Molecular Diagnostics covers current molecular biological techniques used to identify the underlying molecular defects in inherited disease. Although an increasing number of laboratories, both academic and private are moving in that direction, there are only a few books in the existing literature, and they deal only partly with diagnosis at the molecular level. Each chapter includes the principle and a brief description of the technique, followed by exmples from the authors' own epertise. Contributors are well-known experts in their field, and derive from a variety of disciplines, to ensure breadth and depth of coverage.
* Examines widely used molecular biology techniques to screen for genetic defects causing inherited disorders
* Includes state-of-the-art techniques for the detection of the underlying genetic heterogeneity leading to inherited disorders
* Identification of genetically modified organisms (GMO's)
* Forensic analysis and every-day issues in a diagnostic laboratory
* Discusses ethics, genetic counselling and quality management

Mechatronics is a core subject for engineers, combining elements of mechanical and electronic engineering into the development of computer-controlled mechanical devices such as DVD players or anti-lock braking systems. This book is the most comprehensive text available for both mechanical and electrical engineering students and will enable them to engage fully with all stages of mechatronic system design. It offers broader and more integrated coverage than other books in the field with practical examples, case studies and exercises throughout and an Instructor's Manual. A further key feature of the book is its integrated coverage of programming the PIC microcontroller, and the use of MATLAB and Simulink programming and modelling, along with code files for downloading from the accompanying website.
*Integrated coverage of PIC microcontroller programming, MATLAB and Simulink modelling
*Fully developed student exercises, detailed practical examples
*Accompanying website with Instructor's Manual, downloadable code and image bank

In recognition of the fundamental control exerted by weathering on landscape evolution and topographic development, the 35th Binghamton Geomorphology Symposium was convened under the theme of Weathering and Landscape Evolution. The papers and posters presented at the conference imparted the state-of-the-art in weathering geomorphology, tackled the issue of scale linkage in geomorphic studies and offered a vehicle for interdisciplinary communication on research into weathering and landscape evolution. The papers included in this book are encapsulated here under the general themes of weathering mantles, weathering and relative dating, weathering and denudation, weathering processes and controls and the 'big picture'.
* Contains 15 papers on the techniques and methodologies of research
* Provides an up-to-date overview of various aspects of weathering and landscape evolution complemented by a number of excellent case studies
* Contains a wealth of basic field data and relevant information

Whatever your hydraulic applications, Practical Hydraulic Systems: Operation & Troubleshooting For Engineers & Technicians will help you to increase your knowledge of the fundamentals, improve your maintenance programs and become an excellent troubleshooter of problems in this area.
Cutaways of all major components are included in the book to visually demonstrate the components' construction and operation. Developing an understanding of how it works leads to an understanding of how and why it fails. Multimedia views of the equipment are shown, to give as realistic a view of hydraulic systems as possible. The book is highly practical, comprehensive and interactive. It discusses Hydraulic Systems construction, design applications, operations, maintenance, and management issues and provides you with the most up-to-date information and Best Practice in dealing with the subject.
* A focus on maintenance and troubleshooting makes this book essential reading for practising engineers.
* Written to cover the requirements of mechanical / industrial and civil engineering.
* Cutaway diagrams demonstrate the construction and operation of key equipment.

This series describes selected advances in the area of atomic spectroscopy. It is promarily intended for the reader who has a background in atmoic spectroscopy; suitable to the novice and expert. Although a widely used and accepted method for metal and non-metal analysis in a variety of complex samples, "Advances in Atomic Spectroscopy" covers a wide range of materials. Each Chapter will completely cover an area of atomic spectroscopy where rapid development has occurred.

Without sensors most electronic applications would not exist-they perform a vital function, namely providing an interface to the real world. The importance of sensors, however, contrasts with the limited information available on them. Today's smart sensors, wireless sensors, and microtechnologies are revolutionizing sensor design and applications. This volume is an up-to-date and comprehensive sensor reference guide to be used by engineers and scientists in industry, research, and academia to help with their sensor selection and system design. It is filled with hard-to-find information, contributed by noted engineers and companies working in the field today. The book will offer guidance on selecting, specifying, and using the optimum sensor for any given application. The editor-in-chief, Jon Wilson, has years of experience in the sensor industry and leads workshops and seminars on sensor-related topics.
In addition to background information on sensor technology, measurement, and data acquisition, the handbook provides detailed information on each type of sensor technology, covering:
-technology fundamentals
-sensor types, w/ advantages/disadvantages
-manufacturers
-selecting and specifying sensors
-applicable standards (w/ urls of related web sites)
-interfacing information, with hardware and software info
-design techniques and tips, with design examples
-latest and future developments
The handbook also contains information on the latest MEMS and nanotechnology sensor applications. In addition, a CD-ROM will accompany the volume containing a fully searchable pdf version of the text, along with various design tools and useful software.
*The onlycomprehensive book on sensors available!
*Jam-packed with over 800 pages of techniques and tips, detailed design examples, standards, hardware and software interfacing information, and manufacturer pros/cons to help make the best sensor selection for any design
*Covers sensors from A to Z- from basic technological fundamentals, to cutting-edge info. on the latest MEMS and the hottest nanotechnology applications

Immunohistochemistry is the use of specific antibodies to stain particular molecular species in situ. This technique has allowed the identification of many more cell types than could be visualized by classical histology, particularly in the immune system and among the scattered hormone-secreting cells of the endocrine system, and has the potential to improve diagnosis, prognosis and therapeutic options of cancer.
This book discusses all aspects of immunohistochemistry and in situ hybridization technologies and the important role they play in reaching a cancer diagnosis. It provides step-by-step instructions on the methods of additional molecular technologies such as DNA microarrays, and microdissection, along with the benefits and limitations of each method. The topics of region-specific gene expression, its role in cancer development and the techniques that assist in the understanding of the molecular basis of disease are relevant and necessary in science today.
This book is the second volume of three planned, individually-sold volumes on this topic. Like Volume 1, this book fully explains the principles and applications of modern techniques used in the field of molecular genetics. It will be of particular interest to pathologists and molecular pathologists conducting both academic and/or clinical research.
* The only book available that translates molecular genetics into cancer diagnosis
* The results of each Immunohistochemical and in situ hybridization method are presented in the form of color illustrations
* Methods discussed were either developed or refined by expert contributors in their own laboratories

This collection of all of Stan Shiels articles for World Pumps covers specification, operational issues, troubleshooting and the well-known PumpAcademy articles which covered specific topics of importance to pump engineers. The result is a volume which is enjoyable and instructive to read, containing facts and opinions as fresh as the day they were written.
*The late Stan Shiels had over 35 years experience as a professional engineer and over a period of nearly 15 years made a regular contribution to World Pumps magazine.
*This book includes 28 articles which will form a valuable resource to the pump engineer.
*Articles cover many aspects of pump specification, operation and troubleshooting

Volume 9 focuses on natural and anthropogenic environmental contaminants and their implications for human health and the environment. Environmental impacts on soils, groundwater, freshwater, the oceans and atmosphere are examined in the context of both inorganic geochemistry (metals, metalloids, radioactive compounds, mineral dusts, dissolved salts, acidification) and organic geochemistry (halogenated and non-halogenated hydrocarbons, volatile organic compounds, fuel oxygenates, pesticides, nutrients). Issues of risk, toxicity and exposure assessment; contaminant fate and transport; remediation and disposal; and source identification are examined in this context.

Reprinted individual volume from the acclaimed Treatise on Geochemistry, (10 Volume Set, ISBN 0-08-043751-6, published in 2003)
* Comprehensive and authoritative scope and focus
* Reviews from renowned scientists across a range of subjects, providing both overviews and new data, supplemented by extensive bibliographies
* Extensive illustrations and examples from the field

The voices of birds have always been a source of fascination. Nature's Music brings together some of the world's experts on birdsong, to review the advances that have taken place in our understanding of how and why birds sing, what their songs and calls mean, and how they have evolved. All contributors have strived to speak, not only to fellow experts, but also to the general reader. The result is a book of readable science, richly illustrated with recordings and pictures of the sounds of birds.
Bird song is much more than just one behaviour of a single, particular group of organisms. It is a model for the study of a wide variety of animal behaviour systems, ecological, evolutionary and neurobiological. Bird song sits at the intersection of breeding, social and cognitive behaviour and ecology. As such interest in this book will extend far beyond the purely ornithological - to behavioural ecologists psychologists and neurobiologists of all kinds.
* The scoop on local dialects in birdsong
* How birdsongs are used for fighting and flirting
* The writers are all international authorities on their subject

This text provides an overview of the literature on bilingual sentence processing from a psycholinguistic and linguistic perspective. Research focuses on both the visual and spoken modalities, including specific areas of research interest including an integrated review of methods and the utility of those methods which allows readers to have the appropriate background and context for the chapters that follow. Next, issues surrounding acquisition and pragmatic usage are covered with a focus on code-switching and the actual parsing of sentence material both within and between languages. Third, issues regarding memory, placing language in a broader context, are explored as the connection between language, memory, and perception is reviewed for bilingual speakers. Finally, all of this work has direct implications for educational settings-specifically issues surrounding the assessment of proficiency, the development and nature of dominance, and the acquisition of reading skills and reading comprehension for bilingual speakers.

A Student Guide to Object-Oriented Development is an introductory text that follows the software development process, from requirements capture to implementation, using an object-oriented approach. The book uses object-oriented techniques to present a practical viewpoint on developing software, providing the reader with a basic understanding of object-oriented concepts by developing the subject in an uncomplicated and easy-to-follow manner. It is based on a main worked case study for teaching purposes, plus others with password-protected answers on the web for use in coursework or exams. Readers can benefit from the authors' years of teaching experience. The book outlines standard object-oriented modelling techniques and illustrates them with a variety of examples and exercises, using UML as the modelling language and Java as the language of implementation. It adopts a simple, step by step approach to object-oriented development, and includes case studies, examples, and exercises with solutions to consolidate learning. There are 13 chapters covering a variety of topics such as sequence and collaboration diagrams; state diagrams; activity diagrams; and implementation diagrams. This book is an ideal reference for students taking undergraduate introductory/intermediate computing and information systems courses, as well as business studies courses and conversion masters' programmes.

John Ridley provides comprehensive information on usage, design and programming for the Mitsubishi FX range of programmable logic controllers, in this step-by-step, practical guide.
Professional engineers working with Mitsubishi PLCs, as well as students following courses focusing on these devices, will find this book to be an essential resource for this popular PLC family. Numerous worked examples and assignments are included, to reinforce the practical application of these devices, widely used in industry.
Fully updated throughout from coverage of the FX PLC to now cover the FxN PLC family from Mitsubishi, John Ridley also focuses on use of the Fx2N - the most powerful and diverse in function of this PLC group. The second edition contains advanced topics along with numerous ladder diagrams and illustrative examples.
- A hands-on approach to the programming, design and application of FX PLC based systems
- Programmed using GX Developer software - used worldwide for the whole range of the FX PLC family
- Covers Ladder Logic tester - the GX developer simulator that enables students and designers to test and debug their programs without a PLC
- GX Developer demo available on a companion website for the book

This fourth volume in the series on biochemistry looks at foundations in modern biochemistry. Topics covered include: the genetic solution; the genetic basis of development; DNA repair; evolution in an RNA world; nitrogen fixation; solute channels; viruses; biochemistry in retrospect and propspect.

Reinforced concrete is one of the most widely used modern materials of construction. It is comparatively cheap, readily available, and suitable for a variety of building and construction applications.
This reference provides a detailed resource covering all aspects of this important material. Both servicability and durability aspects are well covered, with all the information needed maximise the life of buildings constructed from it.
Containing an up-to-date and comprehensive collection of technical information and data from world renound authors, it will be a valuable source of reference for academics, researchers, students and professionals alike.
*Provides information vital to prolong the life of buildings constructed from this versatile material
* Brings together a disparate body of knowledge from many parts of the world into a concise and authoritative text
*Containing an up-to-date and comprehensive collection of technical information

The view presented in "The Internet and Its Protocols" is at once broad and deep. It covers all the common protocols and how they combine to create the Internet in its totality. More importantly, it describes each one completely, examining the requirements it addresses and the exact means by which it does its job. These descriptions include message flows, full message formats, and message exchanges for normal and error operation. They are supported by numerous diagrams and tables.
This book's comparative approach gives you something more valuable: insight into the decisions you face as you build and maintain your network, network device, or network application. Author Adrian Farrel s experience and advice will dramatically smooth your path as you work to offer improved performance and a wider range of services.
* Provides comprehensive, in-depth, and comparative coverage of the Internet Protocol (both IPv4 and IPv6) and its many related technologies.
* Written for developers, operators, and managers, and designed to be used as both an overview and a reference.
* Discusses major concepts in traffic engineering, providing detailed looks at MPLS and GMPLS and how they control both IP and non-IP traffic.
* Covers protocols for governing routing and transport, and for managing switches, components, and the network as a whole, along with higher-level application protocols.
* Offers thoughtful guidance on choosing between protocols, selecting features within a protocol, and other service- and performance-related decisions."

Communication Networking is a comprehensive, effectively organized introduction to the realities of communication network engineering. Written for both the workplace and the classroom, this book lays the foundation and provides the answers required for building an efficient, state-of-the-art network-one that can expand to meet growing demand and evolve to capitalize on coming technological advances. It focuses on the three building blocks out of which a communication network is constructed: multiplexing, switching, and routing. The discussions are based on the viewpoint that communication networking is about efficient resource sharing. The progression is natural: the book begins with individual physical links and proceeds to their combination in a network. The approach is analytical: discussion is driven by mathematical analyses of and solutions to specific engineering problems. Fundamental concepts are explained in detail and design issues are placed in context through real world examples from current technologies. The text offers in-depth coverage of many current topics, including network calculus with deterministically-constrained traffic; congestion control for elastic traffic; packet switch queuing; switching architectures; virtual path routing; and routing for quality of service. It also includes more than 200 hands-on exercises and class-tested problems, dozens of schematic figures, a review of key mathematical concepts, and a glossary. This book will be of interest to networking professionals whose work is primarily architecture definition and implementation, i.e., network engineers and designers at telecom companies, industrial research labs, etc. It will also appeal to final year undergrad and first year graduate students in EE, CE, and CS programs.

This timely book provides an overview of natural products/botanicals used for the management of insect-pest and diseases. It will help readers to update and widen their knowledge about natural products and their bio-activities against plant pathogens. The volume explores activity, chemistry, toxicity and geographic distribution of plants. Discussions concerning the methodology used for the detection of active principles, their mode of action and commercial prospects are of utmost importance and worthy of note.
* Focuses on recent achievements in natural bio-actives
* Global coverage of natural products / plants
* Targets the most important issues of natural botanicals/ biocides
* Includes innovative ideas with lucid explanations
* Contains specialized chapters, such as, natural control of multi-drug resistant organisms, anti-salmonella agents, natural house-dust-mite control agents, and naturally occurring anti-insect proteins, etc.
* Covers research on bioactives: From Lab to Field and Field to Market
* Includes eco-friendly and economically viable herbal technology

Real advances are not made in blind alleys (or culs-de-sac). In Social Psychology, as in every branch of science, the paths which appear to offer progress do not always result in theoretical elegance. Certain basic problems persistently defy final solution. This volume surveys the foundations and methods of Social Psychology with the aim of identifying ways out of the research maze. It examines the history and traditions of the field, looks at methodology and conceptual schemes, and discusses the actual research methods used.

The flavor of a food is often the most desirable quality characteristic for the consumer, yet the understanding of flavour is a fascinatingly complicated subject, which calls for interdisciplinary research efforts. This latest volume presents the proceedings of the 11th Weurman Flavour Research Symposium and describes the most recent and original research advances related to the flavour of foods and beverages with contributions of experts from 25 countries world-wide.
* Efficiently summarises the current front line research within food flavor
* Highlights the modern approaches to flavor production using biotechnology, enzymes and gene-technology
* The dynamic effects of manipulation of food in the mouth during consumption influencing the release of flavour compounds is discussed in detail

Time-to-contact is the visual information that observers use in fundamental tasks such as landing an airplane or hitting a ball. Time-to-contact has been a hot topic in perception and action for many years and although many articles have been published on this topic, a comprehensive overview or assessment of the theory does not yet exist. This book fills an important gap and will have appeal to the perception and action community. The book is divided into four sections. Section one covers the foundation of time-to-contact, Section two covers different behavioral approaches to time-to-contact estimation, Section three focuses on time-to-contact as perception and strategy, and Section four covers time-to-contact and action regulation.

This book is the latest volume in a highly successful series within Comprehensive Biochemistry and provides a historical and autobiographical perspective of the development of the field through the contributions of leading individuals who reflect on their careers and their impact on biochemistry. The book is essential reading for everybody, from graduate student to professor, placing in context major advances not only in biochemical terms but in relation to historical and social developments. Readers will be delighted by the lively style and the insight into the lives and careers of leading scientists of their time.

Location-based services (LBS) are a new concept integrating a user s geographic location with the general notion of services, such as dialing an emergency number from a cell phone or using a navigation system in a car. Incorporating both mobile communication and spatial data, these applications represent a novel challenge both conceptually and technically.
The purpose of this book is to describe, in an accessible fashion, the various concepts underlying mobile location-based services. These range from general application-related ideas to technical aspects. Each chapter starts with a high level of abstraction and drills down to the technical details. Contributors examine each application from all necessary perspectives, namely, requirements, services, data, and scalability. An illustrative example begins early in the book and runs throughout, serving as a reference.
. This book defines the LBS field and identifies its capabilities, challenges, and technologies.
. The contributors are recognized experts from academia and industry.
. Coverage includes navigation systems, middleware, interoperability, standards, and mobile communications.
. A sample application, the "find-friend" application, is used throughout the book to integrate the concepts discussed in each chapter."

This is the first volume to appear under the joint editorship of J.P. Hirth and F.R.N. Nabarro. While Volume 11 concentrated on the single topic of dislocations and work hardening, the present volume spreads over the whole range of the study of dislocations from the application by Kleman and his colleagues of homotopy theory to classifying the line and point defects of mesomorphic phases to Chaudhri's account of the experimental observations of dislocations formed around indentations.

Chapter 64, by Cai, Bulatove, Chang, Li and Yip, discusses the influence of the structure of the core of a dislocation on its mobility. The power of modern computation allows this topic to be treated from the first principles of electron theory, and with empirical potentials for more complicated problems. Advances in electron microscopy allow these theoretical predictions to be tested.

In Chapter 65, Xu analyzes the emission of dislocations from the tip of a crack and its influence on the brittle to ductile transition. Again, the treatment is predominantly theoretical, but it is consistently related to the very practical example of alpha iron.

In a dazzling interplay of experiment and abstract mathematics, Kleman, Lavrentovich and Nastishin analyze the line and point structural defects of the many mesomorphic phases which have become known in recent years.

Chapter 67, by Coupeau, Girard and Rabier, is essentially experimental. It shows how the various modern techniques of scanning probe microscopy can be used to study dislocations and their interaction with the free surface.

Chapter 68, by Mitchell and Heuer, considers the complex dislocations that can form in ceramic crystals on the basisof observations by transmission electron microscopy and presents mechanistic models for the motion of the dislocations in various temperature regimes.

While the underlying aim of the study of dislocations in energetic crystals by Armstrong and Elban in Chapter 69 is to understand the role of dislocations in the process of detonation, it has the wider interest of studying dislocations in molecular crystals which are elastically soft, plastically hard, and brittle''.

Chaudhri in Chapter 70 discusses the role of dislocations in indentation processes, largely on the basis of the elastic analysis by E.H. Yoffe. The special case of nanoindentations is treated only briefly.