...a book worth having on the shelf to give a different perspective to many issues in environmental biotechnology. - J Chem Technol Biotechnol

Biopharmaceutics and Pharmacokinetics Considerations examines the history of biopharmaceutics and pharmacokinetics. The book provides a biopharmaceutics and pharmacokinetics approach to addressing issues in formulation development and ethical considerations in handling animals. Written by experts in the field, this volume within the Advances in Pharmaceutical Product Development and Research series deepens understanding of biopharmaceutics and pharmacokinetics within drug discovery and drug development. Each chapter delves into a particular aspect of this fundamental field to cover the principles, methodologies and technologies employed by pharmaceutical scientists, researchers and pharmaceutical industries to study the chemical and physical properties of drugs and the biological effects they produce.

Tailor-Made and Functionalized Biopolymer Systems: For Drug Delivery and Biomedical Applications covers the design and application of these functionalized and tailor-made biopolymers and biopolymer systems intended for drug delivery and biomedical applications. Various concepts, design protocols and biomedical applications of tailor-made biopolymer systems are covered, guiding the reader from theoretical knowledge to practical application. Authored by an array of experts from global institutions, this book offers an interdisciplinary approach to how tailor-made biopolymers lead to novel drug delivery and treatment solutions. This will be a useful reference to a broad audience, including biomedical engineers, materials scientists, pharmacologists and chemists.

Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an "inert" immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype. Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome offers a single, comprehensive reference on biomaterials for modulation of the host response, for materials scientists, tissue engineers and those working in regenerative medicine. This book details methods, materials and strategies designed to regulate the host immune response following surgical implantation and thus facilitate specific local cell infiltration and tissue deposition. There has been a dramatic transformation in our understanding of the role of the immune system, both innate and adaptive; these changes include recognition of the plasticity of immune cells, especially macrophages, cross-talk between the immune system and stem cells, and the necessity for in situ transition between inflammatory and regulatory immune cell phenotypes. The exploitation of these findings and the design and manufacture of new biomaterials is occurring at an astounding pace. There is currently no book directed at the interdisciplinary principles guiding the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response. The challenge for academia, industry, and regulatory agencies to encourage innovation while assuring safety and maximizing efficacy has never been greater. Given the highly interdisciplinary requirements for the design, manufacture and use of immunomodulatory biomaterials, this book will prove a useful single resource across disciplines.

Nanotechnology in Conservative Dentistry provides a detailed review of the use of nanotechnology in conservative dentistry, from diagnosis and restorative materials, through to tissue engineering and regeneration. This book covers fundamental topics in the field of conservative dentistry, including caries therapy, dentin reconstruction, pulp protection and more; each chapter reviews and discusses how nanotechnology can be implemented as a novel approach to traditional conservative dentistry techniques, exploring the many uses and advantages of this fast-growing technology. Various nanobiomaterials and technologies are covered, as well as assessment of the biocompatibility and toxicological risks of utilizing nanotechnology in dentistry. Nanotechnology in Conservative Dentistry will help dentists and materials science academics alike, understand the potential of nanotechnology in dentistry, building on and going beyond traditional concepts and techniques in this field.

Bloom Filter: A Data Structure for Computer Networking, Big Data, Cloud Computing, Internet of Things, Bioinformatics, and Beyond focuses on both the theory and practice of the most emerging areas for Bloom filter application, including Big Data, Cloud Computing, Internet of Things, and Bioinformatics. Sections provide in-depth insights on structure and variants, focus on its role in computer networking, and discuss applications in various research domains, such as Big Data, Cloud Computing, and Bioinformatics. Since its inception, the Bloom Filter has been extensively experimented with and developed to enhance system performance such as web cache. Bloom filter influences many research fields, including Bioinformatics, Internet of Things, computer security, network appliances, Big Data and Cloud Computing.

Bioinspired and Biomimetic Materials for Drug Delivery delves into the potential of bioinspired materials in drug delivery, detailing each material type and its latest developments. In the last decade, biomimetic and bioinspired materials and technology has garnered increased attention in drug delivery research. Various material types including polymer, small molecular, protein, peptide, cholesterol, polysaccharide, nano-crystal and hybrid materials are widely considered in drug delivery research. However, biomimetic and bioinspired materials and technology have shown promising results for use in therapeutics, due to their high biocompatibility and reduced immunogenicity. Such materials include dopamine, extracellular exosome, bile acids, ionic liquids, and red blood cell. This book covers each of these materials in detail, reviewing their potential and usage in drug delivery. As such, this book will be a great source of information for biomaterials scientists, biomedical engineers and those working in pharmaceutical research.

Microbial Biofilms: Challenges and Advances in Metabolomics Study, a volume in the Advances in Biotechnology and Bioengineering series, covers the metabolomic characteristics of bacterial biofilms and examines the techniques used in the analysis of the metabolomics of the biofilm, its formation and related infections. The book covers the metabolomics study of various types of biofilms and details new strategies in targeting metabolic pathways for inhibiting the biofilm. The book also details various types of metabolomics studies of biofilm formation such as oral biofilm and biofilm by various nosocomial organisms. Recent advancements on various aspects of metabolomics studies pertaining to biofilms, related infections, their pathogenesis, and present-day treatment strategies are also covered. This book will be a helpful resource to scientists and researchers engaged in studying the formation of biofilms based upon the metabolomics changes taking place within the organism and to clinicians and health professionals interested in chronic infections caused by the biofilm and related metabolomics studies.

Biological systems are extremely complex and have emergent properties that cannot be explained or even predicted by studying their individual parts in isolation. The reductionist approach, although successful in the early days of molecular biology, underestimates this complexity. As the amount of available data grows, so it will become increasingly important to be able to analyse and integrate these large data sets. This book introduces novel approaches and solutions to the Big Data problem in biomedicine, and presents new techniques in the field of graph theory for handling and processing multi-type large data sets. By discussing cutting-edge problems and techniques, researchers from a wide range of fields will be able to gain insights for exploiting big heterogonous data in the life sciences through the concept of 'network of networks'.

Reports up-to-date research developments on purifying and isolation large organic molecules. The text provides information on high-performance liquid chromatography and capillary electrophoresis (CE) as tools for analyzing biomacromolecules and developing new biochemical and medicinal compounds. It applies biochemical separation technology to the study of macromolecules such as proteins, polysaccharides, nucleic acids and more.

Genome Editing in Plants: Principles and Applications addresses the information of genome editing starting from principles and historical aspects to the latest advancements in the field. As genome-editing technology has emerged as promising and cutting edge, researchers around the world have started producing original research outputs, which have significantly improved our current understanding and potential of this technology. The initial chapters of this book describe different genome-editing tools as well as their principles and applications. Other chapters are dedicated to the present status and future applications of genome-editing techniques in various crop improvement programmes. Some of the advanced applications of CRISPR/Cas tools, such as base editing and RNA detection, along with regulatory aspects of genome-edited crops are described in detail. This book serves as a valuable resource to researchers in the field of crop improvement; graduate and postgraduate students engaged in plant molecular biology and biotechnology; academicians; and policy makers. Key Features: Addresses topics associated with historical development and principles of genome-editing technology Addresses basic mechanisms operating under each genome-editing technology Addresses its application in plants to design crops as per the current and future demands Addresses the regulatory mechanisms of genome-edited crops

Biotechnology has not stood still since 1991 when the first edition of Biotechnology - The Science and the Business was published. It was the first book to treat the science and business of technologyas an integrated subject and was well received by both students of biotechnology and business professionals. All chapters in this second edition have been updated and revised and some new chapters have been introduced, including one covering the use of molecular genetic techniques in forensic science. The book is a collection of contributions, by experts in their respective fields, that provides a realistic balance of science and business. A wide range of biotechnologies is included, covering such diverse fields as pesticides, the flavor and fragrance industry, oil production, fermentation and protein engineering to name but a few. On the business side, subjects include managing, financing, and regulation of biotechnology, both in Europe and the USA. Some knowledge of the science behind the technologies is assumed, as well as a layperson's view of buying and selling. As with the first edition, it is expected that this book will be of interest to biotechnology undergraduates, postgraduates and those working in the industry, along with students of business, economics, intellectual property law and communications.

This updated text explains how the advances on mammalian and plant genetics contribute to better therapeutics agents and more wholesome foods. It addresses such topics as new pharmaceutical agents, agribiotechnology, safety evaluation of biotechnology-derived drugs, food safety, nutritional science, and regulatory and environmental aspects of genetically-modified organisms. New to this edition are chapters on biotherapeutics and herbicide-resistant crops. It should be of interest to biotechnology, toxicologists, pharmaceutical scientists, environmental scientists and agriculturalists.

This research level reference book has been co-written by Enrico Drioli, perhaps one of the world's best known researchers into membrane technology. The application of membrane technology to chemical transformation and molecular separation are beginning to be exploited in the pharmaceutical science and biotechnology industries, but there is a need for researchers and students to have up-to-date literature - and this book provides it. The book will be of interest to students of chemistry, chemical engineering, pharmacy and biotechnology.

Green Biocomposites for Biomedical Engineering: Design, Properties, and Applications combines emergent research outcomes with fundamental theoretical concepts relevant to processing, properties and applications of advanced green composites in the field of biomedical engineering. The book outlines the design elements and characterization of biocomposites, highlighting each class of biocomposite separately. A broad range of biomedical applications for biocomposites is then covered, with a final section discussing the ethics and safety regulations associated with manufacturing and the use of biocomposites. With contributions from eminent editors and recognized authors around the world, this book is a vital reference for researchers in biomedical engineering, materials science and environmental science, both in industry and academia.

The book offers comprehensive coverage of the many essential topics in the subject including: Environmental factors and DNA damage Molecular mechanisms associated to DNA damage by various environmental ( Physical, Chemical and Biological) factors Synergistic effects of environmental factors Phytochemicals acting both as DNA protectants and genotoxicants Experimental models for study of genotoxic potential of environmental factors and protection by phytochemicals

Plant and Algal Hydrogels for Drug Delivery and Regenerative Medicine offers a materials-focused and systematic overview of biopolymeric hydrogels utilized for biomedical applications. The book details the synthesis and characterization of plant and algal-based hydrogels, with each chapter addressing a separate polysaccharide hydrogel type. Specific applications in drug delivery and regenerative medicine are also discussed, highlighting the efficacy, biocompatibility, benefits and challenges for each polysaccharide hydrogel subtype. There is increasing demand for biomaterials which reduce/prevent the host response, inflammation and rejection, hence this book provides a timely resource. Biopolymeric hydrogels have skyrocketed because of their necessity in in vivo applications. They create an environment similar to living tissue, which is both biocompatible and biodegradable. Plant and algal polysaccharides in particular are well-equipped with functional groups that are easily modified for beneficial results.

Polysaccharide-Based Nanocomposites for Gene Delivery and Tissue Engineering presents quantitative background on new polysaccharide nanocomposites in a clear and logical way, highlighting the most exciting applications in gene delivery and tissue engineering and their progress. The book focuses on the different types of polysaccharide nanocomposites for gene delivery and tissue engineering and covers polysaccharide hydrogels for tissue engineering and polysaccharide magnetic nanocomposites for gene delivery. Chapters cover various nanocomposites presented in twenty-one separate chapters. This book will be of great interest to all those researching the development and applications of polysaccharide-based nanocomposites for modeling. As polysaccharide-based nanocomposites promise cutting-edge applications in gene delivery and tissue engineering, with their development at the forefront of modern medicine, this book is a welcome title on this exciting science.

Bionanocomposites in Tissue Engineering and Regenerative Medicine explores novel uses of these in tissue engineering and regenerative medicine. This book offers an interdisplinary approach, combining chemical, biomedical engineering, materials science and pharmacological aspects of the characterization, synthesis and application of bionanocomposites. Chapters cover a broad selection of bionanocomposites including chitosan, alginate and more, which are utilized in tissue engineering, wound healing, bone repair, drug formulation, cancer therapy, drug delivery, cartilage regeneration and dental implants. Additional sections of Bionanocomposites in Tissue Engineering and Regenerative Medicine discuss, in detail, the safety aspects and circular economy of bionanocomposites - offering an insight into the commercial and industrial aspects of these important materials. Bionanocomposites in Tissue Engineering and Regenerative Medicine will prove a highly useful text for for those in the fields of biomedical engineering, chemistry, pharmaceutics and materials science, both in academia and industrial R&D groups.

Digital Twins for Healthcare: Design, Challenges and Solutions establishes the state-of-art in the specification, design, creation, deployment and exploitation of digital twins' technologies for healthcare and wellbeing. A digital twin is a digital replication of a living or non-living physical entity. When data is transmitted seamlessly, it bridges the physical and virtual worlds, thus allowing the virtual entity to exist simultaneously with the physical entity. A digital twin facilitates the means to understand, monitor, and optimize the functions of the physical entity and provide continuous feedback. It can be used to improve citizens' quality of life and wellbeing in smart cities and the virtualization of industrial processes.

While advances in marine biotechnology will certainly enhance our capabilities in the marine realm, what we learn there will doubtless provide new insight into the biology of freshwater and terrestrial organisms. This volume is a compilation of information that covers a wide range of animal groups. This book will be of interest not only to biotechnologists but also to aquaculturists, comparative animal physiologists, comparative endocrinologists, and developmental biologists.

Biomedical Applications of Electrospinning and Electrospraying describes the principles and laboratory set up for electrospinning and electrospraying, addressing a range of biomedical applications. Sections cover novel combinational approaches, such as electrospinning/spraying and 3D printing. Electrospinning has evolved from being a technique to prepare random networks of textile fibers to a technique to fabricate highly ordered patterns of biomedical materials of defined scale. The technological advancements in recent years with regard to the way the jet is facilitated, how the jet path is controlled, and how the fibers are collected have provided invaluable insights into controlled fabrication of a material of choice. Additionally, the electrospray technique has also evolved from being a technique to prepare food formulations to a technique to prepare cell encapsulated beads for transplantation in clinics. Several innovations in this line, such as those leading to core-shell materials have tremendously changed the way the technique is used. Thus, a combinational approach using electrospinning, electrospraying and 3D printing has emerged.

Master the design and operation of perfusion cell cultures with this authoritative reference. Discover the current state-of-the-art in the design and operation of continuous bioreactors, with emphasis on mammalian cell cultures for producing therapeutic proteins. Topics include the current market for recombinant therapeutic proteins, current industry challenges and the potential contribution of continuous manufacturing. Provides coverage of every step of process development and reactor operation, including small scale screening to lab-scale and scale-up to manufacturing scale. Illustrated through real-life case studies, this is a perfect resource for groups active in the cell culture field, as well as graduate students in areas such as chemical engineering, biotechnology, chemistry and biology, and to those in the pharmaceutical industry, particularly biopharma, biotechnology and food or agro industry.

This first volume of the Handbook of Biodiesel and Petrodiesel Fuels presents a representative sample of the population papers in the field of biodiesel fuels in general. Part I provides an overview of the research field on both biodiesel and petrodiesel fuels highlighting primary and secondary research fronts in these fields. Part II presents a representative sample of the population papers in the field of biooils covering major research fronts. The research on the biooils is a fundamental part of the research on the biodiesel fuels. The research in this field has intensified in recent years with the application of advanced catalytic technologies and nanotechnologies in both production and upgrading of biooils. It covers pyrolysis, hydrothermal liquefaction, and upgrading, and characterization and properties of biooils besides an overview of the research field. Part III presents a representative sample of the population papers in the field of biodiesel fuels in general covering major research fronts. The research in this field has progressed in the lines of production, properties, and emissions of biodiesel fuels. As in the case of biooils, catalysts and additives play a crucial role for the biodiesel fuels. It covers biomass-based catalyst-assisted biodiesel production, enzymatic biodiesel production, additives in biodiesel production, properties, characterization, performance, and policies of biodiesel fuels besides an overview of the research field. Part IV presents a representative sample of the population papers in the field of glycerol, biodiesel waste, covering major research fronts. The research in this field has intensified in recent years with the increasing volume of biodiesel fuels, creating eco-friendly solutions for these wastes of biodiesel fuels for producing valuable biofuels and biochemicals from glycerol. It covers biohydrogen and propanediol production from glycerol as a case study for bioenergy and biochemicals, respectively. This book will be useful to academics and professionals in the fields of Energy Fuels, Chemical Engineering, Physical Chemistry, Biotechnology and Applied Microbiology, Environmental Sciences, and Thermodynamics. Ozcan Konur is both a materials scientist and social scientist by training. He has published around 200 journal papers, book chapters, and conference papers. He has focused on the bioenergy and biofuels in recent years. In 2018, he edited Bioenergy and Biofuels, which brought together the work of over 30 experts in their respective field. He also edited the Handbook of Algal Science, Technology, and Medicine with a strong section on the algal biofuels in 2020.

This second volume of the Handbook of Biodiesel and Petrodiesel Fuels presents a representative sample of the population papers in the field of feedstock-specific biodiesel fuels. The research on feedstocks for biodiesel fuels has first focused on the edible oils as first-generation biodiesel fuels. However, the public concerns about the competition with foods based on these feedstocks and adverse impact on the ecological diversity and deforestation have resulted in the exploration of nonedible-oil-based biodiesel fuels as second-generation biodiesel fuels in the first instance. Due to the ecological and cost benefits of treating wastes, waste oil-based biodiesel fuels as third-generation biodiesel fuels have emerged. Furthermore, following a series of influential review papers, the research has focused on the algal oil-based biodiesel fuels in recent years. Since the cost of feedstocks in general constitutes 85% of the total biodiesel production costs, the research focused more on improving biomass and lipid productivity in these research fields. Furthermore, since water, CO2, and nutrients (primarily N and P) have been major ingredients for the algal biomass and lipid production, the research has also intensified in the use of wastewaters and flue gases for algal biomass production to reduce the ecological burdens and the production costs. Part 1 presents a representative sample of the population papers in the field of edible oil-based biodiesel fuels covering major research fronts. It covers soybean oil-based biodiesel fuels, palm oil-based biodiesel fuels, and rapeseed oil-based biodiesel fuels as case studies besides an overview paper. Part 2 presents a representative sample of the population papers in the field of nonedible oil-based biodiesel fuels covering major research fronts. It covers Jatropha oil-based biodiesel fuels, polanga oil-based biodiesel fuels, and moringa oil-based biodiesel fuels as case studies besides an overview paper. Part 3 presents a representative sample of the population papers in the field of waste oil-based biodiesel fuels covering major research fronts. It covers wastewater sludge-based biodiesel fuels, waste cooking oil-based biodiesel fuels, and microbial oil-based biodiesel fuels as case studies besides an overview paper. Part 4 presents a representative sample of the population papers in the field of algal oil-based biodiesel fuels covering major research fronts. It covers algal biomass production in general, algal biomass production in wastewaters, algal lipid production, hydrothermal liquefaction of algal biomass, algal lipid extraction, and algal biodiesel production besides an overview paper. This book will be useful to academics and professionals in the fields of Energy Fuels, Chemical Engineering, Physical Chemistry, Biotechnology and Applied Microbiology, Environmental Sciences, and Thermodynamics. Ozcan Konur is both a materials scientist and social scientist by training. He has published around 200 journal papers, book chapters, and conference papers. He has focused on the bioenergy and biofuels in recent years. In 2018, he edited 'Bioenergy and Biofuels', that brought together the work of over 30 experts in their respective field. He also edited 'Handbook of Algal Science, Technology, and Medicine' with a strong section on the algal biofuels in 2020.