Tian Lu's dissertation describes major advances in ultrathin-layer chromatography (UTLC), liquid chromatography and surface-assisted laser desorption ionization (SALDI), and matrix-enhanced SALDI (ME-SALDI) mass spectrometry. Lu describes the fabrication of electrospun polyvinyl alcohol (PVA) UTLC plates using an in-situ crosslinking electrospinning technique. The author improved the efficiency of PVA plates greatly compared to the efficiency of silica HPTLC plates. Also highlighted in this thesis is an edge-plane based ordered-carbon surface that provides unique selectivity in liquid chromatography. Further developments include polar analytes, such as amino acids, nucleotides and nucleosides which can be well-retained and separated in the edge-plane ordered-carbon stationary phase. Also, the author studied and detected mass spectra of organic polymers as high as 900,000 Da, the highest molecular weight that has been studied by SALDI to date using the carbon nanofibrous substrate. This thesis has led to a number of publications in high-impact journals.

Semiconductor nanostructures are attracting a great deal of interest as the most promising device with which to implement quantum information processing and quantum computing. This book surveys the present status of nanofabrication techniques, near field spectroscopy and microscopy to assist the fabricated nanostructures. It will be essential reading for academic and industrial researchers in pure and applied physics, optics, semiconductors and microelectronics.
Key Features: The first up-to-date review articles on various aspects on quantum coherence, correlation and decoherence in semiconductor nanostructures

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

This book provides an introduction to robot-based nanohandling. It presents work on the development of a versatile microrobot-based nanohandling robot station inside a scanning electron microscope (SEM). Those unfamiliar with the subject will find the text, which is complemented throughout by the extensive use of illustrations, clear and simple to understand. The author has published two books and numerous papers in the field, and holds more than 50 patents.

Metal Oxide Nanoparticles in Organic Solvents discusses recent advances in the chemistry involved for the controlled synthesis and assembly of metal oxide nanoparticles, the characterizations required by such nanoobjects, and their size and shape depending properties.

In the last few years, a valuable alternative to the well-known aqueous sol-gel processes was developed in the form of nonaqueous solution routes. Metal Oxide Nanoparticles in Organic Solvents reviews and compares surfactant- and solvent-controlled routes, as well as providing an overview of techniques for the characterization of metal oxide nanoparticles, crystallization pathways, the physical properties of metal oxide nanoparticles, their applications in diverse fields of technology, and their assembly into larger nano- and mesostructures.

Researchers and postgraduates in the fields of nanomaterials and sol-gel chemistry will appreciate this book s informative approach to chemical formation mechanisms in relation to metal oxides.

Inrecentyears, anew?eldinsciencehasbeengrowingtremendously, i. e., theresearch on nanostructures. In the early beginning, impetus came from different disciplines, like physics, chemistry, and biology, that proposed the possibility of producing str- turesinthesub-micronrange. Theworldwideoperatingelectroniccompaniesrealized that this would open up new ?elds of application, and they proposed very challe- ing projects for the near future. Particularly, nanomagnetism became the focus of new concepts and funding programs, like spintronics or magnetoelectronics. These new concepts created a strong impact on the research ?eld of fabricating nanoscaled magnetic structures. Simultaneously, a demand for appropriate analyzing tools with high spatial resolution arose. Since then, the development of new techniques and the improvement of existing techniques that have the potential of analyzing magnetic properties with high spatial resolution have undergone a renaissance. Aiming at s- tems in the range of some 10nm means that the analyzing techniques have to go beyond that scale in their resolving power. In parallel to the efforts in the commercial sector, a new branch has been established in basic research, i. e., nanomagnetism, that is concerned with the underlying physics of the fabrication, analyzing techniques, and nano-scaled structures. The progress in one of these ?elds is inherently coupled with better knowledge or understanding and, hence, success in the other ?elds. The imaging technique as a synonym for spatial resolution plays a key role in this triangle. In this book, we bring together the state-of-the-art techniques of magnetic im- ing."

The main theme of this book is the exploration the underlying physical laws that permit the fabrication of nanometer-scale structures. As researchers attempt to fabricate nanometer-scale structures which do not exist per se, they must still employ the natural laws to fabricate them through processes such as self-assembly. This book will find service both as a reference work for researchers and as a comprehensive didactical text for graduate students.

TiO2 Nanotube Arrays: Synthesis, Properties, and Applications is the first book to provide an overview of this rapidly growing field. Vertically oriented, highly ordered TiO2 nanotube arrays are unique and easily fabricated materials with an architecture that demonstrates remarkable charge transfer as well as photocatalytic properties. This volume includes an introduction to TiO2 nanotube arrays, as well as a description of the material properties and distillation of the current research. Applications considered include gas sensing, heterojunction solar cells, water photoelectrolysis, photocatalytic CO2 reduction, as well as several biomedical applications. Written by leading researchers in the field, TiO2 Nanotube Arrays: Synthesis, Properties, and Applications is a valuable reference for chemists, materials scientists and engineers involved with renewable energy sources, biomedical engineering, and catalysis, to cite but a few examples.

Nanotechnology provides tools for creating functional materials, devices, and systems by controlling materials at the atomic and molecular scales and making use of novel properties and phenomena. Nanotechnology-enabled sensors find applications in several fields such as health and safety, medicine, process control and diagnostics. This book provides the reader with information on how nanotechnology enabled sensors are currently being used and how they will be used in the future in such diverse fields as communications, building and facilities, medicine, safety, and security, including both homeland defense and military operations.

This book presents and introduces ellipsometry in nanoscience and nanotechnology making a bridge between the classical and nanoscale optical behaviour of materials. It delineates the role of the non-destructive and non-invasive optical diagnostics of ellipsometry in improving science and technology of nanomaterials and related processes by illustrating its exploitation, ranging from fundamental studies of the physics and chemistry of nanostructures to the ultimate goal of turnkey manufacturing control. This book is written for a broad readership: materials scientists, researchers, engineers, as well as students and nanotechnology operators who want to deepen their knowledge about both basics and applications of ellipsometry to nanoscale phenomena. It starts as a general introduction for people curious to enter the fields of ellipsometry and polarimetry applied to nanomaterials and progresses to articles by experts on specific fields that span from plasmonics, optics, to semiconductors and flexible electronics. The core belief reflected in this book is that ellipsometry applied at the nanoscale offers new ways of addressing many current needs. The book also explores forward-looking potential applications.

This second edition volume provides an overview of some of the types of nanostructures commonly used in nanobiomedicine. The chapters in this book discuss practical information on the synthesis and characterization of a variety of solution-phase and surface-bound nanomaterials, with examples of how they can be used in sensing, imaging, and therapeutics. Specific topics include the synthesis and characterization of molecule and biomolecule-functionalized nanoconjugates with gold, iron oxide, or polymeric cores; the development of biosensing, imaging, and therapeutic applications of multicomponent/multifunctional nanostructures; and the application of flow cytometry in nanobiomedicine. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.< Thorough and comprehensive, Biomedical Nanotechnology: Methods and Protocols, Second Edition is a useful resource for scientists and researchers at all levels who are interested in working in a new area of nanoscience and technology, or in expanding their knowledge base in their current field.

A fundamental understanding of algorithmic bioprocesses is key to learning how information processing occurs in nature at the cell level. The field is concerned with the interactions between computer science on the one hand and biology, chemistry, and DNA-oriented nanoscience on the other. In particular, this book offers a comprehensive overview of research into algorithmic self-assembly, RNA folding, the algorithmic foundations for biochemical reactions, and the algorithmic nature of developmental processes.

The editors of the book invited 36 chapters, written by the leading researchers in this area, and their contributions include detailed tutorials on the main topics, surveys of the state of the art in research, experimental results, and discussions of specific research goals. The main subjects addressed are sequence discovery, generation, and analysis; nanoconstructions and self-assembly; membrane computing; formal models and analysis; process calculi and automata; biochemical reactions; and other topics from natural computing, including molecular evolution, regulation of gene expression, light-based computing, cellular automata, realistic modelling of biological systems, and evolutionary computing.

This subject is inherently interdisciplinary, and this book will be of value to researchers in computer science and biology who study the impact of the exciting mutual interaction between our understanding of bioprocesses and our understanding of computation.

Ionic Surfactants and Aqueous Solutions: Biomolecules, Metals and Nanoparticles covers a wide range of subjects related to aqueous systems, from reverse micelles as ion exchangers to the study of micellar phase transfer catalysis for nucleophilic substitution reactions. The diverse background, expertise and professional interests of the contributors to this book give to it a unique richness of approach in topics of relevance for biotechnology and environmental studies. Over sixty publications presenting research results are combined and expanded in this book by some of the original researchers. At a mature age, and at the summit of successful professional careers, they have taken a second look to the state of the art in the fields that they had pioneered. Eva Rodil and Ana Soto, who had their research formation in the group of Professor Alberto Arce at Universidade de Santiago de Compostela, Spain, are presently professors at that university, Maen Husein is a professor at University of Calgary, Canada. Remy Dumortier, Mohammad Khoshkbarchi, Hamid Rabie and Younok Dumortier Shin, are presently active leaders in the industrial world in Canada and the USA. The editors are retired academics from McGill University, Montreal, Canada, and coauthors of the book Classical Thermodynamics of Fluid Systems.

Integrating nano and microphysical effects, this book s team of expert authors offers new insights into self-organized structure formation in nanomaterials. A major question addressed in this book is the role of spatial and temporal order. In particular, you ll discover how to apply concepts developed on macroscopic and microscopic scales to structure formation occurring on nanoscales, a key focus of interest at the frontiers of science.

This book, "Integrated Chemical Microsensor Systems in CMOS Technology," provides a comprehensive treatment of the highly interdisciplinary field of CMOS chemical microsensor systems. It is targeted at students, scientists and engineers who are interested in gaining an introduction to the field of chemical sensing since all the necessary fundamental knowledge is included. However, as it provides detailed information on all important issues related to the realization of chemical microsensors in CMOS technology, it also addresses experts well familiar with the field.

After a brief introduction, the fundamentals of chemical sensing are presented. Fabrication and processing steps that are commonly used in the semiconductor industry are then detailed followed by a short description of the microfabrication techniques, and of the CMOS substrate and materials. Thereafter, a comprehensive overview of semiconductor-based and CMOS-based transducer structures for chemical sensors is given. CMOS-technology is then introduced as platform technology, which enables the integration of these microtransducers with the necessary driving and signal conditioning circuitry on the same chip. In a next section, the development of monolithic multisensor arrays and fully developed microsystems with on-chip sensor control and standard interfaces is described. A short section on packaging shows that techniques from the semiconductor industry can be applied to chemical microsensor packaging. The book concludes with a brief outlook on future developments, such as the realization of more complex integrated microsensor systems and methods to interface biological materials, such as cells, with CMOS microelectronics.

This Proceedings contains the papers presented at the third International Symposium on ""Electrochemical Microsystem Technologies"," held in Garmisch-Partenkirchen, on 11-15 September 2000.
The papers in this Special Issue are based on the 90 presentations given. In all, 45 papers were accepted, covering many diverse topics, demonstrating the many advances throughout. Due to their emphasis on different fields, they are arranged as follows:
Introduction and Fundamentals,
Microgalvanics and Microstructuring,
Micromaterials and Surface Analysis,
Corrosion/Surface Modification,
Microanalysis and Applications in Biology,
and Nanoelectrochemistry.

Since the first edition of Protein Nanotechnology Protocols Instruments and Applications the intersection of protein science and nanotechnology has become an exciting frontier in interdisciplinary sciences. The second edition of Protein Nanotechnology Protocols Instruments and Applications expands upon the previous editions with current, detailed chapters that provide examples of proteins which are now being harnessed for a wide range of applications, some more developed than others. This book also delves into engineering proteins and an overview of the sorts of tools that are now readily available to manipulate the structure and function of proteins, both rationally and using methods inspired by evolution. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Protein Nanotechnology Protocols Instruments and Applications, Second Edition seeks to provide an overview of this multi-faceted field and a useful guide to those who wish to contribute to it.

A collection of articles on different approaches to the investigation of surface effects on nanosized magnetic materials, with special emphasis on magnetic nanoparticles. The book provides an overview of progress in the field through recent results.

The development of new high-tech applications and devices has created a seemingly insatiable demand for novel functional materials with enhanced and tailored properties. Such materials can be achieved by three-dimensional structuring on the nanoscale, giving rise to a significant enhancement of particular functional characteristics which stems from the ability to access both surface/interface and bulk properties. The highly ordered, bicontinuous double-gyroid morphology is a fascinating and particularly suitable 3D nanostructure for this purpose due to its highly accessible surface area, connectivity, narrow pore diameter distribution and superb structural stability. The presented study encompasses a wide range of modern nanotechnology techniques in a highly versatile bottom-up nanopatterning strategy that splits the fabrication process into two successive steps: the preparation of mesoporous double-gyroid templates utilizing diblock copolymer self-assembly, and their replication with a functional material employing electrochemical deposition and atomic layer deposition. The double-gyroid structured materials discussed include metals, metal oxides, and conjugated polymers, which are applied and characterized in high-performance devices, such as electrochromic displays, supercapacitors, chemical sensors and photovoltaics. This publication addresses a wide range of readers, from researchers and specialists who are professionally active in the field, to more general readers interested in chemistry, nanoscience and physics.

Using the nano metric resolution of atomic force microscopy techniques, this work explores the rich fundamental physics and novel functionalities of domain walls in ferroelectric materials, the nano scale interfaces separating regions of differently oriented spontaneous polarization. Due to the local symmetry-breaking caused by the change in polarization, domain walls are found to possess an unexpected lateral piezoelectric response, even when this is symmetry-forbidden in the parent material. This has interesting potential applications in electromechanical devices based on ferroelectric domain patterning. Moreover, electrical conduction is shown to arise at domain walls in otherwise insulating lead zirconate titanate, the first such observation outside of multiferroic bismuth ferrite, due to the tendency of the walls to localize defects. The role of defects is then explored in the theoretical framework of disordered elastic interfaces possessing a characteristic roughness scaling and complex dynamic response. It is shown that the heterogeneous disorder landscape in ferroelectric thin films leads to a breakdown of the usual self-affine roughness, possibly related to strong pinning at individual defects. Finally, the roles of varying environmental conditions and defect densities in domain switching are explored and shown to be adequately modelled as a competition between screening effects and pinning.

This book reviews the current state-of-the art of single layer silicene up to thicker silicon nanosheets, and their structure, properties and potential applications. Silicene is a newly discovered material that is one atomic layer think. It is a two-dimensional (2D) nanomaterial that is classified as a nanosheet, which has large lateral dimensions up to micrometres, but thicknesses of only nanometres or less. Silicon nanosheets are currently a very 'hot' area of research. The unique properties and morphology of such materials make them ideal for a variety of applications, including electronic devices, batteries and sensors. 2D nanosheets of silicon can be considered as analogues of graphene. As silicon is already the major component of electronic devices, the significance of nanosheets composed of silicon is that they can be more easily integrated into existing electronic devices. Furthermore, if 2D nanostructured Si can be implemented into such devices, then their size could be reduced into the nano-regime, providing unique properties different from bulk Si that is currently employed. The book is written for researchers and graduate students.

The reader will be introduced to various aspects of the fundamentals of nanotechnology based drug delivery systems and the application of these systems for the delivery of small molecules, proteins, peptides, oligonucleotides and genes. How these systems overcome challenges offered by biological barriers to drug absorption and drug targeting will also be described.

Deniz Yilmaz' thesis describes a combination of orthogonal supramolecular interactions for the design of functional monolayer architectures on surfaces, that can be used as chemical and biosensors in a wide range of applications. The term "orthogonal supramolecular interactions" refers to non-covalent interactions that do not influence each other's assembly properties. Orthogonal self-assembly thus allows extended control over the self-assembly process and promotes new materials properties. The first part of the thesis employs orthogonal host-guest and lanthanide-ligand coordination interaction motifs to create supramolecular luminescent monolayers. The second part of the thesis describes the fabrication of functional monolayers on silicon and gold substrates for applications in electronics. The results illustrate the power of weak supramolecular interactions to direct the immobilization of functional systems on surfaces. The combination of host-guest and lanthanide-ligand coordination interaction motifs on surfaces demonstrates that hybrid, multifunctional supramolecular monolayers can be fabricated by integrating different non-covalent interactions in the same system. This combination opens up new avenues for the fabrication of complex hybrid organic-inorganic materials and stimuli-responsive surfaces. Their utility is demonstrated through applications of the functional interfaces to biosensing and nanotechnology.