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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Genetics (non-medical)

RNA 3D Structure Analysis and Prediction (Hardcover, 2012): Neocles Leontis, Eric Westhof RNA 3D Structure Analysis and Prediction (Hardcover, 2012)
Neocles Leontis, Eric Westhof
R5,695 R4,491 Discovery Miles 44 910 Save R1,204 (21%) Ships in 12 - 17 working days

With the dramatic increase in RNA 3D structure determination in recent years, we now know that RNA molecules are highly structured. Moreover, knowledge of RNA 3D structures has proven crucial for understanding in atomic detail how they carry out their biological functions. Because of the huge number of potentially important RNA molecules in biology, many more than can be studied experimentally, we need theoretical approaches for predicting 3D structures on the basis of sequences alone. This volume provides a comprehensive overview of current progress in the field by leading practitioners employing a variety of methods to model RNA 3D structures by homology, by fragment assembly, and by de novo energy and knowledge-based approaches.

Lung Stem Cells in the Epithelium and Vasculature (Hardcover, 2015 ed.): Amy Firth, Jason X.-J. Yuan Lung Stem Cells in the Epithelium and Vasculature (Hardcover, 2015 ed.)
Amy Firth, Jason X.-J. Yuan
R4,985 Discovery Miles 49 850 Ships in 12 - 17 working days

This book covers the identification and role of endogenous lung stem cells in health and disease, particularly the most recent advances. In addition, it discusses the rapidly growing field of stem cells and cell therapy as it relates to lung biology and disease as well as ex vivo lung bioengineering. Such approaches may provide novel therapeutic approaches for lung diseases. Human pluripotent stem cell differentiation to model the pulmonary epithelium and vasculature is also discussed. World-recognized scientists who specialize in studying both the lung epithelium and pulmonary vasculature contribute the chapters. Topics covered include: stem cell niches in the lung, the role of progenitor cells in fibrosis and asthma, iPSC in modeling lung disease, vascular repair by endothelial progenitor cells and circulating fibrocytes in pulmonary vascular remodeling. This volume of the Stem Cell Biology and Regenerative Medicine series is essential reading for researchers and clinicians interested in stem cells, lung biology and regenerative medicine. It is also an invaluable resource for advanced students studying cell biology, regenerative medicine and lung physiology.

Stem Cell Aging: Mechanisms, Consequences, Rejuvenation (Hardcover, 1st ed. 2015): Hartmut Geiger, Heinrich Jasper, Maria... Stem Cell Aging: Mechanisms, Consequences, Rejuvenation (Hardcover, 1st ed. 2015)
Hartmut Geiger, Heinrich Jasper, Maria Carolina Florian
R4,508 R3,650 Discovery Miles 36 500 Save R858 (19%) Ships in 12 - 17 working days

Aging of somatic stem cells reduces cell function and results in dysfunctional organs and tissues, making it an underlying cause of diseases associated with aging. It might even be the primary cause for age-associated attrition of tissue function in organs that heavily rely on stem cells for maintaining homeostasis, like the skin, blood and intestines. Understanding the molecular and cellular mechanisms involved is critical for developing approaches to attenuate stem cell aging and could pave the way for improved quality of life among the elderly. Written by highly prominent experts in the field, this book presents the current state of knowledge on these mechanisms. It offers insights into stem cell function, explains in detail the mechanisms of stem cell aging in model organisms as well as mammalian systems and describes related diseases and approaches to attenuating stem cell aging or achieving rejuvenation. The book is intended for all scientists and clinicians working with stem cells, aging mechanisms or age-related diseases.

Capillary Electrophoresis of Nucleic Acids (Hardcover, 2001 ed.): Keith R. Mitchelson, Jing Cheng Capillary Electrophoresis of Nucleic Acids (Hardcover, 2001 ed.)
Keith R. Mitchelson, Jing Cheng
R3,007 Discovery Miles 30 070 Ships in 10 - 15 working days

The development of PCR, which enables extremely small amounts of DNA to be amplified, led to the rapid development of a multiplicity of a- lytical procedures to utilize this new resource for analysis of genetic variation and for the detection of disease causing mutations. The advent of capillary electrophoresis (CE), with its power to separate and analyze very small amounts of DNA, has also stimulated researchers to develop analytical procedures for the CE format. The advantages of CE in terms of speed and reproducibility of analysis are manifold. Further, the high sensitivity of detection, and the ab- ity to increase sample throughput with parallel analysis, has led to the creation of a full range of analysis of DNA molecules, from modified DNA-adducts and single-strand oligonucleotides through to PCR-amplified DNA fragments and whole chromosomes. Capillary Electrophoresis of Nucleic Acids focuses on such analytical protocols, which can be used for detection and analysis of mutations and modification, from precise DNA loci through to entire genomes of organisms. Important practical considerations for CE, such as the choice of separation media, electrophoresis conditions, and the influence of buffer additives and dyes on DNA mobility, are discussed in several key chapters and within particular applications.

Handbook of RNA Biochemistry 2e (Hardcover, 2 Rev Ed): RK Hartmann Handbook of RNA Biochemistry 2e (Hardcover, 2 Rev Ed)
RK Hartmann
R9,018 Discovery Miles 90 180 Out of stock

The second edition of a highly acclaimed handbook and ready reference. Unmatched in its breadth and quality, around 100 specialists from all over the world share their up-to-date expertise and experiences, including hundreds of protocols, complete with explanations, and hitherto unpublished troubleshooting hints. They cover all modern techniques for the handling, analysis and modification of RNAs and their complexes with proteins. Throughout, they bear the practising bench scientist in mind, providing quick and reliable access to a plethora of solutions for practical questions of RNA research, ranging from simple to highly complex. This broad scope allows the treatment of specialized methods side by side with basic biochemical techniques, making the book a real treasure trove for every researcher experimenting with RNA.

Cardiac Gene Expression - Methods and Protocols (Hardcover, 2007 ed.): Jun Zhang, Gregg Rokosh Cardiac Gene Expression - Methods and Protocols (Hardcover, 2007 ed.)
Jun Zhang, Gregg Rokosh
R2,998 Discovery Miles 29 980 Ships in 10 - 15 working days

Cardiac Gene Expression: Methods and Protocols presents both cutting-edge and established methods for studying cardiac gene expression. The protocols provide a template for solid research, and cover the process through screening, analysis, characterization, and functional confirmation of novel genes or known genes with a new function.
Section I, Cardiac Gene Expression Profiling: The Global Perspective, discusses several different approaches to examining, identifying, and analyzing changes in transcriptome gene expression. Section II, Cardiac Gene Regulation: Gene-Specific mRNA Measurement in the Myocardium, outlines more sensitive and gene-targeted expression methods. Section III, Cardiac Gene Regulation: Promoter Characterization in the Myocardium, provides protocols for the study of underlying gene regulation mechanisms by focusing on the interaction of transcription factors with their cognate cis binding elements. Section IV, In Silico Assessment of Regulatory cis-Elements and Gene Regulation, and Section V, Cardiac Single Network Polymorphisms, emphasize new analytical approaches for deciphering the functional elements buried in the 3 billion nucleotides of the human genome and other model genomes. The concluding section, Gene Overexpression and Targeting in the Myocardium, highlights methods that facilitate overexpression or cardiac-specific targeted gene deletion.

Somaclonal Variation in Crop Improvement I (Hardcover, 1990 ed.): Professor Dr y. P. S. Bajaj Somaclonal Variation in Crop Improvement I (Hardcover, 1990 ed.)
Professor Dr y. P. S. Bajaj
R8,569 Discovery Miles 85 690 Ships in 12 - 17 working days

Genetic erosions in plant cell cultures, especially in chromosome number and ploidy level, have now been known for over 25 years. Until the mid -1970ssuch changes were consideredundesirable and thereforediscarded because the main emphasis wason clonal propagation and genetic stability of cultures. However, since the publication on somaclonal variation by Larkin and Scowcroft (1981) there has been a renewed interest to utilize these in vitro obtained variations for crop improvement. Studies conduc- ted during the last decade have shown that callus cultures, especially on peridical subculturing over an extended period of time, undergo morpho- logical and genetic changes, i. e. polyploidy, aneuploidy, chromosome breakage, deletions, translocations, gene amplification, inversions, muta- tions, etc. In addition, there are changes at the molecular and biochemical levelsincluding changes in the DNA, enzymes,proteins, etc. Suchchanges are now intentionally induced, and useful variants are selected. For instance in agricultural crops such as potato, tomato, tobacco, maize, rice and sugarcane, plants showing tolerance to a number of diseases, viruses, herbicides and salinity, have been isolated in cell cultures. Likewise induction of male sterility in rice, and wheat showing various levels of fer- tility and gliadin, have been developed in vitro. These academic excercises open new avenues for plant breeders and pathologists. Another area of tremendous commercial importance in the pharmaceuti- cal industry is the selection of cell lines showing high levels of medicinal and industrial compounds. Already high shikonin containing somaclones in Lithospermum are being used commercially.

Thermophiles: Biodiversity, Ecology, and Evolution - Biodiversity, Ecology, and Evolution (Hardcover, 2001 ed.): Anna-Louise... Thermophiles: Biodiversity, Ecology, and Evolution - Biodiversity, Ecology, and Evolution (Hardcover, 2001 ed.)
Anna-Louise Reysenbach, Mary Voytek, Rocco Mancinelli
R3,134 Discovery Miles 31 340 Ships in 10 - 15 working days

These are indeed exciting times to be a microbiologist. With one of the buzzwords of the past decade-"Biodiversity," and microbes are reveling in the attention as they represent by far most of the biodiversity on Earth. Microbes can thrive in almost any environment where there is an exploitable energy source, and, as a result, the possible existence of microbial life elsewhere in the solar system has stimulated the imaginations of many. Extremophiles have taken center stage in these investigations, and thermophiles have taken on the lead roles. Consequently, in the past decade there has been a surge of interest and research in the Ecology, Biology, and Biotechnology of microorganisms from thermal environments. Many of the foundations of thermophile research were laid in Yellowstone National Park, primarily by the research of Professor Thomas Brock's laboratory in the late 1960s and early 1970s. The upper temperature for life was debated, the first thermophilic archeum discovered (although it was only later shown to be an archeum by ribosomal cataloging), and the extremes of light, temperature, pH on the physiology of microorga nisms were explored. Interest in thermophiles increased steadily in the 1970s, and with the discovery of deep-sea hydrothermal vents in 1977, thermophilic research began its expo nential explosion. The development of Taq polymerase in the polymerase chain reaction (peR) focused interest on the biotechnological potential of thermophilic microorganisms and on the thermal features in Yellowstone National Park."

Conservation Genetics (Hardcover): Volker Loeschcke, Etc Conservation Genetics (Hardcover)
Volker Loeschcke, Etc
R2,529 Discovery Miles 25 290 Ships in 12 - 17 working days

This book aims at defining and reassessing the role of population genetics in conservation biology and seeks to identify the progress made in the field during the last decade. It deals with conservation genetics from several currently researched points of view, namely, ecological and demographic measures of rarity or population persistence, loss of genetic variation, inbreeding, reduced migration rates and increased selective pressures under stress and the role of social behaviour and metapopulation structure. The use of molecular variation as the basis of naming or selecting target taxa and some strategic decisions about genetic variance maximization in the conserved population or community units are analysed. Several case studies and scenarios illustrate the application of genetic information in conservation practices.

Developmental Instability: Its Origins and Evolutionary Implications - Proceedings of the International Conference on... Developmental Instability: Its Origins and Evolutionary Implications - Proceedings of the International Conference on Developmental Instability: Its Origins and Evolutionary Implications, Tempe, Arizona, 14-15 June 1993 (Hardcover, Partly reprinted from GENETICA, 89:1-3)
T. a. Markow
R5,881 Discovery Miles 58 810 Ships in 10 - 15 working days

Developmental Instability: Its Origins and Evolutionary Implications is a collection of papers and transcribed discussions from a conference held in Tempe, Arizona in June 1993. The papers represent a wide range of contributions, from the empirical to the theoretical, and include methods for measuring developmental instability across a variety of taxa and traits. This volume presents contrasting views on how to assess developmental instability as well as on the relationship of instability to genotypic factors, environmental factors and the action of natural and sexual selection. Readers will derive a working knowledge of the best way to assess developmental instability and will be able to design future work in an authoritative way.

Spermatogenesis - Methods and Protocols (Hardcover, 2013 ed.): Lori Barnard, Kenneth I. Aston Spermatogenesis - Methods and Protocols (Hardcover, 2013 ed.)
Lori Barnard, Kenneth I. Aston
R5,856 Discovery Miles 58 560 Ships in 10 - 15 working days

Deficiencies in sperm function are usually the result of spermatogenic defects. Spermatogenesis is a biologically complex and essential process during which spermatogonia undergo meiotic recombination, reduction of the genome to a haploid state, and extensive cellular modifications that result in a motile cell capable of traversing the female reproductive tract, withstanding various potential assaults to viability, and finally successfully fertilizing a mature oocyte to give rise to an embryo. Defects in any step of spermatogenesis or spermatogenesis can lead to male infertility, a disease that affects approximately 5-7% of the population."Spermiogenesis and Spermatogenesis: Methods and Protocols"details protocols used in the study of spermatogenesis, clinical analytical protocols, and basic techniques used in clinical andrology laboratories, such as obtaining accurate results for a sperm count, and advanced procedures, such as genome-wide genetic study tools and evaluation of nuclear proteins.Written in the successful"Methods in Molecular Biology "series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.

Authoritative and easily accessible, "Spermiogenesis and Spermatogenesis: Methods and Protocols"isunique in its breadth, and will be a useful reference for clinicians and researchers alike."

Peroxiredoxin Systems - Structures and Functions (Hardcover, 2007 ed.): Leopold Flohe, J.Robin Harris Peroxiredoxin Systems - Structures and Functions (Hardcover, 2007 ed.)
Leopold Flohe, J.Robin Harris
R5,787 Discovery Miles 57 870 Ships in 10 - 15 working days

This book contains a broad survey on the peroxiredoxins. It involves almost all groups that contributed significant insights into the emerging field. Coverage discusses the diverse biological roles of the new protein family in the context of other antioxidant systems like those based on heme or selenium catalysis. In addition, the book highlights related future perspectives.

Epitranscriptomics (Hardcover, 1st ed. 2021): Stefan Jurga, Jan Barciszewski Epitranscriptomics (Hardcover, 1st ed. 2021)
Stefan Jurga, Jan Barciszewski
R5,189 Discovery Miles 51 890 Ships in 12 - 17 working days

This book reviews a novel and exciting field of cellular and molecular biology called epitranscriptomics, which focuses on changes in an organism's cells resulting from the posttranscriptional modification of cellular RNA. RNA-binding proteins (RBPs) play a crucial role in these posttranscriptional modifications and also support several cellular processes necessary for maintaining RNA homeostasis. Exploring the mechanisms underlying RNA modifications and RBP function is an emerging area of biomedical research, taking the study of gene regulation a step beyond epigenetics. This book reveals that the RNA molecule is not just an information-carrying molecule with some secondary structures. Accordingly, how RNA is modified, regulated, packaged, and controlled is an important aspect. Leading experts address questions such as where the over 170 distinct posttranscriptional RNA modifications are located on the genome, what percentage of mRNAs and noncoding RNAs these modifications include, and how an RNA modification impacts a person's biology. In closing, the book reviews the role of RNA modifications and RBPs in a variety of diseases and their pathogenesis. Addressing some of the most exciting challenges in epitranscriptomics, this book provides a valuable and engaging resource for researchers in academia and industry studying the phenomena of RNA modification.

The Cold War Politics of Genetic Research - An Introduction to the Lysenko Affair (Hardcover, 2012 ed.): William Dejong-Lambert The Cold War Politics of Genetic Research - An Introduction to the Lysenko Affair (Hardcover, 2012 ed.)
William Dejong-Lambert
R2,933 Discovery Miles 29 330 Ships in 10 - 15 working days

This book uses the reaction of a number of biologists in the United States and Great Britain to provide an overview of one of the most important controversies in Twentieth Century biology, the "Lysenko Affair." The book is written for advanced undergraduate and graduate students of history/history of science. It covers a number of topics which are relevant to understanding the sources and dimensions of the Lysenko controversy, including the interwar eugenics movement, the Scopes Trial, the popularity of Lamarckism as a theory of heredity prior to the synthesis of genetics and Natural Selection, and the Cold War. The book focuses particularly on portrayals-both positive and negative-of Lysenko in the popular press in the U.S. and Europe, and thus by extension the relationship between scientists and society. Because the Lysenko controversy attracted a high level of interest among the lay community, it constitutes a useful historical example to consider in context with current topics that have received a similar level of attention, such as Intelligent Design or Climate Change.

Leishmania - After the Genome (Hardcover): Peter J. Myler, Nicolas Fasel Leishmania - After the Genome (Hardcover)
Peter J. Myler, Nicolas Fasel
R5,796 Discovery Miles 57 960 Ships in 10 - 15 working days

Leishmania is a vector-borne pathogenic parasite found in 88 countries worldwide and is the causative agent of leishmaniasis. The different Leishmania species infect macrophages and dendritic cells of the host immune system, causing symptoms that range from disfiguring cutaneous and mucocutaneous lesions, widespread destruction of mucous membranes, or visceral disease affecting the haemopoetic organs. The recent publication of the complete genome sequences of three different Leishmania species provides new insights into this leading pathogen and presents scientists with an exciting resource to improve the understanding of its complex molecular and cellular biology. In this book, internationally recognized Leishmania experts critically review the most important aspects of current Leishmania research, providing the first coherent picture of the organism's molecular and cellular biology since the publication of the genome sequence. Chapters are written from a molecular and genomic perspective and discuss in depth Leishmania-specific aspects of trypanosomatid biology and pathology. Topics include: diagnosis and epidemiology, genome structure and content, regulation of gene expression, the Leishmania proteome, the Leishmania metabolome, Leishmania differentiation, interaction with the sand fly vector, drug discovery, drug resistance, and much more. This will be essential reading for all researchers working with Leishmania, trypanosomes, and protozoa; and is recommended for all biology and medical libraries.

Genetics and Eugenics; a Text-book for Students of Biology and a Reference Book for Animal and Plant Breeders (Hardcover):... Genetics and Eugenics; a Text-book for Students of Biology and a Reference Book for Animal and Plant Breeders (Hardcover)
William E. (William Ernest) Castle, Gregor 1822-1884 Versuche UEbe Mendel
R903 Discovery Miles 9 030 Ships in 9 - 15 working days
The Nuclear Matrix and Spatial Organization of Chromosomal DNA Domains (Hardcover, 1997 ed.): Sergey V. Razin The Nuclear Matrix and Spatial Organization of Chromosomal DNA Domains (Hardcover, 1997 ed.)
Sergey V. Razin
R4,537 Discovery Miles 45 370 Ships in 12 - 17 working days

Discusses the problem of structural-functional organization of eukaryotic cell nuclei with special emphasis on the genome spatial organization and functioning. The opening chapters describe the nuclear matrix and the fate of its components in the course of mitosis. In the next eight chapters the organization of chromosomal DNA into large loops and

A Practical Approach to Microarray Data Analysis (Hardcover, 2003 ed.): Daniel P. Berrar, Werner Dubitzky, Martin Granzow A Practical Approach to Microarray Data Analysis (Hardcover, 2003 ed.)
Daniel P. Berrar, Werner Dubitzky, Martin Granzow
R1,605 Discovery Miles 16 050 Ships in 10 - 15 working days

In the past several years, DNA microarray technology has attracted tremendous interest in both the scientific community and in industry. With its ability to simultaneously measure the activity and interactions of thousands of genes, this modern technology promises unprecedented new insights into mechanisms of living systems. Currently, the primary applications of microarrays include gene discovery, disease diagnosis and prognosis, drug discovery (pharmacogenomics), and toxicological research (toxicogenomics). Typical scientific tasks addressed by microarray experiments include the identification of coexpressed genes, discovery of sample or gene groups with similar expression patterns, identification of genes whose expression patterns are highly differentiating with respect to a set of discerned biological entities (e.g., tumor types), and the study of gene activity patterns under various stress conditions (e.g., chemical treatment). More recently, the discovery, modeling, and simulation of regulatory gene networks, and the mapping of expression data to metabolic pathways and chromosome locations have been added to the list of scientific tasks that are being tackled by microarray technology. Each scientific task corresponds to one or more so-called data analysis tasks. Different types of scientific questions require different sets of data analytical techniques. Broadly speaking, there are two classes of elementary data analysis tasks, predictive modeling and pattern-detection. Predictive modeling tasks are concerned with learning a classification or estimation function, whereas pattern-detection methods screen the available data for interesting, previously unknown regularities or relationships.

Evolutionary Genetics of Invertebrate Behavior - Progress and Prospects (Hardcover, 1986 ed.): Milton Davis Huettel Evolutionary Genetics of Invertebrate Behavior - Progress and Prospects (Hardcover, 1986 ed.)
Milton Davis Huettel
R4,544 Discovery Miles 45 440 Ships in 12 - 17 working days

In the preface to Sir Vincent B. Wigglesworth's classic 1939 book on insect physiology he asserted that insects provide an ideal medium in which to study all the problems of physiology. A strong case can be made as well for the use of insects as significant systems for the study of behavior and genetics. Contributions to genetics through decades of research on Drosophila species have made this small fly the most important metazoan in genetics research. At the same time, population and behavioral research on insects and other invertebrates have provid ed new perspectives that can be combined with the genetics approach. Through such in tegrated research we are able to identify evolutionary genetics of behavior as a highly signifi cant emerging area of interest. These perspectives are ably described by Dr. Guy Bush in the introductory chapter of this book. During March 21-24, 1983, many of the world's leading scientists in invertebrate behavioral genetics were drawn together in Gainesville, Florida, for a colloquium entitled "Evolutionary Genetics of Invertebrate Behavior." This conference was sponsored jointly by the Department of Entomology and Nematology, University of Florida, chaired by Dr. Daniel Shankland, and the Insect Attractants, Behavior and Basic Biology Research Laboratory, U.S. Department of Agriculture, directed then by Dr. Derrell Chambers."

Hematopoietic Stem Cell Protocols (Hardcover, 3rd ed. 2014): Kevin D. Bunting, Cheng-Kui Qu Hematopoietic Stem Cell Protocols (Hardcover, 3rd ed. 2014)
Kevin D. Bunting, Cheng-Kui Qu
R5,500 R5,142 Discovery Miles 51 420 Save R358 (7%) Ships in 12 - 17 working days

Updating and building upon previous editions, "Hematopoietic Stem Cell Protocols, Third Edition" provides up-to-date protocols from leading stem cell researchers. This in-depth volume presents a clear view of the landscape of assays available to the stem cell researcher working in the growing hematopoietic stem cell (HSC) field. A robust and active field, it is supported by an abundance of innovative mouse models and molecular tools for analysis of phenotypes and functions in mouse and human cells. Understanding more about hematopoietic stem cell biology is integral if these versatile cells are to be applied effectively to treat and cure a wide range of blood diseases.An introductory chapter puts the major contributions of the book into the proper perspective. Written in the successful "Methods in Molecular Biology" series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.

Essential for the laboratory-based researcher, "Hematopoietic Stem Cell Protocols, Third Edition" is a much needed technical resource in the critically important field of hematopoietic stem cell investigation."

RNA Abundance Analysis - Methods and Protocols (Hardcover, 2012 ed.): Hailing Jin, Walter Gassmann RNA Abundance Analysis - Methods and Protocols (Hardcover, 2012 ed.)
Hailing Jin, Walter Gassmann
R2,977 Discovery Miles 29 770 Ships in 10 - 15 working days

RNA abundance analysis is one of the most important approaches for gene expression studies in the field of molecular biology. In "RNA Abundance Analysis: Methods and Protocols," expert researchers cover a wide range of techniques on RNA extraction, detection, quantification, visualization, and genome-wide profiling, from conventional methods to state-of-the-art high throughput approaches. This volume includes detailed techniques to examine mRNAs, small non-coding RNAs, protein-associated small RNAs, sulfur-containing RNAs, viral and satellite RNAs, RNA isoforms, and alternatively spliced RNA variants from various organisms, as well as key discussions of computational data processing for genome-wide datasets. Written for the highly successful "Methods in Molecular Biology" series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Essential and easy to use, "RNA Abundance Analysis: Methods and Protocols" provides a comprehensive set of techniques and methods on isolating and analyzing mRNAs, small RNAs, and modified RNAs, which can assist you in your gene expression studies."

New Principles in Developmental Processes (Hardcover, 2014 ed.): Hisato Kondoh, Atsushi Kuroiwa New Principles in Developmental Processes (Hardcover, 2014 ed.)
Hisato Kondoh, Atsushi Kuroiwa
R5,308 R4,950 Discovery Miles 49 500 Save R358 (7%) Ships in 12 - 17 working days

During the last decade, modern technologies have made a revolutionary change in developmental biology. The molecular and cellular processes in live embryos can now be visualized thanks to technologies using fluorescent proteins. The whole genome information of a wide range of animal species has now become available, confirming the common principles that operate in every species. These and other advances in our understanding of the developmental processes during embryogenesis and tissue regeneration have put forward new principles. Those new principles will also be important in the stem cell biology, branched from developmental biology, in order to generate a particular tissue by manipulating stem cells. This book is planned to introduce these new principles to readers who are working in developmental biology and/or stem cell biology fields, with an emphasis on genetic and cellular processes.

Advances in Genetics, Volume 36 (Hardcover): Jeffrey C. Hall, Jay C. Dunlap, Theodore Friedmann, Francesco Giannelli Advances in Genetics, Volume 36 (Hardcover)
Jeffrey C. Hall, Jay C. Dunlap, Theodore Friedmann, Francesco Giannelli
R4,278 Discovery Miles 42 780 Ships in 12 - 17 working days

This volume continues to present articles which should be of interest to both human and molecular geneticists. It begins with a review of the various classifications, mechanisms and molecular diagnostic tests of peroneal muscular atrophy (or CMT). An examination of the importance of tumour suppressor genes in human cancer and a number of the significant problems faced by cancer geneticists is included. The notion of genetic redundancy and whether true functional redundancy can exist is investigated and a discussion of recent findings on speciation and the role of hybrid inviability in "drosophila" is conducted. This book also reviews the effects of metal-regulated gene expression in cellular metabolism, pathogenicity and toxicity. In addition, it provides descriptions of chromosomal translocations in Neuraospora and other fungi for use in executing genetic crosses.

Statistical Methods for Microarray Data Analysis - Methods and Protocols (Hardcover, 2013 ed.): Andrei Y. Yakovlev, Lev... Statistical Methods for Microarray Data Analysis - Methods and Protocols (Hardcover, 2013 ed.)
Andrei Y. Yakovlev, Lev Klebanov, Daniel Gaile
R3,816 R3,521 Discovery Miles 35 210 Save R295 (8%) Ships in 12 - 17 working days

Microarrays for simultaneous measurement of redundancy of RNA species are used in fundamental biology as well as in medical research. Statistically, a microarray may be considered as an observation of very high dimensionality equal to the number of expression levels measured on it. In "Statistical Methods for Microarray Data Analysis: Methods and Protocols, " expert researchers in the field detail many methods and techniques used to study microarrays, guiding the reader from microarray technology to statistical problems of specific multivariate data analysis. Written in the highly successful "Methods in Molecular Biology " series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.

Thorough and intuitive, "Statistical Methods for Microarray Data Analysis: ""Methods and Protocols "aids scientists in continuing to study microarrays and the most current statistical methods.

DNA Helicases and DNA Motor Proteins (Hardcover, 2013): Maria Spies DNA Helicases and DNA Motor Proteins (Hardcover, 2013)
Maria Spies
R6,090 R4,886 Discovery Miles 48 860 Save R1,204 (20%) Ships in 12 - 17 working days

In recent years, a number of groundbreaking structural and mechanistic studies deepened our understanding of helicase mechanisms and established new approaches for their analyses. Many fundamental mechanistic questions ranging from the mechanism of force generation, mechanochemical coupling to distinct mechanisms by which the same enzyme translocates on DNA removing obstacles, unwinds DNA and/or remodels nucleoprotein complexes, however, remain to be answered. It is even less understood how the helicase motors are incorporated into a wide range of genome maintenance and repair machines. The field has reached a stage when the studies of molecular mechanisms and basic biology of helicases can and shall be integrated with the studies of development, cancer and longevity. The objective of this book is to provide the first systematic overview of structure, function and regulation of DNA helicases and related molecular motors. By integrating the knowledge obtained through the diverse technical approaches ranging from single-molecule biophysics to cellular and molecular biological studies the editors aim to provide a unified view on how helicases function in the cell, are regulated in response to different cellular stresses and are integrated into large macromolecular assemblies to form a complex and adaptive living system.

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