This volume provides updated, in-depth material on the application of intelligent optimization in biology and medicine. The aim of the book is to present solutions to the challenges and problems facing biology and medicine applications. This Volume comprises of 13 chapters, including an overview chapter, providing an up-to-date and state-of-the research on the application of intelligent optimization for bioinformatics applications, DNA based Steganography, a modified Particle Swarm Optimization Algorithm for Solving Capacitated Maximal Covering Location Problem in Healthcare Systems, Optimization Methods for Medical Image Super Resolution Reconstruction and breast cancer classification. Moreover, some chapters that describe several bio-inspired approaches in MEDLINE Text Mining, DNA-Binding Proteins and Classes, Optimized Tumor Breast Cancer Classification using Combining Random Subspace and Static Classifiers Selection Paradigms, and Dental Image Registration. The book will be a useful compendium for a broad range of readers-from students of undergraduate to postgraduate levels and also for researchers, professionals, etc.-who wish to enrich their knowledge on Intelligent Optimization in Biology and Medicine and applications with one single book.

The aim of Metaheuristics: Progress in Complex Systems Optimization is to provide several different kinds of information: a delineation of general metaheuristics methods, a number of state-of-the-art articles from a variety of well-known classical application areas as well as an outlook to modern computational methods in promising new areas. Therefore, this book may equally serve as a textbook in graduate courses for students, as a reference book for people interested in engineering or social sciences, and as a collection of new and promising avenues for researchers working in this field. Highlighted are recent developments in the areas of Simulated Annealing, Path Relinking, Scatter Search, Tabu Search, Variable Neighborhood Search, Hyper-heuristics, Constraint Programming, Iterated Local Search, GRASP, bio-inspired algorithms like Genetic Algorithms, Memetic Algorithms, Ant Colony Optimization or Swarm Intelligence, and several other paradigms.

In the fifties and sixties, several real problems, old and new, especially in Physics, Mechanics, Fluidodynamics, Structural Engi- neering, have shown the need of new mathematical models for study- ing the equilibrium of a system. This has led to the formulation of Variational Inequalities (by G. Stampacchia), and to the develop- ment of Complementarity Systems (by W.S. Dorn, G.B. Dantzig, R.W. Cottle, O.L. Mangasarian et al.) with important applications in the elasto-plastic field (initiated by G. Maier). The great advan- tage of these models is that the equilibrium is not necessarily the extremum of functional, like energy, so that no such functional must be supposed to exist. In the same decades, in some fields like Control Theory, Net- works, Industrial Systems, Logistics, Management Science, there has been a strong request of mathmatical models for optimizing situa- tions where there are concurrent objectives, so that Vector Optimiza- tion (initiated by W. Pareto) has received new impetus. With regard to equilibrium problems, Vector Optimization has the above - mentioned drawback of being obliged to assume the exis- tence of a (vector) functional. Therefore, at the end of the seventies the study of Vector Variational Inequalities began with the scope of exploiting the advantages of both variational and vector models. This volume puts together most of the recent mathematical results in Vector Variational Inequalities with the purpose of contributing to further research.

This book presents new optimization algorithms designed to improve the efficiency of tool paths for five-axis NC machining of sculptured surfaces. The book covers both the structure of the SLAM problem in general and proposes a new extremely efficient approach. It can be used by undergraduate and graduate students and researchers in the field of NC machining and CAD/CAM as well as by corporate research groups for advanced optimization of cutting operations.

This is an open access book discusses readers to various methods of modeling plans and policies that address public sector issues and problems. Written for public policy and social sciences students at the upper undergraduate and graduate level, as well as public sector decision-makers, it demonstrates and compares the development and use of various deterministic and probabilistic optimization and simulation modeling methods for analyzing planning and management issues. These modeling tools offer a means of identifying and evaluating alternative plans and policies based on their physical, economic, environmental, and social impacts. Learning how to develop and use the mathematical modeling tools introduced in this book will give students useful skills when in positions of having to make informed public policy recommendations or decisions.

In the field of nondifferentiable nonconvex optimization, one of the most intensely investigated areas is that of optimization problems involving multivalued mappings in constraints or as the objective function. This book focuses on the tremendous development in the field that has taken place since the publication of the most recent volumes on the subject. The new topics studied include the formulation of optimality conditions using different kinds of generalized derivatives for set-valued mappings (such as, for example, the coderivative of Mordukhovich), the opening of new applications (e.g., the calibration of water supply systems), or the elaboration of new solution algorithms (e.g., smoothing methods). The book is divided into three parts. The focus in the first part is on bilevel programming. The chapters in the second part contain investigations of mathematical programs with equilibrium constraints. The third part is on multivalued set-valued optimization. The chapters were written by outstanding experts in the areas of bilevel programming, mathematical programs with equilibrium (or complementarity) constraints (MPEC), and set-valued optimization problems.

Structural optimization is currently attracting considerable attention. Interest in - search in optimal design has grown in connection with the rapid development of aeronautical and space technologies, shipbuilding, and design of precision mach- ery. A special ?eld in these investigations is devoted to structural optimization with incomplete information (incomplete data). The importance of these investigations is explained as follows. The conventional theory of optimal structural design - sumes precise knowledge of material parameters, including damage characteristics and loadings applied to the structure. In practice such precise knowledge is seldom available. Thus, it is important to be able to predict the sensitivity of a designed structure to random ?uctuations in the environment and to variations in the material properties. To design reliable structures it is necessary to apply the so-called gu- anteed approach, based on a "worst case scenario" or a more optimistic probabilistic approach, if we have additional statistical data. Problems of optimal design with incomplete information also have consid- able theoretical importance. The introduction and investigations into new types of mathematical problems are interesting in themselves. Note that some ga- theoretical optimization problems arise for which there are no systematic techniques of investigation. This monograph is devoted to the exposition of new ways of formulating and solving problems of structural optimization with incomplete information. We recall some research results concerning the optimum shape and structural properties of bodies subjected to external loadings.

Many of the most challenging problems in the applied sciences involve non-differentiable structures as well as partial differential operators, thus leading to non-smooth distributed parameter systems. This edited volume aims to establish a theoretical and numerical foundation and develop new algorithmic paradigms for the treatment of non-smooth phenomena and associated parameter influences. Other goals include the realization and further advancement of these concepts in the context of robust and hierarchical optimization, partial differential games, and nonlinear partial differential complementarity problems, as well as their validation in the context of complex applications. Areas for which applications are considered include optimal control of multiphase fluids and of superconductors, image processing, thermoforming, and the formation of rivers and networks. Chapters are written by leading researchers and present results obtained in the first funding phase of the DFG Special Priority Program on Nonsmooth and Complementarity Based Distributed Parameter Systems: Simulation and Hierarchical Optimization that ran from 2016 to 2019.

This book presents essential concepts of traditional Flower Pollination Algorithm (FPA) and its recent variants and also its application to find optimal solution for a variety of real-world engineering and medical problems. Swarm intelligence-based meta-heuristic algorithms are extensively implemented to solve a variety of real-world optimization problems due to its adaptability and robustness. FPA is one of the most successful swarm intelligence procedures developed in 2012 and extensively used in various optimization tasks for more than a decade. The mathematical model of FPA is quite straightforward and easy to understand and enhance, compared to other swarm approaches. Hence, FPA has attracted attention of researchers, who are working to find the optimal solutions in variety of domains, such as N-dimensional numerical optimization, constrained/unconstrained optimization, and linear/nonlinear optimization problems. Along with the traditional bat algorithm, the enhanced versions of FPA are also considered to solve a variety of optimization problems in science, engineering, and medical applications.

Bayesian decision theory is known to provide an effective framework for the practical solution of discrete and nonconvex optimization problems. This book is the first to demonstrate that this framework is also well suited for the exploitation of heuristic methods in the solution of such problems, especially those of large scale for which exact optimization approaches can be prohibitively costly. The book covers all aspects ranging from the formal presentation of the Bayesian Approach, to its extension to the Bayesian Heuristic Strategy, and its utilization within the informal, interactive Dynamic Visualization strategy. The developed framework is applied in forecasting, in neural network optimization, and in a large number of discrete and continuous optimization problems. Specific application areas which are discussed include scheduling and visualization problems in chemical engineering, manufacturing process control, and epidemiology. Computational results and comparisons with a broad range of test examples are presented. The software required for implementation of the Bayesian Heuristic Approach is included. Although some knowledge of mathematical statistics is necessary in order to fathom the theoretical aspects of the development, no specialized mathematical knowledge is required to understand the application of the approach or to utilize the software which is provided. Audience: The book is of interest to both researchers in operations research, systems engineering, and optimization methods, as well as applications specialists concerned with the solution of large scale discrete and/or nonconvex optimization problems in a broad range of engineering and technological fields. It may be used as supplementary material for graduate level courses.

In a world with highly competitive markets and economic instability due to capitalization, industrial competition has increasingly intensified. In order for many industries to survive and succeed, they need to develop highly effective coordination between supply chain partners, dynamic collaborative and strategic alliance relationships, and efficient logistics and supply chain network designs. Consequently, in the past decade, there has been an explosion of interest among academic researchers and industrial practitioners in innovative supply chain and logistics models, algorithms, and coordination policies. Mathematically distinct from classical supply chain management, this emerging research area has been proven to be useful and applicable to a wide variety of industries. This book brings together recent advances in supply chain and logistics research and computational optimization that apply to a collaborative environment in the enterprise.

This book describes applications of Jaya and Rao algorithms on real case studies concerning different renewable energy sources. In the last few decades, researchers have focused on renewable energy resources like solar energy, bio-energy, wave energy, ocean thermal energy, tidal energy, geothermal energy, and wind energy. This has resulted in the development of new techniques and tools that could harvest energy from renewable energy sources. Many researchers and scientists have focused on developing and optimizing the energy systems to extract and utilize renewable energy more efficiently. In this book, recently developed Jaya and Rao (Rao-1, Rao-2, and Rao-3) algorithms are introduced for single- and multi-objective optimization of selected renewable energy systems. The results of applications of the different versions of Jaya and Rao algorithms are compared with the other optimization techniques like GA, NSGA-II, PSO, MOPSO, ABC, etc., and the performance of the Jaya and Rao algorithms is highlighted compared to other optimization algorithms in the case of renewable energy systems. The book also includes the validation of different versions of the Jaya and Rao algorithms through the application to complex single- and multi-objective unconstrained benchmark functions. The algorithms and computer codes of different version of Jaya and Rao algorithms are included in the book that will be very much useful to readers in industry and academic research.

This book collects chapters on contemporary topics on metric fixed point theory and its applications in science, engineering, fractals, and behavioral sciences. Chapters contributed by renowned researchers from across the world, this book includes several useful tools and techniques for the development of skills and expertise in the area. The book presents the study of common fixed points in a generalized metric space and fixed point results with applications in various modular metric spaces. New insight into parametric metric spaces as well as study of variational inequalities and variational control problems have been included.

This proceedings volume highlights the state-of-the-art knowledge related to optimization, decisions science and problem solving methods, as well as their application in industrial and territorial systems. It includes contributions tackling these themes using models and methods based on continuous and discrete optimization, network optimization, simulation and system dynamics, heuristics, metaheuristics, artificial intelligence, analytics, and also multiple-criteria decision making. The number and the increasing size of the problems arising in real life require mathematical models and solution methods adequate to their complexity. There has also been increasing research interest in Big Data and related challenges. These challenges can be recognized in many fields and systems which have a significant impact on our way of living: design, management and control of industrial production of goods and services; transportation planning and traffic management in urban and regional areas; energy production and exploitation; natural resources and environment protection; homeland security and critical infrastructure protection; development of advanced information and communication technologies. The chapters in this book examine how to deal with new and emerging practical problems arising in these different fields through the presented methodologies and their applications. The chapter topics are applicable for researchers and practitioners working in these areas, but also for the operations research community. The contributions were presented during the international conference "Optimization and Decision Science" (ODS2017), held at Hilton Sorrento Palace Conference Center, Sorrento, Italy, September 4 - 7, 2017. ODS 2017, was organized by AIRO, Italian Operations Research Society, in cooperation with DIETI (Department of Electrical Engineering and Information Technology) of University "Federico II" of Naples.

Special tools are required for examining and solving optimization problems. The main tools in the study of local optimization are classical calculus and its modern generalizions which form nonsmooth analysis. The gradient and various kinds of generalized derivatives allow us to ac complish a local approximation of a given function in a neighbourhood of a given point. This kind of approximation is very useful in the study of local extrema. However, local approximation alone cannot help to solve many problems of global optimization, so there is a clear need to develop special global tools for solving these problems. The simplest and most well-known area of global and simultaneously local optimization is convex programming. The fundamental tool in the study of convex optimization problems is the subgradient, which actu ally plays both a local and global role. First, a subgradient of a convex function f at a point x carries out a local approximation of f in a neigh bourhood of x. Second, the subgradient permits the construction of an affine function, which does not exceed f over the entire space and coincides with f at x. This affine function h is called a support func tion. Since f(y) ~ h(y) for ally, the second role is global. In contrast to a local approximation, the function h will be called a global affine support.

We always come cross several decision-making problems in our daily life. Such problems are always conflicting in which many different view points should be satisfied. In politics, business, industrial systems, management science, networks, etc. one often encounters such kind of problems. The most important and difficult part in such problems is the conflict between various objectives and goals. In these problems, one has to find the minimum(or maximum) for several objective functions. Such problems are called vector optimization problems (VOP),multi-criteria optimization problems or multi-objective optimization problems. This volume deals with several different topics / aspects of vector optimization theory ranging from the very beginning to the most recent one. It contains fourteen chapters written by different experts in the field of vector optimization.

Many books on optimization consider only finite dimensional spaces. This volume is unique in its emphasis: the first three chapters develop optimization in spaces without linear structure, and the analog of convex analysis is constructed for this case. Many new results have been proved specially for this publication. In the following chapters optimization in infinite topological and normed vector spaces is considered. The novelty consists in using the drop property for weak well-posedness of linear problems in Banach spaces and in a unified approach (by means of the Dolecki approximation) to necessary conditions of optimality. The method of reduction of constraints for sufficient conditions of optimality is presented. The book contains an introduction to non-differentiable and vector optimization. Audience: This volume will be of interest to mathematicians, engineers, and economists working in mathematical optimization.

This book introduces the advances in synchromodal logistics and provides a framework to classify various optimisation problems in this field. It explores the application of this framework to solve a broad range of problems, such as problems with and without a central decision-maker, problems with and without full information, deterministic problems, problems coping with uncertainty, optimisation of a full network design problem. It covers theoretical constructs, such as discrete optimisation, robust optimisation, optimisation under uncertainty, multi-objective optimisation and agent based equilibrium models. Moreover, practical elaborated use cases are presented to deepen understanding. The book gives both researchers and practitioners a good overview of the field of synchromodal optimisation problems and offers the reader practical methods for modelling and problem-solving.

Using numerical examples to illustrate their concepts and results, this book examines recently developed fuzzy multi-criteria methods, such as Intuitionistic Fuzzy TOPSIS, Intuitionistic Fuzzy TOPSIS & DEA-AHP, Intuitionistic VIKOR, Pythagorean WASPAS, Pythagorean ENTROPI, Hesitant CBD, Hesitant MABAC, Triangular EDAS, Triangular PROMETHEE, q-Rung Orthopair COPRAS, and Fuzzy Type - 2 ELECTRE. Each chapter covers practical applications in addition to fresh developments and results. Given its structure and scope, the book can be used as a textbook in graduate courses on operations research and industrial engineering. It also offers a valuable resource for scientists working in a range of disciplines that require multi-criteria decision making.

Give, and it shall be given unto you. ST. LUKE, VI, 38. The book is based on several courses of lectures on control theory and appli cations which were delivered by the authors for a number of years at Moscow Electronics and Mathematics University. The book, originally written in Rus sian, was first published by Vysshaya Shkola (Higher School) Publishing House in Moscow in 1989. In preparing a new edition of the book we planned to make only minor changes in the text. However, we soon realized that we like many scholars working in control theory had learned many new things and had had many new insights into control theory and its applications since the book was first published. Therefore, we rewrote the book especially for the English edition. So, this is substantially a new book with many new topics. The book consists of an introduction and four parts. Part One deals with the fundamentals of modern stability theory: general results concerning stability and instability, sufficient conditions for the stability of linear systems, methods for determining the stability or instability of systems of various type, theorems on stability under random disturbances."

Focusing on the study of nonsmooth vector functions, this book presents a comprehensive account of the calculus of generalized Jacobian matrices and their applications to continuous nonsmooth optimization problems, as well as variational inequalities in finite dimensions. The treatment is motivated by a desire to expose an elementary approach to nonsmooth calculus, using a set of matrices to replace the nonexistent Jacobian matrix of a continuous vector function.

This book defines and studies a combinatorial object called the pedigree and develops the theory for optimising a linear function over the convex hull of pedigrees (the Pedigree polytope). A strongly polynomial algorithm implementing the framework given in the book for checking membership in the pedigree polytope is a major contribution. This book challenges the popularly held belief in computer science that a problem included in the NP-complete class may not have a polynomial algorithm to solve. By showing STSP has a polynomial algorithm, this book settles the P vs NP question. This book has illustrative examples, figures, and easily accessible proofs for showing this unexpected result. This book introduces novel constructions and ideas previously not used in the literature. Another interesting feature of this book is it uses basic max-flow and linear multicommodity flow algorithms and concepts in these proofs establishing efficient membership checking for the pedigree polytope. Chapters 3-7 can be adopted to give a course on Efficient Combinatorial Optimization. This book is the culmination of the author's research that started in 1982 through a presentation on a new formulation of STSP at the XIth International Symposium on Mathematical Programming at Bonn.

This book addresses and disseminates state-of-the-art research and development of differential evolution (DE) and its recent advances, such as the development of adaptive, self-adaptive and hybrid techniques. Differential evolution is a population-based meta-heuristic technique for global optimization capable of handling non-differentiable, non-linear and multi-modal objective functions. Many advances have been made recently in differential evolution, from theory to applications. This book comprises contributions which include theoretical developments in DE, performance comparisons of DE, hybrid DE approaches, parallel and distributed DE for multi-objective optimization, software implementations, and real-world applications. The book is useful for researchers, practitioners, and students in disciplines such as optimization, heuristics, operations research and natural computing.

The field of metaheuristics has been fast evolving in recent years. Techniques such as simulated annealing, tabu search, genetic algorithms, scatter search, greedy randomized adaptive search, variable neighborhood search, ant systems, and their hybrids are currently among the most efficient and robust optimization strategies to find high-quality solutions to many real-life optimization problems. A very large number of successful applications of metaheuristics are reported in the literature and spread throughout many books, journals, and conference proceedings. A series of international conferences entirely devoted to the theory, applications, and computational developments in metaheuristics has been attracting an increasing number of participants, from universities and the industry. Essays and Surveys in Metaheuristics goes beyond the recent conference-oriented volumes in Metaheuristics, with its focus on surveys of recent developments of the main metaheuristics. Well-known specialists have written surveys on the following subjects: simulated annealing (E. Aarts and J. Korst, The Netherlands), noising methods (I. Charon and O. Hudry, France), strategies for the parallel implementation of metaheuristics (V.-D. Cung and C. Roucairol, France, and S.L. Martins and C.C. Ribeiro, Brazil), greedy randomized adaptive search procedures (P. Festa, Italy, and M.G.C. Resende, USA), tabu search (M. Gendreau, Canada), variable neighborhood search (P. Hansen and N. Mladenovic, Canada), ant colonies (V. Maniezzo and A. Carbonaro, Italy), and evolutionary algorithms (H. MA1/4hlenbein and Th. Mahnig, Germany). Several further essays address issues or variants of metaheuristics, as well as innovative orsuccessful applications of metaheuristics to classical or new combinatorial optimization problems.

This book presents a wide range of optimization methods and their applications to various electrical power system problems such as economical load dispatch, demand supply management in microgrids, levelized energy pricing, load frequency control and congestion management, and reactive power management in radial distribution systems. Problems related to electrical power systems are often highly complex due to the massive dimensions, nonlinearity, non-convexity and discontinuity associated with objective functions. These systems also have a large number of equality and inequality constraints, which give rise to optimization problems that are difficult to solve using classical numerical methods. In this regard, nature inspired optimization algorithms offer an effective alternative, due to their ease of use, population-based parallel search mechanism, non-dependence on the nature of the problem, and ability to accommodate non-differentiable, non-convex problems. The analytical model of nature inspired techniques mimics the natural behaviors and intelligence of life forms. These techniques are mainly based on evolution, swarm intelligence, ecology, human intelligence and physical science.