This book offers a comprehensive report on the technological aspects of Mobile Health (mHealth) and discusses the main challenges and future directions in the field. It is divided into eight parts: (1) preventive and curative medicine; (2) remote health monitoring; (3) interoperability; (4) framework, architecture, and software/hardware systems; (5) cloud applications; (6) radio technologies and applications; (7) communication networks and systems; and (8) security and privacy mechanisms. The first two parts cover sensor-based and bedside systems for remotely monitoring patients' health condition, which aim at preventing the development of health problems and managing the prognosis of acute and chronic diseases. The related chapters discuss how new sensing and wireless technologies can offer accurate and cost-effective means for monitoring and evaluating behavior of individuals with dementia and psychiatric disorders, such as wandering behavior and sleep impairments. The following two parts focus on architectures and higher level systems, and on the challenges associated with their interoperability and scalability, two important aspects that stand in the way of the widespread deployment of mHealth systems. The remaining parts focus on telecommunication support systems for mHealth, including radio technologies, communication and cloud networks, and secure health-related applications and systems. All in all, the book offers a snapshot of the state-of-art in mHealth systems, and addresses the needs of a multidisciplinary audience, including engineers, computer scientists, healthcare providers, and medical professionals, working in both academia and the industry, as well as stakeholders at government agencies and non-profit organizations.

This book discusses advancements in the applications of nanoparticles in tissue engineering. It examines the applications of nanobiomaterials in hard tissue regeneration, fabrication, and characterization. The book also analyzes the implication of three-dimensional and four-dimensional fabrication techniques for the production of the scaffold in tissue engineering and their advantages over conventional scaffold production techniques. Further, it presents smart materials used in making 4-D scaffolds that imitate the dynamic response of tissue against natural stimuli and adapt to the microenvironment by changing their conformation or other properties. It also summarizes the growing field of biomolecular detection and biosensors in tissue engineering and the increasing prominence of nanoparticles in the biosensors. Further, it provides the future outlook and associated challenges of the application of nanomaterials in tissue engineering.

"The Imperial Quest and Modern Memory" explores relationships between narrative and imperium in the context of Western Modernism by examining the Quest as a vexed trope in "Heart of Darkness," "Passage to India," "The Sheltering Sky," and "The Quiet American," The book takes stock of twentieth century theory regarding the Quest--as archetype, trope, and construct, considers the dominant expression and the imperial organization of this trope in Western culture and iconography from the Dark Ages to the Age of Empire, explores the ways in which this trope both lingers and changes in the context of Western Modernism, and finally gauges its permutations in Modern discourse. "The Imperial Quest and Modern Memory's" central claim is that the Modern novel simultaneously reinscribes and subverts Western and imperial manifestations of the Quest. "Heart" "of Darkness," "Passage to India," "The Sheltering Sky," and "The Quiet American "are remarkably Modern and subversive narratives. They participate in the revolutionary projects of early and high Modernism and are often in marked opposition to imperial praxis. Yet they are also profoundly influenced by the deep ideological and metaphoric structures of Western culture. Thus, the Quest trope--specifically in its Western and imperial manifestations--lingers in Modern Memory and certainly in the Modern novel. This expansive study emphasizes intriguing intersections between past and present, culture and archetype, norm and narrative, memory and contemporaneity.

Terahertz biomedical imaging has become an area of interest due to its ability to simultaneously acquire both image and spectral information. Terahertz imaging systems are being commercialized, with increasing trials performed in a biomedical setting. As a result, advanced digital image processing algorithms are needed to assist screening, diagnosis, and treatment. "Pattern Recognition and Tomographic Reconstruction" presents these necessary algorithms, which will play a critical role in the accurate detection of abnormalities present in biomedical imaging. Terhazertz tomographic imaging and detection technology contributes to the ability to identify opaque objects with clear boundaries, and would be useful to both in vivo and ex vivo environments, making this book a must-read for anyone in the field of biomedical engineering and digital imaging.

This book is a self-contained, tutorial-based introduction to quantum information theory and quantum biology. It serves as a single-source reference to the topic for researchers in bioengineering, communications engineering, electrical engineering, applied mathematics, biology, computer science, and physics. The book provides all the essential principles of the quantum biological information theory required to describe the quantum information transfer from DNA to proteins, the sources of genetic noise and genetic errors as well as their effects. Integrates quantum information and quantum biology concepts; Assumes only knowledge of basic concepts of vector algebra at undergraduate level; Provides a thorough introduction to basic concepts of quantum information processing, quantum information theory, and quantum biology; Includes in-depth discussion of the quantum biological channel modelling, quantum biological channel capacity calculation, quantum models of aging, quantum models of evolution, quantum models on tumor and cancer development, quantum modeling of bird navigation compass, quantum aspects of photosynthesis, quantum biological error correction.

The current generation of imaging nanoparticles is diverse and dependent on its myriad of applications. This book provides an overview of how these imaging particles can be designed to fulfill specific requirements for applications across different imaging modalities. It presents, for the first time, a comprehensive interdisciplinary overview of the impact nanoparticles have on biomedical imaging and is a common central resource for researchers and teachers.

Applications of Unsaturated Polyester Resins: Synthesis, Modifications, and Preparation Methods takes a practical approach to unsaturated polyester-based materials and their preparation for implementation in a range of innovative areas. Sections introduce the background of polyester and the fundamentals of unsaturated polyester resins (UPRs), including chemistry, additives, curing, and processing methods. Hydrolytic stability and structure-property relationships are also discussed in detail, along with coverage of modification strategies for UPR and the development of bio-composites incorporating natural fiber with unsaturated polyester. Subsequent chapters focus on the preparation of UPR for specific target applications, including in construction, marine and aerospace, adhesives and coatings, insulation systems, electrics, pipeline corrosion, military, biomedicine, and tissue engineering. Finally, the advantages and disadvantages of UPR compared to other resins, in terms of properties and performance, as well as life cycle assessment, are addressed and analyzed.

Ambulation Analysis in Wearable ECG

Subhasis Chaudhuri, Tanmay Pawar, Siddhartha Duttagupta

Ambulation Analysis in Wearable ECG demonstrates why, due to recent developments, the wearable ECG recorder substantiates a significant innovation in the healthcare field.

About this book:

• Examines the viability of wearable ECG in cardiac monitoring.
• Includes chapters written by practitioners who have personally developed such hardware to write about the hardware details.
• Bridges the gap between hardware and algorithmic developments with chapters that specifically discuss the hardware aspects and their corresponding calibration issues.
• Presents a useful text for both practitioners and researchers in biomedical engineering and related interdisciplinary fields.
• Assumes basic familiarity with digital signal processing and linear algebra.

Nanorobotics and Nanodiagnostics in Integrative Biology and Biomedicine "Nanorobotics and nanodiagnostics" can be defined as a new generation of biohybrid and nanorobotics that translate fundamental biological principles into engineering design rules, or integrative living components into synthetic structures to create biorobots and nanodiagnotics that perform like natural systems. Nanorobots or nanobots are structured of a nanoscale made of individual assemblies. They can be termed as intelligent systems manufactured with self-assembly strategies by chemical, physical and biological approaches. The nanorobot can determine the structure and enhance the adaptability to the environment in interdisciplinary tasks. "Nanorobotics and nanodiagnostics" is a new generation of biohybrid that translates fundamental biological principles into engineering design rules to create biorobots that perform like natural systems. These biorobotics and diagnostics can now perform various missions to be accomplished certain tasks in the research areas such as integrative biology and biomedicine. "Nanorobotics and Nanodiagnostics in Integrative Biology and Biomedicine" sheds light on a comprehensive overview of the multidisciplinary areas that explore nanotherapeutics and nanorobotic manipulation in biology and medicine. It provides up-to-date knowledge of the promising fields of integrative biology and biomedicine for nano-assisted biorobotics and diagnostics to detect and treat diseases that will enable new scientific discoveries.

Safety Risk Management for Medical Devices, Second Edition teaches the essential safety risk management methodologies for medical devices compliant with the requirements of ISO 14971:2019. Focusing exclusively on safety risk assessment practices required in the MedTech sector, the book outlines sensible, easily comprehensible, state-of the-art methodologies that are rooted in current industry best practices, addressing safety risk management of medical devices, thus making it useful for those in the MedTech sector who are responsible for safety risk management or need to understand risk management, including design engineers, product engineers, development engineers, software engineers, Quality assurance and regulatory affairs. Graduate-level engineering students with an interest in medical devices will also benefit from this book. The new edition has been fully updated to reflect the state-of-the-art in this fast changing field. It offers guidance on developing and commercializing medical devices in line with the most current international standards and regulations.

This book highlights the latest advances in the application of artificial intelligence to healthcare and medicine. It gathers selected papers presented at the 2019 Health Intelligence workshop, which was jointly held with the Association for the Advancement of Artificial Intelligence (AAAI) annual conference, and presents an overview of the central issues, challenges, and potential opportunities in the field, along with new research results. By addressing a wide range of practical applications, the book makes the emerging topics of digital health and precision medicine accessible to a broad readership. Further, it offers an essential source of information for scientists, researchers, students, industry professionals, national and international public health agencies, and NGOs interested in the theory and practice of digital and precision medicine and health, with an emphasis on risk factors in connection with disease prevention, diagnosis, and intervention.

- First book to focus on deep learning-based approaches in the field of cancer diagnostics. - Covers the state of the art across a wide-range of topics. - Topics include preprocessing data, prediction of cancer susceptibility and reoccurence, detection of different cancers, complexity and challenges.

Explains models from natural flash systems Discusses theoretical considerations of flash systems Presents approaches and procedures for designing synthetic flash systems Explores methods for preparing flash systems for specific applications The design of environment-sensitive devices for biomedical and pharmaceutical applications has improved significantly due to recent advances in smart polymer and hydrogel technology. Despite their capacity to carry out functions that previously were unobtainable, smart polymers and hydrogels tend to have painfully slow response times. On the other hand biological systems go through phase changes at an extremely fast rate. This book examines the natural systems that respond almost instantaneously to environmental stimuli, and thus gives the reader an understanding of the mechanisms that govern these responses. The book includes chapters on how to go about designing a synthetic "flash" system based on the naturally occurring systems. It also deals with potential applications of flash systems in biomedical and pharmaceutical areas.

Nanorobots can be defined as intelligent systems with overall dimensions at or below the micrometer range that are made of assemblies of nanoscale components with individual dimensions ranging between 1 to 100 nm. These devices can now perform a wide variety of tasks at the nanoscale in a wide variety of fields including but not limited to fields such as manufacturing, medicine, supply chain, biology, and aerospace. Nanorobotics: Current Approaches and Techniques offers a comprehensive overview of this emerging interdisciplinary field with a wide ranging discussion that includes nano-manipulation and industrial nanorobotics, nanorobotic manipulation in biology and medicine, nanorobotic sensing, navigation and swarm behavior and CNT, and protein and DNA-based nanorobotics.

Introduces both optical microscopy and medical imaging with an emphasis on recurring themes such as resolution and contrast to reinforce understanding. Includes many illustrations and boxed material that give more detailed explanations. Features hands-on activities and experiments. Provides end-of-chapter problems for self-study. Offers supplementary online materials including a solutions manual.

Hardly any phenomenon in the modern environment is as ubiquitous as electromagnetic fields and waves. We have learned to understand the physical characteristics of these energy forms, and we have applied them in abundant ways to embellish our ways of life and our standards of living. Furthermore, we have come to depend on them for health, safety, information, comfOli, and conveyance. Apart from their intended roles, these electromagnetic fields and waves produce other effects which may influence the activities of living organisms. The effects produced depend on many physical, chemical, and biological factors. They may be grossly apparent and visible soon after exposure of the living organism or they may not appear to have influenced the organism at all upon casual examination. Even then, there may be subtle changes which are only detectable upon careful chemical or microscopic study, or which are apparent only after a considerable time delay. Nevertheless, our understanding of the interaction of electromagnetic fields with living systems is advancing in a wide range of topical areas. This bi-annual series with invited reviews by recognized leaders in their respective specialties, will present progress to date in key areas of research and scholarship. The guiding philosophy of this undertaking is the presentation of integrated, known, and confilmed phenomenological observations, basic mechanism of interactions, and applications in biology and medicine, as well as perspectives on current topics of interest.

Handbook of Modern Biophysics brings current biophysics topics into focus, so that biology, medical, engineering, mathematics, and physical-science students or researchers can learn fundamental concepts and the application of new techniques in addressing biomedical challenges. Chapters will develop the conceptual framework of the physics formalism and illustrate the biomedical applications. With the addition of problem sets, guides to further study, and references, the interested reader can continue to independently explore the ideas presented.Volume 5: Modern Tools of BiophysicsEditor: Thomas Jue, PhDIn Modern Tools of Biophysics, a group of prominent professors have provided insights into the tools used in biophysics with respect to the following topics: Wave Theory of Image Formation in a Microscope: Basic Theory and Experiments Computer Simulations and Nonlinear Dynamics of Cardiac Action Potentials Myoglobin and Hemoglobin Contribution to the NIRS Signal in Muscle Anomalous Low Angle X-Ray Scattering of Membrane with Lanthanides Recording of Ionic Currents under Physiological Conditions-Action Potential-Clamping and "Onion-Peeling" Techniques Patch Clamp Technique and Applications About the EditorThomas Jue is a Professor in the Department of Biochemistry and Molecular Medicine at the University of California, Davis. He is an internationally recognized expert in developing and applying magnetic resonance techniques to study animal as well as human physiology in vivo and has published extensively in the field of magnetic resonance spectroscopy and imaging, near-infrared spectroscopy, bioenergetics, cardiovascular regulation, exercise, and marine biology. He served as a Chair of the Biophysics Graduate Group Program at UC Davis, where he started to develop scholarly approaches to educate graduate students with a balance of physical-science/mathematics formalism and biomedical perspective in order to promote interest at the interface of physical science, engineering, mathematics, biology, and medicine. He continues to develop the biophysics curriculum, and the Handbook of Modern Biophysics represents an aspect of that effort.

This single volume brings together both theoretical developments in the field of motor control and their translation into such fields as movement disorders, motor rehabilitation, robotics, prosthetics, brain-machine interface, and skill learning. Motor control has established itself as an area of scientific research characterized by a multi-disciplinary approach. Its goal is to promote cooperation and mutual understanding among researchers addressing different aspects of the complex phenomenon of motor coordination. Topics covered include recent theoretical advances from various fields, the neurophysiology of complex natural movements, the equilibrium-point hypothesis, motor learning of skilled behaviors, the effects of age, brain injury, or systemic disorders such as Parkinson's Disease, and brain-computer interfaces. The chapter 'Encoding Temporal Features of Skilled Movements-What, Whether and How?' is available open access under a CC BY 4.0 license via link.springer.com.

This book, based on a selection of invited presentations from a topical workshop, focusses on time-variable oscillations and their interactions. The problem is challenging, because the origin of the time variability is usually unknown. In mathematical terms, the oscillations are non-autonomous, reflecting the physics of open systems where the function of each oscillator is affected by its environment. Time-frequency analysis being essential, recent advances in this area, including wavelet phase coherence analysis and nonlinear mode decomposition, are discussed. Some applications to biology and physiology are described. Although the most important manifestation of time-variable oscillations is arguably in biology, they also crop up in, e.g. astrophysics, or for electrons on superfluid helium. The book brings together the research of the best international experts in seemingly very different disciplinary areas.

This book presents emerging contemporary optical techniques of ultrafast science which have opened entirely new vistas for probing biological entities and processes. The spectrum reaches from time-resolved imaging and multiphoton microscopy to cancer therapy and studies of DNA damage. The book displays interdisciplinary research at the interface of physics and biology. Emerging topics on the horizon are also discussed, like the use of squeezed light, frequency combs and terahertz imaging as the possibility of mimicking biological systems. The book is written in a manner to make it readily accessible to researchers, postgraduate biologists, chemists, engineers, and physicists and students of optics, biomedical optics, photonics and biotechnology.

This book reviews the most recent developments in the field of osteochondral tissue engineering (OCTE) and presents challenges and strategies being developed that face not only bone and cartilage regeneration, but also establish osteochondral interface formation in order to translate it into a clinical setting. Topics include nanotechnology approaches and biomaterials advances in osteochondral engineering, advanced processing methodology, as well as scaffolding and surface engineering strategies in OCTE. Hydrogel systems for osteochondral applications are also detailed thoroughly. Osteochondral Tissue Engineering: Nanotechnology, Scaffolding-Related Developments and Translation is an ideal book for biomedical engineering students and a wide range of established researchers and professionals working in the orthopedic field.

Every second, users produce large amounts of image data from medical and satellite imaging systems. Image mining techniques that are capable of extracting useful information from image data are becoming increasingly useful, especially in medicine and the health sciences. Biomedical Image Analysis and Mining Techniques for Improved Health Outcomes addresses major techniques regarding image processing as a tool for disease identification and diagnosis, as well as treatment recommendation. Highlighting current research intended to advance the medical field, this publication is essential for use by researchers, advanced-level students, academicians, medical professionals, and technology developers. An essential addition to the reference material available in the field of medicine, this timely publication covers a range of applied research on data mining, image processing, computational simulation, data visualization, and image retrieval.

This book provides a thorough overview of cutting-edge research on electronics applications relevant to industry, the environment, and society at large. It covers a broad spectrum of application domains, from automotive to space and from health to security, while devoting special attention to the use of embedded devices and sensors for imaging, communication and control. The book is based on the 2015 ApplePies Conference, held in Rome, which brought together researchers and stakeholders to consider the most significant current trends in the field of applied electronics and to debate visions for the future. Areas addressed by the conference included information communication technology; biotechnology and biomedical imaging; space; secure, clean and efficient energy; the environment; and smart, green and integrated transport. As electronics technology continues to develop apace, constantly meeting previously unthinkable targets, further attention needs to be directed toward the electronics applications and the development of systems that facilitate human activities. This book, written by industrial and academic professionals, represents a valuable contribution in this endeavor.

This book discusses the possibilities for the use of international human rights law (and specifically, international biomedical laws related to the protection of human rights and the human genome) to provide a guiding framework for the future regulation of genetic modifications applied to human embryos and other precursor materials, when these are made with the aim of implanting a genetically altered embryo in a woman. The significance and timeliness of the work derives from the recent availability of CRISPR/ Cas9 and other gene editing tools, and from lacunae in international law regarding the legality of embryo modification with these tools and appropriate governance structures for the oversight of resulting practices. The emergence of improved genome editing tools like CRISPR/Cas9, holds the promise of eradicating genetic diseases in the near future. But its possible future applications with Pre-Implantation Genetic Diagnosis (PGD) raises a plethora of legal and ethical concerns about "remaking" future human beings. The work aims to address an urgent call, to embed these rising concerns about biomedical advancements into the fundamental tailoring of legal systems. Suitable regulatory approaches, coupled with careful reflection of global biomedical laws and individual constitutional systems must be explored. The Book analyzes the impact of reproductive biomedical technologies on the legal and ethical dimensions of regulatory frameworks in selected constitutional systems like the US, the UK, Australia, Malaysia and Thailand. Employing a comparative law methodology, the work reveals a dynamic intersection between legal cultures, socio-philosophical reasoning and the development of a human rights-based framework in bio-political studies. Navigating towards a truly internationalized biomedical approach to emerging technologies, it presents an understanding why a renegotiation and reinvigoration of a contemporary and "new" universal shared values system in the international human rights discourse is now necessary.

This book describes current and potential use of artificial intelligence and computational intelligence techniques in biomedicine and other application areas. Medical applications range from general diagnostics to processing of X-ray images to e-medicine-related privacy issues. Medical community understandably prefers methods that have been successful other on other application areas, where possible mistakes are not that critical. This book describes many promising methods related to deep learning, fuzzy techniques, knowledge graphs, and quantum computing. It also describes the results of testing these new methods in communication networks, education, environmental studies, food industry, retail industry, transportation engineering, and many other areas. This book helps practitioners and researchers to learn more about computational intelligence methods and their biomedical applications-and to further develop this important research direction.