This open access book describes modern applications of computational human modelling to advance neurology, cancer treatment, and radio-frequency studies including regulatory, safety, and wireless communication fields. Readers working on any application that may expose human subjects to electromagnetic radiation will benefit from this book's coverage of the latest models and techniques available to assess a given technology's safety and efficacy in a timely and efficient manner. This is an Open Access book.

The goal of this volume is to summarize the state-of-the-art in the utilization of computer vision techniques in the diagnosis of skin cancer. Malignant melanoma is one of the most rapidly increasing cancers in the world. Early diagnosis is particularly important since melanoma can be cured with a simple excision if detected early. In recent years, dermoscopy has proved valuable in visualizing the morphological structures in pigmented lesions. However, it has also been shown that dermoscopy is difficult to learn and subjective. Newer technologies such as infrared imaging, multispectral imaging, and confocal microscopy, have recently come to the forefront in providing greater diagnostic accuracy. These imaging technologies presented in this book can serve as an adjunct to physicians and provide automated skin cancer screening. Although computerized techniques cannot as yet provide a definitive diagnosis, they can be used to improve biopsy decision-making as well as early melanoma detection, especially for patients with multiple atypical nevi.

Features: • Provides an accessible introduction to the subject. • Up to date with the latest advances in emerging technologies and procedures. • Provides a historical overview of CT technology.

This book presents selected papers from the International Conference on Computing, Communication, Electrical and Biomedical Systems (ICCCEBS 2021), held in March 2021 at KPR College of Engineering and Technology, Coimbatore, Tamil Nadu, India. The conference explores the interface between industry and real-time environments with newly developed techniques in computing and communications engineering. The papers describe results of conceptual, constructive, empirical, experimental, and theoretical work in areas of computing, communication, electrical, and biomedical systems. Contributors include academic scientists, researchers, industry representatives, postdoctoral fellows, and research scholars from around the world.

Although many radiation protection scientists and engineers use dose coefficients, few know the origin of those dose coefficients. This is the first book in over 40 years to address the topic of radiation protection dosimetry in intimate detail. Advanced Radiation Protection Dosimetry covers all methods used in radiation protection dosimetry, including advanced external and internal radiation dosimetry concepts and regulatory applications. This book is an ideal reference for both scientists and practitioners in radiation protection and students in graduate health physics and medical physics courses. Features: A much-needed book filling a gap in the market in a rapidly expanding area Contains the history, evolution, and the most up-to-date computational dosimetry models Authored and edited by internationally recognized authorities and subject area specialists Interrogates both the origins and methodologies of dose coefficient calculation Incorporates the latest international guidance for radiation dosimetry and protection

This book joins an international and interdisciplinary group of leading experts on the biomedical, energy and environmental applications of Metal-Organic Frameworks (MOFs). The resulting overview covers everything from the environmentally friendly and scale up synthesis of MOFs, their application in green energy generation and storage, and water purification to their use as drug delivery systems, biosensors, and their association with relevant macromolecules (genes, enzymes). This book is focused on the interest of MOFs in applications such as the leading -edge environmental (energy-related) and biomedical fields. The potential of MOFs in these areas is currently progressing at a fast pace, since the wide possibilities that MOFs offer in terms of composition, topology, incorporation of active species (in their porosity, on their external surface or within the framework), and post-synthetic modifications, among others. The aim here is to provide future research goals that emphasize relevant nuances to this class of materials as a whole.

This book integrates bioengineering for solving health issues. It shows how the use of applied mechanics and strength of materials using 3D printing models, digital correlation techniques and computed tomography images, provides solutions to biology, medicine and mechanical engineering. The book provides clear processes and illustrations, several worked examples, and many projects. It helps scientists to analyze different modes of applying mechanical and biomedical concepts, physical principles to develop devices, sensors, prosthesis, orthotic systems, new materials and techniques that may improve the health system. It can be used in courses such as biomechanics and orthopedics, rehabilitation and mechanical engineering, also in rehabilitation or sports medicine.

Highlights the utilization of nanofillers. Investigates the moisture absorption and ageing on the physio-chemical, mechanical, thermal properties of the vinyl ester-based composites. Considers the influence of hybridization, fibre architecture, and fibre-ply orientation on the mechanical and thermal properties of vinyl ester-based biocomposites. Discusses the effects of the alkali treatment. Chapters are written by global experts to cover a diverse scope of industry applications for fibre-reinforced polymer composites.

This book covers novel and innovative technologies used in development, modeling, chemical/physical investigation and biomedical (in-vitro and in-vivo) trials of nanomaterials and nanocomposites. Novel methods for nanoparticle development and manufacturing are presented, as well as their safety and promising applications. In addition, the book highlights new frontiers in the use of metal / metal oxide nanoparticles, hierarchical nanostructures and organic coatings as sensors for detecting gases, inorganic and organic materials, including biosensors for bacteria and cancers. Organic nanoparticle composites for medical applications (tissue engineering, tissue replacement, regeneration, etc.), including hydroxyapatite NPs, are also covered, together with related in-vitro and preclinical investigations. In closing, the book shares recent findings on orthopedic and dental implant coatings using nanoparticles, their biological efficacy and safety.

This thesis advances the long-standing challenge of measuring oxidative stress and deciphering its underlying mechanisms, and also outlines the advantages and limitations of existing design strategies. It presents a range of approaches for the chemical synthesis of fluorescent probes that detect reversible changes in cellular oxidative stress. The ability to visualise cellular processes in real-time is crucial to understanding disease development and streamline treatment, and this can be achieved using fluorescent tools that can sense reversible disturbances in cellular environments during pathogenesis. The perturbations in cellular redox state are of particular current interest in medical research, since oxidative stress is implicated in the pathogenesis of a number of diseases. The book investigates different strategies used to achieve ratiometric fluorescence output of the reversible redox probes, which nullify concentration effects associated with intensity-based probes. It also describes suitable approaches to target these probes to specific cellular organelles, thereby enabling medical researchers to visualise sub-cellular oxidative stress levels, and addressing the typically poor uptake of chemical tools into biological studies. In total it reports on four new probes that are now being used by over twenty research groups around the globe, and two of which have been commercialised. The final chapters of this thesis demonstrate successful applications of the sensors in a variety of biological systems ranging from prokaryotes to mammalian cells and whole organisms. The results described clearly indicate the immense value of collaborative, cross-disciplinary research.

Composite materials are formed when the combination of separate materials acquire new properties distinct from its components. They have a range of applications in fields such as mechanical and electrical engineering, food science and biomedicine and represent a fast-growing area of research. Composite Materials: Applications in Engineering, Biomedicine and Food Science provides an overview of current technologies and applications related to composite materials in these fields. Organized by discipline, the text encompasses a wide variety of composite materials, including polymer, ceramic, biomaterial, hydroxyapatite, nanofiber and green composites. Early chapters detail the enhanced mechanical, magnetic, dielectric properties of electrical and thermal conductive composite materials, which are essential in daily science. Subsequent chapters focus on filler or reinforcement materials, including carbon materials, hybrid materials and nanomaterials. Particular emphasis is placed on nanocomposite materials, as these have increasingly diverse field applications. Various manufacturing methods, such as the synthesis method and top-down/bottom-up manufacturing, are also discussed. Coverage of the recent progress, challenges and opportunities surrounding composite materials make this text a one-stop reference for engineers, scientists and researchers working in this exciting field.

Nanotechnology has been established in membrane technology for decades. In this book, comprehensive coverage is given to nanotechnology applications in synthetic membrane processes, which are used in different fields such as water treatment, separation of gases, the food industry, military use, drug delivery, air filtration, and green chemistry. Nanomaterials such as carbon nanotubes, nanoparticles, and dendrimers are contributing to the development of more efficient and cost-effective water filtration processes. Gas separation and carbon capture can be significantly improved in flue gas applications. Nanoporous membrane systems engineered to mimic natural filtration systems are being actively developed for use in smart implantable drug delivery systems, bio artificial organs, and other novel nano-enabled medical devices. The microscopic structure of nanoporous ceramic membranes, mainly focusing on zeolite materials, as well as the energy-saving effect of membrane separation, contribute to various chemical synthesis processes. In the food industry, nanotechnology has the potential to create new tools for pathogen detection and packaging. For each application, nanotechnology is mostly used to make composite membranes, and the book provides a detailed look at the mechanisms by which the composite membrane works in each application area.

Image synthesis across and within medical imaging modalities is an active area of research with broad applications in radiology and radiation oncology. This book covers the principles and methods of medical image synthesis, along with state-of-the-art research. First, various traditional non-learning-based, traditional machine-learning-based, and recent deep-learning-based medical image synthesis methods are reviewed. Second, specific applications of different inter- and intra-modality image synthesis tasks and of synthetic image-aided segmentation and registration are introduced and summarized, listing and highlighting the proposed methods, study designs, and reported performances with the related clinical applications of representative studies. Third, the clinical usages of medical image synthesis, such as treatment planning and image-guided adaptive radiotherapy, are discussed. Last, the limitations and current challenges of various medical synthesis applications are explored, along with future trends and potential solutions to solve these difficulties. The benefits of medical image synthesis have sparked growing interest in a number of advanced clinical applications, such as magnetic resonance imaging (MRI)-only radiation therapy treatment planning and positron emission tomography (PET)/MRI scanning. This book will be a comprehensive and exciting resource for undergraduates, graduates, researchers, and practitioners.

This book comprises select peer-reviewed proceedings of the medical challenge - C-NMC challenge: Classification of normal versus malignant cells in B-ALL white blood cancer microscopic images. The challenge was run as part of the IEEE International Symposium on Biomedical Imaging (IEEE ISBI) 2019 held at Venice, Italy in April 2019. Cell classification via image processing has recently gained interest from the point of view of building computer-assisted diagnostic tools for blood disorders such as leukaemia. In order to arrive at a conclusive decision on disease diagnosis and degree of progression, it is very important to identify malignant cells with high accuracy. Computer-assisted tools can be very helpful in automating the process of cell segmentation and identification because morphologically both cell types appear similar. This particular challenge was run on a curated data set of more than 14000 cell images of very high quality. More than 200 international teams participated in the challenge. This book covers various solutions using machine learning and deep learning approaches. The book will prove useful for academics, researchers, and professionals interested in building low-cost automated diagnostic tools for cancer diagnosis and treatment.

This book highlights the advancements in different fields of clinical electrophysiology and gives the reader a good background of the established practices. To tackle such a wide topic, the book focuses on two main aspects: ablation and pacing, discussing the novel energy sources and approaches to rhythm restoration and control; devices and signal processing, highlighting the new available technologies and numerical approaches aiding practice and home medicine. It also presents the reader with selected strategies that could be a paradigm shifts for the field: in situ cell reprogramming, exploiting the newly founded achievements in epigenetic modification of somatic cells; artificial intelligence; cardiac digital twinning, which aims to collect the information from imaging, mechanics and electrophysiology and condense it into a patient-specific model for personalized treatment.

This book gathers selected, extended and revised contributions to the 16th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering, and the 4th Conference on Imaging and Visualization (CMBBE 2019), held on August 14-16, 2019, in New York City, USA. It reports on cutting-edge models and algorithms for studying various tissues and organs in normal and pathological conditions; innovative imaging and visualization techniques; and the latest diagnostic tools. Further topics addressed include: numerical methods, machine learning approaches, FEM models, and high-resolution imaging and real-time visualization methods applied for biomedical purposes. Given the scope of its coverage, the book provides graduate students and researchers with a timely and insightful snapshot of the latest research and current challenges in biomedical engineering, computational biomechanics and biological imaging, as well as a source of inspiration for future research and cross-disciplinary collaborations.

This textbook serves as an introduction to nonlinear dynamics and fractals for physiological modeling. Examples and demonstrations from current research in cardiopulmonary engineering and neuro-systems engineering are provided, as well as lab and computer exercises that encourage readers to apply the course material. This is an ideal textbook for graduate students in biomedical engineering departments, researchers who analyze physiological data, and researchers interested in physiological modeling.

Image synthesis across and within medical imaging modalities is an active area of research with broad applications in radiology and radiation oncology. This book covers the principles and methods of medical image synthesis, along with state-of-the-art research. First, various traditional non-learning-based, traditional machine-learning-based, and recent deep-learning-based medical image synthesis methods are reviewed. Second, specific applications of different inter- and intra-modality image synthesis tasks and of synthetic image-aided segmentation and registration are introduced and summarized, listing and highlighting the proposed methods, study designs, and reported performances with the related clinical applications of representative studies. Third, the clinical usages of medical image synthesis, such as treatment planning and image-guided adaptive radiotherapy, are discussed. Last, the limitations and current challenges of various medical synthesis applications are explored, along with future trends and potential solutions to solve these difficulties. The benefits of medical image synthesis have sparked growing interest in a number of advanced clinical applications, such as magnetic resonance imaging (MRI)-only radiation therapy treatment planning and positron emission tomography (PET)/MRI scanning. This book will be a comprehensive and exciting resource for undergraduates, graduates, researchers, and practitioners.

Introduces both optical microscopy and medical imaging with an emphasis on recurring themes such as resolution and contrast to reinforce understanding. Includes many illustrations and boxed material that give more detailed explanations. Features hands-on activities and experiments. Provides end-of-chapter problems for self-study. Offers supplementary online materials including a solutions manual.

This book focuses on the challenges and potentials of open source and collaborative design approaches and strategies in the biomedical field. It provides a comprehensive set of good practices and methods for making these safe, innovative and certifiable biomedical devices reach patients and provide successful solutions to healthcare issues. The chapters are sequenced to follow the complete lifecycle of open source medical technologies. The information provided is eminently practical, as it is supported by real cases of study, in which collaboration among medical professionals, engineers and technicians, patients and patient associations, policy makers, regulatory bodies, and citizens has proven beneficial. The book is also supported by an online infrastructure, UBORA, through which open-source medical devices can be collaboratively developed and shared for the democratization of medical technology and for promoting accessible biomedical engineering education.

This book provides wide-ranging coverage of current developments in biomedical sensing based on photonic techniques. Biomedical sensing is a dynamic topic that promises to deliver much in the future evolution of medical diagnostics, delivering advanced tools for fundamental research in biology at the micrometre and nanometre scales. The book explores a variety of alternative physical and biological methodologies that have become available for application, such as plasmonic sensors and photonic crystal biosensors. At the same time, it addresses issues that potentially limit the capability of biomedical optical sensing techniques, while reviewing the state-of-the-art in biomedical optical sensing for the future work that will lead to near-universal applications of such techniques. Edited and written by leading experts in this domain, this book is ideal as a comprehensive manual for researchers and graduate students.

Panax ginseng C.A.Mey. is an Araliaceae Panax plant. Along with mink and antler, ginseng is one of the three treasures of Northeast of China, and is a valuable medicine and health care product. The "King of Herbs" is known around the globe; however, a comprehensive source of information on its use is needed. This book is based on a study of 45 samples of ginseng collected from Jilin Province, Heilongjiang Province, Liaoning Province and Korea. These samples, which included 3, 4 and 5-year-old ginseng, were analyzed for various constituents, such as ginsenosides and polysaccharides, providing extensive scientific data. This book not only focuses on the methods of analyzing the nutritional content and functional factors in ginseng, but also presents the findings of these analyses. Uncovering the mysteries of ginseng, offering scientific-technological insights and comparing domestic and foreign ginseng, it is a valuable reference resource for researchers and consumers alike.

This detailed volume focuses on the CRISPR-associated guide RNA and how it can be designed, modified, and validated for a broad repertoire of purposes. Beginning with a section on computational design of target-specific guide RNAs, the book continues by covering chemical modifications to alter guide RNA stability, specificity, and efficiency, as well as to create inducible guide RNAs, append additional functional domains, and express guide RNAs in a conditional manner. It concludes with methods for measuring off-target guide RNA activity. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and essential, CRISPR Guide RNA Design: Methods and Protocols provides a comprehensive pipeline for guide RNA design and aims to be an invaluable resource in applying this powerful technology to basic research and therapeutic applications.

This book presents recent outcomes of the collaborative "Tricorder" project, which brings together partners from industry, research institutes and hospitals to deliver an easy contactless alternative for electrocardiograms (ECG). Featuring contributions investigating the possible applications of laser Doppler vibrometry (LDV) signals for the remote measurement of vital parameters of the heart, the book provides insights into the vision and the history of the "Tricorder" project and the basic differences between the vibrocardiograms and electrocardiograms. It also discusses topics such as signal processing, heartbeat measurement techniques, respiration frequency and oxygen saturation determination, with a particular focus on the diagnostic value of the method presented, e.g., diagnosis of atrial fibrillation and estimation of the oxygen saturation in premature infants. Further, the authors review the advantages and drawbacks of the new method and the specific fields of application. This book will appeal to researchers and industry leaders interested in laser remote sensing for medical applications as well as medical professionals curious about new healthcare technologies.

This study presents an overview of the relationship between biomedical policy and mental health. It explores a broad array of biomedical research and technology issues which impact mental health policy, and it examines how the very conduct of biomedical research and the use of its technology have implications for the mental health of people. Synthesizing mental health history, law, policy, and treatment, Donna Kemp highlights mental health and reproductive technology and research, prevention issues, identification of and intervention in cases of mental disability, and drug treatment and experimentation issues.