Considerable impetus was given to the study and understanding of cere brovascular anatomy by Thomas Willis and his contemporaries in the seventeenth century, yet almost two hundred years were to pass before further significant advances were made in this field. Then, from the mid nineteenth century onwards, the dark ages of cerebrovascular research gradually lifted through the efforts of such workers as Luschka, Heubner, and Windle, whose pioneering anatomical studies formed the basis of the present-day understanding of the morphology of the cerebral circulation. The turn of the century saw an increasing influence of the early neurolo gists in describing anatomy of cerebral vessels in relation to their areas of distribution and to the production of focal deficits through specific vascu lar lesions and anomalies. Later still, Padget and others made important observations concerning phylogenetic and developmental aspects of the cerebral circulation. These anatomical and clinical studies were remarkable enough but the real breakthrough in investigating cerebral pathophysiology and in devis ing appropriate corrective neurosurgical procedures had to await the re markable advances in technology of the past fifty years. These began with the advent of cerebral angiography with all its subsequent refinements and progress has been accelerated through establishing noninvasive Doppler and high resolution ultrasound imaging techniques, methods for the accu rate measurement of cerebral blood flow, CT scanning, PET scanning, and, most recently, imaging and metabolic NMR scanning.

Problem Based Neurosurgery is a remarkable fusion of recent advances in neuro-imaging and neurosurgery with modern teaching of integrated system based curricula. It approaches each problem systematically from history, and physical examination to differential diagnosis, investigations and management options. The book captures four decades of advances and experiences in diagnosis and management of patients. The problems upon which the book is based are real patients and cover all aspects of neurosurgical practice with up to date modern images. The blend of new scientific discoveries, modern imaging and the art of smart history and physical examinations underpins the book to improve diagnosis, investigation and the care of neurosurgical patients.The main thrust of this book is that it is based on clinical problems faced by fellows, residents and students, rather than traditional topic based. Problem based learning and management is the modern method of teaching in the new curriculum of teaching neurosurgery. It is a practical handbook that will help students, residents and community doctors alike. There is no similar book on the market that fulfills the objectives of this handbook.

The perfect white coat study companion for acing the ABNS oral boards! The certification by the American Board of Neurological Surgery is considered as the gold standard for neurosurgeons. The final hurdle in accomplishing the certification process is the challenging oral examination. In 2017, the format of the ABNS oral exam was revised to make it more relevant, rigorous, and reflective of recent advances in neurosurgery. Therefore, in the third edition of Neurosurgery Oral Board Review the authors have expanded on the widely acclaimed prior editions. The user-friendly book is packed with all the essentials that are needed to prepare for the exam. It can be used either for a rapid review a few days prior to the exam or as an outline to organize study preparation. Each chapter starts with a collection of salient facts, followed by cases that simulate the actual oral board experience. Key Highlights Eighty entirely new, first-rate cases supplemented by a large number of images In-depth focus on the current state-of-the-art in neurosurgery, including endovascular and functional approaches, minimally-invasive brain and spine procedures, arthrodesis, etc. More than 300 outstanding anatomic drawings and radiographs to enhance the ability to visualize complex concepts Complications and emergency procedures discussed in greater detail This quintessential pocket-sized oral board review has earned its place as a trusted study companion in the past 15 years. The new and improved edition will continue to play an invaluable role for neurosurgeons prepping for this challenging final stage of ABNS certification. This book includes complimentary access to a digital copy on https://medone.thieme.com.

Recent clinical experience and tremendous technical advances make it more imperative than ever that operators performing embolization have a sound background in functional neuroanatomy and clinical evaluation in addition to technical training. This book provides a description of vascular anatomy that will permit the accurate assessment of variations and functional territories and will make the prediction of the risks and management of cerebral vascular disease possible. Through this type of anatomical analysis every potential arrangement in cerebral vascular development can be predicted. Thus, endovascular procedures in the spinal cord and brain can be best planned and performed. Pierre Lasjaunias, Alejandro Berenstein, and Karel ter Brugge are highly committed to both research and teaching in the clinical field of neurovascular diseases. The first volume of the second edition of Surgical Neuroangiography combines the previous volumes 1 and 3 in one book.

First Prize Winner at the 2018 BMA Medical Book Awards! The highly complex specialty of brainstem surgery requires many years of study, a focus on precision, and a passionate dedication to excellence to prepare the neurosurgeon for navigating significant anatomic challenges. Although the brainstem is technically surgically accessible, its highly eloquent structure demands rigorous surgical decision-making. An in-depth understanding of brainstem and thalamic anatomy and the safe entry zones used to access critical areas of the brainstem is essential to traversing the brainstem safely and successfully. This remarkable, one-of-a-kind atlas draws on the senior author's decades of experience performing more than 1,000 surgeries on the brainstem, thalamus, basal ganglia, and surrounding areas. Its content is organized by anatomic region, enabling readers to study separate subdivisions of the brainstem, each of which has its own unique anatomic and surgical considerations. From cover to cover, the atlas provides readers with technical guidance on approach selection, the timing of surgery, and optimization of outcomes-elucidated by more than 1700 remarkable color illustrations, dissections, clinical images, and line drawings. Key Highlights Beautifully detailed, highly sophisticated brain slices and dissections by Kaan Yagmurlu, who trained under the internationally renowned neuroanatomist and neurosurgeon Albert Rhoton Jr. Color illustrations clearly labeled with callouts and other indicators of foci of interest delineate multiple safe entry zones to the brainstem More than 50 detailed patient cases highlight each patient's history of previous neurological disorders, presenting symptoms, preoperative imaging, diagnosis, the planned surgical approach, patient positioning, intraoperative and postoperative imaging, and outcome Seven animations and more than 50 surgical videos elucidate approach selection, anatomy, and surgical outcomes of thalamic region and brainstem lesions This illuminating atlas provides insights into the complexities of the hallowed halls of the brainstem. Neurosurgeons and neurosurgical residents alike who glean knowledge from the clinical pearls throughout each section will no doubt become more adept surgeons, to the ultimate benefit of their patients.

Endoscopic spine surgery essentials from expert spine surgeons Atlas of Full-Endoscopic Spine Surgery by internationally renowned spine surgeons Christoph Hofstetter, Sebastian Ruetten, Yue Zhou, and Michael Wang provides concise, step-by-step guidance on the latest full endoscopic spine procedures. The book is targeted at practicing spine surgeons, fellows, and residents currently not trained in endoscopic spine surgery who have the desire to learn and incorporate these techniques into clinical practice. It is also an excellent curriculum resource for cadaveric training courses taught at the national and international level. The book lays a solid foundation with opening chapters on anesthesia, OR setup and endoscopic tools, applied anatomy, basic endoscopic surgical tasks, and preoperative diagnostics. Additional sections include step-by-step descriptions of the full spectrum of cervical, thoracic, and lumbar endoscopic approaches. The last section provides invaluable pearls on overcoming challenges, avoiding pitfalls, and optimizing postoperative care. Key Features Transforaminal endoscopic lumbar and thoracic discectomy approaches Trans-SAP endoscopic approach for foraminal and lateral recess decompression Interlaminar endoscopic lumbar discectomy Cervical/thoracic and lumbar unilateral laminotomy for bilateral decompression Special topics including endoscopic management of challenging cases, endoscopic revision surgery, and management of complications. Neurosurgery residents, fellows, young practicing neurosurgeons, and all healthcare practitioners involved in the care of endoscopic spine surgery patients will gain invaluable insights from this book. This book includes complimentary access to a digital copy on https://medone.thieme.com.

This book focuses on subarachnoid hemorrhage (SAH), describing in detail the neurophysiology, anatomy, epidemiology, grading, anesthesia management, coiling and interventional treatment of this dangerous disease. Written by leading international experts, it highlights the state-of-the-art techniques for the diagnosis and treatment (non-surgical and surgical) of SAH and the clinical variations. It also examines the reliability of the new techniques versus the standard clinical methods to predict problems related to SAH and its recent diagnosis and management. The book starts with a brief discussion of the epidemiology of SAH, cerebral circulation, anatomy of brain blood vessels and neurophysiology related to this fatal disease. Then, in the following chapters it covers grading of subarachnoid hemorrhage, anesthesia management of SAH, treatment, subarachnoid hemorrhage coiling and radiological intervention. Lastly, it explores surgical treatment of intracranial aneurysms in more detail, and addresses complications, critical care management and headache in SAH, traumatic SAH and prognosis. Featuring numerous images, tables, schema, illustrations and videos, the book is intended for junior and senior anesthesiologists, neuroscientists, intervention radiologists, intensivists and neurosurgeons.

Selected as a Doody's Core Title for 2021! Written by experts from around the world, the latest edition of this leading reference features contributions from both neurosurgeons and orthopaedic surgeons. Presenting the full scope of spinal surgery, chapters discuss anatomy, biomechanics, complications, instrumentation, preoperative and postoperative care, and other core topics for surgeons. And numerous illustrations and clinical video clips provide critical visual context.   New chapters detail current surgical techniques for idiopathic scoliosis procedures. Over half of the authors are new—bringing fresh perspectives and approaches to surgical preparation and techniques. Technical procedures are written in an easy-to-follow, step-by-step format. Covers a wide spectrum of spinal deformities, degenerative disorders, injuries, and traumatic conditions. Now with more than 4,000 illustrations—including figures that accurately depict anatomy and procedures, and tables and algorithms for absorbing information quickly. Enrich Your Ebook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

The quintessential reference for bedside medical management of neurocritical care patients Medical management of patients in the neurocritical care unit (NCCU) often spells the difference between life or death and return to normal function or a lifetime disability. As such, it is vital that patients with life-threatening neurological and neurosurgical illnesses receive prompt diagnosis and rapid interventions in the NCCU. The Jefferson Manual for Neurocritical Care by renowned neurosurgeon Jack I. Jallo, neurointensive care physician Jacqueline S. Urtecho, and distinguished colleagues is a high-yield pocket resource ideal for the bedside care of patients with serious, life-altering diseases. Nineteen concise chapters encompass cerebrovascular, neuromuscular, oncologic, and traumatic conditions, as well as core clinical topics applicable to the care of neurocritical patients. Key Highlights Evidence-based management strategies created at Thomas Jefferson University's Vickie and Jack Farber Institute for Neuroscience presented in reader-friendly algorithms, pictures, and charts General chapters cover brain death, sodium dysregulation, nutrition, sedation, pain management, neuromonitoring, and ventilation strategies Disease-specific chapters featuring succinct, bulleted format include epidemiology, causes, diagnostic tests, treatment options, symptoms, common clinical presentation, risk factors, differential diagnoses, and more This manual is an indispensable resource for neurocritical care residents and fellows, NCCU nurses, nurse practitioners, physician assistants, general intensive care physicians, and neurointensivists. This book includes complimentary access to a digital copy on https://medone.thieme.com.

The first comprehensive book dedicated solely to the evaluation and treatment of cervical spine deformity! The number of cervical fusion procedures has increased in the U.S. and globally during the last decade, in part due to an aging population and higher incidence of complex cervical problems. Despite advances in the surgical treatment of cervical deformities, few resources detail modern clinical assessment, radiographic evaluation, and surgical approaches. Cervical Spine Deformity Surgery by world-renowned spine surgeons Christopher Ames, K. Daniel Riew, Justin Smith, and Kuniyoshi Abumi fills a void in the literature. It provides a concise, state-of-the-art resource on current cervical deformity knowledge compiled from the literature and recognized masters in the field. The generously illustrated text begins with a background on the marked health impact of cervical deformity. Opening chapters provide primers on the clinical and radiographic assessment of patients, malalignment and disability scores, and the physical exam. Subsequent chapters detail surgical planning and approaches for a full spectrum of cervical spine conditions, such as semi-rigid and rigid deformities, sagittal deformities, distal junctional kyphosis, congenital cervical deformity, and hemivertebra. Key Features Insightful technical nuances and pearls on managing surgical, neurological, and medical complications associated with cervical procedures, as well as risk stratification and patient frailty Diverse osteotomies including low grade, uncovertebral joint (anterior view), cervical pedicle subtraction, cervical opening wedge, upper thoracic, C1-2 joint, and cervical pedicle screw fixation Focused discussion on continuing efforts to create a clinically meaningful comprehensive cervical osteotomy classification system Neurosurgical and orthopaedic residents and practicing spine surgeons who treat patients with cervical deformities will greatly benefit from consulting this comprehensive and unique resource. This book includes complimentary access to a digital copy on https://medone.thieme.com.

This book covers all aspects of the diagnosis and treatment of tumors of the jugular foramen - cranial base lesions that present particular diagnostic and management difficulties and remain challenging to remove despite advances in surgery and interventional neuroradiology. The authors have developed novel concepts and surgical techniques relating to management of the facial nerve, reconstruction of the cranial base, and resection of large tumors with intra- and extracranial extension. These techniques, as well as anatomic studies in cadavers, are presented by means of surgical photographs, illustrations, and videos. Tumors of the Jugular Foramen will be of interest to all specialists involved in the management of these challenging tumors, including neurosurgeons, ENT surgeons, neuroradiologists, neurologists, neurointensivists, radiotherapists, oncologists, and physiotherapists.

The ultimate guide to navigating and treating brainstem pathologies from master neurosurgeon Robert Spetzler The brainstem is one of the last bastions of surgical prohibition because of its densely packed ascending and descending tracts and nuclei carrying information to and from the brain. Although 10% of all pediatric tumors and 5% of all vascular anomalies occur in the brainstem, neurosurgeons have traditionally resisted dissecting lesions in this area. Recent advances in imaging, microscopy, anesthesia, and operative techniques have expanded the treatment paradigm for this most eloquent region of the brain. Surgery of the Brainstem, by internationally renowned neurosurgeons Robert F. Spetzler, M. Yashar S. Kalani, and Michael T. Lawton, along with an impressive cadre of global experts, is a comprehensive guide to managing disorders of the brainstem, thalamic region, and basal ganglia. Organized in seven sections with 33 chapters, the text opens with four sections covering a variety of topics. Section I presents the history of brainstem surgery; Section II examines anatomy, development, and pathology; Section III reviews patient examination, imaging, and monitoring; and Section IV provides a succinct overview of surgical approaches. Sections V-VII cover a wide range of adult and pediatric tumors, ischemia, stroke, aneurysms, arteriovenous malformations, and cerebral cavernous malformations. More than 300 high-quality clinical images and medical illustrations enhance the text. Key Highlights A full spectrum of treatment modalities and outcomes, including open surgery, endoscopic approaches, stereotactic radiosurgery, radiotherapy, endovascular techniques, and revascularization An anatomy chapter featuring stunning Rhoton-style anatomical dissections delineates critical landmarks in the brainstem, thalamus, pineal region, and cranial nerves Detailed discussion of patient positioning and exposure of various brainstem domains Pearls on overcoming psychological, pathological, and anatomical barriers and managing complications Understanding the basic anatomy, pathology, and clinical complexities of the brainstem and thalamic regions is essential for safe navigation and treatment. This remarkable book will provide neurosurgeons with additional insights on performing resections and achieving the best possible outcomes for patients with pathologic conditions in this delicate region. This book includes complimentary access to a digital copy on https://medone.thieme.com.

Neurotrauma and Critical Care of the Brain, 2nd edition by renowned neurosurgeons Jack Jallo and Christopher Loftus incorporates salient components of the highly praised first edition. The updated text reflects cutting-edge discussion on traumatic brain injury management in a neurocritical care setting. Contributions from top experts in neurosurgery, neurology, critical care, cardiac and pulmonary care, and trauma surgery provide a concise review of a complex and evolving field. The book lays a solid foundation with discussion of TBI classification, pathophysiology, key blood biomarkers, noninvasive neuromonitoring in severe TBI patients, multimodality monitoring in neurocritical care, and brain imaging modalities. From the prehospital setting to intensive care, top experts share clinical pearls and core guidelines on the management of mild, moderate, and severe TBI and complications. Chapters new to this edition include concomitant injuries, orbital/facial fractures, vascular injuries, spine fractures, autonomic dysfunction, and temperature management. Key Highlights Specialized topics include wartime penetrating injuries, cardiovascular complications of TBI, venous thromboembolism prophylaxis, ethical considerations, TBI costs in the U.S. and the financial return on helmets Management of pediatric brain injuries in the NICU with illustrative cases Nearly 200 high quality illustrations facilitate understanding of complex anatomy and techniques Summary tables provide a handy overview of injury type, causes, characteristics, and recommended imaging modalities This remarkable resource is essential reading for neurosurgeons, neurologists, trauma physicians, critical care and rehabilitation medicine specialists, and residents in these specialties. Paired with Neurotrauma and Critical Care of the Spine, 2nd edition, this dynamic duo is the most up-to-date neurocritical care reference available today.

A unique resource on glioma leverages advances and firsthand insights to enact meaningful change Glioblastoma (GBM) or glioma is an extremely aggressive and malignant brain tumor, with cell infiltration, rapid invasion, and a high frequency of relapse. The Glioma Book by neurosurgeon Michael Sughrue is a highly personal book - a culmination of two years of writing and more than 1,000 surgeries. It presents a unique viewpoint with the potential to transform the traditional paradigm that too often informs treatment of this universally fatal brain tumor. The book reinterprets the role of the cerebrum and sub-cortex, leverages scientific advances to improve cytoreduction and reduce neurological deficits, and challenges the myth of the "inoperable" glioma. This is the first step-by-step technical guide focused on aggressively resecting different types of gliomas. The book is logically organized, starting with a foundation of fundamental knowledge, then progressing to practical applications. Chapters focus on the skills necessary to perform glioma surgery, specific techniques, and systematic approaches to gliomas in different brain regions. Numerous case examples illuminate concepts introduced earlier in the book and explain how to perform these procedures About 30 high quality videos posted online provide insightful procedural guidance The role of connectomic imaging in visualizing the cerebrum, and other innovative techniques including awake brain mapping and diffusion tensor tractography Neurosurgeons who embrace the concepts in this book will realize they can change the glioma treatment paradigm. Continually improving techniques and viewing a glioma diagnosis as a battle for a patient's life, rather than an exercise in inevitable failure can impart progress in treating this devastating disease. This book includes complimentary access to a digital copy on https://medone.thieme.com.

The quintessential neurosurgical text review for acing the ABNS written exam! Since its publication nearly 20 years ago, Comprehensive Neurosurgery Board Review has garnered legendary status as the leading high-yield review for neurosurgical residents preparing for the American Board of Neurological Surgery (ABNS) primary exam. The updated third edition by Jonathan S. Citow and associate editors R. Loch Macdonald, Ross C. Puffer, Syed I. Khalid, Bob S. Carter, Alan R. Cohen, Robert J. Spinner, and Daniel Refai reflects technological advances made in the past decade. Seven comprehensive, systematically formatted chapters succinctly cover the tested core topics: anatomy, physiology, neuropathology, neuroradiology, neurology, neurosurgery, and critical care. Key Highlights: The streamlined outline format and handy tables enhance memorization and retention of knowledge More than 1200 high-quality illustrations and images, many in full color, detail impacted anatomy and processes Each chapter has concise sections encompassing important concepts, disease states, diagnostic criteria, and treatment approaches As with prior editions, this reader-friendly textbook does a remarkable job summarizing the vast data and knowledge required to ace the ABNS exam. The new edition is destined to build on its legacy as an indispensable resource for every young neurosurgeon sitting for the exam. This book includes complimentary access to a digital copy on https://medone.thieme.com.

A state-of-the-art reference on the management and treatment of neurosurgical emergencies The third edition of this acclaimed book covers frequently encountered neurosurgical emergencies, with contributions from renowned experts in their respective subspecialties. Clinical insights and easy-to-follow protocols are presented for emergencies associated with disease, infection, and trauma - and complications such as status epilepticus and acute shunt malfunction. Injury classification, evaluation, clinical presentation, imaging, surgical indications, approaches, and prognosis are presented for each condition. Concise, evidence-based descriptions enable readers to rapidly gain a solid understanding of the pathogenesis of each problem. The authors retained the scope and content of previous editions and added six new chapters that reflect recent advances. These include novel invasive brain monitoring techniques and their relevance to clinical practice, emergency surgery for stroke, emergency endovascular stroke treatment, cerebral venous thrombosis, consideration of cervical stenosis as an emergency, and emergent presentation and management of spinal dural arteriovenous fistulas and vascular lesions. Key Features Updated from black and white to full-color illustrations Current guidelines for managing a full spectrum of intracranial, spinal, and peripheral nerve emergencies - from assessment of acute loss of consciousness - to pituitary apoplexy, cerebral herniation, and penetrating spine and peripheral nerve injuries Neurosurgical emergencies in pediatric patients including spinal cord injury and perinatal management of myelomeningocele Treatment and management of spontaneous intracerebral, subarachnoid, and intraspinal hemorrhages Recognition and management of intrathecal baclofen and narcotic withdrawal This stellar resource is a must-have for practicing neurosurgeons and emergency medicine specialists. It will also greatly benefit residents and fellows in these fields of medicine.

Seminal resource on state-of-the-art flow diversion techniques from leading neurointerventional experts From detachable balloons and GDC coils to the recent advent of flow diversion, practitioners of endovascular neurosurgery have been fortunate to work in an era of rapid and exciting advances. The first commercially available flow diverter in the U.S. was approved specifically for a small subset of cerebral aneurysms. Recent experience has demonstrated its utility in treating challenging or otherwise untreatable aneurysms, safely and efficaciously. The design of these devices requires learning radically different methods than those used in the deployment of other, non-braided stents. Flow Diversion of Cerebral Aneurysms by Min Park, Philipp Taussky, Felipe Albuquerque, and Cameron McDougall provides step-by-step guidance on utilization of flow diversion technology in clinical practice. Reflecting the combined experience and knowledge of pioneers in neurointerventional surgery, this comprehensive book fills a gap in available resources. Twenty-one chapters cover fundamentals to advanced concepts - historical perspective to future developments. Key Features More than 100 high quality graphics and illustrative case studies reinforce key concepts Techniques and nuances of Pipeline, Silk (Balt Extrusion), Surpass Streamline, and Flow-Redirection Endoluminal Device (FRED) deployment An overview of current flow diversion devices, discussion of coil embolization versus flow diversion, off-label uses, adjuvant approaches, and hemodynamic modifications Pharmacology, flow diversion grading scales, and post-procedure radiographic imaging Clinical pearls on ruptured aneurysms, intraprocedural/postprocedural complications, and management of aneurysm residuals The ultimate goal of incorporating cutting-edge flow diversion techniques into the aneurysm treatment paradigm is improved efficacy and patient outcome. The knowledge gleaned from this outstanding resource will help residents and fellows learn to deploy flow diverters for the first time and enable seasoned clinicians to expand their neurointerventional radiology skills.

As one of the world's leading brain surgeons, Dr Jandial is the last hope for many patients who have extreme forms of cancer - patients who can't be saved, but deserve more time. Life on a Knife's Edge is his account of the resilience, courage and belief he has witnessed in his patients, and the lessons he has learned from them. Both an unflinching account of extreme surgeries and a profound, moving and introspective memoir, this book reveals the depths of a surgeon's psyche who is pushed to his limits, day in, day out. From keeping a gun victim's heart pumping with his own hand, to saving a woman from paralysis and performing brain surgery while time is running out on a haemorrhaging patient, we see how making life and death decisions and facing unimaginable pressure has shaped one man's life. Now, he shares the many truths about human nature that he has learned along the way: from how we deal with trauma, loss and threat to our innate belief and sense of self. From a life spent balancing on the line between life and death, above all else he reveals what it really means to survive.

Das Buch bietet dem Behandler einen UEberblick uber die gangigen klinisch relevanten Konzepte sowie diagnostischen und therapeutischen Massnahmen in der Epileptologie. Mit seinem praxisorientierten Aufbau befahigt das Werk dazu, dieses Wissen im klinischen Kontext direkt anzuwenden.Zahlreiche Kasuistiken beantworten uber die Kapitel hinweg typische Fragen zu Differenzialdiagnostik, Therapie und sozialmedizinischen Aspekten. Bei den Therapien kommen sowohl medikamentoese als auch operative Ansatze zur Sprache. Ein ballastfreies Buch, geschrieben von Epilepsie-Experten aus Deutschland, OEsterreich und der Schweiz, das sich den konkreten klinischen Aspekten widmet und dabei die entsprechenden nationalen und internationalen Leitlinien berucksichtigt.

Top Experts Share Clinical Insights on Biological Interventions for Spine-Related Disease Although there have been significant advancements in minimally invasive spinal surgery techniques in the last few decades, optimal outcomes for chronic low back pain remain elusive. A number of promising clinical trials have been conducted using tissue engineering and biological interventions for disc degeneration. Written by renowned innovators, this is the first book that covers implementation of these groundbreaking approaches for disc disease. The text begins with key fundamentals including anatomy and physiology, pathophysiology, imaging and biomechanics to delineate healthy versus diseased spine. Subsequent sections discuss treatment strategies, research findings, and future developments. Throughout each chapter, renowned spine surgeons and scientists share clinical pearls gleaned from hands-on experience. Key Highlights The current state of the art in biological and tissue engineering procedures for spinal disorders Treatment methodologies including nucleus replacement and repair, annulus fibrosus repair, total disc transplantation, and mechanical total disc replacement Innovative treatment strategies for disc regeneration, such as genes and proteins Growth factors including platelet-rich plasma (PRP), which has shown promise for the stimulation and acceleration of bone and soft tissue healing Cell-based therapy for spinal disc regeneration and repair including the use of stem cells and chondrocytes In-depth discussion of research including animal versus human model, in-vitro, and a summary of biologic clinical trials This is a must-have resource for trainee and practicing orthopaedic surgeons and neurosurgeons who treat patients for spine-related conditions. It is essential reading for all clinicians who have an interest in cutting-edge tissue engineering and biological treatment interventions.

'There are two ways to open a child's head. The pretty way and the quick way. Usually I shave the hair, use a scalpel to nick the skin then apply an electrocautery device to burn down to bone level. It's a slow, precise method and it leaves almost no scarring. But it takes time. Time, the interminable single note of the heart monitor reminds me, I don't have.' ___________ 'Extraordinary' - The Times 'Compelling' - The Daily Mail 'An inspirational book written by a truly remarkable man' - Dr Amanda Brown, author of The Prison Doctor ___________ Jay Jayamohan makes life and death decisions on a daily basis. That's because he's a Consultant Paediatric Neurosurgeon in a busy Oxford hospital. Every day, parents put all their faith in him to make their sick children well again. Though he is proud of his successes, he is haunted by every failure. Jayamohan is known not only for his skill in surgery but also his human touch: to him, no patient is only a number. In this gripping and sometimes heartrending book, Jayamohan - who has featured in two highly acclaimed BBC fly-on-the-wall series following the work of neurosurgeons - brings the highs and lows of the operating theatre into vivid life. Beginning with his struggles as an Asian growing up in 1970s Britain, he chronicles his early days as a medical student and spans decades of extraordinary activity, drawing on case studies from various aspects of his career: not all of which have happy endings. Jayamohan describes how he found the strength to keep going despite terrible setbacks: no matter how many times he is knocked down, he always gets up again to face the next challenge. Everything That Makes Us Human is a pacy, gripping account of Jayamohan's life and work. He pulls no punches and owns his mistakes, but the complete picture is one of a man driven to save as many lives as possible.

Unique skull-base surgical resource features strategic, technical, and philosophical pearls from master surgeons In a sense, surgeons go into battle every time they enter the OR. Like soldiers, they must be prepared to make profound sacrifices to protect innocent people (their patients), while putting egos aside and resisting the call of fame. Skull Base Surgery: Strategies by Walter Jean and distinguished contributors provides eloquent expression to the inner voices that speak to surgeons during each stage of battle. Unlike other textbooks that only emphasize the technical building blocks surgeons need, this resource focuses on state-of-the-art skull-base procedures, important thought processes, and vital strategies required to perform them. Size and shape variations, diverse biological characteristics, different anatomic locations and extensions, and specific relationships and entanglements with nerves and vessels make all skull base tumors unique and highly challenging. In addition to anatomy, two other important factors need to be considered every time a surgeon enters the OR - the particular circumstances of the patient and surgeon. Throughout this remarkable book, master neurosurgeons take readers on an insightful journey exploring the decision-making process of choosing and executing a surgical approach, with firsthand pearls from the battlefield. Key Highlights Nine sections organized by anatomy cover tumors in the anterior, anterolateral, lateral, central, postero-superior, and postero-inferior skull base regions, and clivus, petrous bone, and ventricles Thirty-two systematically organized chapters flow from clinical presentation and radiographic/anatomical findings of specific patients and tumors - to decision-making and execution of the surgical approach Real-life cases enhance understanding of all the elements that go into each operation Perspectives sections at the end of each chapter embrace the concept of diverse surgeon viewpoints on similar ideas, techniques, and approaches This exemplary book is essential reading for neurosurgery and otolaryngology residents, fellows, veteran practitioners, and allied health personnel who care for patients with skull base tumors. This book includes complimentary access to a digital copy on https://medone.thieme.com.

The benchmark reference on endoscopic surgery of the orbit from international experts! The use of endoscopic orbital surgery is rapidly expanding in modern day rhinology and oculoplastic practice. In the past two decades, endoscopic techniques have been adapted for lacrimal and orbital surgery. Significant advances have been made in endoscopic endonasal and periocular approaches to the orbital apex and skull base, especially in the last 3 years. There has been no book dedicated to these recent surgical innovations until Endoscopic Surgery of the Orbit: Anatomy, Pathology, and Management by Benjamin Bleier, Suzanne Freitag, and Raymond Sacks filled this void. This landmark text and its accompanying videos bring together the global experience of thought leaders and pioneers with multidisciplinary backgrounds. The collective expertise shared throughout 20 chapters codifies the current state of endoscopic orbital surgery and sets the stage for future developments. The opening chapters cover anatomy, physiology, and radiologic aspects pertaining to the orbit, paranasal sinuses, and surrounding structures. Subsequent chapters detail evaluation and endoscopic management of a full spectrum of pathologies utilizing orbital and optic nerve decompression, reconstruction, transorbital approaches, and anesthetic techniques. Key Features State-of-the-art evidence-based medicine including the pros and cons of different treatment approaches Management of operative complications such as sinusitis and iatrogenic intraorbital injury, and postoperative challenges Pathology-specific topics including congenital and acquired lacrimal obstruction, thyroid-related eye disease, trauma, orbital neoplasms, and skull-base neoplasms with orbital involvement 138 original illustrations help elucidate complex anatomy High definition, narrated surgical videos delineate specific surgical techniques This is a must-have resource for otolaryngologists in rhinologic and general practice and ophthalmologists in general and oculoplastic practice. It will also benefit neurosurgeons and plastic & reconstructive surgeons. The comprehensive text, clinical pearls, and accompanying videos facilitate incorporating these techniques into practice, whether one is a surgical trainee or veteran practitioner. This book includes complimentary access to a digital copy on https://medone.thieme.com.