There is a perception in the scientific community that the discipline of Physiology is in crisis, or at least, in a phase of profound transition and change. At the root of the problem is confusion between objectives (the biological questions to be solved) and the methods and technologies to be applied. Traditionally, ever since Claude Bernard's concept of the "milieu interieur," Physiology was an integrative science with the prime concern of studying regulatory mechanisms leading to adaptation and homeostasis in the presence of challenges from a dynamic internal and external environment. This study of control mechanisms can be applied on any level of fu- tion whether subcellular, cellular, and organ, but reaches its highest level of complexity with the functioning of the body as a whole and its interaction with the external environment. This involves the determination of the interaction of genetic with environmental factors and the resulting integrated body adaptation. It might seem obvious that in the pursuit of these questions any appropriate combination of techniques on any organizational level could be used. Yet the advent of molecular techniques has resulted in a preoccupation with the problems and challenges inherent in these techniques, sometimes at the expense of the original perspectives and concepts. The many new mechanisms that have been discovered at the molecular level, as well as their economical exploitation, have contributed to a climate of reductionism.

"Fascinating and exhilarating-Sean B. Carroll at his very best."-Bill Bryson, author of The Body: A Guide for Occupants From acclaimed writer and biologist Sean B. Carroll, a rollicking, awe-inspiring story of the surprising power of chance in our lives and the world Why is the world the way it is? How did we get here? Does everything happen for a reason or are some things left to chance? Philosophers and theologians have pondered these questions for millennia, but startling scientific discoveries over the past half century are revealing that we live in a world driven by chance. A Series of Fortunate Events tells the story of the awesome power of chance and how it is the surprising source of all the beauty and diversity in the living world. Like every other species, we humans are here by accident. But it is shocking just how many things-any of which might never have occurred-had to happen in certain ways for any of us to exist. From an extremely improbable asteroid impact, to the wild gyrations of the Ice Age, to invisible accidents in our parents' gonads, we are all here through an astonishing series of fortunate events. And chance continues to reign every day over the razor-thin line between our life and death. This is a relatively small book about a really big idea. It is also a spirited tale. Drawing inspiration from Monty Python, Kurt Vonnegut, and other great thinkers, and crafted by one of today's most accomplished science storytellers, A Series of Fortunate Events is an irresistibly entertaining and thought-provoking account of one of the most important but least appreciated facts of life.

For peoples whose legal agreements, treaties, and other accords and conventions with the United States have been violated, multiculturalism as a pedagogical tool often becomes suspect of reinforcing the continued reification and abstraction of their cultures and nations with little if any real meaning for educational and social transformation. The continued oppression and repression of the exercise of self-determination for African Americans; the persistence of policies aimed at the destruction of indigenous populations and land; the insidious continuation of classical colonialism in the case of Puerto Rico are all vivid reminders to these peoples of the racist, classist, sexist, and homophobic patriarchy that characterizes their status. In order to restore people's rights to fully determine their own histories, Jackson and Solis point out that it is imperative to destroy the material foundations that breed and recycle the ideology, discourse, and cultural practices of domination. It is not enough to celebrate diversity and difference; there must be grand-scale social, political, economic, and educational transformation.

An ideal book for those coming to the anthropology of drugs for the first time, filling a surprisingly big gap in the literature Includes many case studies, such as drug tourism, the opioid crisis and 'county lines' in the UK as well as global examples from the Philippines, Mexico, North America and Europe Helps connect the anthropology of drugs to issues highly relevant to professional working in drug treatment, health, social work and mental health

The events of recent years have demonstrated beyond doubt not only that ethnic pluralism presents major problems for the management of political systems, but that it is also a major cause of their failure and disintegration. This timely and topical book discusses the general issue of ethnic pluralism and considers a range of types of multi-ethnic society within a common analytical framework. It then examines the responses of governments to the problems of ethnic diversity and assesses the effects of ethnic conflict on the development and viability of states.

Clinical Exercise Physiology, Fifth Edition With HKPropel Access, is a comprehensive guide to the clinical aspects of exercise physiology, investigating 24 chronic diseases and conditions and addressing a variety of populations. The text has been a mainstay in the field since its inception in 2003 and is an ideal resource for students preparing for clinical exercise certifications, including those offered by the American College of Sports Medicine (ACSM-CEP), American Council on Exercise (Medical Exercise Specialist), Canadian Society for Exercise Physiology (CSEP-CEP), and Exercise & Sports Science Australia (ESSA-AEP). Clinical Exercise Physiology, Fifth Edition, employs a logical progression of content to provide greater coverage and depth of diseases than is typically found in most clinical exercise physiology textbooks. It examines the effects of exercise on 24 chronic conditions, with each chapter covering the epidemiology, pathophysiology, clinical considerations, drug and surgical therapies, and exercise testing and prescription issues for the chronic condition. Other chapters are devoted to examining exercise-related issues for four special populations. Each chapter in this fifth edition is revised and updated to include the latest research, clinical guidelines, and position statements from professional organizations. In addition, it incorporates the following new elements: An upgrade to a full-color layout, for a more engaging learning experience and enhanced presentation of data New Clinical Exercise Bottom Line sidebars that highlight key information a clinical exercise physiologist needs when working with clinical populations A new chapter on clinical exercise programming that offers detailed recommendations for clinical populations A completely rewritten chapter on spinal cord injury and updates throughout each chapter to reflect the most up-to-date guidelines and position statements Expanded coverage of clinical exercise physiology certification options In addition to practical application sidebars throughout the text, the fifth edition also has related online tools to support student learning. Delivered through HKPropel, more than 60 case studies are presented in a SOAP note format so students can explore clinical evaluations, looking closely at subjective and objective data, assessments, and plans. Discussion questions and interactive key term flash cards foster better understanding and retention, while chapter quizzes can be assigned by instructors through the platform to assess student comprehension. Endorsed by the Clinical Exercise Physiology Association (CEPA), the Canadian Society for Exercise Physiology (CSEP), the British Association of Sport and Exercise Sciences (BASES), and Exercise & Sports Science Australia (ESSA), Clinical Exercise Physiology, Fifth Edition, offers a contemporary review of the variety of diseases and conditions that students and professionals may encounter in the field. New and veteran clinical exercise physiologists, as well as those preparing for clinical exercise certification exams, will appreciate the in-depth coverage of the clinical populations that benefit from physical activity. Note: A code for accessing HKPropel is included with this ebook.

Examining which actors determine undocumented migrants' access to healthcare on the ground, this volume looks at what happens in the daily interactions between administrative personnel, healthcare professionals and migrant patients in healthcare institutions across Europe. Borders across Healthcare explores contemporary moral economies of the healthcare-migration nexus. The volume documents the many ways in which borders come to disrupt healthcare settings and illuminates how judgements of a health-related deservingness become increasingly important, producing hierarchies that undermine a universal right to healthcare.

This book addresses responses to the predicament of medical and social infertility. It draws on international research to examine the dimensions of reproductive citizenship in relation to decision-making about a range of issues: from fertility preservation and the desirability of family creation as a normative expectation of social participation, to how families manage and negotiate engagement with providers of reproductive materials and services around information disclosure and contact, and how they consider their social obligations and responsibilities in relation to the use of assisted reproductive technology (ART).

What is a human being? Philosophical anthropology has approached this question with unusual sophistication, experimentalism, and subtlety. This volume explores the philosophical anthropologies of Scheler, Gehlen, Plessner, and Blumenberg in terms of their relevance to contemporary theories of nature, naturalism, organic life, and human affairs.

James Dawson first published Australian Aborigines in 1881, after deciding that his careful description of the tribes, languages, customs, and characteristics of the indigenous peoples of the western district of Victoria was too bulky for its originally intended publication in a newspaper. Essentially a field-inspired anthropological account of the dwindling Aboriginal population, written before the emergence of anthropology as a formal discipline, Dawson's book draws on his daughter's ability to speak the local languages and attempts a balanced description of a culture he considered ill-used and under-appreciated by white settlers. Minute details about clothing, tools, settlement and beliefs combine to depict a complex society that possessed highly ritualised customs deserving of respect. Dawson also included an extensive vocabulary of words in three indigenous languages that he hoped would facilitate further cross-cultural understanding. His work provides valuable source material for modern researchers in anthropology and linguistics.

Daniele Joly brings together theoretical and empirical research on ethnic minorities in Eastern and Western Europe showing that their positions and the increased prejudices they encounter share many similarities throughout Europe. Whether racism and exclusion are related to exploitation and power relations, ideologies, or social status, they pervade interactions between the majority society and its ethnic minorities. The history of such ideologies, the upsurge of racism and xenophobia through the general crisis of Western Europe and the various 'arenas' of racism in Germany are respectively studied by Eide, Alt and Blaschke, while Jarabova and Matei/Aluas examine prejudice and racism in the Czech lands and Romania. What international legal and theoretical instruments there are to counteract these trends are explored by Phillips and Rex, while Lloyds focuses on the social practice of anti-racist movements. Finally, Anthias theorises the different categories of disadvantage for ethnic minority women experience. Still looking at women, Campani, Vasquez and Xavier de Brito demonstrate how those establish themselves as social actors in the reception country.

Human enhancement has become a major concern in debates about the future of contemporary societies. This interdisciplinary book is devoted to clarifying the underlying ambiguities of these debates, and to proposing novel ways of exploring what human enhancement means and understanding what practices, goals and justifications it entails.

The author deals with the problem in political theory of how modern nation states must be structured in order to realise the two separate goals of equality of opportunity and the recognition of cultural diversity between groups. Subsequent chapters argue against a number of West European critics for a society of this type and the concept of multiculturalism is developed as it is applied in other contexts in Eastern Europe and North America.

"An extraordinary, eye-opening book." --People National Health Information Awards winner "A rousing wake-up call. . . . This highly engaging, provocative book prove[s] beyond a reasonable doubt that millions of lives depend on us finally coming to terms with the long-term consequences of childhood adversity and toxic stress." --Michelle Alexander, author of The New Jim Crow Dr. Nadine Burke Harris was already known as a crusading physician delivering targeted care to vulnerable children. But it was Diego--a boy who had stopped growing after a sexual assault--who galvanized her journey to uncover the connections between toxic stress and lifelong illnesses. The stunning news of Burke Harris's research is just how deeply our bodies can be imprinted by ACEs--adverse childhood experiences like abuse, neglect, parental addiction, mental illness, and divorce. Childhood adversity changes our biological systems, and lasts a lifetime. For anyone who has faced a difficult childhood, or who cares about the millions of children who do, the fascinating scientific insight and innovative, acclaimed health interventions in The Deepest Well represent vitally important hope for preventing lifelong illness for those we love and for generations to come?. "Nadine Burke Harris . . . offers a new set of tools, based in science, that can help each of us heal ourselves, our children, and our world."--Paul Tough, author of How Children Succeed "A powerful--even indispensable--frame to both understand and respond more effectively to our most serious social ills."--New York Times

Parasitic zoonoses, the parasitic diseases transmitted between humans and other vertebrate animals, are widespread. The increasing pace of internationalization changes in diet and easy movement from one part of the world to another has caused parasitic zoonoses to be more prevalent. Consequently, these diseases have become the focus of recent research by parasitologists and pathologists whose work is presented in this book. Included in addition to the pathology of parasitic zoonoses and recent trends in research of imported parasites are the classification of phenotypes of anisakid nematodes, the immunohistopathological diagnostic method, and molecular technology to detect and diagnose parasites. Also included are papers on parasitology and international health and the pathology of cerebral malaria. With 38 color illustrations, this book is an invaluable resource for parasitologists, pathologists, and clinicians.

This work is concerned with a group of proteins which were originally consid ered to be an esoteric phenomenon but which have now been shown to play critical roles both in normal and stressed cells as well as being involved in a variety of human diseases. It is the purpose of this work to give a comprehen sive view of these proteins and their various aspects. After an introductory chapter providing an overview of these proteins, the work is divided into four main sections each of which deals with one important aspect of these proteins. Thus, the first section contains a series of chapters which describe individual stress proteins and their roles in particular biological phenomena. Evidently, the induction of these proteins by elevated tempera ture or other stresses is their defining feature and the second section of this book therefore considers the regulation of stress protein gene expression both by stressful stimuli such as elevated temperature or ischaemia and by non stressful stimuli such as cytokines.

In Bonk, the best-selling author of Stiff turns her outrageous curiosity and insight on the most alluring scientific subject of all: sex. Can a person think herself to orgasm? Why doesn't Viagra help women-or, for that matter, pandas? Can a dead man get an erection? Is vaginal orgasm a myth? Mary Roach shows us how and why sexual arousal and orgasm-two of the most complex, delightful, and amazing scientific phenomena on earth-can be so hard to achieve and what science is doing to make the bedroom a more satisfying place.

Based on fieldwork conducted between 2001-2008 in urban East Africa, this book explores who the patients, practitioners and paraprofessionals doing Chinese medicine were in this early period of renewed China-Africa relations. Rather than taking recourse to the 'placebo effect', the author explains through the spatialities and materialities of the medical procedures provided why - apart from purchasing the Chinese antimalarial called Artemisinin - locals would try out their 'alternatively modern' formulas for treating a wide range of post-colonial disorders and seek their sexual enhancement medicines.

This work describes the beliefs, customs and traditions of this tribe from the Ekat district.

'Endlessly fascinating and full of surprises. Easily one of my books of the year' BILL BRYSON The myth-busting science behind our modern attitudes to exercise: what our bodies really need, why it matters, and its effects on health and wellbeing. In industrialized nations, our sedentary lifestyles have contributed to skyrocketing rates of obesity and diseases like diabetes. A key remedy, we are told, is exercise - voluntary physical activity for the sake of health. However, most of us struggle to stay fit, and our attitudes to exercise are plagued by misconceptions, finger-pointing and anxiety. But, as Daniel Lieberman shows in Exercised, the first book of its kind by a leading scientific expert, we never evolved to exercise. We are hardwired for moderate exertion throughout each day, not triathlons or treadmills. Drawing on over a decade of high-level scientific research and eye-opening insights from evolutionary biology and anthropology, Lieberman explains precisely how exercise can promote health; debunks persistent myths about sitting, speed, strength and endurance; and points the way towards more enjoyable and physically active living in the modern world. 'Myth-busting, illuminating, brilliant - Lieberman will completely change the way you think about your body' Professor ALICE ROBERTS, presenter of Our Incredible Human Journey

Given the very limited capacity of regeneration in the brain, protecting neurons that are on the brink of death is a major challenge for basic and clinical neuroscience, with implications for a broad spectrum of acute and chronic neurological and psychiatric diseases. This book brings together leading experts from neurobiology, neurophysiology, neuropharmacology, neuroimmunology and clinical neuroscience to highlight the most recent milestones in this rapidly evolving field. The book will serve as a reference for both basic neuroscientists and clinicians interested in an authoritative update on the molecular and cellular biology of neuroprotection and its promises for new therapeutic strategies.

This volume is concerned with the enzymes of the nervous system. Cerebral enzymes form the basis of the functional brain. They are needed for the control of the energetics of the nervous system, whether it be their release or their direction; for the elaboration of transmitters and for their destruction; for the synthesis, transport, and breakdown of all metabolites of the nervous system. They are indispensable for the control of the multitude of factors that govern our thinking and our behavior. They make it possible for us to comprehend what is taking place around us and perhaps to understand what may be in store for us. Enzymes are the stuff of life, and no living cell can be without them. They are the results of many millions of years of evolution, from the time when biological membranes first came into being and were folded to produce the first cells within which the earliest enzymes were wrought. Countless changes have taken place within them, so that, now, only those enzymes exist that play specific roles in the functions of the living cells of today. Those in the nervous system possess a mUltiple role: in the creation, maintenance, and ultimate breakdown of the component cells and in enabling consciousness, perception, memory, and thought to become possible. But though life may go on forever, the enzymes that make life possible will undergo the many changes involved in the evolutionary process.

Does the term "Latino"--a construct of the U.S. government--successfully encompass the wide variety of Spanish-speaking people in this country? This introductory topic begins an overview of 10 major controversies that have embroiled U.S. Latinos, including Puerto Ricans, in recent years. Latinos have one of the fastest-growing populations in the United States today, making these issues front-page news across the country.

Issues include:

Race Classification

Assimilation

Bilingual Education

Open Borders

Affirmative Action

Interracial Dating and Marriage

Funding Education and Health Care for Undocumented Immigrant

Amnesty Program

U.S. Military and Political Presence in Cuba

U.S. Military Bases in Puerto Rico

Each topic is presented with a background, pro and con positions, and questions for the purpose of student debate and papers."