relevant equations and parameters for reference; Introduction to the design and engineering of prosthetics and assistive technologies.

This book provides a comprehensive presentation of the most frequently used high resolution manufacturing techniques available, as well as the polymeric materials used for each of the techniques. Divided into two parts covering the technologies and materials used and the impact on different research fields and case studies, High Resolution Manufacturing from 2D to 3D/4D Printing: Applications in Engineering and Medicine addresses issues like throughput improvement by volumetric 3D printing and presenting novel applications and case studies. In addition, this book also covers the latest breakthrough developments and innovations to help readers understand the future applications of this technology across various disciplines, including biomedicine, electronics, energy, and photonics.

Oxides for Medical Applications reviews the most important advances of oxides with optical, magnetic and electronic properties for biomedical applications. Owing to their unusual properties, oxides are expected to play a significant role in the prevention or early treatment of diseases. In addition to catalytically active artificial enzymes based on oxide materials-the book provides comprehensive coverage of the most relevant categories of oxide materials and their properties and applications. Since magnetic oxides are used extensively for a wide range of medical applications, there are numerous chapters that address these materials, including LSMO nanoparticles, ferrites, nanocatalysts, and more. Finally, practical considerations for the translation of these materials from the lab to the clinic are reviewed, including biocompatibility and toxicity of oxide nanoparticles, making this a suitable resource for researchers and practitioners in materials science and engineering in academia and the clinic.

This book facilitates both the theoretical background and applications of fuzzy, intuitionistic fuzzy and rough, fuzzy rough sets in the area of data science. This book provides various individual, soft computing, optimization and hybridization techniques of fuzzy and intuitionistic fuzzy sets with rough sets and their applications including data handling and that of type-2 fuzzy systems. Machine learning techniques are effectively implemented to solve a diversity of problems in pattern recognition, data mining and bioinformatics. To handle different nature of problems, including uncertainty, the book highlights the theory and recent developments on uncertainty, fuzzy systems, feature extraction, text categorization, multiscale modeling, soft computing, machine learning, deep learning, SMOTE, data handling, decision making, Diophantine fuzzy soft set, data envelopment analysis, centrally measures, social networks, Volterra–Fredholm integro-differential equation, Caputo fractional derivative, interval optimization, decision making, classification problems. This book is predominantly envisioned for researchers and students of data science, medical scientists and professional engineers.

"Cell and Tissue Engineering" introduces the principles and new approaches in cell and tissue engineering. It includes both the fundamentals and the current trends in cell and tissue engineering, in a way useful both to a novice and an expert in the field. The book is composed of 13 chapters all of which are written by the leading experts. It is organized to gradually assemble an insight in cell and tissue function starting form a molecular nano-level, extending to a cellular micro-level and finishing at the tissue macro-level. In specific, biological, physiological, biophysical, biochemical, medical, and engineering aspects are covered from the standpoint of the development of functional substitutes of biological tissues for potential clinical use. Topics in the area of cell engineering include cell membrane biophysics, structure and function of the cytoskeleton, cell-extracellular matrix interactions, and mechanotransduction. In the area of tissue engineering the focus is on the in vitro cultivation of functional tissue equivalents based on the integrated use of isolated cells, biomaterials, and bioreactors. The book also reviews novel techniques for cell and tissue imaging and characterization, some of which are described in detail such as atomic force microscopy. Finally, mathematical modeling methods are presented as valuable and indispensable tools in cell and tissue engineering. Numerous illustrations enhance the quality and ease of use of the presented material.

This book provides an interdisciplinary look at emerging trends in signal processing and biomedicine found at the intersection of healthcare, engineering, and computer science. Bringing together expanded versions of selected papers presented at the 2020 IEEE Signal Processing in Medicine and Biology Symposium (IEEE SPMB), it examines the vital role signal processing plays in enabling a new generation of technology based on big data and looks at applications ranging from medical electronics to data mining of electronic medical records. Topics covered include analysis of medical images, machine learning, biomedical nanosensors, wireless technologies, and instrumentation and electrical stimulation. Biomedical Sensing and Analysis: Signal Processing in Medicine and Biology presents tutorials and examples of successful applications, and will appeal to a wide range of professionals, researchers, and students interested in applications of signal processing, medicine, and biology. Presents an interdisciplinary look at research trends in signal processing and biomedicine; Promotes collaboration between healthcare practitioners and signal processing researchers; Includes tutorials and examples of successful applications.

The seven papers of this volume present a glimpse into current research on soft tissue mechanics as well as some future directions. The seven papers concern tissues within the cardiovascular system: three focus on arteries, three on the heart, and one on biaxial testing of planar tissues such as heart valves. Given that cardiovascular disease continues to be the leading cause of death in the developed world, the importance of such research is clear.

There are notable common features of the seven papers. First, most of the proposed constitutive relations are motivated directly by data on the underlying microstructure, and especially the orientations of a structurally important protein (collagen) that forms as undulated cross-linked fibers. Another feature of most of the papers is the consideration of the fact that both arteries and the heart contain muscle and that there is a need to quantify the so-called active (contractile) response in addition to the passive (non-contractile) response. Such relations must not only be structurally motivated, they must ultimately include the kinetics of calcium transport in the muscle. Constitutive relations for active behavior are discussed in the majority of the papers. The growth and remodeling of cardiovascular tissues is another common feature of the papers. Over the last twenty years, separate advances in biochemistry, cell biology, genetic engineering, and biomechanics have focused attention on the ubiquitous role of growth and remodeling of tissues. This volume should be of interest to cardiovascular researchers in particular, and to bioengineers and biomechanics soft tissue researchers in general.

This book reports on cutting-edge digital technologies and their applications in physical activity and sport. Gathering selected chapters from the 1st International Conference on Technology in Physical Activity and Sport, held virtually on November 24-27, 2020, from Seville, Spain, it offers a practice-oriented and evidence-based perspective on how technologies can be used for evaluation and control of different parameter relating to sport, physical activity, and health. It covers how digital technologies can be applied for training and monitoring purposes, and for improving athlete's performance, how they influence sport habits in different populations, demonstrating their growing influence in sport businesses (such as fitness centers) and management, and provides new findings on the connection between physical activity and human health, suggesting some interesting directions for future studies. With a good balance of laboratory research and information relevant for professional trainers, this book will provide bioengineers, sport scientists, and physiotherapists with timely information and a multidisciplinary perspective on the use of digital technologies to improve fitness, wellbeing and health in different population groups.

This book presents the proceedings of the 9th Asian South Pacific Association of Sport Psychology International Congress (ASPASP) 2022, Kuching, Malaysia, which entails the different sporting innovation themes, namely, Applied Sport and Social Psychology, Health and Exercise, Motor Control and Learning, Counselling and Clinical Psychology, Biomechanics, Data Mining and Machine Learning in Sports amongst others. It presents the state-of-the-art technological advancements towards the aforesaid themes and provides a platform to shape the future direction of sport science, specifically in the field sports and exercise psychology.  ​

This timely book presents innovative technologies for use in the diagnosis, monitoring, and treatment of brain disease. These technologies offer exciting possibilities in the medical field owing to their low-cost, portability and safety. The authors address cerebrovascular diseases such as stroke, ischemia, haemorrhage, and vasospasm, these diseases having an ever-increasing societal relevance due to the global ageing population. The authors describe the potential of novel techniques such as microwave imaging and present innovative modalities for treatment of brain tumours using electromagnetic fields and nano-composites, as well as for monitoring brain temperature during surgery. Finally, Emerging Electromagnetic Technologies for Brain Diseases Diagnostics, Monitoring and Therapy addresses the perspectives which arise from multi-modal multi-spectral EM modalities, which make a synergic use of the different portions of the electromagnetic spectrum. This text will be of interest to readers from various different areas, given the fundamental interdisciplinarity of the subject matter. This includes researchers or practitioners in the field of electrical engineering, applied physicists, and applied mathematicians working on imaging applications for biomedical and electromagnetic technologies. Neurologists and radiologists may also find this book of interest, as may graduate students in these areas.

This book aims to highlight the latest achievements in the use of AI and multimodal artificial intelligence in biomedicine and healthcare. Multimodal AI is a relatively new concept in AI, in which different types of data (e.g. text, image, video, audio, and numerical data) are collected, integrated, and processed through a series of intelligence processing algorithms to improve performance. The edited volume contains selected papers presented at the 2022 Health Intelligence workshop and the associated Data Hackathon/Challenge, co-located with the Thirty-Sixth Association for the Advancement of Artificial Intelligence (AAAI) conference, and presents an overview of the issues, challenges, and potentials in the field, along with new research results. This book provides information for researchers, students, industry professionals, clinicians, and public health agencies interested in the applications of AI and Multimodal AI in public health and medicine.

This book helps transform the awareness of the anticipatory perspective into actionable methods for practitioners of medicine. It provides guidance for those who design new means and methods inspired by epigenetics, in particular to those who advance sustainable alternatives.

Published as an Open Access book, IEA Wind Recommended Practices for the Implementation of Renewable Energy Forecasting Solutions translates decades of academic knowledge and standard requirements into applicable procedures and decision support tools for the energy industry. Designed specifically for practitioners in the energy industry, readers will find the tools to maximize the value of renewable energy forecast information in operational decision-making applications and significantly reduce the costs of integrating large amounts of wind and solar generation assets into grid systems through more efficient management of the renewable generation variability. Authored by a group of international experts as part of the IEA Wind Task 36 (Wind Energy Forecasting), the book addresses the issue that many current operational forecast solutions are not properly optimized for their intended applications. It provides detailed guidelines and recommended practices on forecast solution selection processes, designing and executing forecasting benchmarks and trials, forecast solution evaluation, verification, and validation, and meteorological and power data requirements for real-time forecasting applications. In addition, the guidelines integrate probabilistic forecasting, integrate wind and solar forecasting, offer improved IT data exchange and data format standards, and have a dedicated section to dealing with the requirements for SCADA and meteorological measurements. A unique and comprehensive reference, IEA Wind Recommended Practices for the Implementation of Renewable Energy Forecasting Solutions is an essential guide for all practitioners involved in wind and solar energy generation forecasting from forecast vendors to end-users of renewable forecasting solutions.

This book presents select proceedings of the APA Bioforum International e-Conference on Polymeric Biomaterials & Bioengineering (APA Bioforum 2021). This book mainly focuses on developing innovative polymeric materials for bioengineering and human healthcare systems. This book helps in the understanding of molecular architecture and its role in governing physical characteristics which is extremely useful to understand the interactions with the biosystem. The topics covered include polymer synthesis, biopolymers, biomaterials, smart materials, nanotechnology, tissue engineering, wound care system, hydrogel, targeted drug delivery, water decontamination and purification. The book will be a valuable reference for beginners, researchers and professionals interested in polymeric materials and biomaterials.

"Biofilm Eradication and Prevention"s presents the basics of biofilm formation on medical devices, diseases related to this formation, and approaches pharmaceutical researchers need to take to limit this problem. Split into three parts, the first deals with the development and characterization of biofilm on the surfaces of implanted or inserted medical devices. Questions as to why biofilms form over medical device surfaces and what triggers biofilm formation are addressed. In the second section, the author discusses biofilm-mediated chronic infections occurred in various organs (eyes, mouth, wounds) and pharmaceutical and drug delivery knowledge gained from research in these area. The third part explores pharmaceutical approaches like lipid-and polymer-based drug delivery carriers for eradicating biofilm on device-related infections. In addition, this section also explores the topic of novel small molecule (like iron and its complexes/metal chelators) and a quorum-sensing inhibitors to control medical biofilm formation.

This book covers the latest developments in tissue electrical conductivity and current density imaging, increasingly popular as well as challenging applications of MRI. These applications are enabled by the acquisition of high-quality MR phase images. This book provides a practical description of the MRI physics needed to understand and acquire phase images in MRI and the key details required to reconstruct them into conductivity, current density or electric field distributions. Comprehensive details are provided about the electrical properties of biological tissues, computational modeling considerations, experimental methods, construction of non-biological and biological phantoms and MRI pulse sequences. An inclusive review of image reconstruction algorithms, and their potential applications is provided for applications directed at determining current density or electric fields, such as in transcranial DC or AC stimulation techniques; as well as electrical conductivity reconstructions that may be of use in quantitative MRI applications used to detect cancer or other pathologies. This is an excellent book for undergraduate and graduate students beginning to explore phase, current density, and conductivity imaging in MRI, and will also be of great use to researchers interested in the area of MR-based electrical property imaging.

Modeling Biomolecular Networks in Cells shows how the interaction between the molecular components of basic living organisms can be modelled mathematically and the models used to create artificial biological entities within cells. Such forward engineering is a difficult task but the nonlinear dynamical methods espoused in this book simplify the biology so that it can be successfully understood and the synthesis of simple biological oscillators and rhythm-generators made feasible. Such simple units can then be co-ordinated using intercellular signal biomolecules. The formation of such man-made multicellular networks with a view to the production of biosensors, logic gates, new forms of integrated circuitry based on "gene-chips" and even biological computers is an important step in the design of faster and more flexible "electronics". The book also provides theoretical frameworks and tools with which to analyze the nonlinear dynamical phenomena which arise from the connection of building units in a biomolecular network.

This book focuses on biomaterials of different forms used for medical implants. The authors introduce the characteristics and properties of biomaterials and then dedicate special chapters to metallic, ceramic, polymeric and composite biomaterials. Case studies on sterilization methods by biomaterials are also presented. Finally, the authors describe the degradation and effects of biomaterials in living tissue.

This book (Technological Advancement in Instrumentation & Human Engineering) gathers selected papers submitted to the 6th International Conference on Mechanical Engineering Research in fields related to human engineering, ergonomics, vibration, instrumentation, Internet of Things and signal processing. This proceeding consists of papers in aforementioned related fields presented by researchers and scientists from universities, research institutes and industry showcasing their latest findings and discussions with an emphasis on innovations and developments in embracing the new norm, resulting from the COVID pandemic.

This volumes presents the proceedings of the FASMI 2020 conference, held at Taipei Veterans General Hospital on November 20-22, 2020. It presents contributions on all aspects of molecular imaging, discovered by leading academic scientists and researchers. It also provides a premier interdisciplinary treatment of recent innovations, trend, and concerns as well as practical challenges and solutions in Molecular Imaging and put an emphasis on Artificial Intelligence applied to Imaging Data. FASMI is the annual meeting of the Federation of Asian Societies for Molecular Imaging

This book highlights the latest advances on the implementation and adaptation of blockchain technologies in real-world scientific, biomedical, and data applications. It presents rapid advancements in life sciences research and development by applying the unique capabilities inherent in distributed ledger technologies. The book unveils the current uses of blockchain in drug discovery, drug and device tracking, real-world data collection, and increased patient engagement used to unlock opportunities to advance life sciences research. This paradigm shift is explored from the perspectives of pharmaceutical professionals, biotechnology start-ups, regulatory agencies, ethical review boards, and blockchain developers. This book enlightens readers about the opportunities to empower and enable data in life sciences.

This book is focused on marine based biomedical carriers for delivery of therapeutics. Marine biomaterials and bio-based carriers show wide applications in pharmaceutical as well as biomedical fields for delivery of small and large molecules. Biomaterial-based composites, scaffolds or matrix systems are promising systems for controlled and prolonged release of drug in target site and control the premature release of drugs or bioactive compounds. This book discusses the targeted delivery of drugs and therapeutic applications. It also describes the use of marine biopolymers in cancer therapy. Different chapters describe the tissue engineering techniques to develop these carriers. The marine biomaterial-based systems are widely used for tissue engineering, and biomedical imaging. This book is meant for industry experts, students and researchers in the area of pharmaceutical sciences, biomedical engineering and material science and pharmacology.