Materials for Biomedical Engineering: Absorbable Polymers provides a detailed and comprehensive review of recent progress in absorbable biopolymers and their impact on biomedical engineering. The book's main focus lies in their classification, processing, properties and performance, biocompatibility, and their applications in tissue engineering, drug delivery, bone repair and regenerative medicine. The most up-to-date methods used to obtain such polymers and how to improve their properties is discussed in detail. This book provides readers with a comprehensive and updated review of the latest research in the field of absorbable polymers for biomedical applications.

Materials for Biomedical Engineering: Bioactive Materials for Antimicrobial, Anticancer, and Gene Therapy offers an up-to-date perspective on recent research findings regarding the application and use of these materials for disease treatment and prevention. Various types of currently investigated bioactive materials, including therapeutic nanostructures and antimicrobial hydrogels are discussed, as are their properties, impact and future role in therapeutic applications. The book will be extremely useful for new researchers who want to explore more information on the use of bioactive materials or for more experienced researchers who are interested in new trends and specific applications.

Polysaccharide Carriers for Drug Delivery presents the latest information on the selection of safe materials. Due to reported safety profiles on polysaccharides; they have been the natural choice for investigation. A wide variety of drug delivery and biomedical systems have been studied, however, the related information either concept-wise or application-oriented is scattered, therefore becoming difficult for readers and researchers to digest in a concise manner. This gathering of information will help readers easily comprehend the subject matter.

Functional Polysaccharides for Biomedical Applications examines the fundamentals and properties of these natural materials and their potential biomedical applications. With an emphasis on therapeutic and sensing applications, the book also reviews how polysaccharides can be modified for tissue engineering applications. Sections discuss the basics of polysaccharides, give an overview of the potential applications, look at novel materials and technologies for use in tissue regeneration and therapeutics, and detail current biomedical applications. With a strong focus on materials, engineering and applications, this book is a valuable resource for those with an interest in harnessing the biomedical potential of natural polymers.

Biomaterials for Skin Repair and Regeneration examines a range of materials and technologies used for regenerating or repairing skin. With a strong focus on biomaterials and scaffolds, the book also examines the testing and evaluation pathway for human clinical trials. Beginning by introducing the fundamentals on skin tissue, the book goes on to describe contemporary technology used in skin repair as well as currently available biomaterials suitable for skin tissue repair and regeneration. Skin tissue engineering and the ideal requirements to take into account when developing skin biomaterials are discussed, followed by information on the individual materials used for skin repair and regeneration. As evaluation of biomaterials in animal models is mandatory before proceeding into human clinical trials, the book also examines the different animal models available. With a strong focus on materials, engineering, and application, this book is a valuable resource for materials scientists, skin biologists, and bioengineers with an interest in tissue engineering, regeneration, and repair of skin.

Functional Nanostructured Interfaces for Environmental and Biomedical Applications provides an overview on the characteristics of nanostructured interfaces and their processing technologies for a wide range of applications in the sensing, photocatalytic and bioengineering areas. The book focuses on the fundamentals of multifunctional nanostructured interfaces and their associated technologies, including versatile technologies, such as colloidal lithography, scanning probe techniques and laser nanostructuring, which can be used to obtain multifunctional 2D and 3D nanotextured interfaces. The book provides multidisciplinary chapters, summarizes the current status of the field, and covers important scientific and technological developments made over past decades. As such, it is an invaluable reference to those working in the design of novel nanostructured materials.

Advances and Applications of Partitioning Bioreactors, Volume 54, presents an updated reference in the field of partitioning bioreactors, addressing the relevance of kinetic determination, cell deactivation and transport phenomena from an engineering point-of-view. Topics covered in this new release include Mass transport phenomena in partitioning bioreactors, Modelling and design of partitioning bioreactors, Population balances for partitioning bioreactors, Solid-liquid partitioning bioreactors for industrial wastewater treatment, Multiphase bioreactors in the Food Industry, Multiphase bioreactors in the pharmaceutical industry, Biological treatment of gas pollutants in partitioning bioreactors, Hydrocarbon biodegradation using airlift bioreactors, and more.

Theranostic Bionanomaterials is an invaluable study of recent advances and trends in the development and application of functional bionanomaterials for theranostic applications. This book describes the design and characterization of nanomaterials which exhibit distinctive physical, chemical and biological properties and discusses how these functional nanomaterials enable the precise manipulation of architectural, physical and biochemical cell microenvironments in vitro. In addition, it covers how they can act as the carriers of diagnostic or therapeutic agents, thus providing new pathways or strategies for disease diagnosis and treatment. Specific chapters discuss protein delivery, drug delivery, tissue regeneration, bioimaging, biodetection, and much more. This book will be a critical resource for those involved in cutting-edge research in theranostics bionanomaterial.

BIG DATA ANALYTICS AND MACHINE INTELLIGENCE IN BIOMEDICAL AND HEALTH INFORMATICS Provides coverage of developments and state-of-the-art methods in the broad and diversified data analytics field and applicable areas such as big data analytics, data mining, and machine intelligence in biomedical and health informatics. The novel applications of Big Data Analytics and machine intelligence in the biomedical and healthcare sector is an emerging field comprising computer science, medicine, biology, natural environmental engineering, and pattern recognition. Biomedical and health informatics is a new era that brings tremendous opportunities and challenges due to the plentifully available biomedical data and the aim is to ensure high-quality and efficient healthcare by analyzing the data. The 12 chapters in Big Data Analytics and Machine Intelligence in Biomedical and Health Informatics cover the latest advances and developments in health informatics, data mining, machine learning, and artificial intelligence. They have been organized with respect to the similarity of topics addressed, ranging from issues pertaining to the Internet of Things (IoT) for biomedical engineering and health informatics, computational intelligence for medical data processing, and Internet of Medical Things (IoMT). New researchers and practitioners working in the field will benefit from reading the book as they can quickly ascertain the best performing methods and compare the different approaches. Audience Researchers and practitioners working in the fields of biomedicine, health informatics, big data analytics, Internet of Things, and machine learning.

The use of inducible gene expression systems is a rapidly developing area of plant molecular biological research. There is considerable interest in the use of these systems as research tools, not only because they allow expression of genes which may be, for example, developmentally lethal, but also because they allow for controlled experiments to be performed in a true isogenic background. They also have the potential to provide a means by which desired characters are expressed in field-based systems in the future.

Practical Techniques in Molecular Biotechnology intends to familiarise students with the basics of the well-known experiments of molecular biotechnology and related courses like chemical biotechnology and cell biology. The content of the book will be useful in strengthening the basic skills and help students to apply the concepts to real-world problems. This book emphasises important concepts like bioanalytical techniques, biochemical analysis of proteins, recombinant DNA, and protein technology etc. The text will help students to understand the theoretical aspects of the techniques and provide experience with hands-on techniques to demonstrate practical troubleshooting and data analysis. The text is supported with diagrams, data, summaries for the quick recap and appendices with useful protocols and calculation methods.

Nano-Biopesticides Today and Future Perspectives is the first single-volume resource to examine the practical development, implementation and implications of combining the environmentally aware use of biopesticides with the potential power of nanotechnology. While biopesticides have been utilized for years, researchers have only recently begun exploring delivery methods that utilize nanotechnology to increase efficacy while limiting the negative impacts traditionally seen through the use of pest control means. Written by a panel of global experts, the book provides a foundation on nano-biopesticide development paths, plant health and nutrition, formulation and means of delivery. Researchers in academic and commercial settings will value this foundational reference of insights within the biopesticide realm.

The bioactivity potential of marine polysaccharides has long been considered an underexploited aspect. These molecules found in seaweed, microalgae, bacteria, and animal fish (shellfish, mollusks, etc.) and the derived oligosaccharides need to be explored thoroughly with an interdisciplinary approach. They are an extraordinary source of chemical diversity, and the literature highlights many applicative fields, including the food industry, cosmetics, biomedicine, agriculture, environmental protection, wastewater management, etc. More recently, a new challenge has emerged: the exploitation of marine biomass as the source of sustainable energy to participate in the future replacement of fossil resources. Enzymatic Technologies for Marine Polysaccharides provides insight into the recent research developments of marine polysaccharides and their current and potential applications. The first section of the book explores the diversity of marine polysaccharides from various angles, including a description of the chemical complexity and current applications and new perspectives in food, pharmaceutical, cosmetics, and biomaterials offered by recent research. Efficient valorization of the marine polysaccharide biomass requires a rigorous analysis of the polysaccharides structure and their biological properties. The second section of the book concerns the development of extraction techniques and the improvement of the methods aimed at the characterization of their structure and function. Finally, the third and last section of the book articulates the enzymatic technologies from the discovery of novel enzymes to their production pipelines related to the fields of biorefinery, food, pharmaceutics, and other fine chemicals. Presents the latest research in marine oligosaccharides and polysaccharides Written by world-class researchers in marine enzyme technology Discusses the latest developments in extraction methods Presents a detailed overview of enzymatic routes for modification, production, and synthesis of marine oligosaccharides Contains extensive references at the end of each chapter to enhance further study

Polysaccharide-Based Hydrogels: Synthesis, Characterization and Applications looks at the synthesis, characterization and application of polysaccharide-based materials in a broad array of fields. The book discusses the role of polysaccharides in the preparation of hydrogels, the use of hydrogel-based green materials, and their applications in biomedical applications, drug delivery, water purification techniques, food industries, agricultural fields, and pharmaceuticals applications. Written by leading experts in this field, this book will be a valuable reference for scientists, academicians, researchers, technologists, consultants and policymakers.

Time delayed (lagged) variables are an inherent feature of biological/physiological systems. For example, infection from a disease may at first be asymptomatic, and only after a delay is the infection apparent so that treatment can begin.Thus, to adequately describe physiological systems, time delays are frequently required and must be included in the equations of mathematical models. The intent of this book is to present a methodology for the formulation and computer implementation of mathematical models based on time delay ordinary differential equations (DODEs) and partial differential equations (DPDEs). The DODE/DPDE methodology is presented through a series of example applications, particularly in biomedical science and engineering (BMSE). The computer-based implementation of the example models is explained with routines coded (programmed) in R, a quality, open-source scientific computing system that is readily available from the Internet. Formal mathematics is minimized, e.g., no theorems and proofs. Rather, the presentation is through detailed examples that the reader/researcher/analyst can execute on modest computers. The DPDE analysis is based on the method of lines (MOL), an established general algorithm for PDEs, implemented with finite differences. The example applications can first be executed to confirm the reported solutions, then extended by variation of the parameters and the equation terms, and even the forumulation and use of alternative DODE/DPDE models. * Introduces time delay ordinary and partial differential equations (DODE/DPDEs) and their numerical computer-based integration (solution) * Illustrates the computer implementation of DODE/DPDE models with coding (programming) in R, a quality, open-source scientific programming system readily available from the Internet * Applies DODE/DPDE models to biological/physiological systems through a series of examples * Provides the R routines for all of the illustrative applications through a download link * Facilitates the use of the models with reasonable time and effort on modest computers

Proponents of Integrated Pest Management (IPM) advocate its use to reduce or eliminate the use of chemical pesticides in agriculture, since excessive pesticide use may be a threat to both human health and the environment. Proponents of biotechnology believe that the use of novel products, such as transgenic plants with insect resistance, will reduce the need for chemical pesticides. However the use of such novel products within IPM systems may also create potential risks. This volume reviews such issues and discusses the potential benefits of and constraints to the applications of biotechnology in IPM systems, especially in developing countries. It also considers the related policy issues confronting decision-makers in national agricultural research systems and international development agencies. The book consists of revised versions of papers presented at a conference hosted by the Rockefeller Foundation and held in Bellagio, Italy in October 1993.

Alumina Ceramics: Biomedical and Clinical Applications examines the extraordinary material, Alumina, and its use in biomedicine and industry. Sections discuss the fundamentals of Alumina Ceramics, look at the various industrial applications, and examine a variety of medical applications. Readers will find this to be an invaluable and unique resource for researchers, clinical professionals, engineers, and advanced level students. Alumina ceramics are a leading biomaterial used for specialist medical applications, such as bionic implants and tissue engineering, and the only biomaterial commercially viable for use as bearings for orthopedic hip replacements. As such, this book is a timely resource on the topics discussed.

Biotech Juggernaut: Hope, Hype, and Hidden Agendas of Entrepreneurial BioScience relates the intensifying effort of bioentrepreneurs to apply genetic engineering technologies to the human species and to extend the commercial reach of synthetic biology or "extreme genetic engineering." In 1980, legal developments concerning patenting laws transformed scientific researchers into bioentrepreneurs. Often motivated to create profit-driven biotech start-up companies or to serve on their advisory boards, university researchers now commonly operate under serious conflicts of interest. These conflicts stand in the way of giving full consideration to the social and ethical consequences of the technologies they seek to develop. Too often, bioentrepreneurs have worked to obscure how these technologies could alter human evolution and to hide the social costs of keeping on this path. Tracing the rise and cultural politics of biotechnology from a critical perspective, Biotech Juggernaut aims to correct the informational imbalance between producers of biotechnologies on the one hand, and the intended consumers of these technologies and general society, on the other. It explains how the converging vectors of economic, political, social, and cultural elements driving biotechnology's swift advance constitutes a juggernaut. It concludes with a reflection on whether it is possible for an informed public to halt what appears to be a runaway force.

Handbook of Polymers in Medicine combines core concepts and advanced research on polymers, providing a better understanding of this class of materials in medicine. The book covers all aspects of medical polymers from characteristics and biocompatibility, to the diverse array of applications in medicine. Chapters cover an introduction to polymers in medicine and the challenges associated with biocompatibility in human tissue, polyurethane and supramolecular polymers and their specific applications in medicine, from tissue regeneration to orthopedic surgery and cancer therapeutics. This book offers an interdisciplinary approach that will appeal to researchers in a range of disciplines, including biomedical engineering, materials science, chemistry, pharmacology and translational medicine. The book will also make a useful reference for clinicians and those in medical fields who are interested in materials for medical applications, as well as R&D groups involved in medical device design.

Musculoskeletal Disorders Hands-on guidance and tools for the prevention of musculoskeletal injuries in the workplace In Musculoskeletal Disorders: The Fatigue Failure Mechanism, a team of accomplished occupational health experts delivers an essential and incisive discussion of how musculoskeletal disorders (MSDs) develop and progress, as well as how they can be prevented and controlled. Offering a novel, evidence-based approach to this costly problem, the book has broad implications for employers, insurers, and other stakeholders in workplace health and safety. The authors identify new risk assessment approaches based on the cumulative effects of exposure to highly variable loading conditions. These new approaches can also be applied to evaluate the efficacy of job rotation scenarios and to quantify exoskeleton efficacy. The complexities associated with fatigue failure in biological environments are also explored in addition to suggested models for understanding how the body maintains musculoskeletal homeostasis. Readers will also find: Thorough introductions to the material properties of musculoskeletal tissues and the fundamental principles of fatigue failure analysis In-depth explorations of the structure and function of the musculoskeletal system and up-to-date epidemiological research on MSDs Comprehensive discussions of validated fatigue failure risk assessment methods, including continuous exposure assessment to better quantify injury risk Insightful treatments of remodeling and healing processes as they apply to MSD risk, as well as factors that impair the healing process, like stress, obesity, and aging Perfect for occupational and environmental health and safety (OEHS) professionals, Musculoskeletal Disorders: The Fatigue Failure Mechanism will also earn a place in the libraries of ergonomists, physical therapists, biomechanists, industrial hygienists, occupational physicians, orthopedists, and musculoskeletal disorder researchers.

Tissue engineering uniquely applies concepts and techniques from biology and engineering in order to heal or produce new tissues after disease or traumatic injury. A successful tissue engineer must have knowledge of cellular biology, cell signaling, extracellular matrix development, and tissue structure and integrate it with the application of stresses and strains, mass transfer, mechanical properties, and heat transfer. In order to train the next generation of successful tissue engineers, this text gives the reader a background in both the engineering and biology associated with tissue engineering. In reading this text, students will learn about these two different areas of study and how they can be integrated with one another to understand tissues in the human body and solve biomedical problems. Students will be introduced to definitions of engineering concepts, the practical use of stress-strain relationships, material strength, mass transfer, and heat transfer. Through examples and problems, students will apply engineering equations to medical and biomedical situations including actual tissue engineering problems. Students will be introduced to a variety of cell and tissue types and be given the background information necessary to apply the use of cells to the growth and development of new tissues. Students will learn how to select the proper material for the replacement of a particular tissue and why it is important to know about the mechanical properties and degradability of a material prior to implantation. Students will learn how the application of force, material selection, and changes in temperature can positively or negatively affect cell behavior and tissue development. Tissue structure will be described and students will learn about the direct relationship between the structure of a tissue and its properties.

Coronavirus Drug Discovery, Volume Two: Antiviral Agents from Natural Products and Nanotechnological Applications presents detailed information on drug discovery against COVID-19. Sections in this volume present chapters that focus on the various antiviral agents from natural products that have the propensity to be used as chemical scaffolds for the development of drugs against COVID-19. Also captured are the dietary sources of antioxidant bioactives that may help boost the immune system for the management of COVID-19. Other chapters describe the application of nanotechnology for efficient and effective delivery of drugs against COVID-19. Written by global team of experts, this book is an excellent resource for drug developers, medicinal chemists, pharmaceutical companies in R&D and research institutes in both academia and industry.

Nonlinear Control for Blood Glucose Regulation of Diabetic Patients: An LMI-Based Approach exposes readers to the various existing mathematical models that define the dynamics of glucose-insulin for Type 1 diabetes patients. After providing insights into the mathematical model of patients, the authors discuss the need and emergence of new control techniques that can lead to further development of an artificial pancreas. The book presents various nonlinear control techniques to address the challenges that Type 1 diabetic patients face in maintaining their blood glucose level in the safe range (70-180 mg/dl). The closed-loop solution provided by the artificial pancreas depends mainly on the effectiveness of the control algorithm, which acts as the brain of the system. APS control algorithms require a mathematical model of the gluco-regulatory system of the T1D patients for their design. Since the gluco-regulatory system is inherently nonlinear and largely affected by external disturbances and parametric uncertainty, developing an accurate model is very difficult.

Focusing on current and future uses of microbes as production organisms, this practice-oriented textbook complements traditional texts on microbiology and biotechnology. The editors have brought together leading researchers and professionals from the entire field of industrial microbiology and together they adopt a modern approach to a well-known subject. Following a brief introduction to the technology of microbial processes, the twelve most important application areas for microbial technology are described, from crude bulk chemicals to such highly refined biomolecules as enzymes and antibodies, to the use of microbes in the leaching of minerals and for the treatment of municipal and industrial waste. In line with their application-oriented topic, the authors focus on the "translation" of basic research into industrial processes and cite numerous successful examples. The result is a first-hand account of the state of the industry and the future potential for microbes in industrial processes. Interested students of biotechnology, bioengineering, microbiology and related disciplines will find this a highly useful and much consulted companion, while instructors can use the case studies and examples to add value to their teaching.

Advanced and Modern Approaches for Drug Delivery explores novel approaches currently used for drug delivery, including the must up-to-date techniques and technology. The approaches discussed allow pharmaceutical scientists to design effective drug delivery systems or devices for the management and treatment of numerous diseases and conditions. Detailed information on a wide variety of subjects, including dendrimers, lipid nanostructures, solid lipid nanoparticles, stimuli-responsive smart systems, self-assembled protein-drug nanoparticles, nanoconjugate formulations, nanofibers, iontophoretic systems, microneedle systems, ultra-sound triggered systems, targeted carrier-based intracellular delivery systems, resealed erythrocyte-based systems, 3 D-printing tool, site-specific monoclonal antibodies, and bio-inspired systems are all comprehensively discussed. With contributions from those in academia and industry, this book is an excellent reference for all those needing to understand drug delivery systems.