In science, engineering and economics, decision problems are frequently modelled by optimizing the value of a (primary) objective function under stated feasibility constraints. In many cases of practical relevance, the optimization problem structure does not warrant the global optimality of local solutions; hence, it is natural to search for the globally best solution(s). Global Optimization in Action provides a comprehensive discussion of adaptive partition strategies to solve global optimization problems under very general structural requirements. A unified approach to numerous known algorithms makes possible straightforward generalizations and extensions, leading to efficient computer-based implementations. A considerable part of the book is devoted to applications, including some generic problems from numerical analysis, and several case studies in environmental systems analysis and management. The book is essentially self-contained and is based on the author's research, in cooperation (on applications) with a number of colleagues. Audience: Professors, students, researchers and other professionals in the fields of operations research, management science, industrial and applied mathematics, computer science, engineering, economics and the environmental sciences.

The primary objective underlying the Handbook on Modelling for Discrete Optimization is to demonstrate and detail the pervasive nature of Discrete Optimisation. While its applications cut across an wide range of activities, many of the applications are only known to specialists. The aim of this handbook is to correct this. It has long been recognized that modelling is a critically important mathematical activity in designing algorithms for solving these discrete optimization problems. Nevertheless solving the resultant models is also often far from straightforward. In recent years, it has become possible to solve many large-scale discrete optimization problems. However, some problems remain a challenge, even though advances in mathematical methods, hardware, and software technology have pushed the frontiers forward. This handbook couples the difficult, critical-thinking aspects of mathematical modeling with the hot area of discrete optimization. It will be done in an academic handbook treatment outlining the state-of-the-art for researchers across the domains of the Computer Science, Math Programming, Applied Mathematics, Engineering, and Operations Research. Computer Science, and Combinatorics.

This book develops a new approach called parameter advising for finding a parameter setting for a sequence aligner that yields a quality alignment of a given set of input sequences. In this framework, a parameter advisor is a procedure that automatically chooses a parameter setting for the input, and has two main ingredients: (a) the set of parameter choices considered by the advisor, and (b) an estimator of alignment accuracy used to rank alignments produced by the aligner. On coupling a parameter advisor with an aligner, once the advisor is trained in a learning phase, the user simply inputs sequences to align, and receives an output alignment from the aligner, where the advisor has automatically selected the parameter setting. The chapters first lay out the foundations of parameter advising, and then cover applications and extensions of advising. The content * examines formulations of parameter advising and their computational complexity, * develops methods for learning good accuracy estimators, * presents approximation algorithms for finding good sets of parameter choices, and * assesses software implementations of advising that perform well on real biological data. Also explored are applications of parameter advising to * adaptive local realignment, where advising is performed on local regions of the sequences to automatically adapt to varying mutation rates, and * ensemble alignment, where advising is applied to an ensemble of aligners to effectively yield a new aligner of higher quality than the individual aligners in the ensemble. The book concludes by offering future directions in advising research.

Global optimization concerns the computation and characterization of global optima of nonlinear functions. Such problems are widespread in the mathematical modelling of real systems in a very wide range of applications and the last 30 years have seen the development of many new theoretical, algorithmic and computational contributions which have helped to solve globally multiextreme problems in important practical applications. Most of the existing books on optimization focus on the problem of computing locally optimal solutions. Introduction to Global Optimization, however, is a comprehensive textbook on constrained global optimization that covers the fundamentals of the subject, presenting much new material, including algorithms, applications and complexity results for quadratic programming, concave minimization, DC and Lipschitz problems, and nonlinear network flow. Each chapter contains illustrative examples and ends with carefully selected exercises, designed to help students grasp the material and enhance their knowledge of the methods involved. Audience: Students of mathematical programming, and all scientists, from whatever discipline, who need global optimization methods in such diverse areas as economic modelling, fixed charges, finance, networks and transportation, databases, chip design, image processing, nuclear and mechanical design, chemical engineering design and control, molecular biology, and environmental engineering.

This book on PDE Constrained Optimization contains contributions on the mathematical analysis and numerical solution of constrained optimal control and optimization problems where a partial differential equation (PDE) or a system of PDEs appears as an essential part of the constraints. The appropriate treatment of such problems requires a fundamental understanding of the subtle interplay between optimization in function spaces and numerical discretization techniques and relies on advanced methodologies from the theory of PDEs and numerical analysis as well as scientific computing. The contributions reflect the work of the European Science Foundation Networking Programme 'Optimization with PDEs' (OPTPDE).

Optimality Conditions in Convex Optimization explores an important and central issue in the field of convex optimization: optimality conditions. It brings together the most important and recent results in this area that have been scattered in the literature-notably in the area of convex analysis-essential in developing many of the important results in this book, and not usually found in conventional texts. Unlike other books on convex optimization, which usually discuss algorithms along with some basic theory, the sole focus of this book is on fundamental and advanced convex optimization theory. Although many results presented in the book can also be proved in infinite dimensions, the authors focus on finite dimensions to allow for much deeper results and a better understanding of the structures involved in a convex optimization problem. They address semi-infinite optimization problems; approximate solution concepts of convex optimization problems; and some classes of non-convex problems which can be studied using the tools of convex analysis. They include examples wherever needed, provide details of major results, and discuss proofs of the main results.

The book provides readers with a snapshot of the state of the art in the field of nature-inspired computing and its application in optimization. The approach is mainly practice-oriented: each bio-inspired technique or algorithm is introduced together with one of its possible applications. Applications cover a wide range of real-world optimization problems: from feature selection and image enhancement to scheduling and dynamic resource management, from wireless sensor networks and wiring network diagnosis to sports training planning and gene expression, from topology control and morphological filters to nutritional meal design and antenna array design. There are a few theoretical chapters comparing different existing techniques, exploring the advantages of nature-inspired computing over other methods, and investigating the mixing time of genetic algorithms. The book also introduces a wide range of algorithms, including the ant colony optimization, the bat algorithm, genetic algorithms, the collision-based optimization algorithm, the flower pollination algorithm, multi-agent systems and particle swarm optimization. This timely book is intended as a practice-oriented reference guide for students, researchers and professionals.

Nonlinear Assignment Problems (NAPs) are natural extensions of the classic Linear Assignment Problem, and despite the efforts of many researchers over the past three decades, they still remain some of the hardest combinatorial optimization problems to solve exactly. The purpose of this book is to provide in a single volume, major algorithmic aspects and applications of NAPs as contributed by leading international experts. The chapters included in this book are concerned with major applications and the latest algorithmic solution approaches for NAPs. Approximation algorithms, polyhedral methods, semidefinite programming approaches and heuristic procedures for NAPs are included, while applications of this problem class in the areas of multiple-target tracking in the context of military surveillance systems, of experimental high energy physics, and of parallel processing are presented. Audience: Researchers and graduate students in the areas of combinatorial optimization, mathematical programming, operations research, physics, and computer science.

This is the first book presenting a broad overview of parallelism in constraint-based reasoning formalisms. In recent years, an increasing number of contributions have been made on scaling constraint reasoning thanks to parallel architectures. The goal in this book is to overview these achievements in a concise way, assuming the reader is familiar with the classical, sequential background. It presents work demonstrating the use of multiple resources from single machine multi-core and GPU-based computations to very large scale distributed execution platforms up to 80,000 processing units. The contributions in the book cover the most important and recent contributions in parallel propositional satisfiability (SAT), maximum satisfiability (MaxSAT), quantified Boolean formulas (QBF), satisfiability modulo theory (SMT), theorem proving (TP), answer set programming (ASP), mixed integer linear programming (MILP), constraint programming (CP), stochastic local search (SLS), optimal path finding with A*, model checking for linear-time temporal logic (MC/LTL), binary decision diagrams (BDD), and model-based diagnosis (MBD). The book is suitable for researchers, graduate students, advanced undergraduates, and practitioners who wish to learn about the state of the art in parallel constraint reasoning.

In recent years global optimization has found applications in many interesting areas of science and technology including molecular biology, chemical equilibrium problems, medical imaging and networks. The collection of papers in this book indicates the diverse applicability of global optimization. Furthermore, various algorithmic, theoretical developments and computational studies are presented. Audience: All researchers and students working in mathematical programming.

Optimization is everywhere. It is human nature to seek the best option among all that are available. Nature, too, seems to be guided by optimization-many laws of nature have a variational character. Among geometric gures in the plane with a xed perimeter, the circle has the greatest area. Such isoperim- ric problems involving geometric gures date back to ancient Greece. Fermat's principle, discovered in 1629, stating that the tangent line is horizontal at a minimum point, seems to have in uenced the development of calculus. The proofs of Rolle's theorem and the mean value theorem in calculus use the Weierstrass theorem on the existence of maximizers and minimizers. The - troduction of the brachistochrone problem in 1696 by Johann Bernoulli had a tremendous impact on the development of the calculus of variations and in uenced the development of functional analysis. The variational character of laws of mechanics and optics were discovered in the seventeenth and ei- teenth centuries. Euler and Lagrange forged the foundations of the calculus of variations in the eighteenth century. In the nineteenth century, Riemann used Dirichlet's principle, which has a variational character, in his investigations in complex analysis. The simplex method for linear programming was disc- ered shortly after the advent of computers in the 1940s, and in uenced the subsequent development of mathematical programming. The emergence of the theory of optimal control in the 1950s was in response to the need for contr- ling space vehicles and various industrial processes.

• Provides well-written self-contained chapters, including problem sets and exercises, making it ideal for the classroom setting;
• Introduces applied optimization to the hazardous waste blending problem;
• Explores linear programming, nonlinear programming, discrete optimization, global optimization, optimization under uncertainty, multi-objective optimization, optimal control and stochastic optimal control;
• Includes an extensive bibliography at the end of each chapter and an index;
• GAMS files of case studies for Chapters 2, 3, 4, 5, and 7 are linked to http: //www.springer.com/math/book/978-0-387-76634-8;

Solutions manual available upon adoptions.

This book on canonical duality theory provides a comprehensive review of its philosophical origin, physics foundation, and mathematical statements in both finite- and infinite-dimensional spaces. A ground-breaking methodological theory, canonical duality theory can be used for modeling complex systems within a unified framework and for solving a large class of challenging problems in multidisciplinary fields in engineering, mathematics, and the sciences. This volume places a particular emphasis on canonical duality theory's role in bridging the gap between non-convex analysis/mechanics and global optimization. With 18 total chapters written by experts in their fields, this volume provides a nonconventional theory for unified understanding of the fundamental difficulties in large deformation mechanics, bifurcation/chaos in nonlinear science, and the NP-hard problems in global optimization. Additionally, readers will find a unified methodology and powerful algorithms for solving challenging problems in complex systems with real-world applications in non-convex analysis, non-monotone variational inequalities, integer programming, topology optimization, post-buckling of large deformed structures, etc. Researchers and graduate students will find explanation and potential applications in multidisciplinary fields.

The aim in this graduate level text is to outline the key mathematical concepts that underpin these important questions in applied mathematics. These concepts involve discrete mathematics (particularly graph theory), optimization, computer science, and several ideas in biology.

In the quest to understand and model the healthy or sick human body, re searchers and medical doctors are utilizing more and more quantitative tools and techniques. This trend is pushing the envelope of a new field we call Biomedical Computing, as an exciting frontier among signal processing, pattern recognition, optimization, nonlinear dynamics, computer science and biology, chemistry and medicine. A conference on Biocomputing was held during February 25-27, 2001 at the University of Florida. The conference was sponsored by the Center for Applied Optimization, the Computational Neuroengineering Center, the Biomedical En gineering Program (through a Whitaker Foundation grant), the Brain Institute, the School of Engineering, and the University of Florida Research & Graduate Programs. The conference provided a forum for researchers to discuss and present new directions in Biocomputing. The well-attended three days event was highlighted by the presence of top researchers in the field who presented their work in Biocomputing. This volume contains a selective collection of ref ereed papers based on talks presented at this conference. You will find seminal contributions in genomics, global optimization, computational neuroscience, FMRI, brain dynamics, epileptic seizure prediction and cancer diagnostics. We would like to take the opportunity to thank the sponsors, the authors of the papers, the anonymous referees, and Kluwer Academic Publishers for making the conference successful and the publication of this volume possible. Panos M. Pardalos and Jose C."

There has been much recent progress in global optimization algo rithms for nonconvex continuous and discrete problems from both a theoretical and a practical perspective. Convex analysis plays a fun damental role in the analysis and development of global optimization algorithms. This is due essentially to the fact that virtually all noncon vex optimization problems can be described using differences of convex functions and differences of convex sets. A conference on Convex Analysis and Global Optimization was held during June 5 -9, 2000 at Pythagorion, Samos, Greece. The conference was honoring the memory of C. Caratheodory (1873-1950) and was en dorsed by the Mathematical Programming Society (MPS) and by the Society for Industrial and Applied Mathematics (SIAM) Activity Group in Optimization. The conference was sponsored by the European Union (through the EPEAEK program), the Department of Mathematics of the Aegean University and the Center for Applied Optimization of the University of Florida, by the General Secretariat of Research and Tech nology of Greece, by the Ministry of Education of Greece, and several local Greek government agencies and companies. This volume contains a selective collection of refereed papers based on invited and contribut ing talks presented at this conference. The two themes of convexity and global optimization pervade this book. The conference provided a forum for researchers working on different aspects of convexity and global opti mization to present their recent discoveries, and to interact with people working on complementary aspects of mathematical programming."

Performance evaluation of increasingly complex human-made systems requires the use of simulation models. However, these systems are difficult to describe and capture by succinct mathematical models. The purpose of this book is to address the difficulties of the optimization of complex systems via simulation models or other computation-intensive models involving possible stochastic effects and discrete choices. This book establishes distinct advantages of the "softer" ordinal approach for search-based type problems, analyzes its general properties, and shows the many orders of magnitude improvement in computational efficiency that is possible.

Many complex aeronautical design problems can be formulated with efficient multi-objective evolutionary optimization methods and game strategies. This book describes the role of advanced innovative evolution tools in the solution, or the set of solutions of single or multi disciplinary optimization. These tools use the concept of multi-population, asynchronous parallelization and hierarchical topology which allows different models including precise, intermediate and approximate models with each node belonging to the different hierarchical layer handled by a different Evolutionary Algorithm. The efficiency of evolutionary algorithms for both single and multi-objective optimization problems are significantly improved by the coupling of EAs with games and in particular by a new dynamic methodology named "Hybridized Nash-Pareto games". Multi objective Optimization techniques and robust design problems taking into account uncertainties are introduced and explained in detail. Several applications dealing with civil aircraft and UAV, UCAV systems are implemented numerically and discussed. Applications of increasing optimization complexity are presented as well as two hands-on test cases problems. These examples focus on aeronautical applications and will be useful to the practitioner in the laboratory or in industrial design environments. The evolutionary methods coupled with games presented in this volume can be applied to other areas including surface and marine transport, structures, biomedical engineering, renewable energy and environmental problems. This book will be of interest to students, young scientists and engineers involved in the field of multi physics optimization.

Constrained optimization models are core tools in business, science, government, and the military with applications including airline scheduling, control of petroleum refining operations, investment decisions, and many others. Constrained optimization models have grown immensely in scale and complexity in recent years as inexpensive computing power has become widely available. Models now frequently have many complicated interacting constraints, giving rise to a host of issues related to feasibility and infeasibility. For example, it is sometimes difficult to find any feasible point at all for a large model, or even to accurately determine if one exists, e.g. for nonlinear models. If the model is feasible, how quickly can a solution be found? If the model is infeasible, how can the cause be isolated and diagnosed? Can a repair to restore feasibility be carried out automatically? Researchers have developed numerous algorithms and computational methods in recent years to address such issues, with a number of surprising spin-off applications in fields such as artificial intelligence and computational biology. Over the same time period, related approaches and techniques relating to feasibility and infeasibility of constrained problems have arisen in the constraint programming community. Feasibility and Infeasibility in Optimization is a timely expository book that summarizes the state of the art in both classical and recent algorithms related to feasibility and infeasibility in optimization, with a focus on practical methods. All model forms are covered, including linear, nonlinear, and mixed-integer programs. Connections to related work in constraint programming are shown. Part Iof the book addresses algorithms for seeking feasibility quickly, including new methods for the difficult cases of nonlinear and mixed-integer programs. Part II provides algorithms for analyzing infeasibility by isolating minimal infeasible (or maximum feasible) subsets of constraints, or by finding the best repair for the infeasibility. Infeasibility analysis algorithms have arisen primarily over the last two decades, and the book covers these in depth and detail. Part III describes applications in numerous areas outside of direct infeasibility analysis such as finding decision trees for data classification, analyzing protein folding, radiation treatment planning, automated test assembly, etc. A main goal of the book is to impart an understanding of the methods so that practitioners can make immediate use of existing algorithms and software, and so that researchers can extend the state of the art and find new applications. The book is of interest to researchers, students, and practitioners across the applied sciences who are working on optimization problems.

This book is devoted to geometric methods in the theory of differential equations with quadratic right-hand sides (Riccati-type equations), which are closely related to the calculus of variations and optimal control theory. Connections of the calculus of variations and the Riccati equation with the geometry of Lagrange-Grassmann manifolds and classical Cartan-Siegel homogeneity domains in a space of several complex variables are considered. In the study of the minimization problem for a multiple integral, a quadratic partial differential equation that is an analogue of the Riccati equation in the calculus of varatiations is studied. This book is based on lectures given by the author ower a period of several years in the Department of Mechanics and Mathematics of Moscow State University. The book is addressed to undergraduate and graduate students, scientific researchers and all specialists interested in the problems of geometry, the calculus of variations, and differential equations.

This volume contains a selection of contributions that were presented at the Modeling and Optimization: Theory and Applications Conference (MOPTA) held at Lehigh University in Bethlehem, Pennsylvania, USA on August 18-20, 2010. The conference brought together a diverse group of researchers and practitioners, working on both theoretical and practical aspects of continuous or discrete optimization. Topics presented included algorithms for solving convex, network, mixed-integer, nonlinear, and global optimization problems, and addressed the application of optimization techniques in finance, logistics, health, and other important fields. The contributions contained in this volume represent a sample of these topics and applications and illustrate the broad diversity of ideas discussed at the meeting.

This volume contains a selection of contributions that were presented at the Modeling and Optimization: Theory and Applications Conference (MOPTA) held at Lehigh University in Bethlehem, Pennsylvania, USA on August 17-19, 2016. The conference brought together a diverse group of researchers and practitioners, working on both theoretical and practical aspects of continuous or discrete optimization. Topics presented included algorithms for solving convex, network, mixed-integer, nonlinear, and global optimization problems, and addressed the application of deterministic and stochastic optimization techniques in energy, finance, logistics, analytics, health, and other important fields. The contributions contained in this volume represent a sample of these topics and applications and illustrate the broad diversity of ideas discussed at the meeting.

The material of the present book is an extension of a graduate course given by the author at the University "Al.I. Cuza" Iasi and is intended for stu dents and researchers interested in the applications of optimal control and in mathematical biology. Age is one of the most important parameters in the evolution of a bi ological population. Even if for a very long period age structure has been considered only in demography, nowadays it is fundamental in epidemiology and ecology too. This is the first book devoted to the control of continuous age structured populationdynamics.It focuses on the basic properties ofthe solutions and on the control of age structured population dynamics with or without diffusion. The main goal of this work is to familiarize the reader with the most important problems, approaches and results in the mathematical theory of age-dependent models. Special attention is given to optimal harvesting and to exact controllability problems, which are very important from the econom ical or ecological points of view. We use some new concepts and techniques in modern control theory such as Clarke's generalized gradient, Ekeland's variational principle, and Carleman estimates. The methods and techniques we use can be applied to other control problems."