Optimization of Pharmaceutical Processes presents contributions from leading authorities in the fields of optimization and pharmaceutical manufacturing. Formulated within structured frameworks, practical examples and applications are given as guidance to apply optimization techniques to most aspects of pharmaceutical processes from design, to lab and pilot scale, and finally to manufacturing. The increasing demand for better quality, higher yield, more efficient-optimized and green pharmaceutical processes, indicates that optimal conditions for production must be applied to achieve simplicity, lower costs and superior yield. The application of such methods in the pharmaceutical industry is not trivial. Quality of the final product is of major importance to human health and the need for deep knowledge of the process parameters and the optimization of the processes are imperative. The volume, which includes new methods as well as review contributions will benefit a wide readership including engineers in pharmaceuticals, chemical, biological, to name just a few.

The Mathematics of Finance has been a hot topic ever since the discovery of the Black-Scholes option pricing formulas in 1973. Unfortunately, there are very few undergraduate textbooks in this area. This book is specifically written for advanced undergraduate or beginning graduate students in mathematics, finance or economics. This book concentrates on discrete derivative pricing models, culminating in a careful and complete derivation of the Black-Scholes option pricing formulas as a limiting case of the Cox-Ross-Rubinstein discrete model.

This second edition is a complete rewrite of the first edition with significant changes to the topic organization, thus making the book flow much more smoothly. Several topics have been expanded such as the discussions of options, including the history of options, and pricing nonattainable alternatives. In this edition the material on probability has been condensed into fewer chapters, and the material on the capital asset pricing model has been removed.

The mathematics is not watered down, but it is appropriate for the intended audience. Previous knowledge of measure theory is not needed and only a small amount of linear algebra is required. All necessary probability theory is developed throughout the book on a "need-to-know" basis. No background in finance is required, since the book contains a chapter on options. "

This book provides several inventory models for making the right decision in inventory management under different environments. Basically, the optimal ordering policies are determined for situations with and without shortages in production-inventory systems. The chapters in the book include various features of inventory modeling i.e., inflation, deterioration, supply chain, learning, credit financing, carbon emission policy, stock-dependent demand, among others. The book is a useful resource for academicians, researchers, students, practitioners, and managers who can be benefited with the policies provided in the chapters of the book.

* A valuable teaching resource, replete with exercises, for any course of gambling mathematics * Suitable for a wide audience of professionals, researchers and students * Many practical applications for the gambling industry

This book, published in honor of Professor Laurent Praly on the occasion of his 65th birthday, explores the responses of some leading international authorities to new challenges in nonlinear and adaptive control. The mitigation of the effects of uncertainty and nonlinearity - ubiquitous features of real-world engineering and natural systems - on closed-loop stability and robustness being of crucial importance, the contributions report the latest research into overcoming these difficulties in: autonomous systems; reset control systems; multiple-input-multiple-output nonlinear systems; input delays; partial differential equations; population games; and data-driven control. Trends in Nonlinear and Adaptive Control presents research inspired by and related to Professor Praly's lifetime of contributions to control theory and is a valuable addition to the literature of advanced control.

This textbook on Linear and Nonlinear Optimization is intended for graduate and advanced undergraduate students in operations research and related fields. It is both literate and mathematically strong, yet requires no prior course in optimization. As suggested by its title, the book is divided into two parts covering in their individual chapters LP Models and Applications; Linear Equations and Inequalities; The Simplex Algorithm; Simplex Algorithm Continued; Duality and the Dual Simplex Algorithm; Postoptimality Analyses; Computational Considerations; Nonlinear (NLP) Models and Applications; Unconstrained Optimization; Descent Methods; Optimality Conditions; Problems with Linear Constraints; Problems with Nonlinear Constraints; Interior-Point Methods; and an Appendix covering Mathematical Concepts. Each chapter ends with a set of exercises. The book is based on lecture notes the authors have used in numerous optimization courses the authors have taught at Stanford University. It emphasizes modeling and numerical algorithms for optimization with continuous (not integer) variables. The discussion presents the underlying theory without always focusing on formal mathematical proofs (which can be found in cited references). Another feature of this book is its inclusion of cultural and historical matters, most often appearing among the footnotes. "This book is a real gem. The authors do a masterful job of rigorously presenting all of the relevant theory clearly and concisely while managing to avoid unnecessary tedious mathematical details. This is an ideal book for teaching a one or two semester masters-level course in optimization - it broadly covers linear and nonlinear programming effectively balancing modeling, algorithmic theory, computation, implementation, illuminating historical facts, and numerous interesting examples and exercises. Due to the clarity of the exposition, this book also serves as a valuable reference for self-study." Professor Ilan Adler, IEOR Department, UC Berkeley "A carefully crafted introduction to the main elements and applications of mathematical optimization. This volume presents the essential concepts of linear and nonlinear programming in an accessible format filled with anecdotes, examples, and exercises that bring the topic to life. The authors plumb their decades of experience in optimization to provide an enriching layer of historical context. Suitable for advanced undergraduates and masters students in management science, operations research, and related fields."Michael P. Friedlander, IBM Professor of Computer Science, Professor of Mathematics, University of British Columbia

Winner of the 2017 De Groot Prize awarded by the International Society for Bayesian Analysis (ISBA) A relatively new area of research, adversarial risk analysis (ARA) informs decision making when there are intelligent opponents and uncertain outcomes. Adversarial Risk Analysis develops methods for allocating defensive or offensive resources against intelligent adversaries. Many examples throughout illustrate the application of the ARA approach to a variety of games and strategic situations. Focuses on the recent subfield of decision analysis, ARA Compares ideas from decision theory and game theory Uses multi-agent influence diagrams (MAIDs) throughout to help readers visualize complex information structures Applies the ARA approach to simultaneous games, auctions, sequential games, and defend-attack games Contains an extended case study based on a real application in railway security, which provides a blueprint for how to perform ARA in similar security situations Includes exercises at the end of most chapters, with selected solutions at the back of the book The book shows decision makers how to build Bayesian models for the strategic calculation of their opponents, enabling decision makers to maximize their expected utility or minimize their expected loss. This new approach to risk analysis asserts that analysts should use Bayesian thinking to describe their beliefs about an opponent's goals, resources, optimism, and type of strategic calculation, such as minimax and level-k thinking. Within that framework, analysts then solve the problem from the perspective of the opponent while placing subjective probability distributions on all unknown quantities. This produces a distribution over the actions of the opponent and enables analysts to maximize their expected utilities.

This book studies R. Buckminster Fuller's World Game and similar world games, past and present. Proposed by Fuller in 1964 and first played in colleges and universities across North America at a time of growing ecological crisis, the World Game attempted to turn data analysis, systems modelling, scenario building, computer technology, and information design to more egalitarian ends to meet human needs. It challenged players to redistribute finite planetary resources more equitably, to 'make the world work'. Criticised and lauded in equal measure, the World Game has evolved through several formats and continues today in correspondence with debates on planetary stewardship, gamification, data management, and the democratic deficit. This book looks again at how the World Game has been played, focusing on its architecture, design, and gameplay. With hindsight, the World Game might appear naive, utopian, or technocratic, but we share its problems, if not necessarily its solutions. Such a study will be of interest to scholars working in art history, design history, game studies, media studies, architecture, and the environmental humanities.

Set-valued optimization is a vibrant and expanding branch of mathematics that deals with optimization problems where the objective map and/or the constraints maps are set-valued maps acting between certain spaces. Since set-valued maps subsumes single valued maps, set-valued optimization provides an important extension and unification of the scalar as well as the vector optimization problems. Therefore this relatively new discipline has justifiably attracted a great deal of attention in recent years. This book presents, in a unified framework, basic properties on ordering relations, solution concepts for set-valued optimization problems, a detailed description of convex set-valued maps, most recent developments in separation theorems, scalarization techniques, variational principles, tangent cones of first and higher order, sub-differential of set-valued maps, generalized derivatives of set-valued maps, sensitivity analysis, optimality conditions, duality and applications in economics among other things.

This book includes a thorough theoretical and computational analysis of unconstrained and constrained optimization algorithms and combines and integrates the most recent techniques and advanced computational linear algebra methods. Nonlinear optimization methods and techniques have reached their maturity and an abundance of optimization algorithms are available for which both the convergence properties and the numerical performances are known. This clear, friendly, and rigorous exposition discusses the theory behind the nonlinear optimization algorithms for understanding their properties and their convergence, enabling the reader to prove the convergence of his/her own algorithms. It covers cases and computational performances of the most known modern nonlinear optimization algorithms that solve collections of unconstrained and constrained optimization test problems with different structures, complexities, as well as those with large-scale real applications. The book is addressed to all those interested in developing and using new advanced techniques for solving large-scale unconstrained or constrained complex optimization problems. Mathematical programming researchers, theoreticians and practitioners in operations research, practitioners in engineering and industry researchers, as well as graduate students in mathematics, Ph.D. and master in mathematical programming will find plenty of recent information and practical approaches for solving real large-scale optimization problems and applications.

Metaheuristics for Resource Deployment under Uncertainty in Complex Systems analyzes how to set locations for the deployment of resources to incur the best performance at the lowest cost. Resources can be static nodes and moving nodes while services for a specific area or for customers can be provided. Theories of modeling and solution techniques are used with uncertainty taken into account and real-world applications used. The authors present modeling and metaheuristics for solving resource deployment problems under uncertainty while the models deployed are related to stochastic programming, robust optimization, fuzzy programming, risk management, and single/multi-objective optimization. The resources are heterogeneous and can be sensors and actuators providing different tasks. Both separate and cooperative coverage of the resources are analyzed. Previous research has generally dealt with one type of resource and considers static and deterministic problems, so the book breaks new ground in its analysis of cooperative coverage with heterogeneous resources and the uncertain and dynamic properties of these resources using metaheuristics. This book will help researchers, professionals, academics, and graduate students in related areas to better understand the theory and application of resource deployment problems and theories of uncertainty, including problem formulations, assumptions, and solution methods.

In his book "Marktform und Gleichgewicht", published initially in 1934, Heinrich von Stackelberg presented his groundbreaking leadership model of firm competition. In a work of great originality and richness, he described and analyzed a market situation in which the leader firm moves first and the follower firms then move sequentially. This game-theoretic model, now widely known as Stackelberg competition, has had tremendous impact on the theory of the firm and economic analysis in general, and has been applied to study decision-making in various fields of business. As the first translation of von Stackelberg's book into English, this volume makes his classic work available in its original form to an English-speaking audience for the very first time.

This is a book on optimal control problems (OCPs) for partial differential equations (PDEs) that evolved from a series of courses taught by the authors in the last few years at Politecnico di Milano, both at the undergraduate and graduate levels. The book covers the whole range spanning from the setup and the rigorous theoretical analysis of OCPs, the derivation of the system of optimality conditions, the proposition of suitable numerical methods, their formulation, their analysis, including their application to a broad set of problems of practical relevance. The first introductory chapter addresses a handful of representative OCPs and presents an overview of the associated mathematical issues. The rest of the book is organized into three parts: part I provides preliminary concepts of OCPs for algebraic and dynamical systems; part II addresses OCPs involving linear PDEs (mostly elliptic and parabolic type) and quadratic cost functions; part III deals with more general classes of OCPs that stand behind the advanced applications mentioned above. Starting from simple problems that allow a "hands-on" treatment, the reader is progressively led to a general framework suitable to face a broader class of problems. Moreover, the inclusion of many pseudocodes allows the reader to easily implement the algorithms illustrated throughout the text. The three parts of the book are suitable to readers with variable mathematical backgrounds, from advanced undergraduate to Ph.D. levels and beyond. We believe that applied mathematicians, computational scientists, and engineers may find this book useful for a constructive approach toward the solution of OCPs in the context of complex applications.

This book will cover heuristic optimization techniques and applications in engineering problems. The book will be divided into three sections that will provide coverage of the techniques, which can be employed by engineers, researchers, and manufacturing industries, to improve their productivity with the sole motive of socio-economic development. This will be the first book in the category of heuristic techniques with relevance to engineering problems and achieving optimal solutions. Features Explains the concept of optimization and the relevance of using heuristic techniques for optimal solutions in engineering problems Illustrates the various heuristics techniques Describes evolutionary heuristic techniques like genetic algorithm and particle swarm optimization Contains natural based techniques like ant colony optimization, bee algorithm, firefly optimization, and cuckoo search Offers sample problems and their optimization, using various heuristic techniques

Statistical Decision Problems presents a quick and concise introduction into the theory of risk, deviation and error measures that play a key role in statistical decision problems. It introduces state-of-the-art practical decision making through twenty-one case studies from real-life applications. The case studies cover a broad area of topics and the authors include links with source code and data, a very helpful tool for the reader. In its core, the text demonstrates how to use different factors to formulate statistical decision problems arising in various risk management applications, such as optimal hedging, portfolio optimization, cash flow matching, classification, and more. The presentation is organized into three parts: selected concepts of statistical decision theory, statistical decision problems, and case studies with portfolio safeguard. The text is primarily aimed at practitioners in the areas of risk management, decision making, and statistics. However, the inclusion of a fair bit of mathematical rigor renders this monograph an excellent introduction to the theory of general error, deviation, and risk measures for graduate students. It can be used as supplementary reading for graduate courses including statistical analysis, data mining, stochastic programming, financial engineering, to name a few. The high level of detail may serve useful to applied mathematicians, engineers, and statisticians interested in modeling and managing risk in various applications.

This book brings together the current state of-the-art research in Self Organizing Migrating Algorithm (SOMA) as a novel population-based evolutionary algorithm, modeled on the predator-prey relationship, by its leading practitioners. As the first ever book on SOMA, this book is geared towards graduate students, academics and researchers, who are looking for a good optimization algorithm for their applications. This book presents the methodology of SOMA, covering both the real and discrete domains, and its various implementations in different research areas. The easy-to-follow and implement methodology used in the book will make it easier for a reader to implement, modify and utilize SOMA.

This collection of selected contributions gives an account of recent developments in dynamic game theory and its applications, covering both theoretical advances and new applications of dynamic games in such areas as pursuit-evasion games, ecology, and economics. Written by experts in their respective disciplines, the chapters are an outgrowth of presentations from the 11th International Symposium on Dynamic Games and Applications.

Key topics covered include:

* stochastic and differential games

* dynamic games and their applications in various areas, such as ecology and economics

* numerical methods and algorithms in dynamic games

* zero- and nonzero-sum games

* pursuit-evasion games

* evolutionary game theory and applications

The work will serve as a state-of-the art account of recent advances in dynamic game theory and its applications for researchers, practitioners, and advanced students in applied mathematics, mathematical finance, and engineering.

This basic book has been used at the middle schools in Shanghai, China for more than 10 years. The book presents carefully-selected contents in order to achieve the roles of enlightenment and popularization. It mainly includes: Chapter 1: Human Brains, Computers and Fuzzy Mathematics; Chapter 2: Matrix, Fuzzy Relations and Fuzzy Matrix; Chapter 3: Fuzzy Control; Chapter 4: Fuzzy Statistics and Fuzzy Probability and Chapter 5: Fuzzy Linear Programming. It includes at the end of each chapter concise, interesting and profound reading and thinking materials, and a certain amount of exercises so as to make it an informative and interesting textbook. This book can be used not only as a textbook in senior middle schools, and in vocational colleges, but also as a primer for individually learning fuzzy mathematics.

the handbook is a valuable reference to researchers from industry and academia, as well as Masters and PhD students around the globe working in the metaheuristics and applications domain includes contributions from a variety of academics/researchers in the field of metaheuristics

This book offers a timely review of cutting-edge applications of computational intelligence to business management and financial analysis. It covers a wide range of intelligent and optimization techniques, reporting in detail on their application to real-world problems relating to portfolio management and demand forecasting, decision making, knowledge acquisition, and supply chain scheduling and management.

Small satellite technology is opening up a new era in space exploration offering reduced cost of launch and maintenance, operational flexibility with on-orbit reconfiguration, redundancy etc. The true power of such missions can be harnessed only from close and precise formation flying of satellites. Formation flying missions support diverse application areas such as reconnaissance, remote sensing, solar observatory, deep space observatories, etc. A key component involved in formation flying is the guidance algorithm that should account for system nonlinearities and unknown disturbances. The main focus of this book is to present various nonlinear optimal control and adaptive guidance ideas to ensure precise close formation flying in presence of such difficulties. In addition to in-depth discussion of the relevant topics, MATLAB program files for the results included are also provided for the benefit of the readers. Since this book has concise information about the various guidance techniques, it will be useful reference for researchers and practising engineers in the space field.

This book provides a literature review of techniques used to pass from continuous to combinatorial space, before discussing a detailed example with individual steps of how cuckoo search (CS) can be adapted to solve combinatorial optimization problems. It demonstrates the application of CS to three different problems and describes their source code. The content is divided into five chapters, the first of which provides a technical description, together with examples of combinatorial search spaces. The second chapter summarizes a diverse range of methods used to solve combinatorial optimization problems. In turn, the third chapter presents a description of CS, its formulation and characteristics. In the fourth chapter, the application of discrete cuckoo search (DCS) to solve three POCs (the traveling salesman problem, quadratic assignment problem and job shop scheduling problem) is explained, focusing mainly on a reinterpretation of the terminology used in CS and its source of inspiration. In closing, the fifth chapter discusses random-key cuckoo search (RKCS) using random keys to represent positions found by cuckoo search in the TSP and QAP solution space.

This book presents fundamental concepts of optimization problems and its real-world applications in various fields. The core concepts of optimization, formulations and solution procedures of various real-world problems are provided in an easy-to-read manner. The unique feature of this book is that it presents unified knowledge of the modelling of real-world decision-making problems and provides the solution procedure using the appropriate optimization techniques. The book will help students, researchers, and faculty members to understand the need for optimization techniques for obtaining optimal solution for the decision-making problems. It provides a sound knowledge of modelling of real-world problems using optimization techniques. It is a valuable compendium of several optimization techniques for solving real-world application problems using optimization software LINGO. The book is useful for academicians, practitioners, students and researchers in the field of OR. It is written in simple language with a detailed explanation of the core concepts of optimization techniques. Readers of this book will understand the formulation of real-world problems and their solution procedures obtained using the appropriate optimization techniques.

This unique book describes how the General Algebraic Modeling System (GAMS) can be used to solve various power system operation and planning optimization problems. This book is the first of its kind to provide readers with a comprehensive reference that includes the solution codes for basic/advanced power system optimization problems in GAMS, a computationally efficient tool for analyzing optimization problems in power and energy systems. The book covers theoretical background as well as the application examples and test case studies. It is a suitable reference for dedicated and general audiences including power system professionals as well as researchers and developers from the energy sector and electrical power engineering community and will be helpful to undergraduate and graduate students.

- Includes industrial case studies - Includes chapters on cyber physical systems, machine learning, deep learning, cyber security, robotics, smart manufacturing and predictive analytics - surveys current trends and challenges in metaheuristics and industry 4.0