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Books > Science & Mathematics > Biology, life sciences > Microbiology (non-medical) > General

Plant Microbiome for Plant Productivity and Sustainable Agriculture (Hardcover, 1st ed. 2023): Sagar Chhabra, Ramprasad, Naga... Plant Microbiome for Plant Productivity and Sustainable Agriculture (Hardcover, 1st ed. 2023)
Sagar Chhabra, Ramprasad, Naga Raju Maddela, Narendra Tuteja
R5,856 Discovery Miles 58 560 Ships in 18 - 22 working days

This edited book deals with latest comprehensive information on conventional and high throughput techniques and technologies that are recently used to study plant microbial interface for agricultural research and enhancing plant productivity. Plant microbiota are important for many plant growth promotion activity and agricultural productivity and are sustainable green technology for enhancing agricultural productivity under changing environment. The book covers recent information about the plant associated microbiota and their ecology. It discusses technologies to isolate and test microbiota inhabiting in different portion of plants. The book explores the conventional methods as well as the most recently recognized high throughput technologies which are important for productive agroecosystems to feed the growing global population. This book is of interest to teachers, researchers, microbiologist, plant and environmental scientist and those interested in environment stewardship around the world. Also the book serves as additional reading material for undergraduate and graduate students of agriculture, forestry, ecology, soil science, and environmental sciences and policy makers to be a useful to read.

Food Safety Engineering (Hardcover, 1st ed. 2020): Ali Demirci, Hao Feng, Kathiravan Krishnamurthy Food Safety Engineering (Hardcover, 1st ed. 2020)
Ali Demirci, Hao Feng, Kathiravan Krishnamurthy
R6,627 Discovery Miles 66 270 Ships in 10 - 15 working days

Food Safety Engineering is the first reference work to provide up-to-date coverage of the advanced technologies and strategies for the engineering of safe foods. Researchers, laboratory staff and food industry professionals with an interest in food engineering safety will find a singular source containing all of the needed information required to understand this rapidly advancing topic. The text lays a solid foundation for solving microbial food safety problems, developing advanced thermal and non-thermal technologies, designing food safety preventive control processes and sustainable operation of the food safety preventive control processes. The first section of chapters presents a comprehensive overview of food microbiology from foodborne pathogens to detection methods. The next section focuses on preventative practices, detailing all of the major manufacturing processes assuring the safety of foods including Good Manufacturing Practices (GMP), Hazard Analysis and Critical Control Points (HACCP), Hazard Analysis and Risk-Based Preventive Controls (HARPC), food traceability, and recalls. Further sections provide insights into plant layout and equipment design, and maintenance. Modeling and process design are covered in depth. Conventional and novel preventive controls for food safety include the current and emerging food processing technologies. Further sections focus on such important aspects as aseptic packaging and post-packaging technologies. With its comprehensive scope of up-to-date technologies and manufacturing processes, this is a useful and first-of-its kind text for the next generation food safety engineering professionals.

Chemistry of Antibiotics and Related Drugs (Hardcover, 2nd ed. 2022): Mrinal K. Bhattacharjee Chemistry of Antibiotics and Related Drugs (Hardcover, 2nd ed. 2022)
Mrinal K. Bhattacharjee
R1,575 Discovery Miles 15 750 Ships in 10 - 15 working days

This textbook builds on the success of the earlier edition, offering alternative strategies for discovering new antibiotics. It discusses how the various types of antibiotics and related drugs work to cure infections. Then it delves into the very serious matter of how bacteria are becoming resistant to these antibiotics. It also covers the global action plan on antimicrobial resistance from the World Health Organization and discusses several Antibiotic Stewardship Programs adopted by agencies at local levels. Appropriate for a one-semester course at either the graduate or advanced undergraduate level, the book is self-contained and written in accessible language. It includes all necessary background biochemistry material and a discussion of the latest developments in the field of antibiotics. Original research works are frequently cited and experimental procedures and interpretation of results are emphasized.

Intellectual Property Issues in Microbiology (Hardcover, 1st ed. 2019): Harikesh Bahadur Singh, Chetan Keswani, Surya Pratap... Intellectual Property Issues in Microbiology (Hardcover, 1st ed. 2019)
Harikesh Bahadur Singh, Chetan Keswani, Surya Pratap Singh
R4,072 Discovery Miles 40 720 Ships in 18 - 22 working days

In the current era current era of significant innovations, science and technology are powerful tools improving human welfare through prosperity and sustainable development. The development of microbiology based industries in any given country is shaped by the characteristics of its technology-particularly its close relation to scientific knowledge, and by country-specific factors such as the level and nature of the scientific knowledge base, the institutional set-up, and the role assumed by the government, all of which influence the country's ability to exploit the new opportunities. This unique book presents an integrated approach for sustained innovation in various areas of microbiology. Focusing on the industrial and socio-legal implications of IPR in microbiological advances, it offers a comprehensive overview not only of the implications of IPR in omics-based research but also of the ethical and intellectual standards and how these can be developed for sustained innovation. The book is divided into three sections discussing current advances in microbiological innovations, recent intellectual property issues in agricultural, and pharmaceutical microbiology respectively. Integrating science and business, it offers a glimpse behind the scenes of the microbiology industry, and provides a detailed analysis of the foundations of the present day industry for students and professionals alike.

The Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology (Paperback): Fernando Cobo The Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology (Paperback)
Fernando Cobo
R2,629 R2,476 Discovery Miles 24 760 Save R153 (6%) Ships in 10 - 15 working days

The Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology presents the state-of the-art for MALDI-TOF mass spectrometry. It is a key reference defining how MALDI-TOF mass spectrometry is used in clinical settings as a diagnostic tool of microbial identification and characterization that is based on the detection of a mass of molecules. The book provides updated applications of MALDI-TOF techniques in clinical microbiology, presenting the latest information available on a technology that is now used for rapid microbial identification at relatively low cost, thus offering an alternative to conventional laboratory diagnosis and proteomic identification systems. Although the main use of the technology has, until now, been identification or typing of bacteria from a positive culture, applications in the field of virology, mycology, microbacteriology and resistances are opening up new opportunities.

Rhizobium Biology and Biotechnology (Hardcover, 1st ed. 2017): Alexander P. Hansen, Devendra K. Choudhary, Pawan Kumar Agrawal,... Rhizobium Biology and Biotechnology (Hardcover, 1st ed. 2017)
Alexander P. Hansen, Devendra K. Choudhary, Pawan Kumar Agrawal, Ajit Varma
R5,720 Discovery Miles 57 200 Ships in 10 - 15 working days

This book provides in-depth reviews of the role of Rhizobium in agriculture and its biotechnological applications. Individual chapters explore topics such as: the occurrence and distribution of Rhizobium; phenotypic and molecular characteristics of Rhizobium; impact of Rhizobium on other microbial communities in the rhizosphere; N2-fixation ability of Rhizobium; Rhizobium and biotic stress; Rhizobium-mediated restoration of an ecosystem; in silico analysis of the rhizobia pool; further biotechnological perspectives of Rhizobium.

Emulsion-based Encapsulation of Antioxidants - Design and Performance (Hardcover, 1st ed. 2020): M. Ali Aboudzadeh Emulsion-based Encapsulation of Antioxidants - Design and Performance (Hardcover, 1st ed. 2020)
M. Ali Aboudzadeh
R6,581 Discovery Miles 65 810 Ships in 18 - 22 working days

The limited aqueous solubility of bioactive pharmaceutical ingredients presents a tremendous challenge in the development of new drugs. In recent years, methods have been developed to protect these sensitive bioactive compounds, namely antioxidants, with the aim of increasing the public sanitation grades. Emulsion-based systems are particularly interesting as colloidal delivery encapsulation systems, because they can easily be created from food-grade ingredients using relatively simple processing protocols. It is one of the most favorable delivery systems to increase the solubility of phytochemicals, nutraceuticals and food additives. Emulsion-based Encapsulation of Antioxidants: Design and Performance advances the field of colloid science through the investigation of the effects of formulation and process parameters that influence emulsion production. The book offers a deeper comprehension of the technological and biological aspects of the incorporation of encapsulated compounds in food matrices and explication of their activity. Chapters provide an overview of the status of emulsion-based formulations to encapsulate antioxidants, fabrication, properties, applications, and biological fate with emphasis on systems suitable for utilization within industry. Special emphasis is placed on the antioxidant activity of the carriers being the key advantage of these emulsion-based systems. The main aim of the book is to inspire and to guide fellow scientists and students in this field. Filled with illustrations, figures, case studies, practical examples, and historical perspectives, the book can also be used as a practical handbook or graduate textbook. For industry professionals, the book presents easy-to-achieve approaches to industrial pharmaceutical production.

Biofilms in Human Diseases: Treatment and Control (Hardcover, 1st ed. 2019): Sunil Kumar, Niharika Chandra, Leena Singh,... Biofilms in Human Diseases: Treatment and Control (Hardcover, 1st ed. 2019)
Sunil Kumar, Niharika Chandra, Leena Singh, Muhammad Zaffar Hashmi, Ajit Varma
R2,691 Discovery Miles 26 910 Ships in 18 - 22 working days

This book highlights treatment strategies for bacterial biofilms in connection with a variety of human diseases. In particular, it reviews bacterial biofilm formation and its mechanism. Topics covered include biofilms in human health, the role of biofilms in mediating human diseases, and methods for testing bacterial biofilms. Further sections concentrate on biofilm-mediated diseases in different parts of the human gastrointestinal tract, while therapeutic strategies for biofilm control and natural agents that disrupt bacterial biofilms are also covered. Readers will also find the latest advances in probiotics and biofilms, as well as the use of probiotics to counteract biofilm-associated infections. Biofilms and antimicrobial resistance are discussed. Subsequent chapters address the management of inflammatory bowel disease via probiotics biofilms, as well as the role of probiotics bacteria in the treatment of human diseases associated with bacterial biofilms. The book is chiefly intended for clinicians/scientists in the fields of medical microbiology, applied microbiology, biochemistry, and biotechnology.

Sustainable and Clean Energy Production Technologies (Hardcover, 1st ed. 2022): Dan Bahadur Pal, Jay Mant Jha Sustainable and Clean Energy Production Technologies (Hardcover, 1st ed. 2022)
Dan Bahadur Pal, Jay Mant Jha
R5,172 Discovery Miles 51 720 Ships in 18 - 22 working days

This edited book is a comprehensive collection of chapters on various clean energy technology such as solar energy, waste biomass as energy, hydro-electricity generation, biodiesel production from biomass and strategies to cater the demand of clean renewable energy. Clean energy technologies also enhance economic growth by increasing the supply of energy demand and tackling environmental challenges and their impacts due to the use of other conventional sources of energy. The conventional/non-conventional energy production methods are efficient but it has adverse effects on environment and human health. As environmental concerns are not avoidable therefore the necessity of clean energy production comes in to the picture. The clean energy can be produced by different wastes which are caused for the environmental pollution. This book covers various aspects of new and renewable clean energy production technology and its utilization in different fields. This is a useful reading material for students and researchers involved in clean energy study.

Inclusions in Prokaryotes (Hardcover, 2006 ed.): Jessup M. Shively Inclusions in Prokaryotes (Hardcover, 2006 ed.)
Jessup M. Shively
R4,330 Discovery Miles 43 300 Ships in 10 - 15 working days

The new series "Microbiology Monographs" begins with two volumes on intracellular components in prokaryotes. In this first volume, "Inclusions in Prokaryotes," the components, labeled inclusions, are defined as discrete bodies resulting from synthesis of a metabolic product. Research on the biosynthesis and reutilization of the accumulated materials is still in progress, and interest in the inclusions is growing. This comprehensive volume provides historical background and comprehensive reviews of eight well-known prokaryotic inclusions.

Microbial Resource Conservation - Conventional to Modern Approaches (Hardcover, 1st ed. 2018): Sushil K Sharma, Ajit Varma Microbial Resource Conservation - Conventional to Modern Approaches (Hardcover, 1st ed. 2018)
Sushil K Sharma, Ajit Varma
R5,217 Discovery Miles 52 170 Ships in 18 - 22 working days

This book covers broad areas in the conservation of microorganisms. It addresses the short, medium and long-term preservation of agriculturally important microorganisms, as well as culture collections and their roles. The respective chapters address topics such as conventional approaches to bacterial, fungal and algal preservation, as well as methods and strategies for preserving recalcitrant microorganisms. Readers will also find the latest insights into the preservation of vesicular-arbuscular (VA) fungi and ecology, diversity and conservation of endophytes, and entamopathogenic fungi. Microbes of animal and dairy origin, their preservation and biosafety issues are also explored. Microorganisms are the silent and unseen majority of life on Earth, and are characterized by a high degree of genetic and metabolic diversity. It is well documented that no branch of science or society is unaffected by microbial interventions. Researchers have documented microorganisms from such extreme and unique environments as deserts and hydrothermal vents, and with specific traits that are currently being exploited in agriculture, industry, medicine and biotechnological applications. Such great potential can only be found in microorganisms. The aim of this book - the first entirely devoted to the conservation of microorganisms, and to regulatory mechanisms for access and benefits sharing as per Biological Diversity (BD) Act 2002 - is to promote awareness of our world's microbial wealth, and to introduce readers to strategies and methodologies for the conservation of microorganisms, which could ultimately save human life on Earth.

Introduction to Adsorption - Basics, Analysis, and Applications (Paperback): Chi Tien Introduction to Adsorption - Basics, Analysis, and Applications (Paperback)
Chi Tien
R3,984 R3,783 Discovery Miles 37 830 Save R201 (5%) Ships in 10 - 15 working days

Introduction to Adsorption: Basics, Analysis, and Applications presents adsorption basics that are relevant and essential to its application, including data analysis, interpretation and design calculations. The book deliberately keeps background information to a minimum, instead comprehensively covering adsorption of liquid solutions, the difference between equilibrium individual solute uptake and surface excess, a general discussion of adsorbate uptake mechanisms and uptake rate expression, uptake steps, performance models and their generalizations, application of performance models, and design methods based on the constant behavior assumption and unused bed length concept.

Pet-to-Man Travelling Staphylococci - A World in Progress (Paperback): Vincenzo Savini Pet-to-Man Travelling Staphylococci - A World in Progress (Paperback)
Vincenzo Savini
R2,795 R2,627 Discovery Miles 26 270 Save R168 (6%) Ships in 10 - 15 working days

Pet-to-Man Travelling Staphylococci: A World in Progress explores Staphylococci, a dangerous pathogen that affects both humans and animals with a wide range of infection states. This bacteria can spread rapidly as a commensal organism in both humans and pets, and is an agent of disease. Staphylococci are potentially highly virulent pathogens which require urgent medical attention. In addition, Staphylococci remain a threat within hospital environments, where they can quickly spread across a patient population. This book explores the organisms' resistance to many compounds used to treat them, treatment failure and multidrug resistant staphylococci, amongst other related topics.

Emerging Technologies in Food Science - Focus on the Developing World (Hardcover, 1st ed. 2020): Monika Thakur, V.K. Modi Emerging Technologies in Food Science - Focus on the Developing World (Hardcover, 1st ed. 2020)
Monika Thakur, V.K. Modi
R2,688 Discovery Miles 26 880 Ships in 18 - 22 working days

This book provides a comprehensive review of recent innovations in food science that are being used to tackle the challenges of food safety, nutritional security and sustainability. With a major focus on developing nations, like India, the book is divided into four main sections. The first section provides an overview of the food industry, while the second explores food safety in various segments, with an interesting account of street food safety - an important, yet often neglected aspect for safety parameters. The third section, on nutritional security and sustainability, explores various ways of maximizing nutrition and optimizing waste management in the food industry. The book closes with a section on emerging technologies and innovations, which introduces readers to some of the latest technologies in the food industry, including advances in food processing, packaging, nanotechnology, etc. The topics have been divided into 25 different chapters, which offer a diverse blend of perspectives on innovations in the developing world. Ideally suited for students and researchers in the food sciences, the book is also an interesting read for industry experts in Food Science and Technology.

Bacterial Chemosensing - Methods and Protocols (Hardcover, 1st ed. 2018): Michael D. Manson Bacterial Chemosensing - Methods and Protocols (Hardcover, 1st ed. 2018)
Michael D. Manson
R3,377 Discovery Miles 33 770 Ships in 10 - 15 working days

This volume covers a wide range of up-to-date technologies that have been successfully applied to study the chemosensing behavior of the traditional model species, such as Escherichia coli and Salmonella typhimurium, while being also applicable to a wide spectrum of other species. Beginning with an introduction, the sections of the book explore methods for studying bacterial chemotaxis at the population and whole-cell levels, in vivo analysis of receptor function, cryo-EM methods for studying chemoreceptor structure, as well as intracellular movement of chemosensory proteins, high-throughput methods to screen for novel chemoeffectors, and chemical tools and computer simulations for analyzing chemotaxis. Written for the highly successful Methods in Molecular Biology series, chapters include brief introductions to their topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips for troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Bacterial Chemosensing: Methods and Protocols provides an extensive repertoire of approaches that can be extended to understanding chemotaxis, in particular, and chemosensing, in general, in the context of the enormously varied lifestyles adopted in the larger bacterial world.

Microbial Ecology of Extreme Environments (Hardcover, 1st ed. 2017): Caroline Chenard, Federico M. Lauro Microbial Ecology of Extreme Environments (Hardcover, 1st ed. 2017)
Caroline Chenard, Federico M. Lauro
R3,623 R3,363 Discovery Miles 33 630 Save R260 (7%) Ships in 10 - 15 working days

This book explores microbial lifestyles, biochemical adaptations, and trophic interactions occurring in extreme environments. By summarizing the latest findings in the field it provides a valuable reference for future studies. Spark ideas for biotechnological and commercial exploitation of microbiomes at the extremes of life are presented. Chapters on viruses complement this highly informative book. In a vertical journey through the microbial biosphere it covers aspects of cold environments, hot environments, extreme saline environments, and extreme pressure environments, and more. From the deep sea, through polar deserts, up to the clouds in the air - the diversity of microbial life in all habitats is described, explored, and comprehensively reviewed. Possible biotechnical applications are discussed. This book aims to provide a useful reference for those who want to start a research program in extreme microbiology and, hopefully, inspire new research directions.

Aquaculture Microbiology (Hardcover, 1st ed. 2023): John Thomas, Natarajan Amaresan Aquaculture Microbiology (Hardcover, 1st ed. 2023)
John Thomas, Natarajan Amaresan
R4,640 Discovery Miles 46 400 Ships in 10 - 15 working days

This volume details techniques involved to study aquatic pathogens that cause infections, especially in fish. Chapters guide readers through a wide range of basic and advanced methods, viral and fungal pathogens, probiotic bacteria, treatment of pathogens using seaweed extract, medicinal plant extracts, and actinomycetes. Authoritative and cutting-edge, Aquaculture Microbiology aims to be a useful practical guide to researches to help further their study in this field. 

Advances in Applied Microbiology, Volume 90 (Hardcover): Geoffrey Michael Gadd, Sima Sariaslani Advances in Applied Microbiology, Volume 90 (Hardcover)
Geoffrey Michael Gadd, Sima Sariaslani
R3,082 Discovery Miles 30 820 Ships in 10 - 15 working days

A compilation of up to date reviews of topics in biotechnology and medical field.

Confocal Raman Microscopy (Hardcover, 2nd ed. 2018): Jan Toporski, Thomas Dieing, Olaf Hollricher Confocal Raman Microscopy (Hardcover, 2nd ed. 2018)
Jan Toporski, Thomas Dieing, Olaf Hollricher
R6,607 Discovery Miles 66 070 Ships in 10 - 15 working days

This second edition provides a cutting-edge overview of physical, technical and scientific aspects related to the widely used analytical method of confocal Raman microscopy. The book includes expanded background information and adds insights into how confocal Raman microscopy, especially 3D Raman imaging, can be integrated with other methods to produce a variety of correlative microscopy combinations. The benefits are then demonstrated and supported by numerous examples from the fields of materials science, 2D materials, the life sciences, pharmaceutical research and development, as well as the geosciences.

Nano-food Engineering - Volume One (Hardcover, 1st ed. 2020): Umesh Hebbar, Shivendu Ranjan, Nandita Dasgupta, Raghvendra Kumar... Nano-food Engineering - Volume One (Hardcover, 1st ed. 2020)
Umesh Hebbar, Shivendu Ranjan, Nandita Dasgupta, Raghvendra Kumar Mishra
R4,747 Discovery Miles 47 470 Ships in 18 - 22 working days

This extensive and singular work focuses on current applications of nanotechnology in food systems. The functionality and applicability of food-related nanotechnology is covered in depth, presenting a view on the food processing, packaging,storage and safety assessment of nanotechnology in the food industry. Multiple nanostructures are covered, each with their specific ingredient choice, production strategy, functionality and application in food engineering. Individual chapters focus on current processing methods and applications of nanotechnology in foods. Nano-food Engineering Volume One brings together panels of highly accomplished experts in the field of composites, nanotechnology and chemical engineering and food technology. The work encompasses basic studies and addresses novel issues, covering all engineering aspects, opportunities and challenges and solutions of nano-foods.

Advanced Techniques for Studying Microorganisms in Extreme Environments (Hardcover): Etienne Yergeau Advanced Techniques for Studying Microorganisms in Extreme Environments (Hardcover)
Etienne Yergeau
R3,639 Discovery Miles 36 390 Ships in 10 - 15 working days

This book will highlight advanced techniques that were recently used for studying microorganisms in extreme environments. Recent technological leaps in the study of microorganisms in the environment now make it possible to comprehensively study microbes in the environment. Extreme environments could benefit from the application of these techniques, but many challenges such as low biomass, low activity and slow growth has prevented their wide adoption. This book will review recent application of state-of-the-art techniques in extreme environments, helping researcher and graduate students get a better knowledge of the tools available.

Advanced Vaccine Research - Methods for the Decade of Vaccines (Hardcover): Fabio Bagnoli, Rino Rappuoli Advanced Vaccine Research - Methods for the Decade of Vaccines (Hardcover)
Fabio Bagnoli, Rino Rappuoli
R5,325 Discovery Miles 53 250 Ships in 18 - 22 working days
Biosensing and Micro-Nano Devices - Design Aspects and Implementation in Food Industries (Hardcover, 1st ed. 2022): Pranjal... Biosensing and Micro-Nano Devices - Design Aspects and Implementation in Food Industries (Hardcover, 1st ed. 2022)
Pranjal Chandra
R6,551 Discovery Miles 65 510 Ships in 18 - 22 working days

This book reviews applications of nanomaterial and nanodevices in the food industry. It also discusses the advanced bioanalytical techniques, including Enzyme-Linked Immunosorbent Assay (ELISA), immunoanalytical techniques, and monoclonal antibody-based immunological techniques for detecting food adulterations and allergens. It comprehensively covers electrode modification and nano-engineered fabrication of biosensors to enhance their functionalities for utilization in food industries. The book highlights the utilization of nanobiosensors for food safety and quality analysis, such as detection of toxin, food-borne pathogen, allergen, evaluation of toxicity etc. Further, it also summarizes the recent advances in nanodevices such as nano-systems, nano-emulsions, nanopesticides, and nanocapsules and their applications in the food industry. Lastly, it covers nanomaterial-based sensors for drug analysis in diverse matrices. It serves as an invaluable source of information for professionals, researchers, academicians, and students related to food science and technology.

Pesticide Residue in Foods - Sources, Management, and Control (Hardcover, 1st ed. 2017): Mohidus Samad Khan, Mohammad Shafiur... Pesticide Residue in Foods - Sources, Management, and Control (Hardcover, 1st ed. 2017)
Mohidus Samad Khan, Mohammad Shafiur Rahman
R4,275 Discovery Miles 42 750 Ships in 10 - 15 working days

This book presents an in depth study of different aspects of pesticide use in food production. The text covers the sources of pesticide residues in foods, relevant health and environmental concerns, degradation of pesticides after their use, and available laws and regulations to regulate pesticide use. In addition, different pesticide management techniques, such as: reduction of pesticide residues in grains and foods, alternatives to conventional pesticides, and prospects of organic farming are also covered. Pesticide Residue in Foods: Sources, Management, and Control aims to raise awareness of the proper use of these chemicals in order to lower residue in foods and reduce risk for consumers.

Preclinical Evaluation of Antimicrobial Nanodrugs (Hardcover, 1st ed. 2020): Juan Bueno Preclinical Evaluation of Antimicrobial Nanodrugs (Hardcover, 1st ed. 2020)
Juan Bueno
R2,653 Discovery Miles 26 530 Ships in 18 - 22 working days

Translational medicine addresses the gap between research and the clinical application of new discoveries. To efficiently deliver new drugs to care centers, a preclinical evaluation, both in vitro and in vivo, is required to ensure that the most active and least toxic compounds are selected as well as to predict clinical outcome. Antimicrobial nanomedicines have been shown to have higher specificity in their therapeutic targets and the ability to serve as adjuvants, increasing the effectiveness of pre-existing immune compounds. The design and development of new standardized protocols for evaluating antimicrobial nanomedicines is needed for both the industry and clinical laboratory. These protocols must aim to evaluate laboratory activity and present models of pharmacokinetic-pharmacodynamic and toxicokinetic behavior that predict absorption and distribution. Likewise, these protocols must follow a theranostics approach, be able to detect promising formulations, diagnose the infectious disease, and determine the correct treatment to implement a personalized therapeutic behavior. Given the possibilities that nanotechnology offers, not updating to new screening platforms is inadequate as it prevents the correct application of discoveries, increasing the effect of the valley of death between innovations and their use. This book is structured to discuss the fundamentals taken into account for the design of robust, reproducible and automatable evaluation platforms. These vital platforms should enable the discovery of new medicines with which to face antimicrobial resistance (RAM), one of the great problems of our time.

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