Recent advances witness the potential to employ nanomedicine and game-changing methods to deliver drug molecules directly to diseased sites. To optimize and then enhance the efficacy and specificity, the control and guidance of drug carriers in vasculature has become crucial. Current bottlenecks in the optimal design of drug carrying particles are the lack of knowledge about the transport of particles, adhesion on endothelium wall and subsequent internalization into diseased cells. To study the transport and adhesion of particle in vasculature, the authors have made great efforts to numerically investigate the dynamic and adhesive motions of particles in the blood flow. This book discusses the recent achievements from the establishment of fundamental physical problem to development of multiscale model, and finally large scale simulations for understanding transport of particle-based drug carriers in blood flow.

The first part of this book overviews the physics of lasers and describes some of the more common types of lasers and their applications. Applications of lasers include CD/DVD players, laser printers and fiber optic communication devices. Part II of this book describes the phenomenon of Bose-Einstein condensation. The experimental techniques used to create a Bose-Einstein condensate provide an interesting and unconventional application of lasers; that is, the cooling and confinement of a dilute gas at very low temperature.

Fundamental interactions are mediated by bosonic fields, quanta of which are realized as particles. The properties of these fields typically obey certain symmetry rules. In this book we discuss the symmetry between two types of interactions - electromagnetic, which are familiar to anyone who turned on the electric lights, and weak, which govern the nuclear reactions that fuel the Sun. While there is a symmetry between these two types of interactions, it is broken. The unified theory of electroweak interactions was developed over 50 years ago. The Higgs scalar field named after one of the theorists that proposed it, is believed to be responsible for the breaking of the electroweak symmetry. Yet, it is only now after the discovery of the Higgs boson in 2012 by the LHC experiments, that we can study the mechanism of the electroweak symmetry breaking. This book discusses the theoretical developments that led to the construction of this theory, the discovery and the experimental observations that need to come to fully establish the validity of the model.

This unique compendium introduces the field of numerical modelling of water waves. The topics included the most widely used water wave modelling approaches, presented in increasing order of complexity and categorized into phase-averaged and phase-resolving at the highest level.A comprehensive state-of-the-art review is provided for each chapter, comprising the historical development of the method, the most relevant models and their practical applications. A full description on the method's underlying assumptions and limitations are also provided. The final chapter features coupling among different models, outlining the different types of implementations, highlighting their pros and cons, and providing numerous relevant examples for full context.The useful reference text benefits professionals, researchers, academics, graduate and undergraduate students in wave mechanics in general and coastal and ocean engineering in particular.

It is commonly known that three or more particles interacting via a two-body potential is an intractable problem. However, similar systems confined to one dimension yield exactly solvable equations, which have seeded widely pursued studies of one-dimensional n-body problems. The interest in these investigations is justified by their rich and quantitative insights into real-world classical and quantum problems, birthing a field that is the subject of this book. Spanning four bulk chapters, this book is written with the hope that readers come to appreciate the beauty of the mathematical results concerning the models of many-particle systems, such as the interaction between light particles and infinitely massive particles, as well as interacting quasiparticles. As the book discusses several unsolved problems in the subject, it functions as an insightful resource for researchers working in this branch of mathematical physics.In Chapter 1, the author first introduces readers to interesting problems in mathematical physics, with the prime objective of finding integrals of motion for classical many-particle systems as well as the exact solutions of the corresponding equations of motions. For these studied systems, their quantum mechanical analogue is then developed in Chapter 2. In Chapter 3, the book focuses on a quintessential problem in the quantum theory of magnetism: namely, to find all integrable one-dimensional systems involving quasiparticles of interacting one-half spins. Readers will study the integrable periodic chains of interacting one-half spins and discover the integrals of motion for such systems, as well as the eigenvectors of their corresponding Hamiltonians. In the last chapter, readers will study about integrable systems of quantum particles, with spin and mutual interactions involving rational, trigonometric, or elliptic potentials.

This book is an introduction to the mechanical properties, the force generating capacity, and the sensitivity to mechanical cues of the biological system. To understand how these qualities govern many essential biological processes, we also discuss how to measure them. However, before delving into the details and the techniques, we will first learn the operational definitions in mechanics, such as force, stress, elasticity, viscosity and so on. This book will explore the mechanics at three different length scales - molecular, cellular, and tissue levels - sequentially, and discuss the measurement techniques to quantify the intrinsic mechanical properties, force generating capacity, mechanoresponsive processes in the biological systems, and rupture forces.

Optical second harmonic and sum-frequency generation has evolved into a useful spectroscopic tool for material characterization, especially as a viable and powerful technique for probing surfaces and interfaces. This book serves as an introduction on the technique. It provides a comprehensible description on the basics of the technique and gives detailed accounts with illustrating examples on the wide range of applications of the technique. It clearly points out the unique capabilities of the technique as a spectroscopic tool for studies of bulk and interface structures in different disciplines.This book is an updated version of an earlier book on the same subject, but it puts more emphasis on physical concepts and description. It underscores recent advances of sum-frequency spectroscopy at the technical front as well as over its wide range of applications, with the author's perspective in each area. Most chapters end with a section of summary and prospects that hopefully can help stimulate interest to further develop the technique and explore possibilities of applying the technique.

This book summarizes the recent development of nuclear science as an important part of mesoscopic physics, the intermediate world between the macroscopic and microscopic. This fast developing area with many practical applications includes complex atoms, molecules (including biological), nuclei, small-scale solid state systems, and future quantum computers. The complexity of the problem appears due to the richness of problems, from the necessity to study individual quantum levels, to the fundamental features of statistics and thermodynamics.

This book is intended as a textbook on laser physics for advanced undergraduates and first-year graduate students in physics and engineering who need to use lasers in their labs and want to understand the physical processes involved with the laser techniques in their fields of study. This book aims to provide a coherent theoretical framework on the light-matter interaction involved with lasers in such a way that students can easily understand the essential topics related to lasers and their applications and get accustomed to the latest cutting-edge research developments. Most of all, the content of this book is concise to be covered in a semester.

Mechanobiology: From Molecular Sensing to Disease will provide a review of the current state of understanding of mechanobiology and its role in health and disease. It covers: Current understanding of the main molecular pathways by which cells sense and respond to mechanical stimuli, A review of diseases that with known or purported mechanobiological underpinnings; The role of mechanobiology in tissue engineering and regenerative medicine; Experimental methods to capture mechanobiological phenomena; Computational models in mechanobiology.

Semi-Lagrangian Advection Methods and Their Applications in Geoscience provides a much-needed resource on semi-Lagrangian theory, methods, and applications. Covering a variety of applications, the book brings together developments of the semi-Lagrangian in one place and offers a comparison of semi-Lagrangian methods with Eulerian-based approaches. It also includes a chapter dedicated to difficulties of dealing with the adjoint of semi-Lagrangian methods and illustrates the behavior of different schemes for different applications. This allows for a better understanding of which schemes are most efficient, stable, consistent, and likely to introduce the minimum model error into a given problem. Beneficial for students learning about numerical approximations to advection, researchers applying these techniques to geoscientific modeling, and practitioners looking for the best approach for modeling, Semi-Lagrangian Advection Methods and Their Applications in Geoscience fills a crucial gap in numerical modeling and data assimilation in geoscience.

Heat Transport and Energetics of the Earth and Rocky Planets provides a better understanding of the interior of the Earth by addressing the processes related to the motion of heat in large bodies. By addressing issues such as the effect of self-gravitation on the thermal state of the Earth, the effect of length-scales on heat transport, important observations of Earth, and a comparison to the behavior of other rocky bodies, readers will find clearly delineated discussions on the thermal state and evolution of the Earth. Using a combination of fundamentals, new developments and scientific and mathematical principles, the book summarizes the state-of-the-art. This timely reference is an important resource for geophysicists, planetary scientists, geologists, geochemists, and seismologists to gain a better understanding of the interior, formation and evolution of planetary bodies.

Semiconductors and Modern Electronics is a brief introduction to the physics behind semiconductor technologies. Chuck Winrich, a physics professor at Babson College, explores the topic of semiconductors from a qualitative approach to understanding the theories and models used to explain semiconductor devices. Applications of semiconductors are explored and understood through the models developed in the book. The qualitative approach in this book is intended to bring the advanced ideas behind semiconductors to the broader audience of students who will not major in physics. Much of the inspiration for this book comes from Dr. Winrich's experience teaching a general electronics course to students majoring in business. The goal of that class, and this book, is to bring forward the science behind semiconductors, and then to look at how that science affects the lives of people.