This book concerns issues related to biomathematics, medicine, or cybernetics as practiced by engineers. Considered population dynamics models are still in the interest of researchers, and even this interest is increasing, especially now in the time of SARS-CoV-2 coronavirus pandemic, when models are intensively studied in order to help predict its behaviour within human population. The structures of population dynamics models and practical methods of finding their solutions are discussed. Finally, the hypothesis of the existence of non-trivial ergodic properties of the model of erythropoietic response dynamics formulated by A. Lasota in the form of delay differential equation with unimodal feedback is analysed. The research can be compared with actual medical data, as well as shows that the structures of population models can reflect the dynamic structures of reality.

This book reports on the latest advances in concepts and further developments of principal component analysis (PCA), addressing a number of open problems related to dimensional reduction techniques and their extensions in detail. Bringing together research results previously scattered throughout many scientific journals papers worldwide, the book presents them in a methodologically unified form. Offering vital insights into the subject matter in self-contained chapters that balance the theory and concrete applications, and especially focusing on open problems, it is essential reading for all researchers and practitioners with an interest in PCA.

Rapid prototyping is used to design and develop medical devices and instrumentation. This book details research in rapid prototyping of bio-materials for medical applications. It provides a wide variety of examples of medical applications using rapid prototyping, including tissue engineering, dental applications, and bone replacement. Coverage also discusses the emergence of computer aided design in the development of prosthetic devices.

This volume presents a timely recognition, warning and mapping of the fast approaching wave, or "bio-tsunami", of global socio-technical transformation, built by a much wider spectrum of converging powers, including biotechnology, new agriculture, novel foods, health, quality of life, environment, energy, sustainability, education, knowledge management, and design of smart applications. The book contains eight sections corresponding to different clusters of bioeconomic and socio-technical change, as identified by the editors' "Scanning the Horizon" foresight research; it also offers an integrated view of the future bioeconomy landscape though the convergence of several technologies that affect everyday life. The clusters offer methodologies for forecasting the future bioeconomy, and how these predictions can affect target-setting and the orientation of policies and actions to manage cultural and societal change, and achieve sustainable development in less developed areas. The book will be of interest to researchers, producers, logistics experts, policy makers, regulators, business and financial institutions, and biotechnologists (e.g. geneticists, food experts, etc.).

The book set develops a bridge between physiologic mechanisms and diagnostic human engineering. While the first volume is focused on the interface between physiologic mechanisms and the resultant biosignals, this second volume is devoted to the interface between biosignals and biomedical sensors. That is, in the first volume, the physiologic mechanisms determining biosignals are described from the basic cellular level up to their advanced mutual coordination level. This second volume, considers the genesis of acoustic and optic biosignals and the associated sensing technology from a strategic point of view. As a novelty, this book discusses heterogeneous biosignals within a common frame. This frame comprises both the biosignal formation path from the biosignal source at the physiological level to biosignal propagation in the body, and the biosignal sensing path from the biosignal transmission in the sensor applied on the body up to its conversion to a, usually electric, signal. Some biosignals arise in the course of the body's vital functions while others map these functions that convey physiological data to an observer. It is highly instructive how sound and light beams interact with biological tissues, yielding acoustic and optic biosignals, respectively. Discussed phenomena teach a lot about the physics of sound and physics of light (as engineering sciences), and, on the other hand, biology and physiology (as live sciences). The highly interdisciplinary nature of biosignals and biomedical sensors is obviously a challenge. However, it is a rewarding challenge after it has been coped with in a strategic way, as offered here. The book is intended to have the presence to answer intriguing "Aha!" questions.

This book describes new theories and applications of artificial neural networks, with a special focus on answering questions in neuroscience, biology and biophysics and cognitive research. It covers a wide range of methods and technologies, including deep neural networks, large scale neural models, brain computer interface, signal processing methods, as well as models of perception, studies on emotion recognition, self-organization and many more. The book includes both selected and invited papers presented at the XXII International Conference on Neuroinformatics, held on October 12-16, 2020, Moscow, Russia.

This book highlights the use of LEDs in biomedical photoacoustic imaging. In chapters written by key opinion leaders in the field, it covers a broad range of topics, including fundamentals, principles, instrumentation, image reconstruction and data/image processing methods, preclinical and clinical applications of LED-based photoacoustic imaging. Apart from preclinical imaging studies and early clinical pilot studies using LED-based photoacoustics, the book includes a chapter exploring the opportunities and challenges of clinical translation from an industry perspective. Given its scope, the book will appeal to scientists and engineers in academia and industry, as well as medical experts interested in the clinical applications of photoacoustic imaging.

This book reviews the current knowledge on tunable hydrogels, including the range of different materials and applications, as well as the existing challenges and limitations in the field. It covers various aspects of the material design, particularly highlighting biological responsiveness, degradability and responsiveness to external stimuli. In this book, readers will discover original research data and state-of-the-art reviews in the area of hydrogel technology, with a specific focus on biotechnology and medicine. Written by leading experts, the contributions outline strategies for designing tunable hydrogels and offer a detailed evaluation of the physical and synthetic methods currently employed to achieve specific hydrogel properties and responsiveness. This highly informative book provides important theoretical and practical insights for scholars and researchers working with hydrogels for biomedical and biotechnological applications.

This book reviews recent advances in the emerging field of computational network biology with special emphasis on comparative network analysis and network module detection. The chapters in this volume are contributed by leading international researchers in computational network biology and offer in-depth insight on the latest techniques in network alignment, network clustering, and network module detection. Chapters discuss the advantages of the respective techniques and present the current challenges and open problems in the field. Recent Advances in Biological Network Analysis: Comparative Network Analysis and Network Module Detection will serve as a great resource for graduate students, academics, and researchers who are currently working in areas relevant to computational network biology or wish to learn more about the field. Data scientists whose work involves the analysis of graphs, networks, and other types of data with topological structure or relations can also benefit from the book's insights.

Features • Discusses novel methods of cancer diagnostics and cancer treatment. • Details non and minimally-invasive photonics techniques. • Explores the applications of machine learning and artificial intelligence to these novel techniques.

Dental Implants: Materials, Coatings, Surface Modifications and Interfaces with Oral Tissues provides readers with information on past and contemporary advances in the design and modification of dental implants to enhance osseointegration and biocompatibility. The book begins with a look at the current status of dental implants, materials and fabrication methods. Chapters then cover surface modification techniques and a variety of inorganic, organic and biological coatings. Final sections cover tissue-implant interfaces. Written by a multidisciplinary team of materials scientists, dental clinicians and implantologists, this book is an essential reference for materials scientists, dental practitioners and researchers and students in academia.

This book describes the development of portable, wearable, and highly customizable hand exoskeletons to aid patients suffering from hand disabilities. It presents an original approach for the design of human hand motion assistance devices that relies on (i) an optimization-based kinematic scaling procedure, which guarantees a significant adaptability to the user's hands motion, and (ii) a topology optimization-based design methodology, which allowed the design of a lightweight, comfortable device with a high level of performance. The book covers the whole process of hand exoskeleton development, from establishing a new design strategy, to the construction and testing of hand exoskeleton prototypes, using additive manufacturing techniques. As such, it offers timely information to both researchers and engineers developing human motion assistance systems, especially wearable ones.

This book introduces a variety of well-proven and newly developed nature-inspired optimization algorithms solving a wide range of real-life biomedical and healthcare problems. Few solo and hybrid approaches are demonstrated in a lucid manner for the effective integration and finding solution for a large-scale complex healthcare problem. In the present bigdata-based computing scenario, nature-inspired optimization techniques present adaptive mechanisms that permit the understanding of complex data and altering environments. This book is a voluminous collection for the confront faced by the healthcare institutions and hospitals for practical analysis, storage, and data analysis. It explores the distinct nature-inspired optimization-based approaches that are able to handle more accurate outcomes for the current biomedical and healthcare problems. In addition to providing a state-of-the-art and advanced intelligent methods, it also enlightens an insight for solving diversified healthcare problems such as cancer and diabetes.

This book discusses fundamentally new biomedical imaging methods, such as holography, holographic and resonant interferometry, and speckle optics. It focuses on the development of holographic interference microscopy and its use in the study of phase objects such as nerve and muscle fibers subjected to the influence of laser radiation, magnetic fields, and hyperbaric conditions. The book shows how the myelin sheath and even the axon itself exhibit waveguide properties, enabling a fresh new look at the mechanisms of information transmission in the human body. The book presents theoretically and experimentally tested holographic and speckle-optical methods and devices used for investigating complex, diffusely scattering surfaces such as skin and muscle tissue. Additionally, it gives broad discussion of the authors' own original fundamental and applied research dedicated to helping physicians introduce new contact-less methods of diagnosis and treatment of diseases of the cardiovascular and neuromuscular systems into medical practice. The book is aimed at a broad spectrum of scientific specialists in the fields of speckle optics, holography, laser physics, morphology and cytochemistry, as well as medical professionals such as physiologists, neuropathologists, neurosurgeons, cardiologists and dentists.

This book gathers revised selected papers from the 3rd International Workshop on Gerontechnology, IWoG 2020, held on October 5-6, 2020, in Evora, Portugal. They reports on cutting-edge technologies and optimized workflows for promoting active aging and assisting and elderly people at home, as well as in healthcare centers. It discusses the main challenges in the development, use and delivery of health care services and technologies. Not only they proposes solutions for improving in practice the monitoring and management of health parameters and age-related diseases, yet they also describes improved approaches for helping seniors in their daily tasks and facilitating their communication and integration with assistive technologies, thus improving their quality of life, as well as their social integration. The book provides health professionals, researchers, and service providers with extensive information on the latest trends in the development and practical application of gerontechnology in elderly care.

This book constitutes the proceedings of the third international conference AsiaHaptics 2018, held in Songdo, Korea. It presents the state-of-the-art of the diverse haptics (touch)-related research, including perception and illusion, development of haptics devices, and applications to a wide variety of fields such as education, medicine, telecommunication, navigation and entertainment. This book is a valuable resource not only for active haptics researchers, but also for general readers wishing to understand the status quo in this interdisciplinary area of science and technology.

This handbook on Artificial Intelligence (AI) in healthcare consists of two volumes. The first volume is dedicated to advances and applications of AI methodologies in specific healthcare problems, while the second volume is concerned with general practicality issues and challenges and future prospects in the healthcare context. The advent of digital and computing technologies has created a surge in the development of AI methodologies and their penetration to a variety of activities in our daily lives in recent years. Indeed, researchers and practitioners have designed and developed a variety of AI-based systems to help advance health and well-being of humans. In this first volume, we present a number of latest studies in AI-based tools and techniques from two broad categories, viz., medical signal, image, and video processing as well as healthcare information and data analytics in Part 1 and Part 2, respectively. These selected studies offer readers practical knowledge and understanding pertaining to the recent advances and applications of AI in the healthcare sector.

Smart Homes (SH) offer a promising approach to assisted living for the ageing population. Yet the main obstacle to the rapid development and deployment of Smart Home (SH) solutions essentially arises from the nature of the SH field, which is multidisciplinary and involves diverse applications and various stakeholders. Accordingly, an alternative to a one-size-fits-all approach is needed in order to advance the state of the art towards an open SH infrastructure. This book makes a valuable and critical contribution to smart assisted living research through the development of new effective, integrated, and interoperable SH solutions. It focuses on four underlying aspects: (1) Sensing and Monitoring Technologies; (2) Context Interference and Behaviour Analysis; (3) Personalisation and Adaptive Interaction, and (4) Open Smart Home and Service Infrastructures, demonstrating how fundamental theories, models and algorithms can be exploited to solve real-world problems. This comprehensive and timely book offers a unique and essential reference guide for policymakers, funding bodies, researchers, technology developers and managers, end users, carers, clinicians, healthcare service providers, educators and students, helping them adopt and implement smart assisted living systems.

This book explores a sampling of the most powerful and enterprising efforts to achieve biotechnological goals by means of various interdisciplinary approaches. From the fabrication of extremely small units to achieve specific objectives through nano-bio-technology, to devices with artificial intelligence, gene therapy for cerebrovascular anomalies, biodegradable plastics, the use of phyto-stem cells in cosmetology, CarT cell immune therapy, targeted therapies for cancer, 3D printed bones developed by the University of Wollongong in Australia, the sickle cell chip developed by IIT Bombay, and innovative sustainable energy solutions, the book includes a colorful spectrum of reviews on current and future biotech products. Gathering contributions by an international team of researchers, this book offers its audience, and particularly younger readers, revealing information on current and upcoming smart technologies.

This book addresses essential principles of research according to the scientific method for medical imaging technology research. The scope of this book covers the nature of scientific research; quantitative and qualitative approaches essentials; research planning; literature review fundamentals; research methods; data collection, analysis, and interpretation; and communicating research findings. The book meets the educational requirements on Research Principles and Concepts (for entry to practice) of the following professional radiologic technology associations: the American Society of Radiologic Technologists (ASRT), the Canadian Association of Medical Radiation Technologists (CAMRT), the College of Radiographers in the United Kingdom, and radiography societies and associations in Asia, Australia, Europe, and Africa. This is an ideal book for radiologic technologists, nuclear medicine technologists, and radiation therapists seeking to get started in research in their profession. Additionally, biomedical imaging engineering technologists, radiologists, and medical imaging physicists may use this as a "guiding principles" textbook.

This book presents a compilation of state-of-the-art work on biomedical and cyber-physical systems in connection with the Internet of Things, and successfully blends theory and practice. The book covers the studies belonging to Biomedical and Cyber-physical System, so it is a unique effort by the research experts, who are divulging in the domain deeply. The book is very easy for the audience, who are doing study in the Biomedical and Cyber-physical System; it helps to read some real-time scenarios from where the reader in general gets many sparking ideas to convert it into the research problems in their studies. This book is of use to solve down the problems of graduate, postgraduate, doctoral industry executives, who are involving in the cutting-edge work of Internet of Things with Biomedical or Cyber-physical System, with the help of real-time solutions, given in the formation of chapters by subject's experts.The key uses of this book are in the area of Internet of Things in connection with Cyber-physical System as well as Biomedical domain.

This book examines the role of nanobiosensors in point-of-care applications for personalized healthcare and management. It begins by discussing various biomaterials that are used for the development of biosensors in medical diagnostics, and reviews advances in their fabrication and the miniaturization of biosensor devices for lab-on-chip analysis. In turn, it explores the rapidly evolving applications of nanomaterials in the context of biomaterial diagnostics. The book also explores the immense potential of biosensors in medical diagnostics, where they are increasingly being used to detect a wide range of biomolecules and biomarkers. In closing, it discusses the current challenges and outlines the future role of nanobiosensors in the development of next-generation point-of-care applications.

This book highlights the complexity of spinel nanoferrites, their synthesis, physio-chemical properties and prospective applications in the area of advanced electronics, microwave devices, biotechnology as well as biomedical sciences. It presents an overview of spinel nanoferrites: synthesis, properties and applications for a wide audience: from beginners and graduate-level students up to advanced specialists in both academic and industrial sectors. There are 15 chapters organized into four main sections. The first section of the book introduces the readers to spinel ferrites and their applications in advanced electronics industry including microwave devices, whereas the second section mainly focus on the synthesis strategy and their physio-chemical properties. The last sections of the book highlight the importance of this class of nanomaterials in the field of biotechnology and biomedical sector with a special chapter on water purification.

This book is the output of Anthropological Survey of India's National Project "DNA Polymorphism of Contemporary Indian Population" conducted during 2000 to 2018. The book compiles the independent and collaborative work of 49 scientific personnel. Genomics facilitate the study of genetic constitution and diversity at individual and population levels. Genomic diversity explains susceptibility, predisposition and prolongation of diseases; personalized medicine and longevity; prehistoric demographic events, such as population bottleneck, expansion, admixture and natural selection. This book highlights the heterogeneous, genetically diverse population of India. It shows how the central geographic location of India, played a crucial role in historic and pre-historic human migrations, and in peopling different continents of the world. The book describes the massive task undertaken by AnSI to unearth genomic diversity of India populations, with the use of Uni-parental DNA markers mtDNA (mitochondrial DNA) and Y -chromosome in 75 communities. The book talks about the 61 maternal and 35 paternal lineages identified through these studies. It brings forth interesting, hitherto unknown findings such as shared mutations between certain communities. This volume is a milestone in scientific research to understand biological diversity of Indian people at genomic level. It addresses the basic priority to identify different genes underlying various inborn genetic defects and diseases specific to Indian populations. This would be highly interesting to population geneticists, historians, as well as anthropologists.

This book reviews the latest technological developments of bioengineering approaches in cell and tissue research. It is meant to have life and spirit, and to become a pioneer in technology and sciences, especially the life science. The chapters are written by excellent scientists on advanced, frontier technology and address scientific questions that need considerable thinking in terms of engineering. The aims are to provide the readers, including students, faculty, and all scientists working in academia and industry, new information on bioengineering in cell and tissue research to enhance their understanding and innovation.