Optimization of Pharmaceutical Processes presents contributions from leading authorities in the fields of optimization and pharmaceutical manufacturing. Formulated within structured frameworks, practical examples and applications are given as guidance to apply optimization techniques to most aspects of pharmaceutical processes from design, to lab and pilot scale, and finally to manufacturing. The increasing demand for better quality, higher yield, more efficient-optimized and green pharmaceutical processes, indicates that optimal conditions for production must be applied to achieve simplicity, lower costs and superior yield. The application of such methods in the pharmaceutical industry is not trivial. Quality of the final product is of major importance to human health and the need for deep knowledge of the process parameters and the optimization of the processes are imperative. The volume, which includes new methods as well as review contributions will benefit a wide readership including engineers in pharmaceuticals, chemical, biological, to name just a few.

- Includes industrial case studies - Includes chapters on cyber physical systems, machine learning, deep learning, cyber security, robotics, smart manufacturing and predictive analytics - surveys current trends and challenges in metaheuristics and industry 4.0

This book is a new contribution aiming to give some last research findings in the field of optimization and computing. This work is in the same field target than our two previous books published: "Recent Developments in Metaheuristics" and "Metaheuristics for Production Systems", books in Springer Series in Operations Research/Computer Science Interfaces. The challenge with this work is to gather the main contribution in three fields, optimization technique for production decision, general development for optimization and computing method and wider spread applications. The number of researches dealing with decision maker tool and optimization method grows very quickly these last years and in a large number of fields. We may be able to read nice and worthy works from research developed in chemical, mechanical, computing, automotive and many other fields.

the handbook is a valuable reference to researchers from industry and academia, as well as Masters and PhD students around the globe working in the metaheuristics and applications domain includes contributions from a variety of academics/researchers in the field of metaheuristics

Computational and theoretical open problems in optimization, computational geometry, data science, logistics, statistics, supply chain modeling, and data analysis are examined in this book. Each contribution provides the fundamentals needed to fully comprehend the impact of individual problems. Current theoretical, algorithmic, and practical methods used to circumvent each problem are provided to stimulate a new effort towards innovative and efficient solutions. Aimed towards graduate students and researchers in mathematics, optimization, operations research, quantitative logistics, data analysis, and statistics, this book provides a broad comprehensive approach to understanding the significance of specific challenging or open problems within each discipline. The contributions contained in this book are based on lectures focused on "Challenges and Open Problems in Optimization and Data Science" presented at the Deucalion Summer Institute for Advanced Studies in Optimization, Mathematics, and Data Science in August 2016.

This is a book on optimal control problems (OCPs) for partial differential equations (PDEs) that evolved from a series of courses taught by the authors in the last few years at Politecnico di Milano, both at the undergraduate and graduate levels. The book covers the whole range spanning from the setup and the rigorous theoretical analysis of OCPs, the derivation of the system of optimality conditions, the proposition of suitable numerical methods, their formulation, their analysis, including their application to a broad set of problems of practical relevance. The first introductory chapter addresses a handful of representative OCPs and presents an overview of the associated mathematical issues. The rest of the book is organized into three parts: part I provides preliminary concepts of OCPs for algebraic and dynamical systems; part II addresses OCPs involving linear PDEs (mostly elliptic and parabolic type) and quadratic cost functions; part III deals with more general classes of OCPs that stand behind the advanced applications mentioned above. Starting from simple problems that allow a "hands-on" treatment, the reader is progressively led to a general framework suitable to face a broader class of problems. Moreover, the inclusion of many pseudocodes allows the reader to easily implement the algorithms illustrated throughout the text. The three parts of the book are suitable to readers with variable mathematical backgrounds, from advanced undergraduate to Ph.D. levels and beyond. We believe that applied mathematicians, computational scientists, and engineers may find this book useful for a constructive approach toward the solution of OCPs in the context of complex applications.

Written by experts from all over the world, the book comprises the latest applications of mathematical and models in food engineering and fermentation. It provides the fundamentals on statistical methods to solve standard problems associated with food engineering and fermentation technology. Combining theory with a practical, hands-on approach, this book covers key aspects of food engineering. Presenting cuttingedge information, the book is an essential reference on the fundamental concepts associated with food engineering.

This book will cover heuristic optimization techniques and applications in engineering problems. The book will be divided into three sections that will provide coverage of the techniques, which can be employed by engineers, researchers, and manufacturing industries, to improve their productivity with the sole motive of socio-economic development. This will be the first book in the category of heuristic techniques with relevance to engineering problems and achieving optimal solutions. Features Explains the concept of optimization and the relevance of using heuristic techniques for optimal solutions in engineering problems Illustrates the various heuristics techniques Describes evolutionary heuristic techniques like genetic algorithm and particle swarm optimization Contains natural based techniques like ant colony optimization, bee algorithm, firefly optimization, and cuckoo search Offers sample problems and their optimization, using various heuristic techniques

Introduction to the Theory of Optimization in Euclidean Space is intended to provide students with a robust introduction to optimization in Euclidean space, demonstrating the theoretical aspects of the subject whilst also providing clear proofs and applications. Students are taken progressively through the development of the proofs, where they have the occasion to practice tools of differentiation (Chain rule, Taylor formula) for functions of several variables in abstract situations. Throughout this book, students will learn the necessity of referring to important results established in advanced Algebra and Analysis courses. Features Rigorous and practical, offering proofs and applications of theorems Suitable as a textbook for advanced undergraduate students on mathematics or economics courses, or as reference for graduate-level readers Introduces complex principles in a clear, illustrative fashion

This book investigates several duality approaches for vector optimization problems, while also comparing them. Special attention is paid to duality for linear vector optimization problems, for which a vector dual that avoids the shortcomings of the classical ones is proposed. Moreover, the book addresses different efficiency concepts for vector optimization problems. Among the problems that appear when the framework is generalized by considering set-valued functions, an increasing interest is generated by those involving monotone operators, especially now that new methods for approaching them by means of convex analysis have been developed. Following this path, the book provides several results on different properties of sums of monotone operators.

Stealth technology is a crucial pre-requisite in the combat zone, where swiftness, surprise and initiative are the decisive elements for survivability. The supreme goal here is to reduce the visibility of military vehicles by shaping, application of radar absorbing materials, passive cancellation, active cancellation etc. With respect to multilayered radar absorbing structures (RAS), this book presents an efficient algorithm based on particle swarm optimization (PSO), for the material selection as well as optimization of thickness of multilayered RAS models considering both normal as well as oblique incidence cases. It includes a thorough overview of the theoretical background required for the analysis of multilayered RAS as well as the step-by-step procedure for the implementation of PSO-based algorithm. The accuracy and computational efficiency of the indigenously developed code is also clearly established using relevant validations and case studies. FEATURES Provides step-by-step procedure for the implementation of particle swarm optimization (PSO) based algorithm in the context of multilayered radar absorbing structures (RAS) design Helps to understand the EM design, analysis and optimization of multilayered RAS Describes the theoretical background required for the analysis of multilayered RAS Illustrates in detail the theoretical formulation supported by intuitive ray diagrams and comprehensive flowcharts to implement the algorithm with ease Includes elaborate validations and case studies This book will serve as a valuable resource for students, researchers, scientists, and engineers involved in the electromagnetic design and development of multi-layered radar absorbing structures.

Operations research often solves deterministic optimization problems based on elegantand conciserepresentationswhereall parametersarepreciselyknown. In the face of uncertainty, probability theory is the traditional tool to be appealed for, and stochastic optimization is actually a signi?cant sub-area in operations research. However, the systematic use of prescribed probability distributions so as to cope with imperfect data is partially unsatisfactory. First, going from a deterministic to a stochastic formulation, a problem may becomeintractable. Agoodexampleiswhengoingfromdeterministictostoch- tic scheduling problems like PERT. From the inception of the PERT method in the 1950's, it was acknowledged that data concerning activity duration times is generally not perfectly known and the study of stochastic PERT was launched quite early. Even if the power of today's computers enables the stochastic PERT to be addressed to a large extent, still its solutions often require simplifying assumptions of some kind. Another di?culty is that stochastic optimization problems produce solutions in the average. For instance, the criterion to be maximized is more often than not expected utility. This is not always a meaningful strategy. In the case when the underlying process is not repeated a lot of times, let alone being one-shot, it is not clear if this criterion is realistic, in particular if probability distributions are subjective. Expected utility was proposed as a rational criterion from ?rst principles by Savage. In his view, the subjective probability distribution was - sically an artefact useful to implement a certain ordering of solutions.

A new starting-point and a new method are requisite, to insure a complete [classi?cation of the Steiner triple systems of order 15]. This method was furnished, and its tedious and di?cult execution und- taken, by Mr. Cole. F. N. Cole, L. D. Cummings, and H. S. White (1917) [129] The history of classifying combinatorial objects is as old as the history of the objects themselves. In the mid-19th century, Kirkman, Steiner, and others became the fathers of modern combinatorics, and their work - on various objects, including (what became later known as) Steiner triple systems - led to several classi?cation results. Almost a century earlier, in 1782, Euler [180] published some results on classifying small Latin squares, but for the ?rst few steps in this direction one should actually go at least as far back as ancient Greece and the proof that there are exactly ?ve Platonic solids. One of the most remarkable achievements in the early, pre-computer era is the classi?cation of the Steiner triple systems of order 15, quoted above. An onerous task that, today, no sensible person would attempt by hand calcu- tion. Because, with the exception of occasional parameters for which com- natorial arguments are e?ective (often to prove nonexistence or uniqueness), classi?cation in general is about algorithms and computation.

This book contains the most recent progress in data assimilation in meteorology, oceanography and hydrology including land surface. It spans both theoretical and applicative aspects with various methodologies such as variational, Kalman filter, ensemble, Monte Carlo and artificial intelligence methods. Besides data assimilation, other important topics are also covered including adaptive observations, sensitivity analysis, parameter estimation and AI applications. The book is useful to individual researchers as well as graduate students for a reference in the field of data assimilation.

This book includes a thorough theoretical and computational analysis of unconstrained and constrained optimization algorithms and combines and integrates the most recent techniques and advanced computational linear algebra methods. Nonlinear optimization methods and techniques have reached their maturity and an abundance of optimization algorithms are available for which both the convergence properties and the numerical performances are known. This clear, friendly, and rigorous exposition discusses the theory behind the nonlinear optimization algorithms for understanding their properties and their convergence, enabling the reader to prove the convergence of his/her own algorithms. It covers cases and computational performances of the most known modern nonlinear optimization algorithms that solve collections of unconstrained and constrained optimization test problems with different structures, complexities, as well as those with large-scale real applications. The book is addressed to all those interested in developing and using new advanced techniques for solving large-scale unconstrained or constrained complex optimization problems. Mathematical programming researchers, theoreticians and practitioners in operations research, practitioners in engineering and industry researchers, as well as graduate students in mathematics, Ph.D. and master in mathematical programming will find plenty of recent information and practical approaches for solving real large-scale optimization problems and applications.

This book covers the issues related to optimization of engineering and management problems using soft computing techniques with an industrial outlook. It covers a broad area related to real life complex decision making problems using a heuristics approach. It also explores a wide perspective and future directions in industrial engineering research on a global platform/scenario. The book highlights the concept of optimization, presents various soft computing techniques, offers sample problems, and discusses related software programs complete with illustrations. Features Explains the concept of optimization and relevance to soft computing techniques towards optimal solution in engineering and management Presents various soft computing techniques Offers problems and their optimization using various soft computing techniques Discusses related software programs, with illustrations Provides a step-by-step tutorial on how to handle relevant software for obtaining the optimal solution to various engineering problems

Designed for a proof-based course on linear algebra, this rigorous and concise textbook intentionally introduces vector spaces, inner products, and vector and matrix norms before Gaussian elimination and eigenvalues so students can quickly discover the singular value decomposition (SVD)-arguably the most enlightening and useful of all matrix factorizations. Gaussian elimination is then introduced after the SVD and the four fundamental subspaces and is presented in the context of vector spaces rather than as a computational recipe. This allows the authors to use linear independence, spanning sets and bases, and the four fundamental subspaces to explain and exploit Gaussian elimination and the LU factorization, as well as the solution of overdetermined linear systems in the least squares sense and eigenvalues and eigenvectors. This unique textbook also includes examples and problems focused on concepts rather than the mechanics of linear algebra. The problems at the end of each chapter and in an associated website encourage readers to explore how to use the notions introduced in the chapter in a variety of ways. Additional problems, quizzes, and exams will be posted on an accompanying website and updated regularly. The Less Is More Linear Algebra of Vector Spaces and Matrices is for students and researchers interested in learning linear algebra who have the mathematical maturity to appreciate abstract concepts that generalize intuitive ideas. The early introduction of the SVD makes the book particularly useful for those interested in using linear algebra in applications such as scientific computing and data science. It is appropriate for a first proof-based course in linear algebra.

This book presents best practices involving applications of decision sciences, business tactics and behavioral sciences for COVID-19. Addressing concrete problems in these vital fields, it focuses on theoretical and methodological investigations of managerial decisions that drive production and service enterprises' productivity and success. Moreover, it presents optimization techniques and tools that can also be adopted for other applications in various research areas after a thorough analysis of the specific problem. The book is intended for researchers and practitioners seeking optimum solutions to real-life problems in various application areas concerning COVID-19, helping them make scientifically founded decisions.

Metaheuristic optimization is a higher-level procedure or heuristic designed to find, generate, or select a heuristic (partial search algorithm) that may provide a sufficiently good solution to an optimization problem, especially with incomplete or imperfect information or limited computation capacity. This is usually applied when two or more objectives are to be optimized simultaneously. This book is presented with two major objectives. Firstly, it features chapters by eminent researchers in the field providing the readers about the current status of the subject. Secondly, algorithm-based optimization or advanced optimization techniques, which are applied to mostly non-engineering problems, are applied to engineering problems. This book will also serve as an aid to both research and industry. Usage of these methodologies would enable the improvement in engineering and manufacturing technology and support an organization in this era of low product life cycle. Features: Covers the application of recent and new algorithms Focuses on the development aspects such as including surrogate modeling, parallelization, game theory, and hybridization Presents the advances of engineering applications for both single-objective and multi-objective optimization problems Offers recent developments from a variety of engineering fields Discusses Optimization using Evolutionary Algorithms and Metaheuristics applications in engineering

This book is an introduction to the mathematical theory of optimal control of processes governed by ordinary differential eq- tions. It is intended for students and professionals in mathematics and in areas of application who want a broad, yet relatively deep, concise and coherent introduction to the subject and to its relati- ship with applications. In order to accommodate a range of mathema- cal interests and backgrounds among readers, the material is arranged so that the more advanced mathematical sections can be omitted wi- out loss of continuity. For readers primarily interested in appli- tions a recommended minimum course consists of Chapter I, the sections of Chapters II, III, and IV so recommended in the introductory sec tions of those chapters, and all of Chapter V. The introductory sec tion of each chapter should further guide the individual reader toward material that is of interest to him. A reader who has had a good course in advanced calculus should be able to understand the defini tions and statements of the theorems and should be able to follow a substantial portion of the mathematical development. The entire book can be read by someone familiar with the basic aspects of Lebesque integration and functional analysis. For the reader who wishes to find out more about applications we recommend references [2], [13], [33], [35], and [50], of the Bibliography at the end of the book.

This book gathers peer-reviewed contributions submitted to the 21st European Conference on Mathematics for Industry, ECMI 2021, which was virtually held online, hosted by the University of Wuppertal, Germany, from April 13th to April 15th, 2021. The works explore mathematics in a wide variety of applications, ranging from problems in electronics, energy and the environment, to mechanics and mechatronics. Topics covered include: Applied Physics, Biology and Medicine, Cybersecurity, Data Science, Economics, Finance and Insurance, Energy, Production Systems, Social Challenges, and Vehicles and Transportation. The goal of the European Consortium for Mathematics in Industry (ECMI) conference series is to promote interaction between academia and industry, leading to innovations in both fields. These events have attracted leading experts from business, science and academia, and have promoted the application of novel mathematical technologies to industry. They have also encouraged industrial sectors to share challenging problems where mathematicians can provide fresh insights and perspectives. Lastly, the ECMI conferences are one of the main forums in which significant advances in industrial mathematics are presented, bringing together prominent figures from business, science and academia to promote the use of innovative mathematics in industry.

Differential equations play a noticeable role in engineering, physics, economics, and other disciplines. They permit us to model changing forms in both mathematical and physical problems. These equations are precisely used when a deterministic relation containing some continuously varying quantities and their rates of change in space and/or time is recognized or postulated. This book is intended to provide a straightforward introduction to the concept of partial differential equations. It provides a diversity of numerical examples framed to nurture the intellectual level of scholars. It includes enough examples to provide students with a clear concept and also offers short questions for comprehension. Construction of real-life problems is considered in the last chapter along with applications. Research scholars and students working in the fields of engineering, physics, and different branches of mathematics need to learn the concepts of partial differential equations to solve their problems. This book will serve their needs instead of having to use more complex books that contain more concepts than needed.

This book discusses the main techniques and newest trends to manage and optimize the production and service systems. The book begins by examining the three main levels of decision systems in production: the long term (strategic), the middle term (tactical) and short term (operational). It also considers online management as a new level (a sub level of the short term). As each level encounters specific problems, appropriate approaches to deal with these are introduced and explained. These problems include the line design, the line balancing optimization, the physical layout of the production or service system, the forecasting optimization, the inventory management, the scheduling etc. Metaheuristics for Production Systems then explores logistic optimization from two different perspectives: internal (production management), addressing issues of scheduling, layout and line designs, and external (supply chain management) focusing on transportation optimization, supply chain evaluation, and location of production. The book also looks at NP-hard problems that are common in production management. These complex configurations may mean that optimal solutions may not be reached due to variables, but the authors help provide a good solution for such problems. The effective new results and solutions offered in this book should appeal to researchers, managers, and engineers in the production and service industries.

This volume presents significant advances in a number of theories and problems of Mathematical Analysis and its applications in disciplines such as Analytic Inequalities, Operator Theory, Functional Analysis, Approximation Theory, Functional Equations, Differential Equations, Wavelets, Discrete Mathematics and Mechanics. The contributions focus on recent developments and are written by eminent scientists from the international mathematical community. Special emphasis is given to new results that have been obtained in the above mentioned disciplines in which Nonlinear Analysis plays a central role. Some review papers published in this volume will be particularly useful for a broader readership in Mathematical Analysis, as well as for graduate students. An attempt is given to present all subjects in this volume in a unified and self-contained manner, to be particularly useful to the mathematical community.

This book is for those interested in number systems, abstract algebra, and analysis. It provides an understanding of negative and fractional numbers with theoretical background and explains rationale of irrational and complex numbers in an easy to understand format. This book covers the fundamentals, proof of theorems, examples, definitions, and concepts. It explains the theory in an easy and understandable manner and offers problems for understanding and extensions of concept are included. The book provides concepts in other fields and includes an understanding of handling of numbers by computers. Research scholars and students working in the fields of engineering, science, and different branches of mathematics will find this book of interest, as it provides the subject in a clear and concise way.